翻译：李雪瑶 徐州医科大学2023级麻醉学研究生
审校：陈立平 徐州医科大学附属医院疼痛科
《PAIN》2024年11月刊，第165卷，第11期
Commentary 评论
1. A global look at RNA splicing in human dorsal root ganglion: ex uno plures.
全局观察人类背根神经节中RNA的非单克隆剪接过程。
2. Pain after cancer: navigating the complexities and embracing psychological insights.
癌症后的痛苦：驾驭其复杂性并接受其心理学的见解。
3. An attempt to identify nociceptive and nociplastic pain profiles using a clinical test for joint pain.
尝试使用临床测试来识别关节痛中伤害感受性疼痛和伤害性疼痛的特征。
4. “Belief-based” medicine is not evidence-based medicine.
“基于信念”的医学不是循证医学。
Topical Review专题综述
Biomarkers of stress as mind–body intervention outcomes for chronic pain: an evaluation of constructs and accepted measurement.
将压力的生物标志物作为慢性疼痛身心干预的结果：对其结构和公认测量的评估。
Narrative Review 叙述性综述
Bruxism, temporomandibular disorders, and headache: a narrative review of correlations and causalities.
磨牙症、颞下颌关节紊乱和头痛：相关性和因果关系的叙述性综述。
Systematic Review and Meta-Analysis 系统综述和荟萃分析
1. A systematic literature review on patient-reported outcome domains and measures in nonsurgical efficacy trials related to chronic pain associated with endometriosis: an urgent call to action.
在子宫内膜异位症相关的慢性疼痛患者中，有关非手术疗效试验的报告结果和措施形成的系统文献综述：紧急呼吁采取行动。
2. Use of patient-reported global assessment measures in clinical trials of chronic pain treatments: ACTTION systematic review and considerations.
在慢性疼痛治疗的临床试验中使用患者报告的全球评估措施：对ACTTION的系统综述及考虑。
3. The bidirectional relationship between sleep problems and chronic musculoskeletal pain: a systematic review with meta-analysis.
睡眠与慢性肌肉骨骼疼痛之间的双向关系：一项系统综述与荟萃分析。
Research Paper 研究论文
1.RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing.
长读序列生成的人类背根神经节RNA异构体表达图谱。
2.Translation of paclitaxel-induced peripheral neurotoxicity from mice to patients: the importance of model selection.
紫杉醇诱导的小鼠周围神经毒性向患者的转移：模型选择的重要性。
3.Probing white matter microstructure in youth with chronic pain and its relation to catastrophizing using neurite orientation dispersion and density imaging.
使用神经突定向弥散和密度成像来探测慢性疼痛的青少年白质微观结构及其与灾难化的关系
4.The associations of opioid and benzodiazepine prescriptions with injuries among US military service members.
阿片类药物和苯二氮卓类药物处方与美国军人受伤的关联。
5.Who develops chronic pain after an acute lower limb injury? A longitudinal study of children and adolescents.
谁在急性下肢损伤后会出现慢性疼痛？对儿童和青少年的纵向研究。
6.A cellular mechanism contributing to pain-induced analgesia.
一种有助于疼痛诱导镇痛的细胞机制。
7.Terpenes from Cannabis sativa induce antinociception in a mouse model of chronic neuropathic pain via activation of adenosine A2A receptors.
从大麻中提取的萜内酯通过激活腺苷A2A受体来诱导慢性神经性疼痛小鼠模型的抗伤害。
8.Characterization of chronic pain, pain interference, and daily pain experiences in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.
癌症儿童成年幸存者的慢性疼痛、疼痛干扰和日常疼痛经历的特征：一份来自癌症儿童幸存者研究的报告。
9.Physiological profiling of cannabidiol reveals profound inhibition of sensory neurons.
大麻二醇的生理特征揭示了其对感觉神经元的深刻抑制。
10.Job stress and chronic low back pain: incidence, number of episodes, and severity in a 4-year follow-up of the ELSA-Brasil Musculoskeletal cohort.
工作压力与慢性腰痛：4年随访中ELSA-Brasil肌肉骨骼队列的发病率、发作次数和严重程度。
11.Peripherally restricted cannabinoid and mu-opioid receptor agonists synergistically attenuate neuropathic mechanical hypersensitivity in mice.
外周限制性大麻素和μ-阿片受体激动剂协同减弱小鼠的神经性机械超敏反应。
12. A randomised controlled trial of the effect of intra-articular lidocaine on pain scores in inflammatory arthritis.
关节内注射利多卡因对炎性关节炎疼痛评分的影响：一项随机对照试验。
13.Investigating neuroepigenetic alterations in chronic low back pain with positron emission tomography.
使用正电子发射断层扫描研究慢性腰痛的神经表观遗传学改变。
14. Influence of chronotype on pain incidence during early adolescence.
睡眠时间类型对青春期早期疼痛发生率的影响。
15. Efficacy of naproxen in patients with sciatica: multicenter, randomized, double-blind, placebo-controlled trial.
萘普生治疗坐骨神经痛的疗效：一项多中心、随机、双盲、安慰剂对照试验。
Abstract：This trial assessed the efficacy of naproxen in patients with sciatica in outpatient clinics across 4 Norwegian hospitals. A total of 123 adults with radiating pain below the knee (≥4 on a 0-10 numeric rating scale) and signs consistent with nerve root involvement were included. Participants were randomized to receive either naproxen 500 mg or a placebo twice daily for 10 days. The primary outcome, daily leg pain intensity measured on a 0 to 10 numeric rating scale throughout the treatment period, revealed a statistically significant difference in favor of naproxen, with an adjusted mean difference of −0.5 (95% CI −0.8 to −0.1, P = 0.015). In the naproxen group, the treatment effect was significantly related to time, and over the whole 10-day period, the average adjusted difference was −0.6 (95% CI −0.8 to −0.5). Mean numbers needed to treat for 30% and 50% improvement were 9.9 (95% CI 4.7-15.0) and 20.7 (8.7-32.7), respectively. The adjusted mean difference for back pain was −0.4 (95% CI −0.8 to 0.0), and for Roland Morris Disability Questionnaire for Sciatica, it was −1.5 (95% CI −3.0 to 0.0). No differences were found for sciatica bothersomeness or consumption of rescue medication or opioids. Participants in the naproxen group exhibited an adjusted odds ratio of 4.7 (95% CI 1.3-16.2) for improvement by 1 level on the global perceived change scale. In conclusion, naproxen treatment showed small, likely clinically unimportant benefits compared with placebo in patients with moderate-to-severe sciatica.
