全球血脂速递（第038期）丨依洛尤单抗、高胆固醇血症、血脂生物标志物与胃肠道癌症等
健康
2025-02-07 20:06
上海
截至02月07日15点59分，近期共有 302 本期刊发布了 460 篇文章，其中血脂相关的文章共 78 篇，覆盖 23 个领域的内容。其中影响因子最高的是刊登在 European Heart Journal (IF: 37.600) 期刊上标题为《颈动脉粥样硬化：不稳定的机制和临床意义》的文章。17Atherosclerosis(AS)动脉粥样硬化13Total Cholesterol(TC)总胆固醇9Hypercholesterolemia高胆固醇血症6Low-Density Lipoprotein Cholesterol(LDL-C)低密度脂蛋白胆固醇3Apolipoprotein B(ApoB)载脂蛋白B3Colesevelam Hydrochloride考来维仑3Lipoprotein(a)(Lp(a))脂蛋白a2PCSK9 Inhibitors(PCSK9i)前蛋白转化酶枯草溶菌素9抑制剂2Non-high-density Lipoprotein Cholesterol(non-HDL-C)非高密度脂蛋白胆固醇2High Density Lipoprotein Cholesterol(HDL-C)高密度脂蛋白胆固醇1Bile acid sequestrants胆酸清除剂1Primary Hypercholesterolaemia原发性高胆固醇血症JACC IF: 21.700
依洛尤单抗对老年人的长期降脂作用
Samer Al Said, Michelle L O'Donoghue, Xinhui Ran, Sabina A Murphy, Dan Atar, Anthony Keech, etc.Background与年轻患者相比，对老年患者强化低密度脂蛋白胆固醇降低的有效性和安全性的担忧导致美国指南中对75岁以上患者的建议较弱。关于老年患者前蛋白转化酶枯草杆菌蛋白酶/kexin 9型抑制的长期益处的数据很少。Objectives本研究旨在评估依洛尤单抗在≥75岁患者中的长期益处。MethodsFOURIER（高危人群PCSK9抑制的进一步心血管结局研究）试验将27564例18至85岁动脉粥样硬化性心血管疾病患者随机分为依洛尤单抗组和安慰剂组，中位随访时间为2.2年。在开放标签扩展（FOURIER-OLE）中，6635例参与者被转换为开放标签依洛尤单抗，进行额外的5年中位随访。主要终点（心血管死亡，心肌梗塞，卒中，不稳定型心绞痛住院或冠状动脉血运重建）是根据依洛尤单抗与安慰剂的原始分配进行比较的，按年龄分层（<75岁 vs. ≥75岁）。复合终点的单个组成部分的分析能力不足。在FOURIER主试验期间，按随机治疗臂计算了OLE人群各年龄组的相关不良事件年化发生率；在主试验和FOURIER-OLE联合研究期间，按最初分配给依洛尤单抗的患者计算了OLE人群各年龄组的相关不良事件年化发生率。Results在27564例患者中，2526例（9%）在进入FOURIER时年龄≥75岁（中位年龄：77岁[Q1-Q3:76-79岁]）。FOURIER和FOURIER-OLE的中位随访时间为7.1年（第一季度至第三季度：6.7-7.6年），最长为8.7年。依洛尤单抗的早期启动至少降低了老年患者（HR 0.79；95%CI 0.64-0.97）和年轻患者（HR 0.86；95%CI 0.80-0.92；P相互作用=0.43）的主要终点发生率。老年患者的绝对风险降低为5.4%（95%CI -2.0%至12.8%），年轻患者的绝对风险降低为2.3%（95%CI 0.1%-4.5%），分别需要治疗19例和44例。在两个年龄组的治疗组中，安全事件的年发生率通常相似。Conclusions长期依洛尤单抗的早期启动为患有动脉粥样硬化性心血管疾病的老年患者提供了至少与年轻患者一样好的心血管益处，老年患者需要更有利的治疗数量以减少复合终点，并且没有显著的安全性问题。这些发现可能有助于指导未来的建议。JACC | Volumn 85, Issue 510.1016/j.jacc.2024.11.019Cancer medicine IF: 02.900
血脂生物标志物与中国人群胃肠道癌症风险：开滦前瞻性研究
Ying Xiao, Xin Du, Tianjie Wang, Dong Liu, Hongzhao You, Hao Wang, etc.Background目前关于血脂生物标志物与胃肠道癌症风险之间关系的证据仍存在争议，尚未达成共识。Methods研究人员在开滦队列中进行了一项前瞻性队列研究，其中88225例个体具有甘油三酯（TG），总胆固醇（TC），低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的基线信息。从2006年到2021年，跟踪食管癌（EC），胃癌（GC）和结直肠癌（CRC）的发病率。使用Cox比例风险模型和受限三次样条（RCS）分析来估计风险比（HR）和95%置信区间（CI）。ResultsEC风险增加与高HDL-C水平有关（HRQ4 vs. Q1=2.50，95%CI 1.57-3.98），而RCS分析显示HDL-C与EC风险呈U型关系（Poverall≤0.0001，Pnonlinear=0.02）。脂质生物标志物与GC风险之间没有发现强烈的关联。在多变量分析中，CRC风险增加与高TC水平呈正相关（HRQ4 vs. Q1=1.42，95%CI 1.11-1.83，Ptrend=0.03），剂量反应与LDL-C水平呈负相关（HRQ2 vs. Q1=0.83，95%CI 0.66-1.02；HRQ3 vs. Q1=0.86，95%CI 0.69-1.07；HRQ4 vs. Q1=0.68，95%CI 0.53-0.86，Ptrend=0.02），与HDL-C水平呈负相关（HRQ2 vs. Q1=0.75，95%CI 0.60-0.94；HRQ3 vs. Q1=0.76，95%CI 0.61-0.95；HRQ4 vs. Q1=0.91，95%CI 0.74-1.13，Ptrend=0.02）。随后的RCS分析显示，LDL-C（Poverall=0.004，Pnonlinear=0.67）与CRC风险呈线性负相关，HDL-C（Poverall=0.05，Pnonlinear=0.02）与CRC风险呈U型关系。竞争风险分析和敏感性分析证实了结果的稳定性。Conclusion观察到HDL-C水平与EC和CRC风险呈U型关系，LDL-C水平与CRC风险呈线性反比关系。某些胃肠道癌症的高危人群应适当管理相关的血脂水平。Cancer medicine | Volumn 14, Issue 3Nature communications IF: 14.700
