癌症的早筛早诊是国际公认对抗癌症的最有效手段。近年来，多种肿瘤标志物已逐渐被纳入到常规体检项目中。但是，有时肿瘤相关的标志物检测结果异常并不能反应受检者真实健康状况。
扩展知识
Tips:
若发现仅 CA199 单项升高，尤其是低水平升高的情况，不必过于慌张，建议选择固定的临床实验室进行随访。
良性疾病是 CA199 水平升高的主要原因，仅凭一次检测很难做出明确鉴别，应结合临床表现进行动态观察，若持续升高则完善全面检查。
参考文献：
[1] 张东矗等. 正常孕龄妇女月经周期血清 CA125、CA15-3 和 CA19-9 的变化 [J]. 放射免疫学杂志，201225 (6):690.
[2] Claudio Galli et al. CA 19-9: Handle with care. Clin Chem Lab Med 2013; 51(7): 1369–1383.
[3] Luo, G. et al. Optimize CA19-9 in detecting pancreatic cancer by Lewis and secretor genotyping. Pancreatology 16, 1057–1062 (2016).
[4] Guo, M. et al. Distribution of Lewis and secretor polymorphisms and corresponding CA19-9 antigen expression in a Chinese population. FEBS Open Bio. 7, 1660–1671 (2017).
[5] Abe, T. et al. Gene variants that affect levels of circulating tumor markers increase identification of patients with pancreatic cancer. Clin. Gastroenterol. Hepatol. 18, 1161–1169 (2020).
[5] B.J. Kim et al. How do we interpret an elevated carbohydrate antigen 19-9 level in asymptomatic subjects? Digestive and Liver Disease. 4, 1364–369 (2009).
[5] M. Ventrucci et al. ersistent elevation of serum CA 19-9 with no evidence of malignant disease. Digestive and Liver Disease 41 (2009) 357–363.
[7] Sunyoung Kim et al. Carbohydrate antigen 19-9 elevation without evidence of malignant or pancreatobiliary diseases. Scientific Reports (2020) 10:8820.
[8] Sang Pyo Lee et al. Usefulness of Carbohydrate Antigen 9-9 Test in Healthy People and ecessity of Medical Follow-up in ndividuals with Elevated Carbohydrate ntigen 19-9 Level. Korean J Fam Med 2019; 0:314-322
[9] Hye-Ryoun Kim et al. Increased CA 19-9 level in patients without malignant disease. Clin Chem Lab Med 2009;47(6):750–754.
[10] Xiaoxi Wang et al. An extremely increased CA19-9 level due to common bile duct stone: a case report. AME Med J 2017;2:18.
[11] Henry F. Sears. Specific Antigen in Serum of Patients with Colon Carcinoma. Science, 212;1981.
