减肥药对关节炎有缓解作用
Clinical-trial participants saw their knee pain abate and could engage better with activities that got them up and going.
临床试验者发现，他们的膝关节疼痛减轻了，可以更好地站立、活动了。
A blockbuster weight-loss drug sharply reduces pain from obesity-related knee arthritis and improves a person’s ability to engage in activities such as walking. That’s according to a clinical trial conducted in 11 countries—the first of its kind to prove that one of the new wave of anti-obesity drugs can treat arthritis. The drug, semaglutide, provided pain relief on a par with opioid drugs.
一种减肥特效药能大幅减轻肥胖相关的膝关节炎疼痛，并提高患者行走等活动的能力。这是在11个国家进行的一项临床试验得出的结论，首次证明了减肥药可以治疗关节炎。该药物司美格鲁肽和阿片类药物有相同的止痛效果。（阿片类止痛片是从阿片（罂粟）中提取的生物碱及体内外的衍生物，与中枢特异性受体相互作用，能缓解疼痛）
At the end of the trial, many participants’ pain had subsided enough that they were no longer eligible for the study, says Henning Bliddal, a rheumatologist at Copenhagen University Hospital at Bispebejerg and Frederiksberg who helped to conduct the trial. “They got a therapy that was so effective that they more or less were treated out of the study,” he says.
协助这项研究的哥本哈根大学医院风湿病学家Henning Bliddal说，试验结束时，许多实验者的疼痛已经减轻，不再符合研究条件。他说：“他们得到了非常有效的治疗，因此他们不再符合研究。”
The results are “important and could be helpful” for people with knee osteoarthritis, says Leigh Callahan, an epidemiologist at the University of North Carolina, Chapel Hill.
北卡罗来纳大学教堂山分校的流行病学家Leigh Callahan说，这些结果对膝骨关节炎患者来说“非常重要，可能会有所帮助”。
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