联合CAR激动剂/PXR拮抗剂MI-883在饮食诱导的高胆固醇血症模型中的降血脂作用
Jan Dusek, Ivana Mejdrová, Klára Dohnalová, Tomas Smutny, Karel Chalupsky, Maria Krutakova, etc.组成型雄甾烷受体（CAR）和孕烷X受体（PXR）是密切相关的核受体，在异生素清除中具有重叠的调节功能，但在内生素代谢中具有不同的作用。已经证明Car激活通过调节胆固醇代谢和胆汁酸消除来改善高胆固醇血症，而PXR激活与高胆固醇血症和肝脏脂肪变性有关。在这里，研究人员展示了人类CAR激动剂/PXR拮抗剂MI-883，它通过在基因调控中利用CAR和PXR相互作用来有效调节与异生素代谢和胆固醇/胆汁酸稳态相关的基因。通过在喂食高脂肪和高胆固醇饮食的人源化PXR-CAR-CYP3A4/3A7小鼠中利用脂质组学，胆汁酸代谢组学和转录组学进行综合分析，证明MI-883显著降低血浆胆固醇水平并增强粪便胆汁酸排泄。这项工作为靶向多种异生核受体的配体的开发铺平了道路。这种配体具有精确调节肝脏代谢的潜力，为代谢紊乱提供了新的治疗策略。Nature communications | Volumn 16, Issue 110.1038/s41467-025-56642-yEJPC IF: 08.400
总胆固醇和非高密度脂蛋白胆固醇与冠状动脉钙化的存在和程度之间的性别特异性关联
Kasper Westphal Leth, Christine Dalgård, Oke Gerke, Jes S Lindholt, Jess Lambrechtsen, Lars Frost, etc.Aims调查总胆固醇，非高密度脂蛋白胆固醇（非HDL-C）与冠状动脉钙（CAC）评分评估的动脉粥样硬化负担之间的性别特异性关联。Methods丹麦风险评分研究和丹麦心血管筛查试验队列共纳入10049例参与者（女性：958例，男性：9091例），年龄49-75岁，无已知心血管疾病（CVD）或目前使用降脂药物。Logistic回归模型和零膨胀负二项回归模型用于估计总胆固醇，非HDL-C和CAC之间关联的优势比（OR），发生率比（IRR）和95%置信区间（CI）存在（CAC>0）和程度。所有分析均针对年龄，BMI，糖尿病，吸烟，高血压和CVD家族史进行了调整。Results女性CAC和总胆固醇的OR为1.09（95%CI 0.94-1.27），男性为1.26（95%CI 1.19-1.33）。女性存在CAC和非HDL-C的OR为1.12（95%CI 0.96-1.29），男性为1.25（95%CI 1.18；1.33）。无论性别如何，总胆固醇升高与CAC程度之间均无显著相关性（女性：IRR 0.99；95%CI 0.83-1.19；男性：IRR 1.04；95%CI 0.997-1.07）。非HDL-C与男性CAC程度显著相关（IRR 1.04；95%CI 1.001-1.08），但与女性无关（IRR 0.93；95%CI 0.78-1.12）。Conclusion总胆固醇与CAC的存在有关，非HDL-C与男性CAC评分的存在和程度有关。在女性中未发现总胆固醇或非HDL-C的关联。Scientific reports IF: 03.800
残余胆固醇及其变异性与低密度脂蛋白胆固醇无关，可预测代谢功能障碍相关的脂肪变性肝病
Yuting Sun, Xinlei Miao, Manling Hu, Xiaoling Xie, Shuang Liu, Ziping Song, etc.本研究旨在确定残余胆固醇（RC）及其变异性是否可以独立于低密度脂蛋白胆固醇（LDL-C）水平预测代谢功能障碍相关脂肪变性肝病（MASLD）的发作。进行了一项纵向队列研究，涉及43065例接受至少两次体格检查的参与者。本研究使用Cox比例风险模型来评估RC四分位数水平（Q1-Q4），访视变异性和MASLD风险之间的关系。使用几个指标对这种变异性进行了量化：标准差（SD），logSD，平均真实变异性（ARV），logARV，平均绝对偏差（MAD）和logMAD。同时，本研究还对RC组和LDL-C组进行了综合分析，以评估与RC相关的MASLD独立风险。在平均随访3.19年（SD 2.06年）期间，8374例患者（19.45%）发生了MASLD。与Q1相比，Q4的MASLD风险明显更高（危险比[HR] 1.309，95%CI 1.220-1.403，P<0.001）。完全调整后的Cox模型显示，SD、logSD、ARV、logARV、MAD和logMAD的HR分别为1.400（95%CI 1.305-1.502）、1.278（95%CI 1.188-1.374）、1.152（95%CI 1.079-1.229）、1.183（95%CI 1.140-1.227）、1.578（95%CI 1.433-1.737）和1.263（95%CI 1.175-1.358）。在两个LDL-C亚组（≥3.4 mmol/L和<3.4 mmol/L）中，高基线RC与MASLD风险升高相关（HR 1.208，95%CI 1.148-1.270，P<0.001；HR 1.246，95%CI 1.129-1.374，P<0.001）。在健康人中，无论低密度脂蛋白胆固醇水平如何，RC水平都与MASLD独立相关。RC在每次就诊期间的变化为识别MASLD高危人群提供了一个预测指标。Scientific reports | Volumn 15, Issue 110.1038/s41598-025-88000-9European Heart Journal IF: 37.600
Ahead of Print.No.01Correction to: Carotid artery atherosclerosis: mechanisms of instability and clinical implications纠正：颈动脉粥样硬化：不稳定的机制和临床意义DOI: 10.1093/eurheartj/ehaf085JACC IF: 21.700
