全球血脂速递（第037期）丨镁对血脂的影响、间充质干细胞、缺血性卒中后血脂二级预防、血脂与青光眼等
健康
2025-02-06 18:31
上海
截至02月06日15点59分，近期共有 297 本期刊发布了 437 篇文章，其中血脂相关的文章共 62 篇，覆盖 25 个领域的内容。其中影响因子最高的是刊登在 Journal of the American Medical Association (IF: 63.100) 期刊上标题为《辛伐他汀和利福昔明治疗失代偿期肝硬化的随机临床试验》的文章。22Atherosclerosis(AS)动脉粥样硬化6Total Cholesterol(TC)总胆固醇6Low-Density Lipoprotein Cholesterol(LDL-C)低密度脂蛋白胆固醇3Hypercholesterolemia高胆固醇血症2Lipoprotein(a)(Lp(a))脂蛋白a2Non-high-density Lipoprotein Cholesterol(non-HDL-C)非高密度脂蛋白胆固醇1Apolipoprotein B(ApoB)载脂蛋白B1Homozygous Familial Hypercholesterolemia(HoFH)纯合子家族性高胆固醇血症1High Density Lipoprotein Cholesterol(HDL-C)高密度脂蛋白胆固醇1Hypertriglyceridemia(HTG)高甘油三酯血症1Hyperlipoproteinemias高脂蛋白血症Nutrition journal IF: 04.400
补充镁对血脂水平的影响：随机对照试验的最新系统评价和剂量反应荟萃分析
Mitra Hariri, Masoudreza Sohrabi, Ali Gholami, etc.Background一些证据表明，镁可能会降低血脂水平。鉴于这一问题的重要性，研究人员集中开展了一项系统综述和荟萃分析，以探讨补充镁对≥18岁普通人群血清总胆固醇（TC），甘油三酯（TG），低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）水平的影响。Methods按照先进行这项研究的原则，通过检索数据库（包括五个数据库）找到了相关文章， 包括：Cochrane Library,，ClinicalTrials.gov，ISI Web of Science，Scopus和PubMed，直到2024年1月。在实现第一个目标后，计算它们的平均差异和标准偏差以进行荟萃分析。最终，使用I平方统计和Cochran Q检验对干预效果的统计异质性进行评估。Results关于血清TC，TG，LDL-C和HDL-C水平，荟萃分析包括二十一项，二十三项，二十项和二十五项研究。汇总估计显示，镁组和对照组之间的血清TC，TG和LDL-C水平无显著差异（加权平均差（WMD）=0.34 mg/dl，95%CI -1.75至2.43，P=0.749，I²=99.1%；WMD=-2.06 mg/dl，95%CI -6.35至2.23，P=0.346，I² 99.1；WMD 1.71 mg/dl，95%CI -0.81至4.24，P=0.183，I² 99.4）。然而，镁显著增加HDL-C（WMD 1.21 mg/dl，95%CI 0.58至1.85，P<0.001，I² 99.5）。Conclusion总之，研究表明，镁显著增加HDL-C水平。然而，由于高度异质性，必须注意到，需要更多的研究来提出关于临床实践中镁补充的有力建议。Nutrition journal | Volumn 24, Issue 110.1186/s12937-025-01085-wTissue Eng Regen Med IF: 04.400
间充质干细胞在外源性库欣综合征小鼠模型中降低低密度脂蛋白胆固醇
Yu-Hee Kim, Seonghee Jeong, Kyung-Ah Cho, So-Youn Woo, Seung-Ho Han, Kyung-Ha Ryu, etc.Background长期服用糖皮质激素导致的外源性库欣综合征与代谢异常有关。此前，报道了扁桃体来源的间充质干细胞条件培养基（T-MSC-CM）对糖皮质激素信号转导的抑制作用。在这项研究中，研究了T-MSCs在外源性库欣综合征小鼠模型中的治疗效果。Methods通过在饮用水中给予皮质酮5周产生外源性库欣综合征模型小鼠，并且在第三周期间腹膜内注射T-MSC两次。使用化学分析仪测量血脂谱。用地塞米松处理HepG2细胞并与T-MSC共培养。使用实时PCR检查与胆固醇代谢有关的基因的表达水平。使用蛋白质印迹和免疫组织化学测定低密度脂蛋白受体（LDLR）蛋白水平。从CORT和CORT+MSC小鼠组提取的肝脏RNA用于转录组测序分析和蛋白质-蛋白质相互作用分析。Results仅在雌性小鼠中观察到T-MSC给药的体重减轻和血脂异常的改善。T-MSCs通过下调肝脏X受体α（LXRα）和LDLR（IDOL）表达的诱导型降解物来降低循环LDL胆固醇水平，从而稳定肝脏中的LDLR。肝组织的转录组分析揭示了受T-MSCs给药调节的途径。Conclusion向接受慢性皮质酮治疗的雌性小鼠施用MSC通过下调肝细胞中的LXRα-偶像轴来降低循环LDL胆固醇水平。这些结果表明，T-MSCs可能通过调节胆固醇代谢为治疗外源性库欣综合征提供了一种新的治疗策略。Tissue Eng Regen Med | Volumn 22, Issue 210.1007/s13770-024-00697-3Lipids in health and disease IF: 03.900
基于鳄梨的地中海饮食对缺血性卒中后二级预防血脂的影响：一项随机2期对照试验
