全球血脂速递（第027期）丨肥胖和脂质相关指数、PCSK9抑制剂、降脂药物与肾衰竭
健康
2025-01-27 20:02
江西
截至01月27日15点59分，近期共有 152 本期刊发布了 197 篇文章，其中血脂相关的文章共 30 篇，覆盖 17 个领域的内容。其中影响因子最高的是刊登在 The Lancet (IF: 98.400) 期刊上标题为《冠状动脉CT血管造影指导治疗稳定型胸痛患者：苏格兰SCOT-HEART随机对照试验的10年结果》的文章。12Atherosclerosis(AS)动脉粥样硬化3Total Cholesterol(TC)总胆固醇2Hypertriglyceridemia(HTG)高甘油三酯血症1High Density Lipoprotein Cholesterol(HDL-C)高密度脂蛋白胆固醇1Hypercholesterolemia高胆固醇血症1Apolipoprotein B(ApoB)载脂蛋白B1Lipoprotein(a)(Lp(a))脂蛋白a1PCSK9 Inhibitors(PCSK9i)前蛋白转化酶枯草溶菌素9抑制剂Lipids in health and disease IF: 03.900
成年男性15项肥胖和脂质相关指数与睾酮之间的负相关：一项基于人群的横断面研究
Wei Guo, Shuo Zhao, Qinzheng Chang, Jiajia Sun, Yidong Fan, Jikai Liu, etc.Background肥胖与男性睾丸激素水平降低之间存在关联。这项研究的目的是揭示15项与肥胖和血脂水平相关的指标与血清睾酮浓度以及成年美国男性睾酮缺乏症（TD）发生率之间的相关性。Methods该研究利用了2011年至2016年进行的国家健康与营养检查调查（NHANES）收集的信息。这种被称为TD的疾病通常以血清总睾酮水平低于300 ng/dL为特征。该分析采用加权线性和逻辑回归方法，揭示了15个肥胖和血脂相关因素与血清睾酮水平以及TD之间的关联。进一步进行了亚组分析，以确认和验证这些发现。此外，还利用受限三次样条图来检验非线性关系。为15个因素绘制了受试者工作特征（ROC）曲线，并计算了曲线下面积（AUC），以评估每个因素在检测TD方面的疗效。Results在一组3540例成年男性中，观察到所有15个肥胖和脂质相关指标均与睾酮浓度呈负相关，与TD的存在呈直接相关。在考虑了所有协变量后，分析显示，内脏脂肪代谢评分（METS-VF）最高四分位数（Q4）内的个体患TD的概率很高（OR=13.412，95%CIs 4.222，42.262，P<0.001）。此外，METS-VF与TD之间存在非线性关系。在纳入所有调整的模型中，甘油三酯葡萄糖腰高比（TyG WHtR）在预测TD方面表现最佳（总体：AUC=0.762，95%CI 0.743，0.782，临界值=5.186）。Conclusion这15种标志物的水平升高与睾丸激素水平呈负相关，表明TD风险升高。在所有分析的指标中，TyG WHtR表现出最高的预测价值。Lipids in health and disease | Volumn 24, Issue 110.1186/s12944-025-02436-6Clin Investig Arterioscler IF: 01.900
PCSK9抑制剂在现实生活中的有效性和安全性
Antón González-Guerrero, Eugenia Navarrete-Rouco, David Benaiges, Eva Giralt-Steinhauer, Lidia Marcos, Anna Oliveras, etc.Objective确认前蛋白转化酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂在日常临床实践中的有效性和安全性Methods对接受PCSK9抑制剂治疗的医院登记患者进行回顾性观察研究，随访≥6个月。对降脂效果和安全性进行了评价。Results在纳入研究的193例患者中，168例（87%）患有心血管疾病，54例（28%）患有家族性高胆固醇血症；85例（44%）对他汀类药物/依折麦布不耐受。在LDL-C降低率≥50%（82.8% vs. 83.1%）、达到治疗目标（60.9% vs. 65.5%）或完全缓解（60.2% vs. 58.5%）方面，alirocumab组和evolocumab组之间没有差异。记录了一例接受alirocumab治疗的患者注射部位出现红斑，一例接受evolocumab治疗的患者出现荨麻疹。根据逻辑回归分析，接受PCSK9抑制剂治疗的受试者LDL-C的完全缓解与年龄增加（OR 1.045；95%CI 1.0-1.092；P=0.049）和主动吸烟（OR 4.562；95%CI 1.434-14.515；P=0.010）呈正相关，与女性性别（OR 0.403；95%CI 0.171-0.949；P=0.038）、基线LDL-C水平（OR 0.969；95%CI 0.957-0.981；P<0.001）和他汀类药物/依折麦布不耐受（OR 0.03；95%CI 0.176-0.925；P=0.041）呈负相关。Conclusion这项真实世界的实践研究证实，PCSK9抑制剂有效，安全且耐受性良好，无论使用何种单克隆抗体，其降脂效果均与随机对照试验中所述相当。Clin Investig Arterioscler | Ahead of Print.10.1016/j.arteri.2024.500755Lipids IF: 01.800
跨种族孟德尔分析揭示了降脂药物与肾衰竭之间的联系