Volumn 85, Issue 5No.02Social Determinants of Health, Cardiovascular Health, and Mortality in Sexual Minority Individuals in the United States美国性少数群体健康、心血管健康和死亡率的社会决定因素DOI: 10.1016/j.jacc.2024.11.026JACC IF: 21.700
Volumn 85, Issue 5No.03Evolocumab in Older Individuals: Expanding the Age Horizon老年人的依洛尤单抗：扩大年龄范围DOI: 10.1016/j.jacc.2024.11.043Nature aging IF: 17.000
Ahead of Print.No.04Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging衰老过程中伴侣介导的跨组织自噬的性别特异性和细胞类型特异性变化DOI: 10.1038/s43587-024-00799-6Drugs IF: 13.000
Ahead of Print.No.05Ebronucimab: First ApprovalEbronucimab：首次批准DOI: 10.1007/s40265-025-02146-4Water research IF: 11.400
Ahead of Print.No.06Microbial metabolic enzymes, pathways and microbial hosts for co-metabolic degradation of organic micropollutants in wastewater废水中有机微污染物共代谢降解的微生物代谢酶、途径和微生物宿主DOI: 10.1016/j.watres.2025.123229Cardiovascular Diabetology IF: 08.500
Volumn 24, Issue 1No.07The association between stress-induced hyperglycemia ratio and cardiovascular events as well as all-cause mortality in patients with chronic kidney disease and diabetic nephropathy慢性肾脏病和糖尿病肾病患者应激性高血糖率与心血管事件及全因死亡率的关系DOI: 10.1186/s12933-025-02610-1EJPC IF: 08.400
Ahead of Print.No.08Prenatal and Postnatal Nutritional Mismatch, Reflected by Birth Weight and Adult BMI, and Cardiometabolic Disease Risk产前和产后营养不匹配，反映在出生体重和成人BMI以及心脏代谢疾病风险DOI: 10.1093/eurjpc/zwaf059Int J Biol Macromol IF: 07.700
Ahead of Print.No.09Exploration of capsaicin-encapsulated lignin nanoparticles for alleviating non-alcoholic fatty liver disease: In-vitro study辣椒素包裹木质素纳米粒缓解非酒精性脂肪性肝病的体外研究DOI: 10.1016/j.ijbiomac.2025.140616Int J Biol Macromol IF: 07.700
Ahead of Print.No.10Mechanistic insights into alkaloid-based inhibition of squalene epoxidase: A combined in silico and experimental approach for targeting cholesterol biosynthesis基于生物碱抑制角鲨烯环氧化酶的机理研究：一种针对胆固醇生物合成的计算机和实验相结合的方法DOI: 10.1016/j.ijbiomac.2025.140609Clinical nutrition IF: 06.600
Volumn 45, Issue No.11The effects of 6 months dietary counseling on diet quality and cardiovascular risk profile in patients with cardiovascular disease: A randomized controlled trial6个月饮食咨询对心血管疾病患者饮食质量和心血管风险的影响：一项随机对照试验DOI: 10.1016/j.clnu.2024.12.020Molecular biomedicine IF: 06.300
Volumn 6, Issue 1No.12Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10脂肪组织来源的microRNA-450a-5p通过下调DUSP10诱导2型糖尿病DOI: 10.1186/s43556-025-00247-wEuropean Stroke Journal IF: 05.800
Ahead of Print.No.13C-reactive protein expression in acute ischemic stroke blood clots: Implications for etiology急性缺血性卒中血凝块中C反应蛋白的表达：对病因学的影响DOI: 10.1177/23969873251315636Current Atherosclerosis Reports IF: 05.700
Volumn 27, Issue 1, Page 1- 2No.14Highlights of Cardiovascular Disease Prevention Studies Presented at the 2024 American Heart Association Scientific Sessions2024年美国心脏协会科学会议上心血管疾病预防研究的重点DOI: 10.1007/s11883-025-01276-0J Cardiovasc Comput Tomogr IF: 05.500
