全球血脂速递（第023期）丨低密度脂蛋白胆固醇、高脂血症合并高尿酸血症、甘油三酯、低载脂蛋白A-I等
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2025-01-23 19:20
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截至01月23日15点59分，近期共有 297 本期刊发布了 495 篇文章，其中血脂相关的文章共 60 篇，覆盖 20 个领域的内容。其中影响因子最高的是刊登在 The New England Journal of Medicine (IF: 96.200) 期刊上标题为《阿贝拉西单抗与利伐沙班治疗心房颤动的比较》的文章。17Atherosclerosis(AS)动脉粥样硬化8Total Cholesterol(TC)总胆固醇3High Density Lipoprotein Cholesterol(HDL-C)高密度脂蛋白胆固醇3Hypertriglyceridemia(HTG)高甘油三酯血症2Non-high-density Lipoprotein Cholesterol(non-HDL-C)非高密度脂蛋白胆固醇1PCSK9 Inhibitors(PCSK9i)前蛋白转化酶枯草溶菌素9抑制剂1Apolipoprotein B(ApoB)载脂蛋白B1Bile acid sequestrants胆酸清除剂1Low-Density Lipoprotein Cholesterol(LDL-C)低密度脂蛋白胆固醇BMC medicine IF: 07.000
除了低密度脂蛋白胆固醇之外：残余胆固醇与儿童心脏代谢危险因素有关
Ana Torres-Costoso, Vicente Martínez-Vizcaíno, Andreia Oliveira, Mairena Sánchez-López, Eva Rodríguez-Gutiérrez, Sergio Núñez de Arenas-Arroyo, etc.Background来自成人随机对照试验和队列研究的最新证据表明，血浆残余胆固醇（RC）水平可预测心血管疾病。在儿童中，研究很少，尽管高水平的RC可能代表早期动脉粥样硬化损伤的标志。因此，本研究的目的是探讨与RC相关的心脏代谢风险，其范围超出了儿童的低密度脂蛋白胆固醇（LDL-C）。Methods在3417例8-11岁的西班牙学龄儿童中检查了心脏代谢危险因素（血浆胰岛素水平，胰岛素抵抗的稳态模型评估，平均动脉血压[MAP]，腰围[WC]和心肺功能[CRF]）。根据LDL-C≥110 mg/dL和RC≥15 mg/dL的临界值，将儿童分为四个亚组（低与高），以确定更高的水平，并应用ANCOVA模型评估两种脂质参数在心脏代谢风险中的作用。此外，使用多水平混合效应广义线性回归模型来评估RC或LDL-C与心脏代谢危险因素的关联，并检查RC与这些因素之间的关联是否在LDL-c水平低或高的儿童中有所不同。Results高RC亚组的儿童，特别是低LDL-C/高RC和高LDL-C/高RC的儿童，比低RC亚组的同龄人表现出更高的胰岛素水平和WC。RC与心脏代谢危险因素的相关性高于LDL-C（RC和LDL-C的胰岛素 β=2.073/-0.026；HOMA-IR β=0.451/-0.002；MAP β=1.214/0.300；WC β=2.842/1.058；CRF β=-0.316/-0.194）。此外，即使在低LDL-C水平的儿童中，RC也表现出相关性：胰岛素（β=2.305；P＜0.001），HOMA-IR（β=0.499；P＜0.001），MAP（β=1.397，P＜0.001），WC（β=2.842；P＜0.001）和CRF（β=-0.367；P＜0.001）。ConclusionsRC与心脏代谢危险因素之间的关联性强于LDL-C与心脏代谢风险之间的关联性，即使在LDL-C水平较低的儿童中也具有重要意义。这些发现可能在临床上对心血管危险分层和指导儿童未来的干预措施有用，尽管它们应该通过纵向研究得到证实。BMC medicine | Volumn 23, Issue 110.1186/s12916-025-03859-9Frontiers in nutrition IF: 04.000
高脂血症合并高尿酸血症导致NAFPD恶化：脂质组学的大鼠试验
Jingyun Li, Yongjian Chen, Shilin Li, Guorong Lyu, Furong Yan, Jiajing Guo, etc.Background高尿酸血症和非酒精性脂肪性胰腺疾病（NAFPD）是普遍存在的代谢性疾病，但它们之间的关系仍未得到充分探索。Methods将18只Sprague-Dawley大鼠随机分为三组：正常（CON），高脂肪（PO）和高脂肪高尿酸（PH）。12周后，测量血清尿酸（SUA）和三酰基甘油水平。使用苏木精-伊红（HE）染色评估胰腺的病理变化。使用脂质组学技术分析血清样品，并使用多变量统计分析来鉴定脂质代谢的差异。ResultsPO组SUA水平与CON组无显著性差异（P<0.05）。然而，从第4周开始，PH组的SUA水平明显高于PO组和CON组（P<0.05）。HE染色显示CON组大多数大鼠胰岛和腺泡细胞形态正常。PH组的病理NAFPD评分高于PO组。脂质组学分析确定了CON和PO组中的34种潜在血清生物标志物，CON和PH组中的38种，PH和PO组中的32种。这些代谢物主要包括鞘脂类、胆固醇酯、脂肪酸、三酰甘油、磷脂酰胆碱、溶血磷脂酰胆碱、磷脂酰乙醇胺和溶血磷脂酰乙醇胺。Conclusion高脂血症合并高尿酸血症可能加剧NAFPD。甘油磷脂可能是该过程中的关键生物标志物，可能与甘油磷脂介导的慢性炎症反应有关。Frontiers in nutrition | Volumn 11, Issue10.3389/fnut.2024.1437373Scientific reports IF: 03.800
