2025 ASCO GI摘要标题公布!结直肠领域入选超30项中国研究,一起先睹为快

文摘   健康   2024-12-26 17:52   北京  

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2025年美国临床肿瘤学会胃肠道肿瘤研讨会(ASCO GI 2025)将于1月23~25日在美国旧金山召开。这一全球瞩目的盛会汇聚了胃肠道肿瘤领域的前沿研究,涵盖食管癌、肝细胞癌、胃癌及结直肠癌等多个热点方向。大会官网已披露全部的摘要标题,其中不乏来自中国的优秀研究成果,本文特整理出结直肠癌领域的相关摘要内容共31项,以期为读者呈现消化肿瘤研究的最新动向。


本次e-Poster提交将于

2025年1月13日截止,

提醒各位入选专家及时上传。


Trials in Progress Poster Session




1. 摘要号:TPS314

标题:A phase II, randomized study of JMT101 in combination with irinotecan and SG001 versus regorafenib in patients with metastatic colorectal adenocarcinoma (mCRC).


JMT101联合伊立替康和SG001对比瑞戈非尼治疗转移性结直肠腺癌患者的Ⅱ期随机研究

讲者:许剑民 复旦大学附属中山医院



2. 摘要号:TPS315

标题:Chemoradiotherapy (CRT) followed by sequential tislelizumab (TIS) + CAPOX and TIS monotherapy for organ preservation in locally advanced low rectal cancer.


放化疗(CRT)序贯替雷利珠单抗(TIS)+CAPOX及TIS单药治疗以实现对局部晚期低位直肠癌的器官保留

讲者:汤文涛 复旦大学附属中山医院



3. 摘要号:TPS316

标题:Cetuximab and vemurafenib plus liposomal irinotecan (II), leucovorin and fluorouracil for BRAFV600E-mutated advanced colorectal cancer (IMPROVEMENT2): A multicenter, open-label, randomized controlled trial.


西妥昔单抗和维莫非尼联合脂质体伊立替康(II)、亚叶酸钙和氟尿嘧啶治疗BRAFV600E突变型晚期结直肠癌(IMPROVEMENT2):一项多中心、开放标签、随机对照试验

讲者:王湛 海军军医大学长征医院


Poster Session



1. 摘要号:68

标题:Vascular endothelial growth factor receptor (VEGFR) -tyrosine kinase inhibitors combined with programmed death receptor-1 (PD-1) inhibitors as third- or later-line treatment in patients with microsatellite-stable (MSS) metastatic colorectal cancer (mCRC): A retrospective study.


血管内皮生长因子受体(VEGFR)酪氨酸激酶抑制剂联合程序性死亡受体-1(PD-1)抑制剂作为微卫星稳定(MSS)转移性结直肠癌患者的三线或后线治疗:一项回顾性研究

讲者:Xiaoqian Li 山东省肿瘤医院



2. 摘要号:77

标题:Bevacizumab plus mFOLFOX6/FOLFIRI sequential bevacizumab plus capecitabine maintenance in RAS-mutated advanced colorectal cancer: A real-world study of first-line/second-line conversion therapy.


贝伐珠单抗联合mFOLFOX6/FOLFIRI方案序贯贝伐珠单抗联合卡培他滨维持治疗RAS突变晚期结直肠癌:一项一线/二线转化治疗的真实世界研究

讲者:Ying Yan 中国科学技术大学附属第一医院



3. 摘要号:128

标题:Phase Ⅰb/Ⅱ study of fruquintinib plus 5-fluorouracil/leucovorin after progression on fruquintinib monotherapy in metastatic colorectal cancer.


呋喹替尼联合5-氟尿嘧啶/亚叶酸钙在经呋喹替尼单药治疗后出现进展的转移性结直肠癌的Ⅰb/Ⅱ期研究

讲者:Wenwei Yang 中国医学科学院肿瘤医院



4. 摘要号:133

标题:Total neoadjuvant therapy with FOLFOX plus bevacizumab and short-course radiotherapy for Ras mutant, high-risk, locally advanced rectal cancer: The TRAINER trial.


FOLFOX联合贝伐珠单抗及短程放疗作为RAS突变、高风险局晚期直肠癌的全程新辅助治疗:TRAINER试验

讲者:Jingyi Liu 上海交通大学医学院附属瑞金医院



5. 摘要号:145

标题:Updated analysis of a phase 2 study of fruquintinib plus trifluridine/tipiracil (TAS-102) as third-line treatment in patients with metastatic colorectal adenocarcinoma.


呋喹替尼联合曲氟尿苷替匹嘧啶(TAS-102)作为转移性结直肠腺癌患者的三线治疗的Ⅱ期研究:最新分析结果

讲者:彭建军 中山大学附属第一医院



6. 摘要号:150

标题:Short-course radiotherapy-based total neoadjuvant therapy combined with tislelizumab in the treatment of locally advanced rectal cancer (Neo-STAR): Early outcomes of a prospective, randomized phase II trial.