Ahead of Print.No.15Prediction of obstructive coronary artery disease using coronary calcification and epicardial adipose tissue assessments from CT calcium scoring scansCT钙评分扫描冠状动脉钙化和心外膜脂肪组织评估预测阻塞性冠状动脉疾病DOI: 10.1016/j.jcct.2025.01.007Diabetes, obesity & metabolism IF: 05.400
Ahead of Print.No.16Comparison of the efficacy and safety of GLP-1 receptor agonists on cardiovascular events and risk factors: A review and network meta-analysisGLP-1受体激动剂对心血管事件和危险因素的有效性和安全性比较：综述和网络荟萃分析DOI: 10.1111/dom.16228Heart IF: 05.100
Ahead of Print.No.17Pulse pressure and aortic valve peak velocity and incident heart failure after myocardial infarction: a cohort study脉压和主动脉瓣峰值速度与心肌梗死后心力衰竭的队列研究DOI: 10.1136/heartjnl-2024-324517Journal of lipid research IF: 05.000
Ahead of Print.No.18A Multi-Ancestry Genome Wide Association Study and Evaluation of Polygenic Scores of LDL-C levels多血统全基因组关联研究和LDL-C水平多基因评分的评估DOI: 10.1016/j.jlr.2025.100752Atherosclerosis IF: 04.900
Volumn 401, Issue No.19Using omics data and genome editing methods to decipher GWAS loci associated with coronary artery disease使用组学数据和基因组编辑方法破译与冠状动脉疾病相关的GWAS基因座DOI: 10.1016/j.atherosclerosis.2024.118621Atherosclerosis IF: 04.900
Ahead of Print.No.20Pericoronary adipose tissue attenuation on coronary computed tomography angiography: Possibilities and challenges冠状动脉CT血管造影中冠状动脉周围脂肪组织的衰减：可能性和挑战DOI: 10.1016/j.atherosclerosis.2025.119105Front Cell Infect Microbiol IF: 04.600
Volumn 14, Issue No.21High-density lipoprotein cholesterol as a prognostic marker for 90-day transplant-free mortality in hepatitis B virus-related acute-on-chronic liver failure高密度脂蛋白胆固醇作为乙型肝炎病毒相关性慢加急性肝衰竭90天无移植死亡率的预后指标DOI: 10.3389/fcimb.2024.1458818Frontiers in nutrition IF: 04.000
Volumn 12, Issue No.22Decreased vitamin D increase the risk for subclinical hypothyroidism in individuals with T2DM: a cross-sectional study维生素D降低会增加T2DM患者亚临床甲状腺功能减退的风险：一项横断面研究DOI: 10.3389/fnut.2025.1509465Frontiers in endocrinology IF: 03.900
Volumn 16, Issue No.23Association between triglyceride-glucose index and all-cause mortality in critically ill patients with acute myocardial infarction: analysis of the MIMIC-IV database急性心肌梗死危重患者甘油三酯-葡萄糖指数与全因死亡率的关系：MIMIC-IV数据库的分析DOI: 10.3389/fendo.2025.1447053Frontiers in endocrinology IF: 03.900
Volumn 16, Issue No.24The prognostic association of triglyceride-glucose index and its derived indicators with stable coronary artery disease patients undergoing percutaneous coronary intervention甘油三酯-葡萄糖指数及其衍生指标与稳定型冠心病患者经皮冠状动脉介入治疗预后的关系DOI: 10.3389/fendo.2025.1465376Lipids in health and disease IF: 03.900
Volumn 24, Issue 1No.25The diagnostic value of the combined application of blood lipid metabolism markers and interleukin-6 in osteoporosis and osteopenia血脂代谢标志物和白细胞介素-6联合应用对骨质疏松症和骨质减少症的诊断价值DOI: 10.1186/s12944-025-02456-2Frontiers in endocrinology IF: 03.900
