药明康德有机合成路线设计擂台赛2023年第四期竞赛试题
学术
科技
2023-10-27 11:20
上海
各位化学同仁:
金秋十月,日渐寒凉,街头巷尾氤氲着桂花的香气。几片泛黄的梧桐叶盘旋而下,预示着秋日的来临。自古逢秋悲寂寥,然久违的清爽为人们带来自省的宁静。天高云淡,更胜春朝。
药明康德有机合成路线设计擂台赛近日于上海、天津、武汉、南通及成都五个赛区再度拉开序幕。化学技术部悉心整理好本期的竞赛试题,在此分享给大家。文末附有往期试题,供君一览。秉承惯例,试题解析还将以网络直播的形式择时分享,敬请关注!
1. 请写出以下多步转化的产物结构(每题4分,共计20分; 相对构型需要标注明确)。Please provide the structures of products after multi-step transformations (20 points, 4 points for each question; the Relative Configuration needs to be clearly labeled).Please propose two reasonable synthetic routes to synthesize below target starting from commercially available reagents (20 points).3. 使用不同的关环策略设计两条路线合成以下化合物(20分)。 Please propose two reasonable synthetic routes to synthesize below target starting from commercially available reagents (20 points).4. 使用不同的关环策略设计两条路线合成以下化合物(20分)。Please propose two reasonable synthetic routes to synthesize below target starting from commercially available reagents (20 points).Please propose one reasonable synthetic route to synthesize below target starting from commercially available reagents (20 points).Please propose two reasonable synthetic route to synthesize below chiral target starting from commercially available reagents (20 points).感谢回顾往期竞赛试题及解析,如有任何建议,欢迎留言交流讨论!