《信号转导与靶向治疗》（Signal Transduction and Targeted Therapy，以下简称STTT）是信号转导与靶向治疗领域具有国际影响力和号召力的高水平学术期刊。期刊涵盖的学科包括基础医学、临床医学、分子生物学、细胞生物学、药理学、药物化学和生物信息学等等，旨在从多学科交叉角度发表肿瘤、自身免疫病等人类疾病的分子机理、信号转导以及相关靶向治疗的最新研究进展。STTT目前已被国内外多个数据库收录，包括Science Citation Index Expanded（SCIE）（影响因子39.3），Journal Citation Reports/Science Edition，BIOSIS previews，Directory of Open Access Journals (DOAJ)，MEDLINE，PubMed Central（PMC），Scopus和中国科学引文数据库（Chinese Science Citation Database，CSCD）核心库、中国科技核心期刊数据库、世界期刊影响力指数（WJCI）报告等。
2023年第11期文章已全部上线，欢迎阅览。
封面文章：Zhang, TQ., Geng, ZJ., Zuo, MX. et al. Camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and hepatic artery infusion chemotherapy for hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (TRIPLET): a phase II study. Sig Transduct Target Ther 8, 413 (2023). https://doi.org/10.1038/s41392-023-01663-6
2023年10月27日，中山大学顾仰葵及吴沛宏研究团队共同在Signal Transduction and Targeted Therapy发表了题为“Camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and hepatic artery infusion chemotherapy for hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (TRIPLET): a phase II study”的研究论文，该研究评估了卡瑞利珠单抗和阿帕替尼联合HAIC-FOLFOX治疗BCLC C期HCC患者的益处。研究表明卡瑞利珠单抗、阿帕替尼和HAIC联合方案治疗巴塞罗那C期HCC患者具有良好的疗效和安全性。在不久的将来，三期临床试验可能会得出更有力的结论。
Feature Articles
Wang, Y., Tong, C., Lu, Y. et al. Characteristics of premanufacture CD8+ T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma. Sig Transduct Target Ther 8, 409 (2023). https://doi.org/10.1038/s41392-023-01659-2
Martin-Broto, J., Martinez-Garcia, J., Moura, D.S. et al. Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A. Sig Transduct Target Ther 8, 405 (2023). https://doi.org/10.1038/s41392-023-01661-8
Que, Y., Wang, J., Sun, F. et al. Safety and clinical efficacy of sintilimab (anti-PD-1) in pediatric patients with advanced or recurrent malignancies in a phase I study. Sig Transduct Target Ther 8, 392 (2023). https://doi.org/10.1038/s41392-023-01636-9
He, R., Zheng, X., Zhang, J. et al. SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals. Sig Transduct Target Ther 8, 393 (2023). https://doi.org/10.1038/s41392-023-01650-x
2023 Volume 8 Issue 11 目录
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