全球血脂速递（第036期）丨家族性高胆固醇血症、小而密低密度脂蛋白胆固醇、多环芳烃与糖脂代谢、依洛尤单抗等
健康
2025-02-05 22:13
上海
截至02月05日15点59分，近期共有 240 本期刊发布了 360 篇文章，其中血脂相关的文章共 58 篇，覆盖 16 个领域的内容。其中影响因子最高的是刊登在 Molecular cancer (IF: 27.700) 期刊上标题为《癌细胞通过脂肪酸结合蛋白避免免疫细胞诱导的铁浓化》的文章。18Total Cholesterol(TC)总胆固醇17Atherosclerosis(AS)动脉粥样硬化3Hypercholesterolemia高胆固醇血症2Lipoprotein(a)(Lp(a))脂蛋白a1PCSK9 Inhibitors(PCSK9i)前蛋白转化酶枯草溶菌素9抑制剂1Non-high-density Lipoprotein Cholesterol(non-HDL-C)非高密度脂蛋白胆固醇1High Density Lipoprotein Cholesterol(HDL-C)高密度脂蛋白胆固醇1Low-Density Lipoprotein Cholesterol(LDL-C)低密度脂蛋白胆固醇Atherosclerosis IF: 04.900
巴基斯坦近亲家族性高胆固醇血症队列的级联筛查：鉴定7例新的纯合子患者
Quratul Ain, Jaka Sikonja, Fouzia Sadiq, Saeed Shafi, Jan Kafol, Tevz Gorjanc, etc.Background and aims家族性高胆固醇血症（FH）是一种遗传性疾病，其特征是出生时低密度脂蛋白胆固醇（LDL-C）水平升高，显著增加了早发心脏事件和死亡的风险。在巴基斯坦，尽管有FH的潜在负担，但评估其遗传特征，级联筛查意义和脂蛋白(a)[Lp(a)]水平的综合研究仍然很少。了解这些因素对于巴基斯坦人群中FH的有效诊断，风险评估和管理至关重要。Methods在鉴定出具有高LDL-C和高Lp(a)水平以及心血管疾病的阳性个人和家族史的临床纯合子FH的索引病例后，对来自近亲家庭的66例亲属进行了级联筛查。从所有受试者身上采集血液样本进行生化和遗传分析。Simon Broome标准适用于儿童的临床FH诊断。荷兰脂质诊所网络评分是针对年龄≥16岁的个体计算的。使用下一代测序进行基因筛选，以分析以下基因的所有编码区和外显子-内含子边界：ALMS1，APOA1，APOB，APOA5，APOC2，APOC3，APOE，ABCA1，ABCG5，ABCG8，CREB3L3，GPIHBP1，LDLR，LDLRAP1，LIPA，LMF1，LPL和PCSK9。已确定的变异通过Sanger测序法进行了确认。Results级联筛选确定了7例LDLR基因具有致病变异的纯合子和25例杂合子FH患者（NM_000527.5: c.2416dupG: p. Val806GlyfsTer11）。此外，还在另外4例受试者中发现了意义不明的杂合变异。Conclusion这项研究强调了在近亲家庭和社会中进行级联筛查的高效性，这可能导致早期发现和预防。Atherosclerosis | Ahead of Print.10.1016/j.atherosclerosis.2025.119118Frontiers in endocrinology IF: 03.900
绝经过渡期妇女小而密低密度脂蛋白胆固醇水平的测定
Qingfang He, Yujia Fang, Lixin Wang, Mingbin Liang, Xiangyu Chen, Ruying Hu, etc.Objective关于小而密低密度脂蛋白胆固醇（sdLDL-C）和绝经状态的研究仍然很少。本研究的目的是评估中国女性人群血清sdLDL-C水平与不同绝经状态之间的关系。Methods研究人员于2022年进行了一项横断面研究，包括电子标准化问卷调查，人体测量和基于社区的生物标本检查。招募了居住在浙江省两个社区并于5月26日至9月17日参加社区健康检查的30-69岁常住成年人。根据绝经状况，符合条件的女性受试者分为绝经前，围绝经期和绝经后。采用SAS软件建立Logistic回归模型，探讨sdLDL-C水平与不同绝经状态的关系。Results共纳入2062例女性受试者，中位年龄为57（51,63）岁。绝经前451例（21.9%），围绝经期87例（4.2%），绝经后1524例（73.9%）。中位sdLDL-C水平为0.937（0.685，1.209）mmol/L，绝经前，围绝经期和绝经后女性的sdLDL-C水平呈逐渐显著上升的趋势，并且在绝经后女性中达到峰值。Logistic回归分析显示，在控制混杂因素后，与绝经前相比，绝经后与sdLDL-C浓度升高显著相关（OR=1.514，95%CI 1.025-2.238），而血清sdLDL-C与围绝经期（与绝经前相比）或血清sdLDL-C与绝经后（与围绝经期相比）之间均无显著相关性。ConclusionssdLDL-C水平升高与绝经后显著相关，与年龄无关。该研究支持sdLDL-C是绝经过渡的有希望的风险生物标志物。未来的研究应该考虑更广泛的人群和更严格和彻底的研究设计，以验证这些发现。Frontiers in endocrinology | Volumn 15, Issue10.3389/fendo.2024.1500712Frontiers in public health IF: 03.000
海口市孕妇及其新生儿多环芳烃暴露来源及其对糖脂代谢的影响