血糖水平对高脂血症性急性胰腺炎患者血清甘油三酯清除率的影响
Yuxin Liu, Shuqi Qin, Si Dai, Jing Zhou, Zhendan Wang, Guojian Yin, etc.预防中重度和重症急性胰腺炎（MSAP＆SAP）是高脂血症性急性胰腺炎（HLAP）管理的主要目标。这项研究的主要目的是调查影响血清甘油三酯（TG）清除率的因素，特别是血糖（GLU）水平，这可能有助于预防MSAP和SAP的发展。收集177例MSAP＆SAP患者和195例轻度急性胰腺炎（MAP）患者发病后第1-6天的临床资料，并通过多因素logistic回归分析，以确定影响HLAP严重程度的因素，尤其是TG。通过受试者工作特征（ROC）分析获得最佳TG阈值，以区分TG快速清除患者和TG缓慢清除患者，如本研究所定义。进一步分析了可能干扰TG清除的代谢相关因素，例如GLU，糖尿病（DM），肥胖和尿酸。第2天TG是HLAP患者MSAP和SAP的独立危险因素（OR：3.718，95%CI 2.042-6.77；P<0.001）。而TG慢清除的患者（第2天TG≥7.335 mmol/L）更有可能发展为MSAP和SAP（敏感性0.932，特异性0.898，严重的胰腺坏死和死亡。DM（OR：3.574,95%CI 1.13–11.308，P<0.001） 和第2天GLU（OR：1.537,95%CI 1.292–1.675；P<0.001）是TG慢清除的独立危险因素，但不是HLAP严重程度的独立危险因素（OR：1.728，P=0.253和OR：1.119，P=0.059）。DM和非糖尿病患者（NDM）患者的第2天GLU分别降至13.07 mmol/L和6.575 mmol/L以下，导致第2天的TG降至7.335 mmol/L。第2天的TG水平对HLAP的严重程度影响最大，这也准确预测了MSAP和SAP的发生。值得注意的是，GLU 能否在第2天达到目标值，因为它可以直接影响TG清除率，间接影响HLAP的严重程度。Scientific reports | Volumn 15, Issue 110.1038/s41598-024-83342-2J Stroke Cerebrovasc Dis IF: 02.000
低载脂蛋白A-I作为颈动脉易损斑块替代指标的潜力
Saya Tsuchigauchi, Toshinori Matsushige, Yukishige Hashimoto, Hosogai Masahiro, Hiroki Takahashi, Shohei Kobayashi, etc.Objective最近的研究表明，对致动脉粥样硬化脂蛋白的医学控制不足以预防卒中。低载脂蛋白A-I（apoA-I）水平可能在高密度脂蛋白（HDL-C）的抗动脉粥样硬化作用中起关键作用，也可能与颈动脉狭窄的症状性易损斑块有关。因此，本研究调查了apoA-I水平与颈动脉狭窄状态之间的关系。Methods对91例颈动脉狭窄患者进行了检查。颈动脉斑块的状态分为有症状（n=47）和无症状（n=44）。研究人员检查了患者概况，包括合并症和实验室脂质数据，以及通过超声检查，MRI和数字减影血管造影可视化的斑块特征。研究斑块不稳定性与颈动脉狭窄危险因素之间的关系。Results有症状和无症状患者的概况没有观察到显著差异。关于斑块特征，溃疡，低回声亮度和T1加权图像上斑块中的高信号强度与症状斑块相关。有症状患者的ApoA-I，总胆固醇和非HDL-C水平显著低于无症状患者。多变量logistic回归分析确定低ApoA-I水平，溃疡和低回声亮度是症状性颈动脉狭窄的预测因素。当以下四个因素结合时，预测症状性颈动脉狭窄的诊断准确性为0.84：溃疡，低回声亮度，T1加权图像上的高信号强度和apoA-I水平。ConclusionsapoA-I水平低与症状性颈动脉狭窄有关。因此，ApoA-I水平有可能作为检测不稳定颈动脉斑块的替代指标。J Stroke Cerebrovasc Dis | Ahead of Print.10.1016/j.jstrokecerebrovasdis.2025.108231Lipids IF: 01.800
前蛋白转化酶枯草杆菌蛋白酶/kexin 9型抑制剂对高危人群颈动脉粥样硬化的消退作用
