Leandro Slipczuk, Toshiki Kuno, Santica Marcovina, Katrina Swett, Kate K Orroth, J Antonio G López, etc.Importance载脂蛋白B（apoB）的分布及其作为动脉粥样硬化性心血管疾病（ASCVD）风险增强因子在不同西班牙裔或拉丁裔背景的个体中的意义尚未被描述。Objective描述apoB在西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）队列中的分布，并描述基线社会人口统计学和临床变量与apoB和自我识别的西班牙裔或拉丁裔背景的关联。Design, setting, and participantsHCHS/SOL是一项基于人群的前瞻性队列研究，研究对象是2008年3月至2011年6月期间招募和筛查的居住在美国的西班牙裔或拉丁裔成年人。抽样权重用于生成居住在美国4个大都市地区（纽约布朗克斯、伊利诺伊州芝加哥、佛罗里达州迈阿密和加利福尼亚州圣地亚哥）的18至74岁西班牙裔或拉丁裔参与者的基于人群的样本。在HCHS/SOL的参与者中测量了ApoB浓度，并比较了不同人口群体的ApoB三分位数，包括自我识别的西班牙裔或拉丁裔背景。在ApoB三分位数中比较了大陆遗传祖先（西非，美洲印第安人和欧洲人）的中位百分比。Exposure使用免疫比浊法从血清或血浆中以mg/dL测量ApoB。Main outcomes and measures测定ApoB三分位数，并在ApoB三分位数中评估传统脂质。ApoB和传统脂质测量在ASCVD风险类别中进行评估。此外，创建散点图以观察apoB与低密度脂蛋白胆固醇或非高密度脂蛋白胆固醇之间的相关性。Results总体平均（SD）apoB浓度为99.8（0.4）mg/dL，男性参与者的平均水平显著高于女性参与者（分别为102.4和97.4 mg/dL）。平均（SD）参与者年龄为41.1（0.8）岁，8376例参与者（51.9%）为女性。ApoB水平在老年组中较高。在自我识别的西班牙裔或拉丁裔背景组中，平均ApoB浓度存在显著的异质性，范围从多米尼加个体的95.1 mg/dL到古巴个体的104.8 mg/dL。在较高的预测ASCVD风险类别中，ApoB升高（≥130 mg/dL）的患病率更高。在10年预测ASCVD风险为7.5%或更高的参与者中，26.5%的ApoB升高。在ApoB的较高三分位数中，西非血统的中位数较低。Conclusions and relevance在这项针对HCHS/SOL参与者的队列研究中，在对处于中度或高度预测ASCVD风险的西班牙裔或拉丁裔个体进行的多种队列研究中，有四分之一的人存在ApoB升高。西班牙裔或拉丁裔个体中ApoB分布的差异可能对ApoB在ASCVD风险评估中的使用具有重要意义。本文由 赵婷 编辑扫描二维码查看源文JAMA Cardiology | Ahead of Print.10.1001/jamacardio.2024.478902
Journal of lipid research IF: 05.000
与颈动脉粥样硬化相关的缺血性卒中后LDL和HDL的改变在1年后逆转
Núria Puig, Pol Camps-Renom, Martin Hermansson, Ana Aguilera-Simón, Rebeca Marín, Olga Bautista, etc.大约20%的缺血性卒中归因于动脉粥样硬化的存在。脂蛋白在动脉粥样硬化的发展过程中起着至关重要的作用，低密度脂蛋白（LDL）会促进动脉粥样硬化的发生，而高密度脂蛋白（HDL）则会抑制动脉粥样硬化的发生。因此，脂蛋白的浓度及其生物特性是动脉粥样硬化过程中的决定性因素。在这项研究中，研究人员检查了颈动脉粥样硬化缺血性卒中患者脂蛋白的定性特征。在缺血性卒中后7天和1年，从健康对照（n=27）和颈动脉粥样硬化患者（n=64）的血液中分离脂蛋白。与对照组相比，卒中后7天患者的LDL显示载脂蛋白C III，三酰甘油和神经酰胺水平升高，胆固醇和磷脂含量降低。来自患者的LDL比来自对照的LDL在巨噬细胞中诱导更多的炎症。卒中后7天从患者中分离出的HDL显示载脂蛋白货物发生改变，与对照组相比，apoA-I水平降低，apoA II和apoC III水平升高。与对照组相比，患者的HDL还显示出更高的电负电荷，并且部分丧失了抵抗LDL修饰和修饰LDL的炎症作用的能力。卒中发作一年后，患者的LDL和HDL组成与对照组相似。同时，LDL和HDL获得正电荷，LDL不易氧化和聚集，HDL恢复了保护特性。总之，颈动脉粥样硬化缺血性卒中患者的LDL和HDL表现出组成和功能的改变，卒中后1年部分逆转。本文由 赵婷 编辑扫描二维码查看源文Journal of lipid research | Ahead of Print.10.1016/j.jlr.2024.10073903
Frontiers in pharmacology IF: 04.400
老年高血压患者外周动脉疾病的多种二级预防药物不持久
Martin Wawruch, Miriam Petrova, Denisa Celovska, Sofa D Alfian, Tomas Tesar, Jan Murin, etc.Introduction患有外周动脉疾病（PAD）的高血压患者的二级预防的益处是基于持续同时服用他汀类药物，抗血小板药物和抗高血压药物，优选血管紧张素转换酶抑制剂（ACEI）或血管紧张素受体阻滞剂（ARB）。研究旨在分析多种药物类别的非持续性程度，以及确定与非持续性可能性相关的因素。Methods在这项的队列研究中，对3401例年龄≥65岁的高血压患者（1853例女性和1548例男性）同时接受他汀类药物，抗血小板药物和ACEI/ARB治疗，并对2012年新诊断的PAD进行了分析。当患者在三种分析药物类别中至少有一种是非持续性的时，他/她被归类为非持续性。使用Cox回归确定了与非持久性概率相关的最重要特征。Results在随访期结束时（平均长度1.8年），1869例（55.0%）患者（包括1090例女性和779例男性）被归类为非持续性。在整个研究队列中，与非持续用药相关的因素有女性性别、心房颤动和新使用至少一种分析药物类别；在男性中，与非持续用药相关的因素有大学教育程度、心房颤动和癫痫；在女性中，与新使用药物相关。Conclusion识别与非持续性相关因素的性别差异，可以确定应特别注意通过联合用药改善其持续性的患者群体，以确保成功的PAD二级预防。本文由 赵婷 编辑扫描二维码查看源文Frontiers in pharmacology | Volumn 15, Issue10.3389/fphar.2024.146468904
J Res Med Sci IF: 01.500
