内容简介
本研究论文结合多种表面改性技术在低模量钛合金表面构建功能复合改性层，利用含有纳米银和生物陶瓷的纳米管提升耐磨性、抗菌性能和体外生物相容性。理想的钛基关节植入物应避免应力屏蔽, 且具有良好的生物活性和抗感染性能。为满足这些要求, 研究人员以低弹性模量合金Ti–35Nb–2Ta–3Zr为基体, 采用阳极氧化、沉积和旋涂等方法制备含有生物陶瓷和银离子的功能涂层, 并将其涂覆在TiO2纳米管 ((80 ± 20) nm 和(150 ± 40) nm) 表面。研究了生物陶瓷 (nano-β-TCP, micro-HA, meso-CaSiO3) 和Ag纳米颗粒 ((50 ± 20) nm) 对纳米管的抗菌活性、摩擦、腐蚀和早期体外成骨行为的影响。摩擦和腐蚀结果表明, 磨损率和腐蚀速率与纳米管表面形貌密切相关。由于黏着磨损和磨粒磨损, 生物陶瓷micro-HA 表现出优异的耐磨性, 磨损率为(1.26 ± 0.06)×10–3 mm3/(N m)。生物陶瓷meso-CaSiO3显示出良好的细胞黏附、增殖能力和碱性磷酸酶活性。含有纳米银的涂层具有良好的抗菌活性, 对大肠杆菌的抗菌率 ≥ 89.5%。研究结果表明, 该功能涂层具有促进成骨的潜力。
引用本文（点击最下方阅读原文可下载PDF）
Wang Q, Liu J, Wu H, et al., 2024. Enhanced wear resistance, antibacterial performance, and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro. Bio-des Manuf 7(5):670–686. https://doi.org/10.1007/s42242-024-00279-1
文章导读
图1 (a) 功能复合改性层制备流程示意图；(b) TiNT、(c) TiNTAg、(d) TiNTAg@HA、(e) TiNTAg@CaSiO3、(f) TiNTAg@β-TCP的形貌图；(g-h) 银纳米颗粒在纳米管中的明场像；(i) 银纳米颗粒的高分辨透射图像；(j)银纳米颗粒的选区电子衍射图谱
图2 (a) 样品在SBF溶液中摩擦腐蚀的摩擦系数(虚线表示摩擦过程中各涂层的失效点)；(b) 磨道截面图；(c)磨损率；(d-i) βTi、TiNT、TiNTAg、TiNTAg@HA、TiNTAg@CaSiO3、TiNTAg@β-TCP摩擦腐蚀后的三维表面形貌
图3 (a-b) βTi、(c-d) TiNT、(e-f) TiNTAg、(g-h) TiNTAg@HA、(i-j) TiNTAg@CaSiO3、(k-l) TiNTAg@β-TCP的磨痕形貌；(m) TiNT和(n) TiNTAg@HA摩擦腐蚀示意图
图4 (a) 钙黄绿素荧光染色活细胞图；(b) CCK-8法评估MC3T3-E1细胞1、3和5天的细胞活性
图5 (a) 各样品在大肠杆菌中孵育12h的抑菌圈；(b) 各样品对大肠杆菌的抑菌率；(c) 平板涂布后大肠杆菌生长情况
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