内容简介
本研究论文聚焦药物研发中缺少合适工具以及动物实验的伦理问题，提出了模块化纸芯片概念，有望成为药物研发新工具。纸质微芯片具有生物相容性好、制作简单、易操作等优势，成为临床诊断等领域的理想材料。本研究描述了一种基于投影式3D打印（PBP）技术开发模块化3D纸基微流控芯片的方法。设计并制作了一系列2D纸基微流控模块。在评估了曝光时间对流道精度的影响后，分析了该流道的分辨率。此外，通过不同的方法，在2D芯片的基础上组装了3D纸基微流控芯片，其流道连接性良好。验证了基于3D纸基微流控芯片的支架式2D细胞培养和水凝胶式3D细胞培养系统的可行性。此外，通过将挤出式生物3D打印技术与所提出的3D纸基微流控芯片相结合，通过在3D纸基微流控芯片上直接打印3D水凝胶结构，建立了多器官微流控芯片，这证实了所制备的模块化3D纸基微流控芯片在生物医学应用中具有潜在的应用前景。
引用本文（点击最下方阅读原文可下载PDF）
Xie M, Fu Z, Lu C, et al., 2024. Rapid fabrication of modular 3D paper-based microfluidic chips using projection-based 3D printing. Bio-des Manuf 7(5):611–623. https://doi.org/10.1007/s42242-024-00298-y
文章导读
图1 基于投影式光固化3D打印技术制造模块化3D纸基微流控芯片示意图
图2 2D纸基模块的流道测试
图3 用于3D纸基微流控芯片的多功能模块设计
图4 3D纸基微流控芯片的装配方法与联通测试
图5 多器官微流控芯片的建立
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Bio-Design and Manufacturing（中文名《生物设计与制造》），简称BDM，是浙江大学主办的专业英文双月刊，主编杨华勇院士、崔占峰院士，2018年新创，2019年被SCI-E等库检索，2023年起改为双月刊，年末升入《2023年中国科学院文献情报中心期刊分区表》医学一区，2024年公布的最新影响因子为8.1，位列JCR的Q1区，13/122。
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