By taking a holistic approach, it was possible to assign
structures to all 15 degradation products above the reporting
threshold. For five degradation products (A2, D1, G, G1, and
H), the assignments were based upon the availability of
authentic samples. For four degradation products (A, B, C, and
D), the assignments were “tentative” as they were based purely
on mass spectrometry data. For six degradation products (A1,
A3, E, F, F1, and G2), the assignments were made following
NMR analysis of components derived from a forced
degradation sample. In all cases, the degradants were produced
through oxidative pathways, with all except Degradant G
incorporating additional oxygen molecules. Many of the
structures identified showed significant structural differences
from those of naloxone. For the ten degradants, where
authentic samples were not available, the structural assignments could be verified if samples were to be prepared by
chemical synthesis. 降解路径分析 降解路径分析 降解路径分析 降解路径分析 https://doi.org/10.1021/acs.oprd.4c00215