Verónica V Olavarría, Paola R Campodónico, Valeska Vollrath, Paula von Geldern, Carolina Velásquez, Patricia Pavez, etc.Background健康饮食对缺血性卒中（IS）二级预防的影响仍不确定。低密度脂蛋白胆固醇（LDL-C）水平与IS复发风险呈负相关。地中海饮食（MeDi），包括偏爱鱼类/家禽，橄榄油，水果，蔬菜，全谷物，豆类/坚果和有限的红肉，动物脂肪和甜味饮料中的单饱和脂肪，可降低代谢综合征，LDL-C水平和卒中风险。鳄梨还能降低代谢综合征和低密度脂蛋白胆固醇（LDL-C）水平，但不属于传统的地中海饮食。研究了以鳄梨为基础的地中海饮食对低密度脂蛋白胆固醇的影响，并与先前IS患者的低脂饮食进行了比较。Methods基于鳄梨的地中海饮食对缺血性卒中后血清脂质二级预防的影响（ADD-SPISE）是一项前瞻性、随机、开放标签、盲法结果评估的第二阶段临床试验。参与者是前一个月患有IS的成年人，他们以1:1的比例随机分配到中等或低脂饮食中三个月。实验室结果和数据分析师的结果评估者被掩盖了。主要终点是90天时各组之间LDL-C的平均差异，并通过他汀类药物的使用进行调整。还评估了安全性，可行性和可接受性（通过对所有完成随访的患者进行的14项问卷调查进行评估）。Results从2018年8月到2022年10月，共招募了200例参与者（97例随机分配到低脂饮食，103例随机分配到MeDi），其中189例（94.5%）完成了研究。在90天时，MeDi组和低脂组之间的LDL-C水平没有显著差异：MeDi组为66.5 mg/dL（95%CI 59.6-73.4），随访结束时低脂组为69.9 mg/dL（62.6-77.2）。调整后的差异为-3.4 mg/dL（-13.4至-6.62）；P=0.50。干预组在地中海饮食依从性方面有显著改善（P＜0.01）。此外，两组之间未观察到不良事件的显著差异。Conclusion与低脂饮食相比，基于鳄梨的MeDi在三个月后并没有显著降低IS患者的LDL-C。干预是安全的，可行的，并且被广泛接受。更大规模的试验应该确定更长时间的饮食干预是否可以在这些患者中产生临床上显著的益处。该研究在www.ADD-SPISE下注册。Lipids in health and disease | Volumn 24, Issue 110.1186/s12944-025-02454-4British journal of ophthalmology IF: 03.700
血脂与青光眼之间的关系：一项针对400229例英国生物库参与者的队列研究
Yiyuan Ma, Yue Wu, Leyi Hu, Wen Chen, Xinyu Zhang, Danying Zheng, etc.Purpose检查常用血脂指标（高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），总胆固醇（TC）和甘油三酯（TG））与青光眼的关系。Methods这项前瞻性队列研究包括来自英国生物库的400229例参与者。研究采用了Cox回归和限制性立方样条模型以及多基因风险评分来研究血清脂质与青光眼之间的关系。Results平均随访14.44年，6868例（1.72%）参与者患上了青光眼。多因素Cox回归分析显示，HDL-C水平升高与青光眼风险增加有关（HDL-C 1-SD升高的HR为1.05，95%CI 1.02-1.08，P=0.001），而LDL-C水平升高（HR为0.96，95%CI 0.94-0.99，P=0.005），TC（HR为0.97，95%CI 0.94-1.00，P=0.037）和TG（HR为0.96，95%CI 0.94-0.99，P=0.008）均与风险降低有关。研究血脂多基因风险评分与青光眼之间关系的分析显示，HDL-C遗传风险每增加1-SD，青光眼风险增加5%（HR 1.05，95%CI 1.00-1.11，P=0.031）。然而，LDL-C，TC和TG的多基因风险评分与青光眼没有显著相关性。ConclusionsHDL-C升高与青光眼风险增加有关，而LDL-C，TC和TG水平升高与青光眼风险降低有关。这项研究增强了对脂质谱与青光眼之间关系的理解，并值得进一步研究青光眼管理中以脂质为中心的治疗方法。British journal of ophthalmology | Ahead of Print.Naunyn Schmiedebergs Arch Pharmacol IF: 03.100
替米沙坦/瑞舒伐他汀/依折麦布/氨氯地平80/20/10/5 mg固定剂量组合与依折麦布/瑞舒伐他汀10/20 mg和替米沙坦/氨氯地平80/5 mg松散剂量组合在健康男性受试者中的药代动力学比较
Sooyoun Lee, Hyun Chul Kim, Kyung Tae Kim, Seung-Hyun Kang, SeungHwan Lee, Kyung-Sang Yu, etc.本研究旨在比较替米沙坦/瑞舒伐他汀/依折麦布/氨氯地平80/20/10/5 mg的固定剂量组合（FDC）片剂和两种FDC片剂的松散剂量组合（LDC）的药代动力学（PK）曲线，依折麦布/瑞舒伐他汀10/20 mg和替米沙坦/氨氯地平80/5 mg，在健康的韩国男性受试者中。本研究是一项随机、开放标签、双序列、四期交叉研究。受试者接受替米沙坦，瑞舒伐他汀，依折麦布和氨氯地平的FDC或LDC两次，每次21天冲洗。每个序列依次由FDC/LDC/FDC/LDC或LDC/FDC/LDC/FDC组成。在瑞舒伐他汀给药后48小时和替米沙坦，依折麦布和氨氯地平给药后72小时收集用于PK分析的系列血样。PK参数通过非隔室方法计算，并且在整个研究中评估安全性概况。