2型糖尿病患者一氧化氮水平和血脂水平与内皮功能障碍的关系
Hamza Algomizy, Amjad Khan, Osama Smettei, Mahmoud Elhabiby, Ayman Abu Mustafa, Abdelmarouf Mohieldein, etc.Background循证筛查对于检测高危糖尿病患者的心肌缺血至关重要。研究探讨了2型糖尿病合并冠状动脉疾病（CAD）患者一氧化氮（NO）水平，血脂指数和血浆致动脉粥样硬化指数（AIP）之间的关系，并确定其作为预后标志物的潜力。Materials and methods病例对照研究包括50例患有CAD的糖尿病患者（病例），30例无CAD的糖尿病患者（对照1）和23例健康对照（对照2）。使用标准方案确定生化参数；通过Griess反应测量血浆NO。Results病例的NO，空腹血糖，糖化血红蛋白（HbA1c）和甘油三酯水平最高，总胆固醇（TC），高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平最低。病例表现出最高的TC:HDL-C，LDL-C:HDL-C和AIP比率。NO与HbA1c呈显著正相关（r=0.328，P=0.020）。Conclusion慢性高血糖可以增强由诱导型同种型驱动的NO过量产生，表明慢性高血糖在糖尿病内皮功能障碍和血管并发症中的潜在作用。本文由 赵婷 编辑扫描二维码查看源文J Res Med Sci | Volumn 29, Issue10.4103/jrms.jrms_686_23其他发布内容Other Published Articles
Diabetes care IF: 14.800
Ahead of Print.No.01Proteomic and Metabolomic Signatures in Prediabetes Progressing to Diabetes or Reversing to Normoglycemia Within 1 Year糖尿病前期进展为糖尿病或在1年内逆转为正常血糖的蛋白质组学和代谢组学特征DOI: 10.2337/dc24-1412
J Clin Invest IF: 13.300
Volumn 135, Issue 1No.02Clonal hematopoiesis JAKs up plaque formation克隆造血加速斑块形成DOI: 10.1172/JCI187529
Theranostics IF: 12.400
Volumn 15, Issue 2No.03Inhibition of nitric oxide synthase transforms carotid occlusion-mediated benign oligemia into de novo large cerebral infarction一氧化氮合酶的抑制将颈动脉闭塞介导的良性低血症转化为新生大脑梗死DOI: 10.7150/thno.104132
Ahead of Print.No.05Association between genetically predicted leisure and social activities and cardiovascular disease and other health outcomes基因预测的休闲和社交活动与心血管疾病和其他健康结果之间的关联DOI: 10.1038/s44161-024-00581-2
Nature Cardiovascular Research IF: 09.400
Ahead of Print.No.06Social isolation negatively affects oxytocin production and accelerates atherosclerosis社会隔离对催产素的产生产生负面影响并加速动脉粥样硬化DOI: 10.1038/s44161-024-00602-0
Nature Cardiovascular Research IF: 09.400
Ahead of Print.No.07Spatial transcriptomic mapping of coronary atherosclerosis in the luminal plaque and beyond管腔斑块内外冠状动脉粥样硬化的空间转录组学定位DOI: 10.1038/s44161-024-00568-z
Ahead of Print.No.09Investigating the Role of TRPV4 and GPR35 Interaction in Endothelial Dysfunction in Aging Mice研究TRPV4和GPR35相互作用在衰老小鼠内皮功能障碍中的作用DOI: 10.1111/acel.14469
Molecular metabolism IF: 07.000
Ahead of Print.No.10Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice线粒体转运蛋白SLC25A47的缺乏对禁食和饮食诱导的肥胖小鼠肝脏脂质代谢的影响最小DOI: 10.1016/j.molmet.2024.102092
International Journal of Stroke IF: 06.300
Ahead of Print.No.11Prevalence and Risk Factors of Covert Brain Infarction: a Community-based Cross-sectional Study隐性脑梗塞的患病率和危险因素：基于社区的横断面研究DOI: 10.1177/17474930241313435
European Stroke Journal IF: 05.800
Ahead of Print.No.12Rescue stenting after failed mechanical thrombectomy: The RES-CAT studyRES-CAT研究：机械血栓切除术失败后的抢救性支架置入术DOI: 10.1177/23969873241308680
European Stroke Journal IF: 05.800
Ahead of Print.No.13Mortality in ischaemic stroke patients without standard modifiable risk factors: An analysis of the Riksstroke registry没有标准可修改危险因素的缺血性卒中患者的死亡率：Riks卒中登记处的分析DOI: 10.1177/23969873241309516