Albert Z Luu, Yasaman Hajiesmaeili, Sholeh Faezi, J David Spence, Daniel G Hackam, Hamed Hadizadeh, etc.前蛋白转化酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂代表了一种降低胆固醇并因此减轻动脉粥样硬化负担的新方法。然而，关于PCSK9抑制剂对动脉粥样硬化斑块的可能影响的数据有限。评估PCSK9抑制剂在降低高危颈动脉粥样硬化疾病患者颈动脉斑块进展方面的疗效。使用颈动脉总斑块面积（TPA）来评估动脉粥样硬化的负担。在PCSK9抑制剂治疗开始之前和之后获得颈动脉的超声成像。研究人员选择了动脉粥样硬化的高危病例，至少进行了三次超声检查，一年前，一次在开始PCSK9抑制剂时，一次在开始PCSK9抑制剂后1年。使用具有限制最大似然（REML）的混合效应模型进行统计分析。研究回顾了131例患者的数据，平均随访6（±4）年。患者是高危患者，其中大多数患有糖尿病或高血压。TPA有所降低，尤其是在开始PCSK9抑制剂治疗后的前3年（P<0.05）。此外，观察到基线血清低密度脂蛋白胆固醇（LDL-C）水平较高的个体TPA下降幅度更大（P<0.05）。PCSK9抑制剂可有效实现动脉粥样硬化高危患者的斑块消退。这一点很重要，因为斑块消退与卒中、心肌梗死或血管性死亡的风险降低相关。AJCD IF: 01.300
SGLT-2抑制剂对心力衰竭患者血脂谱的影响：系统评价和荟萃分析
Seyed Mohammad Mahdi Meybodi, Mohammad Amin Karimi, Kourosh Mousazadeh, Kamyar Khorsand, Samira Masoumi, Seyed Abbas Pakmehr, etc.Background and aim钠-葡萄糖协同转运蛋白两种抑制剂可以通过调节心力衰竭患者的血脂谱来减少心血管事件，而与糖尿病状态无关。在这项研究中，旨在通过荟萃分析评估SGLT-2抑制剂对心力衰竭患者血脂谱的影响。Methods在PubMed、Scopus、Web of Science和Google Scholar数据库中检索了截至2023年的相关文章标题、摘要和全文。使用STATA软件进行荟萃分析。Result接受SGLT-2抑制剂治疗的患者空腹血糖水平的森林图与对照组有显著差异（平均差异=-0.08，95%CI -0.13至-0.02，P＜0.05）。接受SGLT-2抑制剂的HF患者的血脂谱参数（包括总胆固醇，甘油三酯，HDL和LDL）分析与对照组无显著差异（P>0.005）。然而，平均差异是降低LDL，胆固醇和甘油三酯，并显示HDL水平升高。Egger的发表偏倚测试显示出一些发表偏倚（P<0.05）。Conclusion这项主题分析未发现脂质谱有任何显著变化。为了达成更明确的协议，有必要对心力衰竭患者进行进一步研究，因为目前证据不足。AJCD | Volumn 14, Issue 6NEJM IF: 96.200
Volumn 392, Issue 4No.01Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation阿贝拉西单抗与利伐沙班治疗心房颤动的比较DOI: 10.1056/NEJMoa2406674Advanced science IF: 14.300
Ahead of Print.No.02Multiple Enzymes Expressed by the Gut Microbiota Can Transform Typhaneoside and Are Associated with Improving Hyperlipidemia肠道微生物群表达的多种酶可以转化伤寒杆菌肽，并与改善高脂血症有关DOI: 10.1002/advs.202411770Advanced science IF: 14.300
Ahead of Print.No.03The Metabolite Indole-3-Acetic Acid of Bacteroides Ovatus Improves Atherosclerosis by Restoring the Polarisation Balance of M1/M2 Macrophages and Inhibiting Inflammation卵形拟杆菌的代谢产物吲哚-3-乙酸通过恢复M1/M2巨噬细胞的极化平衡和抑制炎症来改善动脉粥样硬化DOI: 10.1002/advs.202413010Gut microbes IF: 12.200
Volumn 17, Issue 1No.04Bacterial extracellular vesicles in the initiation, progression and treatment of atherosclerosis细菌胞外囊泡在动脉粥样硬化的发生、发展和治疗中的作用DOI: 10.1080/19490976.2025.2452229Seminars in immunopathology IF: 07.900
Volumn 47, Issue 1No.05Maternal lipids in overweight and obesity: implications for pregnancy outcomes and offspring's body composition超重和肥胖的母体脂质：对妊娠结局和后代的影响'；s身体成分DOI: 10.1007/s00281-024-01033-6Investigative radiology IF: 07.000