招募了54例健康的韩国男性受试者，其中42例受试者完成了研究。FDC组和LDC组之间替米沙坦，瑞舒伐他汀，依折麦布和氨氯地平的浓度-时间曲线相似。对于每种化合物，FDC与LDC的血浆浓度-时间曲线下峰浓度和面积的几何平均比（90%置信区间）在0.8-1.25的常规生物等效性标准内。FDC和LDC治疗均耐受性良好，并被确定为安全的。替米沙坦，瑞舒伐他汀，依折麦布和氨氯地平的FDC和LDC治疗显示出药代动力学生物等效性，表明替米沙坦/瑞舒伐他汀/依折麦布/氨氯地平80/20/10/5 mg的FDC可用作LDC治疗的替代品。Naunyn Schmiedebergs Arch Pharmacol | Ahead of Print.10.1007/s00210-025-03863-zFrontiers in public health IF: 03.000
使用2015年CHARLS数据开发和验证中国中老年人高脂血症风险预测模型
Li-Xiang Zhang, Shan-Bing Hou, Fang-Fang Zhao, Ting-Ting Wang, Ying Jiang, Xiao-Juan Zhou, etc.Objective为了开发和验证中国中老年人高脂血症风险的预测模型，本研究旨在为识别高危人群提供有效的筛查工具。Methods在这项研究中，纳入了6629例45岁及以上的中老年人，他们符合2015年中国健康与退休纵向研究（CHARLS）的纳入标准，作为研究对象。利用套索回归和多因素Logistic回归方法，分析了这些受试者中与高脂血症相关的独立危险因素。随后，使用统计软件Stata 17.0建立了中老年人群高脂血症的风险预测模型。Results6629例中老年参与者中高脂血症的患病率为26.32%（6629例中有1745例）。LASSO回归和多因素Logistic回归分析均显示，体重指数（BMI）、空腹血糖、血尿酸、C反应蛋白和白细胞计数是该人群高脂血症的独立危险因素（优势比（OR）大于1，P值小于0.05）。根据这些发现，构建了列线图预测模型来估计中老年人高脂血症的风险。列线图的受试者工作特征（ROC）曲线（AUC）下面积为0.717（95%CI 0.703-0.731），表明区分良好。决策曲线分析（DCA）表明，当中老年人群高脂血症的概率介于0.11和0.61之间时，列线图的应用产生最高的净收益，表明列线图模型具有良好的临床适用性。Spiegelhalter的z统计量检验证实，列线图模型的预测概率与观察到的高脂血症频率（i p/i 0.560）非常吻合。列线图模型的Brier得分为17.1%，低于25%的阈值，表明校准良好。为了内部验证列线图模型，进行了500次自举重采样。来自该内部验证的列线图模型的C统计量为0.716，Brier得分为11.4%，表明该模型不仅具有良好的预测效率，而且具有良好的稳定性。Conclusion列线图模型结合了已确定的中老年人高脂血症的危险因素，已证明具有良好的预测效率和临床适用性。它可以作为一种有价值的工具，帮助医疗保健专业人员筛查高危人群并实施有针对性的预防干预措施。通过这样做，它有可能显著降低这一人群中高脂血症的发生率。Frontiers in public health | Volumn 13, Issue10.3389/fpubh.2025.1420596JAMA IF: 63.100
Ahead of Print.No.01Simvastatin and Rifaximin in Decompensated Cirrhosis: A Randomized Clinical Trial辛伐他汀和利福昔明治疗失代偿期肝硬化的随机临床试验DOI: 10.1001/jama.2024.27441JACC IF: 21.700
Volumn 85, Issue 5No.02Secondary Prevention Medications in 17 Countries Grouped by Income Level (PURE): A Prospective Cohort Study按收入水平分组的17个国家的二级预防药物（PURE）：一项前瞻性队列研究DOI: 10.1016/j.jacc.2024.10.121Nature communications IF: 14.700
Volumn 16, Issue 1No.03Differential transport pathways of saturated and unsaturated fatty acid esters in male mouse hepatocytes饱和和不饱和脂肪酸酯在雄性小鼠肝细胞中的差异转运途径DOI: 10.1038/s41467-025-56620-4Gut microbes IF: 12.200
Volumn 17, Issue 1No.04Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism古细菌产甲烷菌通过塑造肠道微生物群、丁酸盐和组氨酸代谢与认知能力相关DOI: 10.1080/19490976.2025.2455506British journal of pharmacology IF: 06.800
Ahead of Print.No.05Silencing drug transporters in human primary muscle cells modulates atorvastatin pharmacokinetics: A pilot study沉默人原代肌肉细胞中的药物转运蛋白可调节阿托伐他汀的药代动力学：一项初步研究DOI: 10.1111/bph.17449Journal of Cardiac Failure IF: 06.700
