点击上方蓝色文字进行关注
背景介绍
先转化为Weinreb 酰胺，再与锂试剂或格式试剂反应（为啥没有二烷基化？因为加成中间体比较稳定，只有在进一步酸性条件下淬灭，才会转化为酮）； 先转化为1, 3-二羰基化合物，再酸性下脱羧（为啥没有二烷基化？因为1, 3-二羰基化合物的中间碳的酸性也不弱）； 过渡金属催化的酯基的偶联反应，如镍等。
底物范围
实验操作
Reactions were performed on a 1.00 mmol scale unless otherwise noted. To a screw-cap vial with a magnetic stirbar was added sodium methanesulfinate (0.306 g, 3.00 mmol, 3.00 equiv.), lithium bis(trimethylsilyl)amide 1.0 M in toluene (3.00 mL, 3.00 mmol, 3.00 equiv.), and ester (1), (1.00 mmol, 1.00 equiv.). The final concentration of the limiting reagent (1) is 0.33 M. Then the vial was sealed and heated at 80 °C on a heating block for 3 h. The reaction mixture was cooled to ambient temperature, diluted with saturated aqueous ammonium chloride (4 mL per mmol of 3). The mixture was concentrated to dryness, and the product was purified on silica gel.
扫码关注我们
分子实用合成
了解更多合成方法
点了在看的人都很有趣~
点击左下角“阅读原文”，了解更多