Ahead of Print.No.06Differentiation of Atherosclerotic Carotid Plaque Components With Dual-Energy Computed Tomography双能CT鉴别颈动脉粥样硬化斑块成分DOI: 10.1097/RLI.0000000000001153NPJ Parkinson's disease IF: 06.700
Volumn 11, Issue 1No.07A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson's disease基于网络的系统遗传学框架确定了帕金森病的病理生物学和药物再利用'；s病DOI: 10.1038/s41531-025-00870-yAm J Clin Nutr IF: 06.500
Ahead of Print.No.08Gut microbiota may modify the association between dietary polyphenol intake and circulating levels of hippuric acid: results from a 1-year longitudinal study in China肠道微生物群可能会改变膳食多酚摄入量与马尿酸循环水平之间的关系：中国一项为期1年的纵向研究结果DOI: 10.1016/j.ajcnut.2025.01.018Diabetes IF: 06.200
Volumn 74, Issue 2No.09Mechanistic Insights Into the Exercise-Induced Changes in Muscle Lipids and Insulin Sensitivity-Expanding on the "Athlete's Paradox": Revisiting a 2011 Diabetes Classic by Amati et al运动引起的肌肉脂质变化和胰岛素敏感性在“运动员悖论”中扩展的机制性见解：重新审视Amati等人2011年的糖尿病经典DOI: 10.2337/dbi24-0030Circ Cardiovasc Interv IF: 06.100
Ahead of Print.No.10FFR-Negative Nonculprit High-Risk Plaques and Clinical Outcomes in High-Risk Populations: An Individual Patient-Data Pooled Analysis From COMBINE (OCT-FFR) and PECTUS-obsFFR阴性的非罪犯高危斑块和高危人群的临床结果：来自COMBINE（OCT-FFR）和PECTUS obs的个体患者数据汇总分析DOI: 10.1161/CIRCINTERVENTIONS.124.014667J Transl Med IF: 06.100
Volumn 23, Issue 1No.11Serum HDL and their subfractions are impaired in multisystem inflammatory syndrome in children (MIS-C)儿童多系统炎症综合征（MIS-C）血清HDL及其亚组分受损DOI: 10.1186/s12967-025-06123-zCurrent Atherosclerosis Reports IF: 05.700
Volumn 27, Issue 1, Page 1- 2No.12Exposomic Determinants of Atherosclerosis: Recent Evidence动脉粥样硬化的暴露决定因素：最新证据DOI: 10.1007/s11883-025-01274-2Atherosclerosis IF: 04.900
Ahead of Print.No.13VLDL triglycerides and cholesterol in non-alcoholic fatty liver disease and myocardial infarction非酒精性脂肪肝病和心肌梗死中的VLDL甘油三酯和胆固醇DOI: 10.1016/j.atherosclerosis.2024.119094Journal of ethnopharmacology IF: 04.800
Ahead of Print.No.14Polysaccharide extracted from Phellinus igniarius attenuated hyperuricemia by modulating bile acid metabolism and inhibiting uric acid synthesis in adenine/potassium oxonate-treated mice桑黄多糖通过调节腺嘌呤/氧酸钾处理小鼠的胆汁酸代谢和抑制尿酸合成来减轻高尿酸血症DOI: 10.1016/j.jep.2025.119365Toxicology IF: 04.800
Ahead of Print.No.15Cadmium promotes hyaluronan synthesis by inducing hyaluronan synthase 3 expression in cultured vascular endothelial cells via the c-Jun N-terminal kinase-c-Jun pathway镉通过c-Jun N末端激酶-c-Jun途径诱导培养的血管内皮细胞中透明质酸合酶3的表达，从而促进透明质酸的合成DOI: 10.1016/j.tox.2025.154062Front Cell Infect Microbiol IF: 04.600