Xiaomei Cheng, Haifeng Gao, Qiaojun Li, Naifan Zhang, Ying Lu, etc.Background多环芳烃（PAHs）是一类持续存在于环境中的大型有机化合物，被归类为持久性有机污染物（POPs）的重要子集。本研究旨在评估中国海口市孕妇和新生儿的PAH暴露情况，并评估其对糖脂代谢的影响。Methods在2022年5月至2023年12月期间，共选择了300例孕妇及其新生儿进行研究。收集生活方式和饮食习惯的数据，并使用气相色谱-质谱法测量静脉血和脐带血中的PAH水平。此外，还测量了糖脂代谢指标，包括空腹血浆葡萄糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）。进行乐相关和回归分析以探索PAH暴露与代谢指标之间的关系。Results在母体和脐带血中检测到13种多环芳烃。母体血液中∑PAHs的中位浓度（检测到的16种PAHs的总浓度）为11.211 μg/L，新生儿为10.921 μg/L。PAH暴露与糖脂代谢之间存在显著相关性，PAH暴露与TC和TG水平降低有关。靠近道路，烹饪燃料类型和饮食习惯等因素影响PAH水平。较高的教育水平与较低的PAH浓度有关，而住在道路附近和使用天然气作为烹饪燃料会增加暴露。Conclusion受环境和生活方式因素的影响，海口孕妇和新生儿存在明显的PAH暴露风险。怀孕期间接触PAH可能会影响母亲和新生儿的糖脂代谢，这突出表明需要采取干预措施来减少暴露。Frontiers in public health | Volumn 12, Issue10.3389/fpubh.2024.1510517Journal of sports sciences IF: 02.300
怀孕期间同时进行的运动训练与IL-8升高时更有利的母体血脂水平有关
Pedro Acosta-Manzano, Marta Flor-Alemany, Mireille N M Van Poppel, Irene Coll-Risco, Víctor Segura-Jiménez, Kristin I Stanford, etc.目前尚不清楚运动诱导的刺激如何影响并转化为怀孕期间的免疫代谢适应。之前发现运动会影响母胎循环细胞因子（IL-1β、IL-6、IL-8、IL-10、TNF-α）。本项研究调查了i）怀孕期间运动训练计划对母体，脐带动脉和静脉血清中代谢标志物（血糖和脂质标志物以及C反应蛋白）的影响；ii）这些细胞因子是否介导了运动对代谢标志物的影响。将88例孕妇分为运动组（i n/i 44）和对照组（i n/i 44），参加了这项准实验研究。运动组每周3天进行60分钟的同时（有氧+阻力）运动训练。使用标准生化方法和Luminex xMAP技术在第17周和第34周以及出生时测量血糖和脂质标志物以及C反应蛋白浓度和细胞因子水平。总体而言，运动在怀孕期间并未引起母体代谢标志物的可检测变化，除了那些IL-8水平升高的运动者，其与母体总胆固醇降低有关（间接效应=-9.1；95%CI -24.6至-1.1）和低密度脂蛋白胆固醇增加（-8.9；-21.9至-1.1）。这表明运动可以优化脂质代谢调节的机制。此外，运动与较低的脐带动脉血糖水平有关。进一步的研究，特别是关于胎儿代谢的研究是必要的。Journal of sports sciences | Ahead of Print.10.1080/02640414.2025.2456384Expert Rev Cardiovasc Ther IF: 01.800
依洛尤单抗降低HIV患者心血管风险：这是临床医生对艾滋病患者的最佳选择吗？
Francisco Akira Malta Cardozo, Luciana Dornfeld Bichuette, Bruno Caramelli, etc.Introduction艾滋病毒感染者（PLHIV）患心血管疾病（CVD）的风险较高，血脂异常是一种普遍的合并症，需要有效治疗。他汀类药物的使用局限性（如药物相互作用和不良反应）凸显了对替代疗法的需求。Areas covered这篇综述评估了PCSK9抑制剂在降低血脂异常的PLHIV心血管风险中的作用。分析了PUBMED上可用的研究，使用关键词HIV，血脂异常，PCSK9抑制剂和他汀类药物不耐受。讨论了心血管风险增加的潜在机制，他汀类药物的局限性，包括最近使用PCSK9抑制剂的研究。依洛尤单抗显著降低PLHIV中LDL-C水平56.9%，72.5%的患者LDL-C降低≥50%。试验证实了该药的安全性。此外，PCSK9抑制剂显示脂蛋白(a)和炎症标志物减少。Expert opinionPCSK9抑制剂为PLHIV的血脂管理提供了一种前景广阔的选择，尤其是对他汀类药物不耐受者或他汀类药物治疗后仍有残余风险者。针对不良血脂的其他非他汀类药物治疗，包括低HDL-C，高甘油三酯和脂蛋白(a)，正在开发中。结合反义寡核苷酸（ASO）和siRNA技术的进步，有望改变PLHIV中血脂异常和心血管疾病的治疗方法。Expert Rev Cardiovasc Ther | Ahead of Print.10.1080/14779072.2025.2463348Molecular cancer IF: 27.700
Volumn 24, Issue 1No.01Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins癌细胞通过脂肪酸结合蛋白避免免疫细胞诱导的铁浓化DOI: 10.1186/s12943-024-02198-2Nature communications IF: 14.700
Volumn 16, Issue 1No.02Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting非经典溶酶体脂解作用通过禁食促进脂肪组织能量储存的动员DOI: 10.1038/s41467-025-56613-3International journal of surgery IF: 12.500
