图片来源：Org. Lett.
图片来源：Org. Lett.
图片来源：Org. Lett.
General Procedure for optimization of reaction conditions：
To a solution of substituted proline in anhydrous DCM (0.2 M) were added Tf2O and Et3SiH successively. The reaction mixture was stirred in a sealed tube at room temperature. After the reaction was completed (identified by TLC analysis), it was quenched with saturated NaHCO3 aqueous until the pH > 7. After separation of organic phase, the aqueous phase was extracted with DCM. The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The crude residue was purified by silica gel column chromatography using the indicated conditions to afford the desired products. Be cautious that toxic CO gas could be generated from the reaction system！
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