Ahead of Print.No.06Evaluating incident Atrial Fibrillation and incident Heart Failure as time-varying covariates for Time to Event Analysis among adults 55 years and older in the Multi-Ethnic Study of Atherosclerosis (MESA)在多种族动脉粥样硬化研究（MESA）中，评估事件性心房颤动和事件性心力衰竭作为55岁及以上成年人时间-事件分析的时变协变量DOI: 10.1016/j.cardfail.2025.01.012Circ Cardiovasc Imaging IF: 06.500
Ahead of Print.No.07Letter by Natale et al Regarding Article, "Association of Lipoprotein(a) With Changes in Coronary Atherosclerosis in Patients Treated With Alirocumab"Natale等人关于文章的信；脂蛋白（a）与接受阿利西尤单抗治疗的患者冠状动脉粥样硬化变化的关系；DOI: 10.1161/CIRCIMAGING.124.017942Circ Cardiovasc Imaging IF: 06.500
Ahead of Print.No.08Response to Letter Regarding Article, "Association of Lipoprotein(a) With Changes in Coronary Atherosclerosis in Patients Treated With Alirocumab"对关于第条的信件的回复；脂蛋白（a）与接受阿利西尤单抗治疗的患者冠状动脉粥样硬化变化的关系；DOI: 10.1161/CIRCIMAGING.125.017965J Anim Sci Biotechnol IF: 06.300
Volumn 16, Issue 1No.09A novel protein encoded by porcine circANKRD17 activates the PPAR pathway to regulate intramuscular fat metabolism猪circANKRD17编码的一种新蛋白激活PPAR通路调节肌内脂肪代谢DOI: 10.1186/s40104-025-01153-5Acta Neuropathol Commun IF: 06.200
Volumn 13, Issue 1No.10X-linked ubiquitin-specific peptidase 11 (USP11) increases susceptibility to Cushing's disease in womenX连锁泛素特异性肽酶11（USP11）增加了对库欣的敏感性；女性s病DOI: 10.1186/s40478-025-01938-9Diabetes Res Clin Pract IF: 06.100
Ahead of Print.No.11Achievement of guideline targets among people with type 2 diabetes with eASCVD and high risk of ASCVD in the UAE: Results of the PACT-MEA-UAE cohort阿联酋2型糖尿病合并eASCVD和ASCVD高危人群指南目标的实现：PACT-MEA-UAE队列的结果DOI: 10.1016/j.diabres.2025.112030Frontiers in immunology IF: 05.700
Volumn 16, Issue No.12Adropin: a key player in immune cell homeostasis and regulation of inflammation in several diseasesAdropin：几种疾病中免疫细胞稳态和炎症调节的关键参与者DOI: 10.3389/fimmu.2025.1482308Journal of lipid research IF: 05.000
Ahead of Print.No.13Efficacy of a novel PCSK9 inhibitory peptide alone and with evinacumab in a mouse model of atherosclerosis新型PCSK9抑制肽单独和与依那单抗联合在动脉粥样硬化小鼠模型中的疗效DOI: 10.1016/j.jlr.2025.100753Nutrition & diabetes IF: 04.600
Volumn 15, Issue 1No.14Associations between hypovitaminosis D, adiposity indices and insulin resistance in adolescents: mediation analyses from NHANES 2011-2018青少年维生素D缺乏症，肥胖指数和胰岛素抵抗之间的关联：NHANES 2011-2018的中介分析DOI: 10.1038/s41387-025-00358-xAm J Prev Cardiol IF: 04.300
