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结直肠癌免疫治疗持续探索并不断取得新突破
抗血管生成药物联合治疗 mCRC 前景可期
免疫及靶向新药探索是 mCRC 治疗新方向
邓艳红 教授
中山大学附属第六医院
● 教授、主任医师、博士生导师,博士后合作导师,
● 中山大学医学院肿瘤教研室主任
● 中山大学附属第六医院副院长,高质量发展办公室主任,肿瘤科主任,国家药物临床试验机构主任,消化系统疾病学部主任
● 留学美国西雅图Fred Hutchinson/华盛顿大学癌症研究中心。主持开展的FOWARC研究2次获得ASCO口头报告,OPTICAL研究获2022年ASCO口头报告,并在J Clin Oncol、JAMA、Lancet Oncology等高水平学术期刊发表论文140余篇,其中第一作者或通信作者70余篇。主持多项国家重点研发计划(课题)、国家自然科学基金、广东省自然科学基金等。获得国家级高层次人才,广东省特支计划青年拔尖人才,广东省医学杰出青年人才,2016年国家科技进步二等奖(第五),2018年广东省科技进步一等奖(第四),第六届中国女医师协会五洲女子科技奖,2023年广东省先进女职工,2023年广东省五一劳动奖章获得者等。
● 中国结直肠癌诊疗规范(国家卫健委)专家组成员
● 中国抗癌协会大肠癌整合科普专业委员会副主任委员
● 中国抗癌协会肿瘤精准治疗专业委员会常委
● 中国抗癌协会整合肿瘤学分会常委
● 中国抗癌协会肿瘤支持与营养治疗专业委员会常委
● 中国临床肿瘤学会结直肠专家委员会常委
● 中国医师协会结直肠专业委员会青年委员会副主任委员
● 中国南方肿瘤临床研究协会结直肠癌专业委员会副主委
● 广东省医学会肿瘤学分会副主任委员
● 广东省研究型医院学会秘书长
● 广东省南方肿瘤临床研究学会副会长
肖像获得专家知情同意
审批码:PP-FR-CN-1376
参考文献:
[1] Chalabi M, et al. Neoadjuvant immunotherapy in locally advanced MMR-deficient colon cancer: 3-year disease-free survival from NICHE-2. 2024 ESMO LBA24.
[2] GOOYER P D, VERSCHOOR Y, DUNGEN L V, et al. Neoadjuvant nivolumab plus Relatlimab in MMR-deficient Colon Cancer: Results of the NICHE-3 Study. 2024 ESMO. 503O.
[3] Tougeron D et al. Pembrolizumab in combination with CAPOX and bevacizumab in patients with microsatellite stable metastatic colorectal cancer and a high immune infiltrate: preliminary results of FFCD 1703 POCHI trial.2024 ESMO 502O.
[4] Deng Y, et al. The efficacy and safety of ivonescimab with or without ligufalimab in combination with FOLFOXIRI as first-line (1L) treatment for metastatic colorectal cancer (mCRC).2024 ESMO 514MO.
[5] Prager GW, et al; SUNLIGHT Investigators. Trifluridine-Tipiracil and Bevacizumab in Refractory Metastatic Colorectal Cancer. N Engl J Med. 2023 May 4;388(18):1657-1667.
[6] Wakabayashi M, et al. A phase Il study of intrapatient dose escalation of biweekly trifluridine/tipiracil plus bevacizumab for colorectal cancer (E-BiTS study).2024 ESMO 523P.
[7] Li J, et al. Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial. JAMA. 2018 Jun 26;319(24):2486-2496.
[8] Dasari A,et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study. Lancet. 2023;402(10395):41-53.
[9] Garcia-Carbonero G, et al. Efficacy and safety of fruquintinib in patients with refractory metastatic colorectal cancer with and without liver metastasis: A subgroup analysis of the phase III FRESCO-2 trial.2024 ESMO 520Р.
[10] Elez Fernandez M.E, et al. Efficacy and safety of fruquintinib in refractory metastatic colorectal cancer: A FRESCO-2 subgroup analysis by age.2024 ESMO 526Р.
[11] Pietrantonio F, et al. Amivantamab plus FOLFOX or FOLFIRI in metastatic colorectal cancer: Results from OrigAMI-1, an open-label, phase Ib/ll study.2024 ESMO 513MO.
[12] Hendifar A, et al. Phase Ib/ll study of ompenaclid (RGX-202-01), a first-in-class oral inhibitor of the creatine transporter SLC6A8, in combination with FOLFIRI and bevacizumab (BEV) in RAS mutated (RASmt) second-line (2L) advanced/metastatic colorectal cancer (mCRC): Updated results.2024 ESMO 575Р.
[13] Siena S, et al. Sotorasib (soto), panitumumab (pani) and FOLFIRI in the first-line (1L) setting for KRAS G12C-mutated metastatic colorectal cancer (mCRC): Safety and efficacy analysis from the phase Ib CodeBreaK 101 study.2024 ESMO 505O.
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内容策划:季慧敏
项目审核:李淳
题图来源:丁香园设计