文献题目Hydroformylation and Late-Stage Diversification on Densely Functionalized Cores of Influenza Endonuclease Inhibitors 文献摘要Our approaches toward this goal encompass (i) the development of a modular, diastereoselective route to the tricyclic cores and (ii) the use of advanced intermediates for late-stage diversification. Key to realizing both strategies is the development of an efficient, functional group-tolerant, chemoselective hydroformylation step that can be executed in the presence of the metal binding motif common to this inhibitor family.