Volumn 14, Issue No.16Clinical features and risk factors of HIV-infected patients with intracerebral hemorrhage: a retrospective study with propensity score matching analysisHIV感染脑出血患者的临床特征和危险因素：倾向评分匹配分析的回顾性研究DOI: 10.3389/fcimb.2024.1498327Frontiers in pharmacology IF: 04.400
Volumn 15, Issue No.17Gallic acid: a dietary metabolite's therapeutic potential in the management of atherosclerotic cardiovascular disease没食子酸：一种膳食代谢物'；动脉粥样硬化性心血管疾病的治疗潜力DOI: 10.3389/fphar.2024.1515172Frontiers in pharmacology IF: 04.400
Volumn 15, Issue No.18Hepatotoxicity of statins: a real-world study based on the US Food and Drug Administration Adverse Event Reporting System database他汀类药物的肝毒性：基于美国食品和药物管理局不良事件报告系统数据库的现实研究DOI: 10.3389/fphar.2024.1502791BMC biology IF: 04.400
Volumn 23, Issue 1No.19Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis血流紊乱的内皮细胞释放细胞外囊泡，促进巨噬细胞的炎症极化，加速动脉粥样硬化DOI: 10.1186/s12915-025-02125-xFrontiers in pharmacology IF: 04.400
Volumn 15, Issue No.20Identification of ALEKSIN as a novel multi-IRF inhibitor of IRF- and STAT-mediated transcription in vascular inflammation and atherosclerosisALEKSIN作为IRF和STAT介导的血管炎症和动脉粥样硬化转录的新型多IRF抑制剂的鉴定DOI: 10.3389/fphar.2024.1471182Frontiers in pharmacology IF: 04.400
Volumn 15, Issue No.21High mobility group box 1 (HMGB1) mediates nicotine-induced podocyte injury高迁移率族蛋白B1（HMGB1）介导尼古丁诱导的足细胞损伤DOI: 10.3389/fphar.2024.1540639Biochim Biophys Acta Mol Basis Dis IF: 04.200
Ahead of Print.No.22The lipocalin saga: Insights into its role in cancer-associated cachexia脂质运载蛋白传奇：洞察其在癌症相关恶病质中的作用DOI: 10.1016/j.bbadis.2025.167684Frontiers in nutrition IF: 04.000
Volumn 11, Issue No.23The relationship between non-HDL-C/HDL-C ratio and bone mineral density: an NHANES study非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值与骨密度的关系：NHANES研究DOI: 10.3389/fnut.2024.1486370Frontiers in endocrinology IF: 03.900
Volumn 15, Issue No.24Association between triglyceride glucose index-related indices and kidney stones in adults based on NHANES 2007-2020基于NHANES 2007-2020的成人甘油三酯-葡萄糖指数相关指数与肾结石的关系DOI: 10.3389/fendo.2024.1516982Frontiers in endocrinology IF: 03.900
