有感看到题目，第一感觉不像是单纯企业的文章Catalytic Activity of Triphenylphosphine for Electrophilic Aromatic Bromination Using N‑Bromosuccinimide and Process SafetyEvaluation直接看作者信息，验证了感觉Masahiro Hosoya − API R&D Laboratory, Pharmaceutical Technology Research Division, Shionogi and Co., Ltd., Toyonaka, Osaka 561-0825, Japan; Department of Chemical Science and Engineering, Kobe University, Kobe 657-8501, Japan; orcid.org/0000-0001-9605-9848; Kentaro Okano − Department of Chemical Science and Engineering, Kobe University, Kobe 657-8501, Japan; orcid.org/0000-0003-2029-8505; 再看内容，文章亮点值得一看，对于有些NBS溴代案例，采用加酸、加碱催化，效果不好，可以尝试一下加点三苯基膦 案例分享
实验操作A solution of 5d (8.00 g, 74.0 mmol) and triphenylphosphine (970.0 mg, 3.70 mmol, 0.05 equiv) in N,N-dimethylformamide (40 mL, 5.0 mL/g) was cooled to 0°C in a batch reactor (EasyMax 100 mL). To the batch reactor, N-bromosuccinimide (3.95 g, 22.2 mmol, 0.3 equiv) was added at 0 °C. The reaction mixture was stirred using a threeblade retreat curve impeller at 600 rpm at 0 °C for 30 min. Addition of N-bromosuccinimide and stirring for 30 min were further repeated 3 times (total amount of N-bromosuccinimide: 15.80 g, 88.8 mmol, 1.2 equiv). An aliquot of the reaction mixture (100 mg) was taken and quenched with 20 wt% aqueous solution of sodium hydrogen sulfite. 参考文献https://doi.org/10.1021/acs.oprd.4c00307