Diabetes, obesity & metabolism IF: 05.400
Ahead of Print.No.14The predictive value of estimated glucose disposal rate and its association with myocardial infarction, heart failure, atrial fibrillation and ischemic stroke估计葡萄糖处置率的预测价值及其与心肌梗死、心力衰竭、心房颤动和缺血性卒中的关系DOI: 10.1111/dom.16132
Journal of ethnopharmacology IF: 04.800
Ahead of Print.No.15Serum pharmacochemistry combined with network pharmacology reveals the hepatotoxicity mechanism of Alangium chinense (Lour.) Harms血清药物化学结合网络药理学揭示了八角莲的肝毒性机制DOI: 10.1016/j.jep.2024.119312
European radiology IF: 04.700
Ahead of Print.No.16High-risk characteristics of recurrent ischemic stroke after intensive medical management for 6-month follow-up: a histogram study on vessel wall MRI强化医疗管理6个月随访后复发性缺血性卒中的高危特征：血管壁MRI直方图研究DOI: 10.1007/s00330-024-11304-3
J Neurointerv Surg IF: 04.500
Ahead of Print.No.17Hemodynamic evaluation of symptomatic and asymptomatic intracranial atherosclerotic stenosis using cerebral angiographic images: an exploratory study使用脑血管造影图像对有症状和无症状颅内动脉粥样硬化狭窄的血流动力学评估：一项探索性研究DOI: 10.1136/jnis-2024-022455
Journal of cellular physiology IF: 04.500
Volumn 240, Issue 1No.18Vacuolar H+-ATPase and Megalin-Mediated Prorenin Uptake: Focus on Elements Beyond the (Pro)Renin Receptor液泡H+-ATPase和巨蛋白介导的肾素原摄取：关注（前）肾素受体以外的元素DOI: 10.1002/jcp.31518
Frontiers in pharmacology IF: 04.400
Volumn 15, Issue No.19Investigating the anti-obesity potential of Nelumbo nucifera leaf bioactive compounds through machine learning and computational biology methods通过机器学习和计算生物学方法研究莲叶生物活性化合物的抗肥胖潜力DOI: 10.3389/fphar.2024.1500865
Frontiers in nutrition IF: 04.000
Volumn 11, Issue No.20The mediating role of vitamin D in the relationship between triglyceride glucose index and mortality in patients with diabetes mellitus: a causal mediation analysis维生素D在甘油三酯-葡萄糖指数与糖尿病患者死亡率关系中的中介作用：因果中介分析DOI: 10.3389/fnut.2024.1492647
Scientific reports IF: 03.800
Volumn 15, Issue 1No.21Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis半乳糖蛋白-8 DNA甲基化通过MAPK/mTOR途径介导巨噬细胞自噬以减轻动脉粥样硬化DOI: 10.1038/s41598-024-85036-1
Pol Arch Intern Med IF: 03.800
Ahead of Print.No.22Prevalence of cardiovascular comorbidities in psoriatic arthritis: relationship to clinical phenotype and treatment in a real-life study银屑病关节炎心血管合并症的患病率：与临床表型和治疗的关系DOI: 10.20452/pamw.16911
Scientific reports IF: 03.800
Volumn 15, Issue 1No.23Exploring the causal impact of body mass index on metabolic biomarkers and cholelithiasis risk: a Mendelian randomization analysis探索体重指数对代谢生物标志物和胆石症风险的因果影响：孟德尔随机分析DOI: 10.1038/s41598-024-83217-6
Int J Food Sci Nutr IF: 03.500
Ahead of Print.No.24The impact of breakfast skipping on plasma glucose levels in non-diabetic individuals: gender-based differences and implications不吃早餐对非糖尿病患者血糖水平的影响：基于性别的差异及其意义DOI: 10.1080/09637486.2024.2446886
Frontiers in physiology IF: 03.200
Volumn 15, Issue No.25LIM kinases in cardiovascular health and diseaseLIM激酶在心血管健康和疾病中的作用DOI: 10.3389/fphys.2024.1506356