Naidan Zhang, Chaixia Ji, Baibing Xie, Yaoyang Liu, Chengliang Yuan, etc.降脂药物已广泛应用于临床。目前尚不清楚这些药物是否对肾功能衰竭有影响。研究人员选择高密度脂蛋白胆固醇（ieu-b-109）、低密度脂蛋白胆固醇（ieu-a-300）、甘油三酯（ieu-b-111）和总胆固醇（ebi-a-GCST90038690）作为暴露量。药物基因附近的SNP是工具变量。从GWAS目录中选择欧洲人的急性肾衰竭（ARF）和慢性肾衰竭（CRF）作为结果。东亚人和南亚人肾功能衰竭的数据集用于验证。逆方差加权（IVW）是药物靶向孟德尔随机化的主要方法。在欧洲人中，使用PPARG的人将ARF风险降低了69.3%（OR 0.307，95%CI 0.171-0.553，P=0.015）。NPC1L1抑制剂使ARF风险增加了2.684倍（OR 2.684，95%CI 2.027-3.341，P=0.003）。APOE使ARF危险增加了1.987倍（OR 1.987，95%CI 1.062-3.716，P=0.032），但使CRF危险降低了49.7%（OR 0.503，95%CI 0.283-0.894，P=0.019）。TNFSF12使CRF危险增加了3.866倍（OR 3.866，95%CI 1.174–12.729，P=0.026）。在东亚人中，PPARG将CRF风险降低了85.8%（OR 0.142，95%CI 0.054–0.371，P<0.001）。在南亚人中，APOE将ARF风险降低了99.8%（OR 0.002，95%CI 2.12e-05-0.179，P=0.007）。研究发现PPARG可以降低欧洲人和亚洲人的肾功能衰竭风险。APOE可能在欧洲人中引起ARF，但在南亚人中具有保护作用。临床医生在给不同种族的患者用药之前，需要考虑当地人口的特点。The Lancet IF: 98.400
Volumn 405, Issue 10475No.01Coronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT-HEART randomised controlled trial in Scotland冠状动脉CT血管造影指导治疗稳定型胸痛患者：苏格兰SCOT-HEART随机对照试验的10年结果DOI: 10.1016/S0140-6736(24)02679-5Am J Kidney Dis IF: 09.400
Ahead of Print.No.02Arterial Stiffness and Subsequent Incidence of CKD and Kidney Function Decline in a Large Longitudinal Community Cohort: The Atherosclerosis in Communities (ARIC) Study大型纵向社区队列中的动脉僵硬度和随后的CKD发生率和肾功能下降：社区动脉粥样硬化（ARIC）研究DOI: 10.1053/j.ajkd.2024.11.011Cancer letters IF: 09.100
Ahead of Print.No.03Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis双重靶向PPARα和NPC1L1代谢脆弱性阻断肿瘤发生DOI: 10.1016/j.canlet.2025.217493JPAD IF: 08.500
Volumn 12, Issue 2No.04Association of statins use and genetic susceptibility with incidence of Alzheimer's disease他汀类药物使用和遗传易感性与阿尔茨海默病发病率的关系；s病DOI: 10.1016/j.tjpad.2024.100025Stem cell research & therapy IF: 07.100
Volumn 16, Issue 1No.05Cardio-renal effect of dapagliflozin and dapagliflozin- saxagliptin combination on CD34 + ve hematopoietic stem cells (HSCs) and podocyte specific markers in type 2 diabetes (T2DM) subjects: a randomized trial达格列净和达格列净-沙格列汀联合用药对2型糖尿病（T2DM）患者CD34+ve造血干细胞（HSC）和足细胞特异性标志物的心肾作用：一项随机试验DOI: 10.1186/s13287-025-04130-xChemico-biological interactions IF: 04.700
Ahead of Print.No.06Timosaponin B II as a novel KEAP1-NRF2 inhibitor to alleviate alcoholic liver disease:Receptor structure-based virtual screening and biological evaluationTimosaponin B II作为减轻酒精性肝病的新型KEAP1-NRF2抑制剂：基于受体结构的虚拟筛选和生物学评估DOI: 10.1016/j.cbi.2025.111390Int J Med Microbiol IF: 04.500
Ahead of Print.No.07Mycoplasma pneumoniae drives macrophage lipid uptake via GlpD-mediated oxidation, facilitating foam cell formation肺炎支原体通过GlpD介导的氧化驱动巨噬细胞脂质摄取，促进泡沫细胞形成DOI: 10.1016/j.ijmm.2025.151646International journal of obesity IF: 04.200
