化学家们也是做了大量的努力,如使用衍生的氟烷基化的劳森试剂,通过固相萃取分离,只不过这试剂看结构也知道价格感人。
但从后处理方法入手,或许2021年Beilstein J. Org. Chem. 上的一篇文献报道可以参考一下;
To a 500 mL three-necked flask, 42.3 g of N-p-methylphenylbenzamide (0.20 mol), 42.0 g of Lawesson’s reagent (0.104 mol), and 200 mL of toluene were added. The mixture was heated to reflux under a nitrogen atmosphere. The reaction was completed in 3 h by TLC monitoring. Then, to the cooled mixture, were added 100 mL of ethylene glycol (excess), together with 1.0 mL of water, and the resulting mixture was stirred at 95 °C. TLC monitoring of the toluene layer showed that the byproduct A from Lawesson’s reagent had disappeared after 3.5 h. The slightly cooled mixture was transferred to a separation funnel.分液,甲苯相根据物料情况选择处理方式;