Volumn 21, Issue No.15Elevated plasma trimethyllysine is associated with incident atrial fibrillation血浆三甲基赖氨酸升高与心房颤动有关DOI: 10.1016/j.ajpc.2025.100932Hypertension Research IF: 04.300
Volumn 48, Issue 2No.16Assessment of renal artery stenosis using renal fractional flow reserve and correlation with angiography and color Doppler ultrasonography: data from FAIR-pilot trial肾血流储备分数评估肾动脉狭窄及其与血管造影和彩色多普勒超声的相关性：来自FAIR pilot试验的数据DOI: 10.1038/s41440-024-01948-5Obesity IF: 04.200
Ahead of Print.No.17Alternate-day fasting enhanced weight loss and metabolic benefits over pair-fed calorie restriction in obese mice隔日禁食增强了肥胖小鼠的体重减轻和代谢益处，而不是成对喂养的卡路里限制DOI: 10.1002/oby.24211Am J Physiol Endocrinol Metab IF: 04.200
Ahead of Print.No.18A novel soluble guanylate cyclase activator, avenciguat, in combination with empagliflozin, protects against renal and hepatic injury in diabetic db/db mice新型可溶性鸟苷酸环化酶激活剂avenciguat与empagliflozin联合使用可预防糖尿病db/db小鼠的肾脏和肝脏损伤DOI: 10.1152/ajpendo.00254.2024Obesity IF: 04.200
Ahead of Print.No.19Efficacy and safety of a novel oral hydrogel capsule in adults with overweight or obesity: the pivotal randomized RESET study新型口服水凝胶胶囊对超重或肥胖成年人的疗效和安全性：关键的随机重置研究DOI: 10.1002/oby.24240Hum Vaccin Immunother IF: 04.100
Volumn 21, Issue 1No.20Recent advances in immunotherapy targeting CETP proteins for atherosclerosis prevention靶向CETP蛋白预防动脉粥样硬化的免疫治疗进展DOI: 10.1080/21645515.2025.2462466European journal of nutrition IF: 04.100
Volumn 64, Issue 2No.21Serum homocysteine is a biomarker for hearing loss associated with or without cardiovascular risk: a cross-sectional study in men血清同型半胱氨酸是与心血管风险相关或不相关的听力损失的生物标志物：男性的横断面研究DOI: 10.1007/s00394-025-03592-2Obesity facts IF: 03.900
Ahead of Print.No.22Association of abdominal volume index with asymptomatic intracranial arterial stenosis in rural Chinese adults: a population-based study中国农村成年人腹部容积指数与无症状颅内动脉狭窄的关系：一项基于人群的研究DOI: 10.1159/000543790Frontiers in endocrinology IF: 03.900
Volumn 15, Issue No.23Development and validation of machine learning models for MASLD: based on multiple potential screening indicatorsMASLD机器学习模型的开发和验证：基于多个潜在的筛选指标DOI: 10.3389/fendo.2024.1449064Food and chemical toxicology IF: 03.900
Ahead of Print.No.24Oral exposure to nanoplastics altered lipid profiles in mouse intestine口服纳米塑料改变了小鼠肠道的脂质分布DOI: 10.1016/j.fct.2025.115304Scientific reports IF: 03.800
Volumn 15, Issue 1No.25Prevalence and associated factors of epiretinal membrane using spectralis OCT in Fujian Eye Study福建眼科spectralis OCT视网膜前膜患病率及相关因素研究DOI: 10.1038/s41598-025-88234-7Scientific reports IF: 03.800