以短程放疗为基础的新辅助治疗联合替雷利珠单抗治疗局部晚期直肠癌(Neo-STAR):一项前瞻性、随机Ⅱ期试验的早期结果

讲者:吴凤鹏 河北医科大学第四医院



7. 摘要号:151

标题:Fruquintinib combined with FOLFIRI/mFOLFOX6 as second-line treatment in patients with RAS-mutant metastatic colorectal cancer (mCRC): A multicenter, open-label, phase II study.


呋喹替尼联合FOLFIRI/mFOLFOX6用于RAS突变转移性结直肠癌患者的二线治疗:一项多中心、开放标签、Ⅱ期研究

讲者:Yun Xu 复旦大学附属肿瘤医院



8. 摘要号:155

标题:Phase II study of trifluridine/tipiracil (TAS-102) plus irinotecan in combination with bevacizumab as a second‐line therapy for patients with metastatic colorectal cancer.


曲氟尿苷替匹嘧啶(TAS-102)联合伊立替康和贝伐珠单抗用于转移性结直肠癌患者二线治疗的Ⅱ期研究

讲者:孙永琨 中国医学科学院肿瘤医院



9. 摘要号:157

标题:Prognosis of patients with liver single-organ metastases: Updated survival results of BBCAPX-II.


肝脏单器官转移患者的预后:BBCAPX-II的最新生存结果

讲者:袁瑛 浙江大学医学院附属第二医院



10. 摘要号:166

标题:Efficacy and safety of fruquintinib alternating with bevacizumab plus capecitabine as maintenance therapy after first-line treatment in metastatic colorectal cancer (mCRC): A multicenter, open-label, phase II study.


呋喹替尼与贝伐珠单抗加卡培他滨交替用于转移性结直肠癌(mCRC)一线治疗后维持治疗的疗效和安全性:一项多中心、开放标签、Ⅱ期研究

讲者:廖旺军 南方医科大学南方医院



11. 摘要号:167

标题:Updated survival results of ZL-IRIAN: Irinotecan plus anlotinib or in combination with penpulimab as second-line treatment of metastatic colorectal cancer.


ZL-IRIAN研究的最新生存结果:伊立替康联合安罗替尼或联合penpulimab对转移性结直肠癌进行二线治疗

讲者:王辰辰 复旦大学附属肿瘤医院



12. 摘要号:170

标题:Updated efficacy and subgroup analysis of first-line serplulimab plus bevacizumab and XELOX versus placebo plus bevacizumab and XELOX in metastatic colorectal cancer: A phase 2/3 study.


Serplulimab联合贝伐珠单抗和XELOX vs. 安慰剂加贝伐珠单抗和XELOX 一线治疗转移性结直肠癌的最新疗效及亚组分析:一项Ⅱ/Ⅲ期研究

讲者:徐瑞华 中山大学肿瘤防治中心



13. 摘要号:174

标题:Exploratory study of TAS-102 combined with intermittent administration of fruquintinib in the treatment of third-line metastatic colorectal cancer.


TAS-102随后呋喹替尼间歇给药三线治疗转移性结直肠癌的探索性研究

讲者:Jiayu Niu 中国科学技术大学西区第一附属医院(安徽省立医院)



14. 摘要号:177

标题:OP-TNT: Phase II study of total neoadjuvant chemoradiotherapy followed by local resection for early distal rectal carcinoma.


OP-TNT:早期远端直肠癌全程新辅助放化疗后进行局部切除的Ⅱ期研究

讲者:Zhang Xian 复旦大学附属中山医院



15. 摘要号:185

标题:Neoadjuvant PD-1 blockade in mismatch repair-deficient or microsatellite instability-high, locally advanced and resectable colorectal cancer: A retrospective real-world analysis.


PD-1抑制剂新辅助治疗错配修复缺陷或微卫星不稳定性高的局部晚期可切除结直肠癌:一项回顾性真实世界分析

讲者:Yugui Lian 郑州大学第一附属医院



16. 摘要号:190

标题:QL1203 vs placebo plus mFOLFOX6 as first-line therapy in RAS wild-type, metastatic colorectal cancer (mCRC): Interim analysis (IA) of a multicenter, randomized, double-blinded, parallel, phase 3 trial.


QL1203联合mFOLFOX6对比安慰剂联合mFOLFOX6作为RAS野生型转移性结直肠癌的一线治疗:一项多中心、随机、双盲、平行、Ⅲ期试验的中期分析

讲者:郭伟剑 复旦大学附属肿瘤医院



17. 摘要号:192

标题:Short-course radiotherapy (SCRT) followed by fruquintinib plus adebrelimab and CAPOX in the total neoadjuvant therapy of locally advanced rectal cancer (LARC): A multicenter, single-arm, open-label, phase II study (UNION TNT).


