DBU和DBN相比另外三个更容易水解开环 TBD can be considered a stronger nucleophile than DBU, DBN, TMG, or its analogue MeTBD. However, DBN should be significantly stronger than DBU or MeTBD, and DABCO should be the best base for this transformation, which is not in line with the results obtained previously
Bersacapavir的合成策略如下 化合物1和化合物2反应制备化合物3，继续和化合物4反应制备化合物5，后续制备API。
数据对比
从数据上看，当量的TBD数据很好，催化量的TBD和当量的DBU数据相似，催化量TBD并没有明显优势。 文献里的成本因素：At the time of this evaluation, here is a price comparison at 5 metric ton scale: TBD was charged about 70 USD/mol versus DBU at about 3 USD/mol
总体数据相似，催化量TBD路线，PMI降低有限，但是质量稍差 文献提示，最后基于质量因素仍选择DBU，team to select the DBU process for further production campaigns.
守恒方程式整理，体系释放氯仿，也会有杂质7产生 小编：这种羧基容易发生脱羧反应
如果采用DBU，可能需要研究下图杂质
TMG可能引入杂质
