《信号转导与靶向治疗》(Signal Transduction and Targeted Therapy,以下简称STTT)是信号转导与靶向治疗领域具有国际影响力和号召力的高水平学术期刊。期刊涵盖的学科包括基础医学、临床医学、分子生物学、细胞生物学、药理学、药物化学和生物信息学等,旨在从多学科交叉角度发表肿瘤、自身免疫病等人类疾病的分子机理、信号转导以及相关靶向治疗的最新研究进展。STTT目前已被国内外多个数据库收录,包括Science Citation Index Expanded(SCIE)(影响因子39.3),Journal Citation Reports/Science Edition,BIOSIS previews,Directory of Open Access Journals (DOAJ),MEDLINE,PubMed Central(PMC),Scopus和中国科学引文数据库(Chinese Science Citation Database,CSCD)核心库、中国科技核心期刊数据库、世界期刊影响力指数(WJCI)报告等。
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Meng, H., Liao, Z., Ji, Y. et al. FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection. Sig Transduct Target Ther 9, 104 (2024). https://doi.org/10.1038/s41392-024-01790-8
原文链接:
https://www.nature.com/articles/s41392-024-01790-8
广州国家实验室及广州医科大学刘会生/徐涛/赵金存团队于2024年4月23日在Signal Transduction and Targeted Therapy发表封面文章 “FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection”。研究团队利用胰岛类器官、临床样本和小鼠模型,系统研究了新冠感染下FGF7上调ACE2在胰岛(尤其是β细胞)中表达水平以及加重新冠对胰岛的侵染。(点击下方图片可查看封面文章详细解读)
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Cheng, B., Li, C., Li, J. et al. The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial. Sig Transduct Target Ther 9, 93 (2024). https://doi.org/10.1038/s41392-024-01799-z
原文链接:
https://www.nature.com/articles/s41392-024-01799-z
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Wang, H., Feng, J., Liu, Y. et al. Phase II study of novel orally PI3Kα/δ inhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma. Sig Transduct Target Ther 9, 99 (2024). https://doi.org/10.1038/s41392-024-01798-0
原文链接:
https://www.nature.com/articles/s41392-024-01798-0
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Chen, Y., Xu, Y., Chi, Y. et al. Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial. Sig Transduct Target Ther 9, 102 (2024). https://doi.org/10.1038/s41392-024-01793-5
原文链接:
https://www.nature.com/articles/s41392-024-01793-5
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Wang, J., Zhang, J., Yu, S. et al. Gene replacement therapy in Bietti crystalline corneoretinal dystrophy: an open-label, single-arm, exploratory trial. Sig Transduct Target Ther 9, 95 (2024). https://doi.org/10.1038/s41392-024-01806-3
原文链接:
https://www.nature.com/articles/s41392-024-01806-3
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