翻译：白钰阳 徐州医科大学2024级麻醉学研究生
审校：陈立平 徐州医科大学附属医院疼痛科
《European Journal of Pain 》2024年11月刊，第28卷第10期
《European Journal of Pain 》2024年10月刊，第28卷第9期
《European Journal of Pain 》2024年9月刊，第28卷第8期
《European Journal of Pain 》2024年8月刊，第28卷第7期
《European Journal of Pain 》2024年7月刊，第28卷第6期
ORIGINAL ARTICLE论著
1.Prescribing pattern insights from a longitudinal study of older adult inpatients with polypharmacy and chronic non-cancer pain
一项多药物治疗和慢性非癌性疼痛的老年住院患者的纵向研究的处方模式见解
2.Topically applied novel TRPV1 receptor antagonist, ACD440 Gel, reduces evoked pain in healthy volunteers, a randomized, double-blind, placebo-controlled, crossover study
一项随机、双盲、安慰剂对照、交叉研究表明，局部应用新型TRPV1受体拮抗剂ACD440凝胶可减轻健康志愿者的诱发疼痛。
3.Potential analgesic effect of a novel cannabidiol nanocrystals powder for the treatment of neuropathic pain
新型大麻二酚纳米晶体粉末在神经病理性疼痛治疗中的潜在镇痛作用
Abstract
Background:The current analgesics often prevent patients from getting effective treatment due to their adverse effects. Cannabidiol (CBD) is well tolerated, has few side effects and has been extensively investigated in analgesia. However, its oral bioavailability is extremely low. In order to solve this problem, we developed the cannabidiol nanocrystals (CBD-NC) in the earlier stage.
Methods:In this study, we evaluated the nociceptive behaviours associated with neuropathic pain (NP) induced by the spared nerve injury (SNI) model. Assessment of pain threshold was evaluated by paw withdraw threshold (PWT) and paw withdrawal latency (PWL). The improving effect on the motor dysfunction was determined by rota-rod testing. To assess the neuroprotective effect, nerve demyelination and expression of peripheral myelin protein PMP22 were measured with myelin sheath staining and western blotting. Protein expressions in microglia of spinal cord were tested by western blot to explore the underlying mechanism.
Results:Compared with the CBD oil solution, CBD-NC significantly reduced mechanical allodynia and thermal hyperalgesia in rats. CBD-NC could improve motor dysfunction induced by SNI in rats, significantly reverse the demyelination and increase the expression of the marker protein of peripheral myelin. Underlying spinal analgesic mechanism of microglia and related factors were preliminarily confirmed.
Conclusions:CBD-NC administration is an effective treatment for NP associated with SNI, and the analgesic effect of CBD-NC was significantly better than that of CBD oil sol. By contrast, CBD-NC has a fast-acting and long-term effect in the treatment of NP. Our study further supports the potential therapeutic effect of CBD-NC on NP.
Significance:The absolute bioavailability of the CBD-NC intramuscular injection formulation can reach 203.31%, which can solve the problem of low oral bioavailability. This research evaluated the therapeutic effect of CBD-NC on NP associated with the SNI model for the first time. All available date showed that whatever the analgesic or neuroprotective effect of CBD-NC, it was significantly better than that of CBD oil sol., which was consistent with the results of the pharmacokinetic. This research supports the initiation of more trials testing the efficacy of CBD-NC for treating NP.