Ahead of Print.No.03Effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial帕瑞昔布对高脂血症患者术后谵妄的影响：一项随机、双盲、单中心、优越性试验DOI: 10.1097/JS9.0000000000002286Cardiovascular Research IF: 10.200
Ahead of Print.No.04CircRNAs increase during vascular cell differentiation and are biomarkers for vascular diseasecircRNA在血管细胞分化过程中增加，是血管疾病的生物标志物DOI: 10.1093/cvr/cvaf013Brain, behavior, and immunity IF: 08.800
Ahead of Print.No.05Biological pathways underlying the relationship between childhood maltreatment and Multimorbidity: A Two-Step, multivariable Mendelian randomisation study儿童期虐待与多发病之间关系的生物学途径：一项两步多变量孟德尔随机研究DOI: 10.1016/j.bbi.2025.01.024Food chemistry IF: 08.500
Ahead of Print.No.06Main lipid sources affecting key aroma volatile compounds in Chinese native chicken影响中国土鸡关键香气挥发性化合物的主要脂质来源DOI: 10.1016/j.foodchem.2025.142990Biofabrication IF: 08.200
Ahead of Print.No.07Current progress of in vitro vascular models on microfluidic chips微流控芯片体外血管模型研究进展DOI: 10.1088/1758-5090/adb182Int J Biol Macromol IF: 07.700
Ahead of Print.No.08Polyguluronate sulfate has potential to mitigate hyperlipidemia by inhibiting the PCSK9-mediated degradation of LDLR聚谷氨酸钠硫酸盐有可能通过抑制PCSK9介导的LDLR降解来减轻高脂血症DOI: 10.1016/j.ijbiomac.2025.140585Environmental pollution IF: 07.600
Ahead of Print.No.096-PPD triggered lipid metabolism disorder and inflammatory response in larval zebrafish (Danio rerio) by regulating PPARγ/NF-κB pathway6-PPD通过调节PPARγ/NF-κB途径触发斑马鱼幼虫脂质代谢紊乱和炎症反应DOI: 10.1016/j.envpol.2025.125785Circ Cardiovasc Imaging IF: 06.500
Ahead of Print.No.10Longitudinal Assessment of Subclinical Arterial Inflammation in Patients Receiving Immune Checkpoint Inhibitors by Sequential [18F]FDG PET Scans通过顺序[18F]FDG PET扫描对接受免疫检查点抑制剂的患者亚临床动脉炎症的纵向评估DOI: 10.1161/CIRCIMAGING.124.016851Diabetes Res Clin Pract IF: 06.100
Ahead of Print.No.11Evolution of myocardial steatosis in high cardiovascular risk T2DM patients treated by GLP1 receptor agonists: LICAS studyGLP1受体激动剂治疗的高危T2DM患者心肌脂肪变性的演变：LICAS研究DOI: 10.1016/j.diabres.2025.112017Non-coding RNA research IF: 05.900
Volumn 11, Issue No.12Long non-coding RNA AK023617 orchestrates atherosclerosis by regulating the circadian rhythm of immunity-related GTPase family M protein in macrophages长链非编码RNA AK023617通过调节巨噬细胞中免疫相关GTPase家族M蛋白的昼夜节律来协调动脉粥样硬化DOI: 10.1016/j.ncrna.2024.12.008European Stroke Journal IF: 05.800
