《信号转导与靶向治疗》（Signal Transduction and Targeted Therapy，以下简称STTT）是信号转导与靶向治疗领域具有国际影响力和号召力的高水平学术期刊。期刊涵盖的学科包括基础医学、临床医学、分子生物学、细胞生物学、药理学、药物化学和生物信息学等，旨在从多学科交叉角度发表肿瘤、自身免疫病等人类疾病的分子机理、信号转导以及相关靶向治疗的最新研究进展。STTT目前已被国内外多个数据库收录，包括Science Citation Index Expanded（SCIE）（影响因子40.8），Journal Citation Reports/Science Edition，BIOSIS previews，Directory of Open Access Journals (DOAJ)，MEDLINE，PubMed Central（PMC），Scopus和中国科学引文数据库（Chinese Science Citation Database，CSCD）核心库、中国科技核心期刊数据库、世界期刊影响力指数（WJCI）报告等。
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He, F., Wu, Z., Liu, C. et al. Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration. Sig Transduct Target Ther 9, 139 (2024). https://doi.org/10.1038/s41392-024-01838-9
原文链接：
https://www.nature.com/articles/s41392-024-01838-9
复旦大学基础医学院朱棣及王明伟共同通讯在Signal Transduction and Targeted Therapy 发表题为“Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration”的研究论文。研究团队发现靶向BCL9/BCL9L通过刺激cDC1 激活和浸润到肿瘤中来增强抗原呈递，用新型抑制剂hsBCL9z96或Bcl9/Bcl9l敲除小鼠抑制BCL9/BCL9L可显著延缓肿瘤生长并促进抗肿瘤CD8+ T细胞应答。（点击下方图片可查看封面文章详细解读）
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Zhou, B., Chen, J., Liu, T. et al. Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia: a multicenter, randomized, open-label, phase 3 trial. Sig Transduct Target Ther 9, 108 (2024). https://doi.org/10.1038/s41392-024-01820-5
原文链接：
https://www.nature.com/articles/s41392-024-01820-5
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Gao, Y., He, H., Li, X. et al. Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study. Sig Transduct Target Ther9, 121 (2024). https://doi.org/10.1038/s41392-024-01825-0
原文链接：
https://www.nature.com/articles/s41392-024-01825-0
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Yan, M., Gao, J., Lan, M. et al. DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure. Sig Transduct Target Ther 9, 127 (2024). https://doi.org/10.1038/s41392-024-01831-2
原文链接：
https://www.nature.com/articles/s41392-024-01831-2
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Shin, H.J., Lee, W., Ku, K.B. et al. SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation. Sig Transduct Target Ther 9, 125 (2024). https://doi.org/10.1038/s41392-024-01836-x
原文链接：
https://www.nature.com/articles/s41392-024-01836-x
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