Volumn 16, Issue No.26Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke代谢紊乱在缺血性卒中后认知功能障碍发生发展中的机制及标志物研究进展DOI: 10.3389/fendo.2025.1500650Clinical Research in Cardiology IF: 03.800
Ahead of Print.No.27Inflammation, Lp(a) and cardiovascular mortality: results from the LURIC study炎症、Lp（a）和心血管死亡率：LURIC研究的结果DOI: 10.1007/s00392-025-02609-4Scientific reports IF: 03.800
Volumn 15, Issue 1No.28Effect of supplementation of phytoadditive mixtures on live weight, blood indices, hormonal profile and reproductive performance in Black Bengal goats添加植物添加剂混合物对黑孟加拉山羊体重、血液指标、激素谱和繁殖性能的影响DOI: 10.1038/s41598-025-89026-9Journal of intensive care IF: 03.800
Volumn 13, Issue 1No.29Association between the triglyceride-glucose index and the risk of acute kidney injury in critically ill patients with acute pancreatitis: a retrospective study重症急性胰腺炎患者甘油三酯-葡萄糖指数与急性肾损伤风险的关系：一项回顾性研究DOI: 10.1186/s40560-025-00779-xAnimal Model Exp Med IF: 03.800
Ahead of Print.No.30Development of an atherosclerosis rabbit model to evaluate the hemodynamic impact of extracorporeal circulation动脉粥样硬化兔模型的建立，以评估体外循环对血流动力学的影响DOI: 10.1002/ame2.12556European radiology experimental IF: 03.700
Volumn 9, Issue 1No.31A minimally invasive animal model of atherosclerosis and neointimal hyperplasia for translational research动脉粥样硬化和新内膜增生的微创动物模型用于转化研究DOI: 10.1186/s41747-025-00558-1American Heart journal IF: 03.700
Ahead of Print.No.32Rationale, design and pre-randomization data for a cluster randomized trial to assess the effect of a digitally enabled quality improvement intervention on LDL-C control in established atherosclerotic cardiovascular disease patients: The SAPPHIRE-LDL Trial集群随机试验的基本原理、设计和预随机化数据，以评估数字质量改进干预对已确诊的动脉粥样硬化性心血管疾病患者LDL-C控制的影响：SAPPHIRE-LDL试验DOI: 10.1016/j.ahj.2025.01.019J Trace Elem Med Biol IF: 03.600
Ahead of Print.No.33Sub-lethal toxicity effects of iron oxide nanoparticles (IONPs) on the biochemical, oxidative biomarkers, and metabolic profile in Caridina fossarum氧化铁纳米颗粒（IONPs）对加勒比海生物化学、氧化生物标志物和代谢特征的亚致死毒性作用DOI: 10.1016/j.jtemb.2025.127613J Cell Commun Signal IF: 03.600
Volumn 19, Issue 1No.34Role of the calcium-sensing receptor in regulating vascular function钙敏感受体在调节血管功能中的作用DOI: 10.1002/ccs3.70004Journal of Clinical Lipidology IF: 03.600
Ahead of Print.No.35Achilles tendon palpation for diagnosis of familial hypercholesterolemia: The compelling need to restore a valuable lost art跟腱触诊诊断家族性高胆固醇血症：迫切需要恢复有价值的丢失的artDOI: 10.1016/j.jacl.2024.12.002BMC public health IF: 03.500
Volumn 25, Issue 1No.36The triglyceride-glucose index trajectories are associated with cardiovascular diseases in people living with HIV: evidence from a prospective cohort study in China, 2005-2022甘油三酯-葡萄糖指数轨迹与HIV感染者的心血管疾病相关：来自中国2005-2022年前瞻性队列研究的证据DOI: 10.1186/s12889-025-21744-1Surg Obes Relat Dis IF: 03.500