Ahead of Print.No.13Vessel wall enhancement and high-sensitivity CRP as prognostic markers in intracranial atherosclerotic stroke: A prospective cohort study血管壁增强和高敏CRP作为颅内动脉粥样硬化性卒中预后标志物的前瞻性队列研究DOI: 10.1177/23969873251317341European journal of neurology IF: 04.500
Volumn 32, Issue 2No.14Tirofiban Benefits the Outcome of Stroke Patients With Large Artery Atherosclerosis Achieving Full Reperfusion and High NIHSS Scores替罗非班有利于大动脉粥样硬化卒中患者实现完全再灌注和高NIHSS评分DOI: 10.1111/ene.70070Inflammation IF: 04.500
Ahead of Print.No.15A Comprehensive Review of Contemporary Bioreactors for Vascular Inflammation Studies当代血管炎症研究生物反应器的综述DOI: 10.1007/s10753-024-02231-yAquatic toxicology IF: 04.100
Ahead of Print.No.16Transcriptional modulation in Mediterranean Mussel Mytilus galloprovincialis following exposure to four pharmaceuticals widely distributed in coastal areas暴露于沿海地区广泛分布的四种药物后，地中海贻贝Mytilus galloprovincialis的转录调控DOI: 10.1016/j.aquatox.2025.107255Frontiers in endocrinology IF: 03.900
Volumn 15, Issue No.17Value of triglyceride glucose-body mass index in predicting nonalcoholic fatty liver disease in individuals with type 2 diabetes mellitus甘油三酯-葡萄糖体重指数对2型糖尿病患者非酒精性脂肪肝的预测价值DOI: 10.3389/fendo.2024.1425024Frontiers in endocrinology IF: 03.900
Volumn 15, Issue No.18The atherogenic index of plasma is associated with an increased risk of diabetes in non-obese adults: a cohort study一项队列研究表明，血浆致动脉粥样硬化指数与非肥胖成年人患糖尿病的风险增加有关DOI: 10.3389/fendo.2024.1477419Scientific reports IF: 03.800
Volumn 15, Issue 1No.19Nonlinear associations of the hs-CRP/HDL-C index with metabolic dysfunction-associated steatotic liver disease and advanced liver fibrosis in US adults: insights from NHANES 2017-2018美国成年人hs-CRP/HDL-C指数与代谢功能障碍相关的脂肪变性肝病和晚期肝纤维化的非线性关联：NHANES 2017-2018的见解DOI: 10.1038/s41598-025-88685-yCurrent medicinal chemistry IF: 03.500
Ahead of Print.No.20Lipid Biochemistry and its Role in Human Diseases脂质生物化学及其在人类疾病中的作用DOI: 10.2174/0109298673351452241220071215Journal of sleep research IF: 03.400
Ahead of Print.No.21Characterisation of nocturnal arrhythmia avalanche dynamics: Insights from generalised linear model analysis夜间心律失常雪崩动力学的表征：来自广义线性模型分析的见解DOI: 10.1111/jsr.14465Chemical biology & drug design IF: 03.200
Volumn 105, Issue 2No.22Embelin Elevates Endoplasmic Reticulum Calcium Levels and Blocks the Sterol Regulatory Element-Binding Protein 2 Mediated Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Improves the Low-Density Lipoprotein Receptor Mediated Lipid Clearance on HepatocytesEmbelin提高内质网钙水平，阻断固醇调节元件结合蛋白2介导的前蛋白转化酶枯草杆菌蛋白酶/Kexin 9型表达，改善低密度脂蛋白受体介导的肝细胞脂质清除DOI: 10.1111/cbdd.70055Renal failure IF: 03.000
