成都大学胡旭麟博士等 | 3D打印神经再生支架材料、结构及神经重塑策略

文摘   2024-10-18 17:29   浙江  

内容简介


本综述论文聚焦于神经再生支架制造及3D打印神经再生支架的最新发展趋势和相关研究进展。神经再生对于治疗严重影响人类健康的骨科及神经系统疾病领域至关重要,其再生过程涉及各种细胞类型和信号通路之间复杂的相互作用。与手术和药物治疗相比,3D打印技术可以制造各种尺寸和形状的复杂结构支架和导管。3D打印还可以构建神经模型模仿神经的结构特性,有助于研究人员研究疾病机制和开发新疗法。3D打印支架虽然可实现高度仿生,但仍难以匹配复杂的神经环境。3D打印技术结合多种生物材料和药物,可以加速神经系统的病理研究和临床治疗,有望推动神经再生领域的发展与应用。文章在介绍基于3D打印技术构建神经再生支架的生物材料的基础上,系统阐述和分析如何提高支架神经再生能力和研发策略。


引用本文(点击最下方阅读原文可下载PDF)

He J, Qiao L, Li J, et al., 2024. Advanced strategies for 3D-printed neural scaffolds: materials, structure, and nerve remodeling. Bio-des Manuf 7(5):747–770. https://doi.org/10.1007/s42242-024-00291-5

文章导读



图1 神经再生支架的设计策略与构建方式


图2 3D打印技术制备的神经再生支架


图3 自体神经移植材料构建的3D神经再生支架


图4 3D打印神经支架促进周围神经再生


图5 促进骨修复的3D 打印神经支架

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Bio-Design and Manufacturing(中文名《生物设计与制造》),简称BDM,是浙江大学主办的专业英文双月刊,主编杨华勇院士、崔占峰院士,2018年新创,2019年被SCI-E等库检索,2023年起改为双月刊,年末升入《2023年中国科学院文献情报中心期刊分区表》医学一区,2024年公布的最新影响因子为8.1,位列JCR的Q1区,13/122。


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