摘要：该试验评估了挪威4家医院门诊使用萘普生治疗坐骨神经痛患者的疗效。该试验共纳入 123名患有膝下放射痛（0-10 数字评定量表 ≥4）及神经根受累症状一致的成年人。参与者被随机分配至接受萘普生500mg组或安慰剂组，每天给药两次，持续10天。主要结局为整个治疗期间以0到10数字评定量表测量的每日腿痛强度，结果显示与安慰剂组相比，萘普生组具有显著的统计学差异，调整后的平均差异为-0.5（95% CI -0.8 至 -0.1，P = 0.015）。在萘普生组中，治疗效果与时间显著相关：在10天内，平均调整差异为 -0.6 （95% CI -0.8 至 -0.5）。达到改善30%和50%疼痛疗效所需的平均治疗人数分别为9.9（95% CI 4.7-15.0） 和20.7（8.7-32.7）。背部疼痛调整后的平均差异为- 0.4 (95% CI为- 0.8至0.0)，Roland Morris残疾问卷对坐骨神经痛的调整后平均差异为- 1.5（95% CI为- 3.0至0.0）。在坐骨神经痛的困扰、急救药物或阿片类药物的消耗方面未发现差异。萘普生组的参与者在整体感知变化量表上改善1个水平的调整优势比为4.7 （95% CI 1.3-16.2）。总之，在中重度坐骨神经痛患者中，与安慰剂相比，萘普生治疗显示出很小的、可能临床上不重要的益处。
16. Diversity of microglial transcriptional responses during opioid exposure and neuropathic pain.
在阿片类药物暴露和神经性疼痛期间小胶质细胞转录反应的多样性。
17. Burden of chronic pain among adult pastoralists in Ethiopia: a cross-sectional household survey.
埃塞俄比亚成年牧民的慢性疼痛负担：一项横断面家庭调查。
Abstract：Chronic pain is a major global health problem. Untreated pain causes particular suffering in marginalized communities. Most studies investigating chronic pain in sub-Saharan Africa stem from South Africa and Nigeria. Pastoralists are particularly underrepresented in pain research. The main objective of this study is to investigate the burden of chronic pain in adult pastoralists in the Somali Regional State of Ethiopia. We conducted a cross-sectional household survey among adult pastoralists (aged 18 years or older, N = 299) by face-to-face interviews. To randomly select households, we applied GPS-based household localization and recruitment. Chronic pain was self-reported by 17.0% (95% CI: 10.8-25.7) of male and 34.7% (95% CI: 28.4-41.5) of female adult pastoralists. The prevalence of chronic pain increased with age from 5.4% (95% CI: 0.8-30.1; 18-34 years) to 27.1% (95% CI: 15.1-43.7; 35-54 years) to 69.1% (95% CI: 53.7-81.1; 55 years and older). The body sites most commonly affected among those with chronic pain were knees (37.2%), followed by lower back (33.7%) and head (23.3%). The data for the first time provide insights into the burden of chronic pain among Somali pastoralists and reveal associated risk factors. The results support the planning of locally adapted health interventions for pastoralist-specific pain management considering the effects of chronic pain on pastoralists' daily lives.
摘要：慢性疼痛是一个主要的全球健康问题。未经治疗的疼痛在边缘化社区造成了特别的痛苦。大多数调查撒哈拉以南非洲地区慢性疼痛的研究都来自南非和尼日利亚。牧民在疼痛研究中的代表性尤其不足。本研究的主要目的是调查埃塞俄比亚索马里地区成年牧民的慢性疼痛负担。我们通过面对面访谈对成年牧民（18岁或以上，N = 299）进行了横断面家庭调查。为了随机选择住户，我们采用了基于GPS的住户定位和招募模式。17.0% （95% CI：10.8-25.7） 的男性和 34.7% （95% CI：28.4-41.5） 的女性成年牧民自我报告了慢性疼痛。慢性疼痛的患病率随年龄增长，从5.4%（95% CI：0.8-30.1;18-34岁）增加到27.1%（95% CI：15.1-43.7;35-54岁）到 69.1%（95% CI：53.7-81.1;55 岁及以上）。慢性疼痛患者最常受影响的身体部位是膝盖（37.2%），其次是下背部（33.7%）和头部（23.3%）。这些数据首次提供了对索马里牧民慢性疼痛负担的见解，并揭示了相关的风险因素。考虑到慢性疼痛对牧民日常生活的影响，研究结果支持针对牧民管理特定疼痛制定适合当地的健康干预措施。
18. Musculoskeletal pain among Chinese women during the menopausal transition: findings from a longitudinal cohort study.
中国女性绝境过渡期的肌肉骨骼疼痛：一项纵向队列研究的结果。
Correspondence 信函
1.Musculoskeletal pain during menopausal transition.
绝经过渡期的肌肉骨骼疼痛。
2.Reply to Li et al.
回复Li et al。