Ahead of Print.No.37Obesity/overweight prevalence and economic burdens by bariatric surgery, metabolic syndrome, and related comorbidity in 2013-2019: a nationwide descriptive analysis2013-2019年减肥手术、代谢综合征和相关合并症的肥胖/超重患病率和经济负担：全国描述性分析DOI: 10.1016/j.soard.2024.12.026BMC infectious diseases IF: 03.400
Volumn 25, Issue 1No.38Triglyceride-glucose index and mortality risks in Helicobacter pylori-infected patients: a national cohort study幽门螺杆菌感染患者的甘油三酯-葡萄糖指数和死亡风险：一项全国队列研究DOI: 10.1186/s12879-025-10556-8Genomics IF: 03.400
Ahead of Print.No.39Biological effects of baicalin on the ovine mammary cells and regulatory mechanism study by transcriptomic analysis黄芩苷对绵羊乳腺细胞的生物学效应及其调控机制的转录组学研究DOI: 10.1016/j.ygeno.2025.111012Biol Trace Elem Res IF: 03.400
Ahead of Print.No.40The Protective Effect of Boric Acid Against High Fructose-Induced Liver and Kidney Damage in Rats硼酸对高果糖诱导的大鼠肝肾损伤的保护作用DOI: 10.1007/s12011-025-04542-zBiochimie IF: 03.300
Ahead of Print.No.41Metabolic adaptation mechanisms of glycogen reduction and lipid accumulation in testicular protection in Daurian ground squirrels during hibernationDaurian地鼠冬眠期间睾丸保护中糖原减少和脂质积累的代谢适应机制DOI: 10.1016/j.biochi.2025.01.014IJC IF: 03.200
Ahead of Print.No.42Temporal trends of characteristics and management of patients with suspected MINOCA疑似MINOCA患者的特征和管理的时间趋势DOI: 10.1016/j.ijcard.2025.133039Indian J Dermatol Venereol Leprol IF: 03.200
Ahead of Print.No.43Topical egg yolk oil (4% cholesterol) and oral rosuvastatin for the treatment of disseminated superficial actinic porokeratosis局部蛋黄油（4%胆固醇）和口服瑞舒伐他汀治疗播散性浅表光化性汗孔角化病DOI: 10.25259/IJDVL_1026_2024Advanced biology IF: 03.200
Ahead of Print.No.44The Role and Molecular Pathways of SIRT6 in Senescence and Age-related DiseasesSIRT6在衰老和年龄相关疾病中的作用及其分子途径DOI: 10.1002/adbi.202400469Indian J Dermatol Venereol Leprol IF: 03.200
Ahead of Print.No.45The additional effect of 5% atorvastatin shampoo in the treatment of adult patients with mild to moderate seborrheic dermatitis of the scalp: A prospective, randomised, double-blind trial5%阿托伐他汀洗发水治疗成人轻度至中度头皮脂溢性皮炎的额外效果：一项前瞻性，随机，双盲试验DOI: 10.25259/IJDVL_245_2024Clinical oral investigations IF: 03.100
Volumn 29, Issue 2No.46Systemic risk factors contributing to sialolithiasis: a big-data retrospective analysis导致唾液结石的系统性危险因素：大数据回顾性分析DOI: 10.1007/s00784-025-06179-7Frontiers in medicine IF: 03.100
Volumn 11, Issue No.47Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized controlled pilot study大剂量阿托伐他汀作为美沙拉嗪辅助治疗减轻溃疡性结肠炎患者炎症和症状的效果：一项随机对照试验研究DOI: 10.3389/fmed.2024.1490178High Blood Press Cardiovasc Prev IF: 03.100