Volumn 15, Issue 1No.26Virgin and photo-degraded microplastics induce the activation of human vascular smooth muscle cells原始和光降解的微塑料诱导人血管平滑肌细胞的活化DOI: 10.1038/s41598-025-89006-zClinical Research in Cardiology IF: 03.800
Ahead of Print.No.27Letter to the editor: "Cardiovascular magnetic resonance reveals myocardial involvement in patients with active stage of inflammatory bowel disease"致编辑的信：；心血管磁共振显示炎症性肠病活动期患者的心肌受累；DOI: 10.1007/s00392-025-02605-8Scientific reports IF: 03.800
Volumn 15, Issue 1No.28Epidemiological surveys, antibiotic resistance, and related risk factors of Helicobacter pylori in Quanzhou, China: a cross-sectional study泉州市幽门螺杆菌流行病学调查、耐药性及相关危险因素的横断面研究DOI: 10.1038/s41598-025-89073-2Eur J Hum Genet IF: 03.700
Ahead of Print.No.29Two for the heart: Dutch Pharmacogenetic Working Group prescribing guidance on statins and sulfonylureas to reduce cardiometabolic risk心脏的两个：荷兰药物遗传学工作组为他汀类药物和磺脲类药物提供指导，以降低心脏代谢风险DOI: 10.1038/s41431-025-01796-yBMC public health IF: 03.500
Volumn 25, Issue 1No.30Status of sleeping habits and its influence on growth and metabolism of children in Beijing: a population-based cross-sectional study北京市儿童睡眠习惯现状及其对生长代谢的影响DOI: 10.1186/s12889-025-21637-3Int J Food Sci Nutr IF: 03.500
Ahead of Print.No.31Association between Healthy Eating Index 2015 and metabolic syndrome among US cancer survivors: evidence from NHANES 2005-20162015年健康饮食指数与美国癌症幸存者代谢综合征之间的关联：来自NHANES 2005-2016的证据DOI: 10.1080/09637486.2025.2461144Cardiovascular Toxicology IF: 03.400
Ahead of Print.No.32Mercury-Mediated Cardiovascular Toxicity: Mechanisms and Remedies汞介导的心血管毒性：机制和补救措施DOI: 10.1007/s12012-025-09966-6Evolution letters IF: 03.400
Volumn 9, Issue 1No.33Shared genetic architecture links energy metabolism, behavior and starvation resistance along a power-endurance axis共享的遗传结构将能量代谢、行为和饥饿抵抗力沿着力量耐力轴联系起来DOI: 10.1093/evlett/qrae062Metabolic brain disease IF: 03.200
Volumn 40, Issue 2No.34Impact of neuroinflammation on brain glutamate and dopamine signalling in schizophrenia: an update神经炎症对精神分裂症患者脑谷氨酸和多巴胺信号传导的影响：最新进展DOI: 10.1007/s11011-025-01548-3Clinical therapeutics IF: 03.200
Ahead of Print.No.35Effects of Coenzyme Q10 Supplementation on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis补充辅酶Q10对2型糖尿病患者代谢指标的影响：系统评价和荟萃分析DOI: 10.1016/j.clinthera.2024.12.010Frontiers in medicine IF: 03.100
Volumn 11, Issue No.36Recommendations for the primary prevention of atherosclerotic cardiovascular disease in primary care: a systematic guideline review初级保健中动脉粥样硬化性心血管疾病一级预防的建议：系统指南综述DOI: 10.3389/fmed.2024.1494234Diabetes Metab Syndr Obes IF: 02.800