摘要
背景：目前的镇痛药因其不良反应而常常无法使患者获得有效的治疗。大麻二酚(CBD)具有良好的耐受性，副作用少，并且在镇痛方面得到了广泛的研究。然而，其口服生物利用度极低。为了解决这个问题，我们在早期阶段开发了大麻二酚纳米晶体（CBD-NC）。
方法：在这项研究中，我们评估了由节段性神经损伤（SNI）模型诱导的神经性疼痛 （NP） 相关的痛觉行为。通过缩爪阈值（PWT）和缩爪潜伏期（PWL）来评估疼痛阈值。通过旋转杆试验评估了运动功能障碍的改善效果。为了评估神经保护作用，通过髓鞘染色和 Western blot测量神经脱髓鞘和外周髓鞘蛋白PMP22的表达。通过Western blot检测脊髓小胶质细胞中的蛋白质表达，探索其作用机制。
结果：与CBD油溶液相比，CBD-NC显著降低了大鼠的机械性痛觉过敏和热痛觉过敏。CBD-NC可以改善SNI诱导的大鼠运动功能障碍，显著逆转脱髓鞘，增加外周髓鞘标记蛋白的表达。初步证实了小胶质细胞的潜在脊髓镇痛机制和相关因素。
结论：CBD-NC给药是治疗与 SNI相关的NP的有效方法，且CBD-NC的镇痛效果明显优于CBD油溶胶。相比之下，CBD-NC在治疗NP方面具有快速和长期的效果。我们的研究进一步支持CBD-NC对NP的潜在治疗效果。
意义：CBD-NC肌肉注射制剂的绝对生物利用度可达203.31%，可以解决口服生物利用度低的问题。本研究首次评估了CBD-NC对与SNI模型相关的NP的治疗效果。所有可用的数据都表明，无论CBD-NC的镇痛或神经保护作用如何，都明显优于CBD油溶胶，这与药代动力学的结果一致。这项研究支持开展更多试验，以验证CBD-NC治疗NP的疗效。
4.IL18 rs360717 and rs187238 genetic variants are associated with migraine diagnosis
白介素18 rs360717和rs187238遗传变异与偏头痛诊断相关
5.Enhancing placebo analgesia: Unravelling the powerful interplay of ownership and verbal suggestion
增强安慰剂镇痛效应：揭示所有权与口头建议的强大相互作用
6.General practitioners' and community pharmacists' beliefs and practices on opioids for non-malignant pain
全科医生和社区药剂师对阿片类药物治疗非恶性疼痛的看法和经验
7.Nocebo belief and attitudes towards side effect disclosure: A general population-based online survey in Europe and North America
Nocebo 对副作用披露的信念和态度：一项基于欧洲和北美一般人群的在线调查
8.European randomized controlled trial evaluating differential target multiplexed spinal cord stimulation and conventional medical management in subjects with persistent back pain ineligible for spine surgery: 24-month results
欧洲随机对照试验评估差异性靶向多重脊髓刺激与传统医疗管理在不适合脊柱手术的持续性背痛患者中的疗效：24个月的结果
Abstract
Background：Differential target multiplexed spinal cord stimulation (DTM SCS) was shown to be superior to conventional SCS for treating chronic low back pain (CLBP) in subjects with persistent spinal pain syndrome with previous spinal surgery (PSPS-T2) or ineligible for it (PSPS-T1). This study reports 24-month efficacy and safety of DTM SCS vs. conventional medical management (CMM) in PSPS-T1 subjects across four European countries.
Methods：This is a prospective, multicenter, open-label, randomized, controlled trial with optional crossover. Subjects randomized 1:1 to DTM SCS or CMM. Primary endpoint was responder rate (% subjects reporting ≥50% CLBP relief) at 6 months. A superiority test compared responder rates between treatments. CLBP and leg pain levels, functional disability, quality of life (QoL), patient satisfaction and global impression of change were evaluated for 24 months. A Composite Responder Index (CRI) was obtained using CLBP relief, disability and QoL. Incidence of study-related adverse events evaluated safety.
Results：A total of 55 and 57 subjects were randomized to DTM SCS and CMM respectively. DTM SCS was superior, with CLBP responder rates ≥80% and CLBP relief >5.6 cm (>70% reduction) through the 24-month follow-up. Improvements with DTM SCS in other outcomes were sustained. The CRI was >80% for DTM SCS through 24 months. Opioid medication intake decreased in subjects treated with DTM SCS. Most patients treated with DTM SCS felt satisfied and improved at the end of the study. Safety was congruent with other studies.
Conclusion：DTM SCS is efficacious and safe during 24 months for the treatment of CLBP and leg pain in PSPS-T1 patients ineligible for spine surgery.
Significance statement：This randomized controlled trial shows that Differential Target Multiplexed SCS (DTM SCS) is an effective and safe long-term treatment for PSPS type 1 patients suffering from axial low back pain with or without leg pain and who are ineligible for spinal surgery. Currently, CMM treatments are their only option and provide limited benefits. Besides superior pain relief, DTM SCS provides significant improvements in functional disability, quality of life, high levels of satisfaction and perceived impression of change.