Ahead of Print.No.48Cardiovascular Risk Factors and Diseases and Awareness of Related Burden in Women: Results of a Survey in Italian Pharmacies女性心血管危险因素和疾病以及对相关负担的认识：意大利药店的一项调查结果DOI: 10.1007/s40292-025-00701-4J Pharm Biomed Anal IF: 03.100
Ahead of Print.No.49Reprogramming of lipids and amino acids metabolism is an early event in myocardium of type 1 diabetic rhesus monkeys脂质和氨基酸代谢的重编程是1型糖尿病恒河猴心肌的早期事件DOI: 10.1016/j.jpba.2025.116699Frontiers in medicine IF: 03.100
Volumn 12, Issue No.50Association between SPISE and NAFLD in patients with type 2 diabetes2型糖尿病患者SPISE与NAFLD的关系DOI: 10.3389/fmed.2025.1454938Renal failure IF: 03.000
Volumn 47, Issue 1No.51The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007-2018)估计的肾小球滤过率和身体圆度指数在美国成年人尿酸降低治疗抵抗性痛风风险评估中的作用：来自国家健康和营养检查调查（2007-2018）的证据DOI: 10.1080/0886022X.2024.2441398J Hum Nutr Diet IF: 02.900
Volumn 38, Issue 1No.52Development and Validation of Healthy and Unhealthy Plant-Based Diet Propensity Scores in European Children, Adolescents and Adults From the I.Family StudyI.家庭研究中欧洲儿童、青少年和成年人健康和不健康植物饮食倾向评分的开发和验证DOI: 10.1111/jhn.70021PloS one IF: 02.900
Volumn 20, Issue 2No.53Drug-induced autoimmune-like hepatitis: A disproportionality analysis based on the FAERS database药物诱导的自身免疫性肝炎：基于FAERS数据库的不成比例分析DOI: 10.1371/journal.pone.0317680JBIC IF: 02.700
Ahead of Print.No.54Donut-shaped [NaP5W30O110]14- polyoxometalate as a promising antidiabetic drug-candidate: putative mechanisms of action甜甜圈形状的[NaP5W30O110]14-多金属氧酸盐作为一种有前途的抗糖尿病候选药物：推定的作用机制DOI: 10.1007/s00775-025-02098-wFrontiers in veterinary science IF: 02.600
Volumn 11, Issue No.55Ferula (Ferula elaeochytris) as a phytoestrogen: Use of Ferula in laying hens阿魏作为植物雌激素：阿魏在蛋鸡中的应用DOI: 10.3389/fvets.2024.1525101Drug testing and analysis IF: 02.600
Ahead of Print.No.56Impact of Menstrual Cycle and Oral Contraceptives on Haematological and Inflammatory Biomarkers in Highly Trained Female Athletes月经周期和口服避孕药对训练有素的女运动员血液学和炎症生物标志物的影响DOI: 10.1002/dta.3859Journal of movement disorders IF: 02.500
Ahead of Print.No.57Drug Repositioning and Repurposing for Disease-Modifying Effects in Parkinson's Disease药物重新定位和重新利用帕金森病的疾病缓解作用'；s病DOI: 10.14802/jmd.25008Preventive medicine reports IF: 02.400
Volumn 50, Issue No.58Cardiovascular diseases health literacy among Italian navy personnel: A cross-sectional survey意大利海军人员心血管疾病健康素养的横断面调查DOI: 10.1016/j.pmedr.2025.102978Res Pharm Sci IF: 02.100
Volumn 19, Issue 6No.59Ultra-small phospholipid nanoparticles in the treatment of combined hyperlipidemia: a randomized placebo-controlled clinical trial超小磷脂纳米粒治疗合并高脂血症的随机安慰剂对照临床试验DOI: 10.4103/RPS.RPS_274_23BMC Cardiovascular Disorders IF: 02.000
Volumn 25, Issue 1No.60Unraveling the association and regulatory role of miR-146b-5p in coronary artery disease揭示miR-146b-5p在冠状动脉疾病中的关联和调节作用DOI: 10.1186/s12872-025-04530-0Statistics in medicine IF: 01.800