Ahead of Print.No.08Association of long-term weight management pharmacotherapy with multiple health outcomes: an umbrella review and evidence map长期体重管理药物治疗与多种健康结果的关联：综述和证据图DOI: 10.1038/s41366-025-01719-3Obesity facts IF: 03.900
Ahead of Print.No.09Higher visceral and lower peripheral adiposity characterize fat distribution and insulin resistance in Asian Indian women with Polycystic Ovary Syndrome in Mauritius毛里求斯患有多囊卵巢综合征的亚裔印度女性的内脏肥胖率较高，外周肥胖率较低，这是其脂肪分布和胰岛素抵抗的特征DOI: 10.1159/000543332Lipids in health and disease IF: 03.900
Volumn 24, Issue 1No.10Association between the hemoglobin A1c/High-density lipoprotein cholesterol ratio and stroke incidence: a prospective nationwide cohort study in China血红蛋白A1c/高密度脂蛋白胆固醇比值与卒中发病率的关系：一项前瞻性全国队列研究DOI: 10.1186/s12944-025-02438-4Scientific reports IF: 03.800
Volumn 15, Issue 1No.11Characteristics of transition to turbulence in a healthy thoracic aorta using large eddy simulation健康胸主动脉向湍流过渡的大涡模拟特征DOI: 10.1038/s41598-025-86983-zJournal of Clinical Lipidology IF: 03.600
Ahead of Print.No.12A novel variant in the ABCA1 gene for Tangier Disease with diffuse histiocytosis of bone marrow伴有骨髓弥漫性组织细胞增多症的丹吉尔病ABCA1基因的新变异DOI: 10.1016/j.jacl.2024.12.008Cardiovascular Toxicology IF: 03.400
Ahead of Print.No.13ETV5-Mediated Transcriptional Repression of DDIT4 Blocks Macrophage Pro-Inflammatory Activation in Diabetic AtherosclerosisETV5介导的DDIT4转录抑制阻断糖尿病动脉粥样硬化中巨噬细胞的促炎激活DOI: 10.1007/s12012-024-09956-0Experimental gerontology IF: 03.300
Ahead of Print.No.14CircXYLT1 suppresses oxidative stress and promotes vascular remodeling in aging mice carotid artery injury model of atherosclerosis via PTBP1CircXYLT1通过PTBP1抑制衰老小鼠动脉粥样硬化颈动脉损伤模型中的氧化应激并促进血管重塑DOI: 10.1016/j.exger.2025.112690Parasites & vectors IF: 03.000
Volumn 18, Issue 1No.15The developmental lipidome of Nippostrongylus brasiliensis巴西刺参的发育脂质组DOI: 10.1186/s13071-024-06654-2J Atheroscler Thromb IF: 03.000
Ahead of Print.No.16A Significant Effect of Pemafibrate on Carotid and Cerebral Atherosclerosis in Patients with Hypertriglyceridemia and Stroke培马贝特对高甘油三酯血症和卒中患者颈动脉粥样硬化和脑动脉粥样硬化的显着影响DOI: 10.5551/jat.ED277Clinical nutrition ESPEN IF: 02.900
Ahead of Print.No.17The predictive value of triglyceride-glucose-high density lipoprotein-body mass index (TGH-BMI) for different degrees of hepatic steatosis and liver fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD)甘油三酯-葡萄糖-高密度脂蛋白体重指数（TGH-BMI）对代谢功能障碍相关性脂肪肝（MASLD）不同程度肝脂肪变性和肝纤维化的预测价值DOI: 10.1016/j.clnesp.2025.01.041BMC endocrine disorders IF: 02.800
Volumn 25, Issue 1No.18Triglyceride-glucose index in predicting the risk of new-onset diabetes in the general population aged 45 years and older: a national prospective cohort study甘油三酯-葡萄糖指数预测45岁及以上普通人群新发糖尿病的风险：一项全国前瞻性队列研究DOI: 10.1186/s12902-025-01848-wClinical biochemistry IF: 02.500