Volumn 47, Issue 1No.23The atherogenic index of plasma increases the risk of incident kidney stones: a nested case-control study in Chinese adults血浆致动脉粥样硬化指数增加肾结石发生的风险：中国成年人的巢式病例对照研究DOI: 10.1080/0886022X.2025.2458757PloS one IF: 02.900
Volumn 20, Issue 2No.24Fecal bacteria transplantation replicates aerobic exercise to reshape the gut microbiota in mice to inhibit high-fat diet-induced atherosclerosis粪便细菌移植复制有氧运动，重塑小鼠肠道微生物群，抑制高脂饮食诱导的动脉粥样硬化DOI: 10.1371/journal.pone.0314698Curr Top Med Chem IF: 02.900
Ahead of Print.No.25Therapeutic Potential of Simvastatin: Cellular Mechanism, Binding Energetics, and Resistance Developments辛伐他汀的治疗潜力：细胞机制，结合能学和耐药性发展DOI: 10.2174/0115680266327892241223052456Climacteric : IF: 02.900
Ahead of Print.No.26Relationship between insulin resistance surrogates and bone mineral density in postmenopausal women绝经后妇女胰岛素抵抗替代指标与骨密度的关系DOI: 10.1080/13697137.2025.2455164The journal of dermatology IF: 02.900
Ahead of Print.No.27Corticosteroids combined with low-dose methotrexate in the treatment of pemphigus vulgaris: A retrospective cohort study皮质类固醇联合小剂量甲氨蝶呤治疗寻常型天疱疮的回顾性队列研究DOI: 10.1111/1346-8138.17636Diabetes Metab Syndr Obes IF: 02.800
Volumn 18, Issue No.28Outcomes Following Metabolic Bariatric Surgery at a Single Center in the United Arab Emirates在阿拉伯联合酋长国的一个中心进行代谢减肥手术后的结果DOI: 10.2147/DMSO.S499361Endocrinol Diabetes Metab IF: 02.700
Volumn 8, Issue 2No.29Association Between TyG-BMI Index and Hyperuricemia in Adult Women成年女性TyG BMI指数与高尿酸血症的关系DOI: 10.1002/edm2.70028Clin Med Insights Endocrinol Diabetes IF: 02.700
Volumn 18, Issue No.30The Relationship Between LRP-5 and LRP-6 Gene Mutations and Postmenopausal Type 2 Diabetes and ObesityLRP-5和LRP-6基因突变与绝经后2型糖尿病和肥胖的关系DOI: 10.1177/11795514241307180BMC pulmonary medicine IF: 02.600
Volumn 25, Issue 1No.31Impact of COVID-19 on metabolic parameters in patients with type 2 diabetes mellitus新型冠状病毒肺炎对2型糖尿病患者代谢参数的影响DOI: 10.1186/s12890-025-03529-9Current Cardiology Reviews IF: 02.400
Ahead of Print.No.32Pharmacogenomics and its Role in Cardiovascular Diseases: A Narrative Literature Review药物基因组学及其在心血管疾病中的作用：叙述性文献综述DOI: 10.2174/011573403X334668241227074314BMJ open IF: 02.400
Volumn 15, Issue 2No.33mHealth Intervention for Dementia Prevention through lifestyle Optimisation (MIND-PRO) in a primary care setting: protocol for a randomised controlled trial in people with low SES and/or migration background初级保健环境中通过生活方式优化（MIND-PRO）预防痴呆症的mHealth干预：针对低SES和/或移民背景人群的随机对照试验方案DOI: 10.1136/bmjopen-2024-088324Animal Bioscience IF: 02.400