短程放疗(SCRT)随后呋喹替尼、阿得贝利单抗和CAPOX方案作为局部晚期直肠癌(LARC)全程新辅助治疗:一项多中心、单臂、开放标签、Ⅱ期研究(UNION TNT)

讲者:林振宇 华中科技大学同济医学院附属协和医院



18. 摘要号:194

标题:Efficacy and safety of anlotinib as a later-line treatment for advanced colorectal cancer.


安罗替尼作为晚期结直肠癌后线治疗的疗效和安全性研究

讲者:宋扬 空军军医大学唐都医院



19. 摘要号:195

标题:Liposomal irinotecan + 5-fluorouracil + leucovorin + bevacizumab as second-line therapy in metastatic colorectal cancer (IRIS): A multi-center, single-arm, prospective, phase II study.


脂质体伊立替康联合5-氟尿嘧啶、亚叶酸钙和贝伐珠单抗作为转移性结直肠癌的二线治疗(IRIS):一项多中心、单臂、前瞻性Ⅱ期研究

讲者:胡旭华 河北医科大学第四医院



20. 摘要号:198

标题:Preliminary safety and efficacy of upfront FOLFOXIRI and bevacizumab with cadonilimab in patients with proficient mismatch repair/microsatellite stable (pMMR/MSS) metastatic colorectal cancer: A multicenter phase II study (SYLT-026).


先期FOLFOXIRI和贝伐珠单抗联合卡度尼利单抗治疗错配修复功能正常/微卫星稳定(pMMR/MSS)转移性结直肠癌患者:一项多中心Ⅱ期研究(SYLT-026)的初步疗效和安全性

讲者:林榕波 福建省肿瘤医院



21. 摘要号:201

标题:Neoadjuvant chemotherapy with FOLFOXIRI for high-risk relapsed locally advanced colon cancer: A single-arm phase II trial.


FOLFOXIRI新辅助化疗治疗高风险复发局部晚期结肠癌:一项单臂Ⅱ期试验

讲者:周裕文  四川大学华西医院



22. 摘要号:203

标题:Real-world outcomes of targeted therapies and local interventions in BRAF V600E–mutated metastatic colorectal cancer: A single-center retrospective study.


BRAF V600E突变型转移性结直肠癌的靶向治疗与局部干预的真实世界疗效:一项单中心回顾性研究

讲者:Ziqin Lin  中山大学附属第六医院



23. 摘要号:LBA210

标题:Short-course radiation(SCRT) followed by 6 cycles of cadonilimab plus mFOLFOX6 as neoadjuvant therapy for patients with locally advanced rectal cancer (LARC): A multicenter, single arm, phase II trial (NeoCaCRT).


短程放射治疗(SCRT)后接6个周期的卡度尼利单抗加 mFOLFOX6 作为局部晚期直肠癌(LARC)患者的新辅助治疗:一项多中心、单组、Ⅱ期试验(NeoCaCRT)

讲者:何婉 深圳市人民医院



24. 摘要号:240

标题:Utilization of SDC2 gene in conjunction with SEPTIN9 gene methylation analysis for the diagnosis and efficacy assessment of colorectal cancer.


SDC2结合SEPTIN9的基因甲基化分析在结直肠癌诊断及疗效评估中的应用

讲者:Rongjia Xie 同济大学附属第十人民医院



25. 摘要号:246

标题:Effects of targeting CTMP on immunogenicity of MSI-L colon adenocarcinoma cells by metabolism and cell cycle modulation.


靶向CTMP通过代谢与细胞周期调控对微卫星低度不稳定型结肠腺癌细胞免疫原性的影响

讲者:Cheng Gu 同济大学医学院附属上海市第十人民医院



26. 摘要号:278

标题:Comprehensive landscape of FGFR variations and prognosis revelance in colorectal cancer from circulating tumor DNA and tissue gene analyses in 2083 patients.


基于2083例结直肠癌患者的循环肿瘤DNA及组织基因分析中对FGFR变异的全景图谱及预后的相关性分析

讲者:Xiaoshuang Lyu 中山大学附属第六医院



27. 摘要号:292

标题:The role and molecular mechanism of GDF5 in regulating cell migration and angiogenesis via the Hippo-YAP signaling pathway in colorectal cancer.


GDF5通过Hippo-YAP信号通路调控结直肠癌细胞迁移和血管生成的作用及分子机制

讲者:雷佩捷 青岛大学附属医院



28. 摘要号:

标题:Development and validation of a deep learning–based pathomics signature for prognosis and chemotherapy benefits in colorectal cancer: A retrospective multicenter cohort study.


基于深度学习的病理组学特征在结直肠癌预后和化疗获益中的开发与验证:一项回顾性多中心队列研究

讲者:娄盛涵 哈尔滨医科大学附属肿瘤医院

本文按摘要号进行排序。

如有遗漏或疑问,欢迎留言!


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