Volumn 15, Issue No.25A real-world analysis of 1,823 hospitalized osteoporotic fractures in Northeast China中国东北地区1823例住院骨质疏松性骨折的现实分析DOI: 10.3389/fendo.2024.1520229Scientific reports IF: 03.800
Volumn 15, Issue 1No.26Integrated analysis of genetic, proteinic, and metabolomic alterations in Behcet's disease白塞病遗传、蛋白质和代谢组学改变的综合分析DOI: 10.1038/s41598-025-87130-4Scientific reports IF: 03.800
Volumn 15, Issue 1No.27Association of the triglyceride glucose index with all cause and CVD mortality in the adults with diabetes aged < 65 years without cardiovascular disease65岁以下无心血管疾病的糖尿病成人甘油三酯葡萄糖指数与全因死亡率和心血管疾病死亡率的关系DOI: 10.1038/s41598-025-86612-9Scientific reports IF: 03.800
Volumn 15, Issue 1No.28BMI gain and dietary characteristics are risk factors of MASLD in non-obese individualsBMI增加和饮食特征是非肥胖个体MASLD的危险因素DOI: 10.1038/s41598-025-86424-xJ Trace Elem Med Biol IF: 03.600
Ahead of Print.No.29The gut microbiota: A key player in cadmium toxicity - implications for disease, interventions, and combined toxicant exposures肠道微生物群：镉毒性的关键参与者-对疾病，干预措施和联合毒物暴露的影响DOI: 10.1016/j.jtemb.2024.127570Free radical research IF: 03.600
Ahead of Print.No.30Effect of repeated sprint training in hypoxia on acute and chronic redox balance modulation低氧条件下反复短跑训练对急慢性氧化还原平衡调节的影响DOI: 10.1080/10715762.2024.2443609Br J Health Psychol IF: 03.500
Volumn 30, Issue 1No.31The association between depressive symptoms and lower urinary tract symptoms and impact among women: Investigating behavioural, cognitive and physiological pathways抑郁症状与下尿路症状之间的关系及其对女性的影响：调查行为，认知和生理途径DOI: 10.1111/bjhp.12768J Clin Exp Hepatol IF: 03.300
Volumn 15, Issue 3No.32Glycerol-3-Phosphate Dehydrogenase 1 Deficiency and Steatotic Liver Disease in Children: Our Cases and Review of Literature儿童甘油-3-磷酸脱氢酶1缺乏症和脂肪变性肝病：我们的病例和文献回顾DOI: 10.1016/j.jceh.2024.102484Neuroepidemiology IF: 03.200
Ahead of Print.No.33Hearing Loss as a Risk Factor for Dementia: A Nationwide 15-Year Follow-Up Cohort Study in Taiwan听力损失是痴呆症的危险因素：台湾全国15年随访队列研究DOI: 10.1159/000542602Frontiers in medicine IF: 03.100
Volumn 11, Issue No.34Efficacy of an intervention to increase therapeutic adherence in patients with secondary prevention for cardiovascular disease: a study protocol for a randomized controlled trial提高心血管疾病二级预防患者治疗依从性的干预效果：一项随机对照试验的研究方案DOI: 10.3389/fmed.2024.1510744Frontiers in medicine IF: 03.100
