小鼠 | 人类 | |
B淋巴细胞祖细胞 | Lin- CD117- Ly6- Ly6D+ IL-7 Ra+ Flt-3+ | CD10+ CD34+ Pax5+ |
B1祖细胞 | Lin- CD45R low CD19+ CD93+ | -- |
B2祖细胞 | Lin- CD45R+ CD19- CD93- | -- |
Pre-Pro B cell | Lin- CD45R+ CD19- CD24 low CD43+
CD93+ CD117- CXCR4+ FLt-3+ IL-7Ra+ IgM- | CD117 low CD10+ CD34+ CD38+ Pax5+ |
祖B细胞 | Lin- CD45R+ CD19+ CD24 + CD43+ CD117 low IL-7Ra+ IgM- | CD117 low CD10+ CD19+ CD20+ CD24+ CD34+ CD38+ CD93+ IL3R+ IL-7 Ra+ Pax5+ |
前B细胞 | Lin- CD45R+ CD19+ CD24 + CD43- IL-7Ra+ IgM- | CD117- CD10+ CD19+ CD20+ CD24+ CD34- CD38+
CD93+ IL-3 R+ IL-4 Ra+ IL-7 Ra+ Pax5+ |
未成熟B细胞 | CD45R+ CD19+ CD23- CD24+ CD43- CD93+ IgD- IgM+ | CD117- CD10+ CD19+ CD20+ CD21+ CD24+ CD27-
CD38+ CD40+ CD93+ IL-4 Ra+ IL-7 Ra |
B1a细胞 | CD1d mid CD5+ CD19 high CD23- CD43+ | -- |
B1b细胞 | CD1d mid CD5- CD19 high CD23- CD43+ | -- |
过渡性B细胞 | CD45R+ CD19+ CD24+ CD43- CD93+ IgM+ IgD low/+ (T1/T2) | CD10 low CD5+ CD19+ CD20+ CD21+ CD23+ CD24+
CD27- CD38+ CD93+ TACI+ |
边缘区B细胞 | CD45R+ CD1d+ CD19 mid CD21 high
CD23- CD43- CD93- IgM high IgD low | CD1c+ CD19+ CD20+ CD21+ CD27+ FCRL3+ TACI+ |
滤泡B细胞 | CD45R+ CD1d mid CD19 mid CD21
low CD23+ CD43- CXCR5 + IgM low IgD high | CD10- CD19+ CD20+ CD21+ CD22+ CD23+ CD24 low CD27- CD38low CXCR5+ TAC+ MHC II+ |
活化生发中心B细胞 | CD45R+ CD19+ CD40+ MHC II+ | CD19+ CD20+ CD27+ CD38+ CD40+ CD83+ TACI+ MHC II+ |
记忆B细胞 | CD45R low CD19+ CD21+ CD27 mid/+ CD40+ MHC II+ | CD19+ CD20+ CD21+ CD27+ CD93- TACI+ |
浆母细胞 | CD45R low CD19+ CD27 high CD38+ CD138+ | BCMA+ CD19 low CD27 high CD38+ CD93+ CD138-/low |
浆细胞 | CD45R low BLIMP1+ CD19- CD27
high CD38 low CXCR4 high CD138+ MHC II -/low | BCMA+ BLIMP1+ CD19 low CD20-/low CD27 high CD38 high CD138 + CXCR4+ MHC II low |
调节性B细胞 | CD1d+ CD5+ CD19+ CD23-/low CD24+ CD93-/low TIM-1+ IL-10+ IL-35+ TGF-b+ | CD1d+ CD5+ CD19+ CD21+ CD24+ IL-10+ IL-35+ TGF-b+ |