Volumn 18, Issue No.37FTO rs17817449 Variant Increases the Risk of Severe Obesity in a Brazilian Cohort: A Case-Control StudyFTO rs17817449变异增加了巴西队列中严重肥胖的风险：一项病例对照研究DOI: 10.2147/DMSO.S451401Open Heart IF: 02.800
Volumn 12, Issue 1No.38Revealing the limitations of 10-year MACE observations: 20-year observed total cardiovascular burden in the EPIC-Norfolk study揭示10年MACE观察的局限性：EPIC诺福克研究中20年观察到的总心血管负担DOI: 10.1136/openhrt-2024-002981Sports health IF: 02.700
Ahead of Print.No.39Effects of Supramaximal Intensity Interval Training on Resistin and Cardiometabolic Health Indices in Overweight Nonpostmenopausal Women超最大强度间歇训练对超重非绝经后妇女抵抗素和心脏代谢健康指标的影响DOI: 10.1177/19417381251315059Molecular biology reports IF: 02.600
Volumn 52, Issue 1No.40Fibrinopeptide a promotes the proliferation and migration of vascular smooth muscle cells by regulating the integrin αVβ3/PI3K/AKT signaling pathway纤维蛋白肽a通过调节整合素αVβ3/PI3K/AKT信号通路促进血管平滑肌细胞的增殖和迁移DOI: 10.1007/s11033-025-10314-8BMC oral health IF: 02.600
Volumn 25, Issue 1No.41Correlates of oral health-related quality of life in a sample of patients with rheumatoid arthritis类风湿性关节炎患者口腔健康相关生活质量的相关性DOI: 10.1186/s12903-024-05403-2IJCHV IF: 02.500
Volumn 56, Issue No.42Coronary artery calcifications are not associated with epicardial adipose tissue volume and attenuation on computed tomography in 1,945 individuals with various degrees of glucose disorders1945例患有不同程度葡萄糖紊乱的个体的冠状动脉钙化与心外膜脂肪组织体积和计算机断层扫描衰减无关DOI: 10.1016/j.ijcha.2025.101613Heart, Lung and Circulation IF: 02.200
Ahead of Print.No.43Cardiovascular Risk and Knowledge, Attitudes and Beliefs of Football Referees Towards Acute Coronary Syndrome Events足球裁判员对急性冠状动脉综合征事件的心血管风险和知识、态度和信念DOI: 10.1016/j.hlc.2024.09.010Journal of Applied Oral Science IF: 02.200
Volumn 33, Issue No.44Microbial signatures in head and neck squamous cell carcinoma: an in silico study头颈部鳞状细胞癌的微生物特征：计算机研究DOI: 10.1590/1678-7757-2024-0392BMC nephrology IF: 02.200
Volumn 26, Issue 1No.45Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis透析人群血脂与全因死亡率之间的剂量反应关系：荟萃分析DOI: 10.1186/s12882-025-03981-zBMC neurology IF: 02.200
Volumn 25, Issue 1No.46Identification of specific risk factors and predictive analytics for cardio-cerebral arterial stenosis: a comparative study utilizing framingham risk stratification insights心脑动脉狭窄的特定危险因素识别和预测分析：利用framingham风险分层见解的比较研究DOI: 10.1186/s12883-025-04024-8ABC Cardiol IF: 02.000