Volumn 11, Issue No.35Correlation between hepatic steatosis severity diagnosed by ultrasound and metabolic indexes in elderly patients with MAFLD老年MAFLD患者超声诊断肝脂肪变性程度与代谢指标的相关性DOI: 10.3389/fmed.2024.1467773Frontiers in public health IF: 03.000
Volumn 12, Issue No.36Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional study高甘油三酯-葡萄糖指数和甘油三酯-葡萄糖体重指数对中国中老年非糖尿病女性骨骼肌减少症的保护作用：一项横断面研究DOI: 10.3389/fpubh.2024.1475330Endocrine IF: 03.000
Ahead of Print.No.37Prevalence of metabolic syndrome among pregnant women: a systematic review and meta-analysis孕妇代谢综合征患病率的系统评价和荟萃分析DOI: 10.1007/s12020-025-04160-8Quant Imaging Med Surg IF: 02.900
Volumn 15, Issue 1No.38Chemical shift encoding based double bonds quantification in triglycerides using deep image prior基于化学位移编码的深度图像先验甘油三酯双键定量DOI: 10.21037/qims-24-1507Frontiers in neurology IF: 02.700
Volumn 15, Issue No.39Statins and the incidence of post-stroke depression: a systematic review and meta-analysis他汀类药物与卒中后抑郁的发生率：系统综述和荟萃分析DOI: 10.3389/fneur.2024.1486367Frontiers in neurology IF: 02.700
Volumn 15, Issue No.40Cognition and influencing factors of secondary prevention in patients with ischemic stroke 1 year after discharge in Southwest China: a cross-sectional survey西南地区缺血性卒中患者出院1年后二级预防认知及影响因素的横断面调查DOI: 10.3389/fneur.2024.1488180Arch Physiol Biochem IF: 02.500
Ahead of Print.No.41Self-paced combined training alleviated oxidative stress, inflammatory responses and hyperlipidaemia in people living with multiple sclerosis: a randomised controlled trial自定步调的联合训练减轻了多发性硬化症患者的氧化应激、炎症反应和高脂血症：一项随机对照试验DOI: 10.1080/13813455.2024.2440346BMC gastroenterology IF: 02.500
Volumn 25, Issue 1No.42Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study基于非胰岛素的胰岛素抵抗替代指标与幽门螺杆菌感染之间的关联：一项基于人群的研究DOI: 10.1186/s12876-025-03610-xJ Med Microbiol IF: 02.400
Volumn 74, Issue 1No.43The Apoprotein E4 isotype does not affect the severity of COVID-19 infection and other flu-like syndromes载脂蛋白E4同种型不影响COVID-19感染和其他流感样综合征的严重程度DOI: 10.1099/jmm.0.001951Acta paediatrica IF: 02.400
Ahead of Print.No.44Pharmacological Strategies for High-Output Ileostomies in Children: A Narrative Review儿童高输出回肠造口术的药理学策略：叙述性综述DOI: 10.1111/apa.17587Journal of cosmetic dermatology IF: 02.300
Volumn 24, Issue 1No.45Tea (Camellia sinensis) Seed Saponins Act as Sebosuppression Agents via the AMPK/mTOR Pathway茶（Camellia sinensis）种子皂苷通过AMPK/mTOR途径充当皮脂抑制剂DOI: 10.1111/jocd.16793Comp Biochem Physiol A Mol Integr Physiol IF: 02.100
