区分17种B细胞的标志物

健康   2024-11-04 08:16   上海  


小鼠人类
B淋巴细胞祖细胞Lin- CD117- Ly6- Ly6D+ IL-7 Ra+ Flt-3+CD10+ CD34+ Pax5+
B1祖细胞Lin- CD45R low CD19+ CD93+--
B2祖细胞Lin- CD45R+ CD19- CD93---
Pre-Pro B cellLin- CD45R+ CD19- CD24 low CD43+  CD93+ CD117- CXCR4+
   FLt-3+ IL-7Ra+ IgM-
CD117 low CD10+ CD34+ CD38+ Pax5+
祖B细胞Lin- CD45R+ CD19+ CD24 + CD43+ CD117 low IL-7Ra+ IgM-CD117 low CD10+ CD19+ CD20+ CD24+ CD34+ CD38+ CD93+ IL3R+  IL-7 Ra+ Pax5+
前B细胞Lin- CD45R+ CD19+ CD24 + CD43- IL-7Ra+ IgM- CD117- CD10+ CD19+ CD20+ CD24+ CD34- CD38+  CD93+ IL-3 R+
   IL-4 Ra+ IL-7 Ra+ Pax5+
未成熟B细胞CD45R+ CD19+ CD23- CD24+ CD43- CD93+ IgD- IgM+ CD117- CD10+ CD19+ CD20+ CD21+ CD24+ CD27-  CD38+ CD40+
   CD93+ IL-4 Ra+ IL-7 Ra
B1a细胞CD1d mid CD5+ CD19 high CD23- CD43+--
B1b细胞CD1d mid CD5- CD19 high CD23- CD43+--
过渡性B细胞CD45R+ CD19+ CD24+ CD43- CD93+ IgM+ IgD low/+ (T1/T2) CD10 low CD5+ CD19+ CD20+ CD21+ CD23+ CD24+  CD27- CD38+
   CD93+ TACI+
边缘区B细胞CD45R+ CD1d+ CD19 mid CD21 high  CD23- CD43- CD93-
   IgM high IgD low
CD1c+ CD19+ CD20+ CD21+ CD27+  FCRL3+ TACI+
滤泡B细胞CD45R+ CD1d mid CD19 mid CD21  low CD23+ CD43- CXCR5
   + IgM low IgD high
CD10- CD19+ CD20+ CD21+ CD22+  CD23+ CD24 low CD27- CD38low CXCR5+ TAC+ MHC II+
活化生发中心B细胞CD45R+ CD19+ CD40+ MHC II+CD19+ CD20+ CD27+ CD38+ CD40+  CD83+ TACI+ MHC II+
记忆B细胞CD45R low CD19+ CD21+ CD27 mid/+ CD40+ MHC II+CD19+ CD20+ CD21+ CD27+ CD93-  TACI+
浆母细胞CD45R low CD19+ CD27 high CD38+ CD138+ BCMA+ CD19 low CD27 high CD38+ CD93+  CD138-/low
浆细胞CD45R low BLIMP1+ CD19- CD27  high CD38 low CXCR4 high
   CD138+ MHC II -/low
BCMA+ BLIMP1+ CD19 low CD20-/low  CD27 high CD38 high CD138 + CXCR4+ MHC II low
调节性B细胞CD1d+ CD5+ CD19+ CD23-/low CD24+ CD93-/low TIM-1+ IL-10+  IL-35+ TGF-b+CD1d+ CD5+ CD19+ CD21+ CD24+  IL-10+ IL-35+ TGF-b+

闲谈 Immunology
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