前言
哺乳动物皮肤、气道和肠道等上皮屏障，是宿主免疫防御的第一道屏障。因而适应环境暴露，形成快速反应机制，是屏障组织的一种保守特性。
屏障组织，在接收新的刺激，形成免疫防御事件后，以最佳的方式进行记忆存储。当再次遇到外界微生物等信息时，他们快速检索之前的记忆存储，启动快速的免疫应答，以便第一时间间清除不良信息，保护机体。
经典免疫记忆（炎症记忆）被认为主要由适应性免疫系统承担，但是越来越多的研究显示，组织实质细胞也在参与免疫记忆。
记忆存储或检索中的偏差会使组织产生病理后果：记忆不足会导致感染增加；过度的记忆检索会导致慢性炎症；恶性肿瘤可能是由于记忆不足和过度记忆所致。
CD8+T细胞对于清除内病原体和恶性细胞至关重要。激活后，抗原特异性CD8+T细胞增殖并分化为一个异源群体，通过细胞溶解和炎性细胞因子提供免疫防御。
效应细胞群体的一部分是终末分化的-提供即时、急性的功能，在感染解决后凋亡。一部分形成表型，功能异质性的长期存活记忆性群体。
根据表型及功能，记忆T细胞可以分为六类，如下表：
基质细胞也可以表现出炎症记忆的特征。
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