Ahead of Print.No.34Effects of a multi-strain probiotic on rabbits productive traits, antioxidant defence, caecal microbiota and short‑chain fatty acids, and intestinal histomorphology多菌株益生菌对兔生产性状、抗氧化防御、盲肠微生物群和短链脂肪酸以及肠道组织形态学的影响DOI: 10.5713/ab.24.0716Clinical Cardiology IF: 02.400
Volumn 48, Issue 2No.35Prognosis of Out-of-Hospital Cardiac Arrest in Underserved Rural Area服务不足的农村地区院外心脏骤停的预后DOI: 10.1002/clc.70059Chemistry & biodiversity IF: 02.300
Ahead of Print.No.36Bioactive Polysaccharides From Cremastra Appendiculata Attenuate Lipid Accumulation In Vitro Model of Non-Alcoholic Fatty Liver Disease阑尾乳香生物活性多糖在非酒精性脂肪性肝病体外模型中减轻脂质积累DOI: 10.1002/cbdv.202402772Heart, Lung and Circulation IF: 02.200
Ahead of Print.No.37Ezetimibe Eligibility and Prescribing in Patients With Acute Coronary Syndrome急性冠状动脉综合征患者的依折麦布资格和处方DOI: 10.1016/j.hlc.2024.12.009Physiological reports IF: 02.200
Volumn 13, Issue 3No.38Exercise-induced effects on the metabolome of endurance and strength-trained athletes in comparison with sedentary subjects: A pilot study与久坐的受试者相比，运动对耐力和力量训练运动员代谢组的影响：一项初步研究DOI: 10.14814/phy2.70206Medical science monitor IF: 02.200
Volumn 31, Issue No.39Serum Trimethylamine N-Oxide Levels as a Predictor of Peripheral Arterial Disease in Kidney Transplant Recipients血清三甲胺N-氧化物水平作为肾移植受者外周动脉疾病的预测指标DOI: 10.12659/MSM.947197BMC Cardiovascular Disorders IF: 02.000
Volumn 25, Issue 1No.40The relationship between the atherogenic index of plasma and postoperative myocardial injury following non-cardiac surgery under general anaesthesia: a retrospective cohort study全麻下非心脏手术后血浆致动脉粥样硬化指数与术后心肌损伤的关系：一项回顾性队列研究DOI: 10.1186/s12872-025-04534-wPhysiological Research IF: 01.900
Volumn 73, Issue 6No.41LDHA- Mediated Histone Lactylation Promotes the Nonalcoholic Fatty Liver Disease Progression Through Targeting The METTL3/ YTHDF1/SCD1 m6A AxisLDHA介导的组蛋白乳酰化通过靶向METTL3/YTHDF1/SCD1 m6A轴促进非酒精性脂肪肝疾病的进展https://pubmed.ncbi.nlm.nih.gov/39903889Physiological Research IF: 01.900
Volumn 73, Issue 6No.42Physiology and Pathobiology of Perivascular Adipose Tissue: Inflammation-based Atherogenesis血管周围脂肪组织的生理学和病理生物学：基于炎症的动脉粥样硬化https://pubmed.ncbi.nlm.nih.gov/39903884Physiological Research IF: 01.900
Volumn 73, Issue 6No.43Adipokine Levels of RBP4, Resistin and Nesfatin-1 in Women Diagnosed With Gestational Diabetes妊娠期糖尿病患者RBP4、抵抗素和Nesfatin-1的脂肪因子水平https://pubmed.ncbi.nlm.nih.gov/39903893Int Urol Nephrol IF: 01.800