Volumn 44, Issue 5No.61Time-Dependent ROC Curve for Multiple Longitudinal Biomarkers and Its Application in Diagnosing Cardiovascular Events多纵向生物标志物的时间依赖性ROC曲线及其在心血管事件诊断中的应用DOI: 10.1002/sim.10318Korean J Physiol Pharmacol IF: 01.600
Ahead of Print.No.62Cholestyramine in hemodialysis: a new approach for hyperphosphatemia management血液透析中的消胆胺：高磷血症管理的新方法DOI: 10.4196/kjpp.24.269Int J Med Mushrooms IF: 01.400
Volumn 27, Issue 4No.63Antihyperlipidemic Effect of Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) Extract in Rats with Postnatal Sucrose Consumption Whose Mothers Also Consumed Sucrose牡蛎烹饪药用蘑菇平菇提取物对出生后食用蔗糖且母亲也食用蔗糖的大鼠的降血脂作用DOI: 10.1615/IntJMedMushrooms.2024057783Med Lett Drugs Ther IF: 01.400
Volumn 67, Issue 1721No.64Comparison chart: Safety of drugs for IBS in pregnancy and lactation对比图：妊娠期和哺乳期IBS药物的安全性DOI: 10.58347/tml.2025.1721bMed Lett Drugs Ther IF: 01.400
Volumn 67, Issue 1721No.65Comparison chart: Some drugs for irritable bowel syndrome with diarrhea (IBS-D)对比图：一些治疗腹泻型肠易激综合征（IBS-D）的药物DOI: 10.58347/tml.2025.1721fAnatomy & cell biology IF: 01.400
Ahead of Print.No.66The effect of rosuvastatin coated by nano-chitosan on developing hippocampus: association with hippocampal neurogenesis and memory in an Alzheimer's induced model of rats纳米壳聚糖包覆瑞舒伐他汀对发育中海马的影响：与阿尔茨海默病患者海马神经发生和记忆的关系'；s诱导的大鼠模型DOI: 10.5115/acb.24.250Turk J Gastroenterol IF: 01.400
Ahead of Print.No.67Metabolic and Hepatic Profiles of Non-Obese and Obese Metabolic Dysfunction-Associated Steatotic Liver Disease in Adolescents: The Role of FibroScan Parameters,Fibroblast Growth Factor-21, and Cytokeratin-18青少年非肥胖和肥胖代谢功能障碍相关脂肪变性肝病的代谢和肝脏特征：纤维扫描参数、成纤维细胞生长因子21和细胞角蛋白18的作用DOI: 10.5152/tjg.2025.24760Turk J Gastroenterol IF: 01.400
Ahead of Print.No.68IREB2 Knockdown Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by TLR4/NF-κB Signaling InactivationIREB2基因敲除通过TLR4/NF-κB信号失活减轻高脂饮食诱导的非酒精性脂肪肝DOI: 10.5152/tjg.2025.24054Med Lett Drugs Ther IF: 01.400
Volumn 67, Issue 1721No.69Drugs for irritable bowel syndrome肠易激综合征的药物DOI: 10.58347/tml.2025.1721aCurēus IF: 01.000
Volumn 17, Issue 1No.70Efficacy of Low-Carbohydrate Diets Versus Low-Fat Diets in Glycemic Control Among Patients With Type 2 Diabetes: A Systematic Review低碳水化合物饮食与低脂饮食对2型糖尿病患者血糖控制效果的系统评价DOI: 10.7759/cureus.77004Special care in dentistry IF: 00.900
Volumn 45, Issue 1No.71Sedation in Home Care Surgical Procedures for a Patient With Dental Phobia: A Case Report牙科恐惧症患者家庭护理手术中的镇静：一例病例报告DOI: 10.1111/scd.70006BMJ case reports IF: 00.600
Volumn 18, Issue 2No.72Incidental diagnosis of familial hypercholesterolaemia in a mother-daughter pair: the underdiagnosis of the disease highlighting the need for universal screening母女对家族性高胆固醇血症的偶然诊断：该疾病的诊断不足突出了普遍筛查的必要性DOI: 10.1136/bcr-2024-263538
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