Ahead of Print.No.46Phylogenetic and lipid metabolic differences between migratory and Egyptian-domesticated Mallard ducks (Anas platyrhynchos)迁徙和埃及驯化野鸭（Anas platyrhynchos）的系统发育和脂质代谢差异DOI: 10.1016/j.cbpa.2025.111814Frontiers in pediatrics IF: 02.100
Volumn 12, Issue No.47Changes in blood glucose and lipid metabolism levels in children with central precocious puberty and its correlation with obesity中枢性性早熟儿童血糖和血脂代谢水平的变化及其与肥胖的相关性DOI: 10.3389/fped.2024.1488522JMIR formative research IF: 02.000
Volumn 9, Issue No.48AI Machine Learning-Based Diabetes Prediction in Older Adults in South Korea: Cross-Sectional Analysis基于人工智能机器学习的韩国老年人糖尿病预测：横断面分析DOI: 10.2196/57874Revista Paulista de Pediatria IF: 01.400
Volumn 43, Issue No.49Association of the combination of corporal adiposity and cardiorespiratory fitness with cardiometabolic risk factors in children - PREVOI Study儿童身体肥胖和心肺健康与心脏代谢危险因素的关联-PREVOI研究DOI: 10.1590/1984-0462/2025/43/2024105Revista Paulista de Pediatria IF: 01.400
Volumn 43, Issue No.50Metabolic dysfunction-associated liver disease and biliary lithiasis in children with Down Syndrome: a retrospective study唐氏综合征患儿代谢功能障碍相关肝病和胆管结石的回顾性研究DOI: 10.1590/1984-0462/2025/43/2024130Curēus IF: 01.000
Volumn 16, Issue 12No.51Racial Disparities in Cardiometabolic Disorders Among Alzheimer's Disease Patients: A Study on Native Hawaiians and Pacific Islanders阿尔茨海默病患者心脏代谢紊乱的种族差异'；s病患者：对夏威夷原住民和太平洋岛民的研究DOI: 10.7759/cureus.76197J Community Hosp Intern Med Perspect IF: 00.900
Volumn 14, Issue 6No.52Type B Aortic Dissection Secondary to Non-typhoidal Salmonella Aortitis: A Case Report and Literature Review非伤寒沙门氏菌主动脉炎继发B型主动脉夹层1例并文献复习DOI: 10.55729/2000-9666.1419Biomedica IF: 00.800
Volumn 44, Issue Sp. 2No.53A hidden enemy: Understanding the hemophagocytic syndrome in children under five years of age in a high-complexity institution in southwestern Colombia隐藏的敌人：了解哥伦比亚西南部一所高度复杂的机构中五岁以下儿童的噬血细胞综合征DOI: 10.7705/biomedica.7526Federal practitioner
Volumn 41, Issue 11No.54Effect of Alirocumab Monotherapy vs Ezetimibe Plus Statin Therapy on LDL-C Lowering in Veterans With History of ASCVD阿利西尤单抗单药治疗与依折麦布联合他汀类药物治疗对有ASCVD病史的退伍军人LDL-C降低的影响DOI: 10.12788/fp.0522
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