Ahead of Print.No.44Effect of selenium supplementation on hemodialysis patients: a meta-analysis补充硒对血液透析患者影响的荟萃分析DOI: 10.1007/s11255-025-04400-wComb Chem High Throughput Screen IF: 01.600
Ahead of Print.No.45Study on the Mechanism of the Leaves of Dimocarpus longan Lour. in the Management of Type 2 Diabetes based on Metabolomics龙眼叶片形成机制的研究。基于代谢组学的2型糖尿病管理DOI: 10.2174/0113862073335304241023153906Journal of community genetics IF: 01.500
Ahead of Print.No.46Enhancing familial hypercholesterolemia diagnosis in pediatrics through universal screening and provider education通过普遍筛查和提供者教育加强儿科家族性高胆固醇血症的诊断DOI: 10.1007/s12687-025-00773-8Iranian journal of public health IF: 01.300
Volumn 54, Issue 1No.47Correlation between Obesity and Risk Factors of Cardiovascular Diseases in Military Personnel军人肥胖与心血管疾病危险因素的相关性研究DOI: 10.18502/ijph.v54i1.17592Cent Eur J Public Health IF: 01.100
Volumn 32, Issue 4No.48Risk of metabolic syndrome linked to tobacco smoking and caffeine consumption among Palestinian university students巴勒斯坦大学生吸烟和咖啡因摄入与代谢综合征相关的风险DOI: 10.21101/cejph.a7320Curēus IF: 01.000
Volumn 17, Issue 1No.49Exploring Serum Anti-thyroid Peroxidase Antibodies and High-Sensitivity C-reactive Protein as Inflammatory Markers in Subclinical Hypothyroidism: A Comprehensive Study探索血清抗甲状腺过氧化物酶抗体和高敏C反应蛋白作为亚临床甲状腺功能减退症炎症标志物的综合研究DOI: 10.7759/cureus.76906SAGE open medical case reports IF: 00.600
Volumn 13, Issue No.50Diagnosis of Turner syndrome after presenting with ischemic cardiomyopathy: A case report缺血性心肌病后诊断Turner综合征1例DOI: 10.1177/2050313X251318519Patient preference and adherence
Volumn 19, Issue No.51Suitability of Measures of Pharmacy-Based Medication Adherence for Routine Clinical Use Among Patients with Chronic Diseases: A Systematic Review慢性病患者常规临床使用基于药房的药物依从性测量的适用性：系统评价DOI: 10.2147/PPA.S492461JNET : JNET :
Volumn 19, Issue 1No.52A Case of Acute Ischemic Stroke due to Tandem Lesion Treated with Endovascular Thrombectomy by Internal Carotid Artery Direct Puncture颈内动脉直接穿刺血管内血栓切除术治疗串联病变所致急性缺血性卒中1例DOI: 10.5797/jnet.cr.2024-0087Pharmaceutical nanotechnology
Ahead of Print.No.53Diosgenin-Loaded Silver Nanoparticles Mitigate B[a]P-Induced Lung Fibrosis Through Modulation of Oxidative Stress and Inflammatory Pathways负载薯蓣皂苷元的银纳米粒子通过调节氧化应激和炎症途径减轻B[a]P诱导的肺纤维化DOI: 10.2174/0122117385337401250116040312
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