Ahead of Print.No.19Assessing the predictive value of elevated triglycerides, triglyceride-glucose index (TyG), and TG/HDL ratios for cardiovascular disease and mortality during 20 years of follow-up: Tehran lipid and glucose study评估20年随访期间甘油三酯，甘油三酯-葡萄糖指数（TyG）和TG/HDL比值升高对心血管疾病和死亡率的预测价值：德黑兰脂质和葡萄糖研究DOI: 10.1016/j.clinbiochem.2025.110891BMJ open IF: 02.400
Volumn 15, Issue 1No.20Single-centre, double-blinded, randomised placebo-controlled trial to determine the effect of a 12-week home-based programme of footplate neuromuscular electrical stimulation on walking capacity in people with peripheral artery disease: a protocol for the Foot-PAD trial单中心、双盲、随机安慰剂对照试验，以确定为期12周的足板神经肌肉电刺激家庭计划对外周动脉疾病患者步行能力的影响：足垫试验方案DOI: 10.1136/bmjopen-2024-093162Heart, Lung and Circulation IF: 02.200
Ahead of Print.No.21Elucidating the Causal Link Between Treg-Related Immune Traits and Atherosclerosis-Related Cardiovascular Diseases: A Bidirectional Mendelian Randomisation Analysis阐明Treg相关免疫性状与动脉粥样硬化相关心血管疾病之间的因果关系：双向孟德尔随机分析DOI: 10.1016/j.hlc.2024.10.016BMC rheumatology IF: 02.100
Volumn 9, Issue 1No.22A rare intersection: squamous cell carcinoma of the tonsil and the anti-TIF1 syndrome masquerade一个罕见的交叉点：扁桃体鳞状细胞癌和抗TIF1综合征伪装DOI: 10.1186/s41927-025-00460-8BMC Cardiovascular Disorders IF: 02.000
Volumn 25, Issue 1No.23Prophylactic and therapeutic effects of EsV3 on atherosclerotic lesions in ApoE-/- miceEsV3对ApoE-/-小鼠动脉粥样硬化病变的预防和治疗作用DOI: 10.1186/s12872-025-04497-yMed Oral Patol Oral Cir Bucal IF: 01.800
Ahead of Print.No.24Assessment of the association between coronary artery blockage and periodontal health status in patients undergoing coronary angiography: a cross-sectional study冠状动脉造影患者冠状动脉阻塞与牙周健康状况关系的横断面研究DOI: 10.4317/medoral.26946Annals of Vascular Surgery IF: 01.400
Ahead of Print.No.25Biomarkers and Social Determinants in atherosclerotic Arterial Diseases: A Scoping Review动脉粥样硬化性动脉疾病的生物标志物和社会决定因素：范围界定综述DOI: 10.1016/j.avsg.2024.12.076JACC: Advances
Ahead of Print.No.26Associations of Serum Urate and Cardiovascular Events in a Clinical Trial of Interleukin-1β Blockade白细胞介素-1β阻断剂临床试验中血清尿酸盐与心血管事件的关系DOI: 10.1016/j.jacadv.2024.101583Zhonghua neike zazhi
Volumn 64, Issue 2No.27[Study of the occurrence of metabolic dysfunction-associated fatty liver disease in obstructive sleep apnea hypopnea syndrome and its risk factors][阻塞性睡眠呼吸暂停低通气综合征代谢功能障碍相关脂肪肝的发生及其危险因素研究]DOI: 10.3760/cma.j.cn112138-20240812-00506
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