摘要
背景：差异性靶向多重脊髓刺激（DTM SCS）在治疗既往接受过脊柱手术（PSPS-T2）或不符合脊柱手术条件（PSPS-T1）的持续性脊柱疼痛综合征患者的慢性腰痛（CLBP）方面优于传统 SCS。本研究报告了DTM SCS与常规医疗管理（CMM）在四个欧洲国家的 PSPS-T1 受试者中的24个月疗效和安全性。
方法：这是一项前瞻性、多中心、开放标签、随机对照试验，可选择交叉。受试者以 1：1的比例随机分配到DTM SCS或CMM组。主要结局是6个月时的应答率（报告CLBP缓解≥50%的受试者百分比）。优效性检验比较了不同治疗之间的应答率。连续评估了24个月CLBP和腿部疼痛水平、功能障碍、生活质量（QoL）、患者满意度和整体变化印象。综合反应指数（CRI）由CLBP 缓解、残疾和QoL组成。研究相关不良事件的发生率用于评估安全性。
结果：共有55名和57名受试者分别被随机分配到DTM SCS和CMM组。DTM SCS的效果优于CMM，在24个月的随访中，CLBP应答率为≥80%，CLBP缓解程度>5.6 cm（减少>70%）。DTM SCS在其他结局指标中的改善是持续的。DTM SCS 24个月内的CRI为>80%。接受DTM SCS治疗的受试者的阿片类药物摄入量减少。大多数接受DTM SCS治疗的患者在研究结束时表示满意和改善。安全性与其他研究一致。
结论：对于不适合脊柱手术的PSPS-T1患者，DTM SCS在24个月内治疗的CLBP和腿部疼痛是有效且安全的。
重要性声明：这项随机对照试验表明，对于患有轴性下背痛（伴或不伴腿痛）且不适合脊柱手术的PSPS 1型患者，差异性靶向多重脊髓刺激（DTM SCS）是一种有效且安全的长期治疗方法。目前，CMM 治疗是他们唯一的选择，而且疗效有限。除了提供优越的疼痛缓解外，DTM SCS还在功能障碍、生活质量、高满意度和感知变化印象方面也有显著改善。
9.Chronic fatigue in the general population: Prevalence, natural course and associations with chronic pain (the HUNT pain study)
一般人群中的慢性疲劳：患病率、自然病程和与慢性疼痛的关系（HUNT疼痛研究）
10.High-frequency, high-intensity TENS compared to standard treatment with opioids for postoperative pain relief after laparoscopic cholecystectomy: A multicentre randomized controlled trial
高频高强度经皮电神经刺激与阿片类药物标准治疗在腹腔镜胆囊切除术后疼痛缓解的比较：一项多中心随机对照试验
11.Spatiotemporal characterization of an experimental model of muscle pain in humans based on short-wave diathermy
基于短波透热疗法的人体肌肉疼痛实验模型的时空特征分析
12.Primary care seeking among adults with chronic neck and low back pain in Norway: A prospective study from the HUNT study linked to Norwegian primary healthcare registry
挪威成人慢性颈部和下背痛的初级保健寻求：一项与挪威初级保健注册相关的HUNT研究的前瞻性研究
13.Dectin-1 induces TRPV1 sensitization and contributes to visceral hypersensitivity of irritable bowel syndrome in male mice
Dectin-1诱导TRPV1致敏并导致雄性小鼠肠易激综合征的内脏超敏反应
14.Temporomandibular disorder pain is associated with increased sick leave and reduced health related quality of life
颞下颌关节紊乱疼痛与病例增加和健康生活相关质量降低相关
15.Short- and medium-term effects of a single session of pain neuroscience education on pain and psychological factors in patients with chronic low back pain. A single-blind randomized clinical trial
单次疼痛神经科学教育对慢性腰痛患者疼痛和心理因素的中短期影响：一项单盲随机临床试验
16.Topical capsaicin modulates the two-point discrimination threshold—Modulation depends on stimulation modality and intensity
外用辣椒素调节两点鉴别阈值—调节取决于刺激方式和强度