Volumn 122, Issue 1No.47Association between Estimated Small Dense Low-Density Lipoprotein-cholesterol (sdLDL-C) and Atherosclerotic Cardiovascular Disease Risk估计的小密度低密度脂蛋白胆固醇（sdLDL-C）与动脉粥样硬化性心血管疾病风险之间的关联DOI: 10.36660/abc.20240265Braz J Med Biol Res IF: 01.900
Volumn 58, Issue No.48Modulation of sirtuin expression by a high-sugar diet and regular swimming trained precedes the loss of kidney function在肾功能丧失之前，通过高糖饮食和定期游泳训练调节sirtuin的表达DOI: 10.1590/1414-431X2024e13043J Ocul Pharmacol Ther IF: 01.900
Ahead of Print.No.49A Multicenter, Randomized, Clinical Trial Assessing the Effect of rTG-Omega 3 Supplementation on Meibomian Gland Dysfunction Patients after Cataract Surgery rTG-Omega 3 for Meibomian Gland Dysfunction一项多中心，随机，临床试验，评估补充rTG Omega 3对白内障手术后睑板腺功能障碍患者的影响rTG Omega 3治疗睑板腺功能障碍DOI: 10.1089/jop.2024.0160J Gastrointest Cancer IF: 01.600
Volumn 56, Issue 1No.50Low-Density Lipoprotein (LDL) is Associated with Earlier Progression in Synchronous Metastatic Colorectal Cancer Treated without Curative Intent低密度脂蛋白（LDL）与无治愈意图治疗的同步转移性结直肠癌的早期进展有关DOI: 10.1007/s12029-025-01166-3Transfus Apher Sci IF: 01.400
Ahead of Print.No.51Comparative assessment of hemostasis in septic patients and healthy controls using standard coagulation tests and whole-blood thromboelastometry使用标准凝血试验和全血血栓弹力测定法比较脓毒症患者和健康对照者的止血效果DOI: 10.1016/j.transci.2025.104082Curēus IF: 01.000
Volumn 17, Issue 1No.52Digital Cyanosis as a Manifestation of Upper Limb Atherosclerosis: A Case Report以数字发绀为表现的上肢动脉粥样硬化1例DOI: 10.7759/cureus.76947Curēus IF: 01.000
Volumn 17, Issue 1No.53Clinical Outcomes and Healthcare Utilization in Pulmonary Embolism Patients With and Without Prothrombin G20210A Mutation: A National Retrospective Cohort Study有和没有凝血酶原G20210A突变的肺栓塞患者的临床结果和医疗保健利用：一项全国回顾性队列研究DOI: 10.7759/cureus.76921Am J Case Rep IF: 01.000
Volumn 26, Issue No.54Extreme Pregnancy-Induced Hypertriglyceridemia Resulting in Pancreatitis: A Case Report极端妊娠高甘油三酯血症致胰腺炎1例DOI: 10.12659/AJCR.946974Journal of medical case reports IF: 00.900
Volumn 19, Issue 1No.55Rheumatoid-like hand deformities and aortic valve disease in a 13-year-old girl with homozygous familial hypercholesterolemia: a case report13岁纯合子家族性高胆固醇血症女孩类风湿样手畸形和主动脉瓣疾病1例DOI: 10.1186/s13256-025-05070-zRespirology case reports IF: 00.800
Volumn 13, Issue 2No.56Tuberculosis Associated Chylothorax: A Case Report结核相关性乳糜胸1例DOI: 10.1002/rcr2.70107
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