Frontiers in medicine IF: 03.100
Volumn 11, Issue No.26The association between type 1 diabetes mellitus and the risk of immunoglobulin A nephropathy: a Mendelian randomization study1型糖尿病与免疫球蛋白A肾病风险之间的关联：孟德尔随机研究DOI: 10.3389/fmed.2024.1429369
British journal of nutrition IF: 03.000
Volumn 132, Issue 12No.27Prevalence of cardiometabolic diseases in underweight: a nationwide cross-sectional study体重不足的心脏代谢疾病患病率：一项全国性横断面研究DOI: 10.1017/S0007114524002885
PloS one IF: 02.900
Volumn 20, Issue 1No.28Association between the triglyceride-glucose index and its combined obesity indicators and the risk of hypertension in middle-aged and older Chinese adults: A nationwide cross-sectional study中国中老年人甘油三酯-葡萄糖指数及其肥胖综合指标与高血压风险之间的关系：一项全国性横断面研究DOI: 10.1371/journal.pone.0316581
American journal of therapeutics IF: 02.900
Ahead of Print.No.29Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk-A Systematic Review and Meta AnalysisOlezarsen治疗心血管高危患者高甘油三酯血症的系统评价和荟萃分析DOI: 10.1097/MJT.0000000000001877
Frontiers in veterinary science IF: 02.600
Volumn 11, Issue No.30Sijunzi San alleviates the negative energy balance in postpartum dairy cows by regulating rumen fermentation capacity四君子散通过调节瘤胃发酵能力缓解产后奶牛的负能量平衡DOI: 10.3389/fvets.2024.1512081
Endocrine connections IF: 02.600
Ahead of Print.No.31Short-term effects of follicle stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men促卵泡激素对短暂去势男性免疫功能、脂质和维生素代谢的短期影响DOI: 10.1530/EC-24-0587
World journal of hepatology IF: 02.500
Volumn 16, Issue 12No.32Clinical profiles and their interaction of concurrent metabolic associated steatotic liver disease and hepatitis B virus infection并发代谢相关脂肪变性肝病与乙型肝炎病毒感染的临床特征及其相互作用DOI: 10.4254/wjh.v16.i12.1429
World journal of hepatology IF: 02.500
Volumn 16, Issue 12No.33Multiple intrahepatic artery aneurysms during the treatment for IgG4-related sclerosing cholangitis: A case reportIgG4相关性硬化性胆管炎治疗过程中多发性肝内动脉瘤1例DOI: 10.4254/wjh.v16.i12.1505
Lasers in medical science IF: 02.100
Volumn 40, Issue 1No.34Percutaneous photoacoustic debulking of infra-inguinal atherosclerotic disease- early European experience with a novel, solid-state, pulsed -wave, ultraviolet 355 nm laser经皮光声消肿腹股沟下动脉粥样硬化性疾病-早期欧洲使用新型固态脉冲波紫外线355 nm激光的经验DOI: 10.1007/s10103-024-04216-7
Eur J Obstet Gynecol Reprod Biol IF: 02.100
Ahead of Print.No.35The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and risk of infertility among US adults: A cross-sectional NHANES study美国成年人非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值（NHHR）与不孕症风险之间的关系：NHANES横断面研究DOI: 10.1016/j.ejogrb.2024.12.041
Cerebrovascular Diseases. Extra IF: 02.000
Ahead of Print.No.36The Prevalence of CYP2C19 Polymorphism in Patients with Symptomatic Intracranial Atherosclerosis症状性颅内动脉粥样硬化患者CYP2C19基因多态性的患病率DOI: 10.1159/000543331
Gynecological endocrinology IF: 02.000
Volumn 41, Issue 1No.37Systematic review and meta-analysis on the association of metabolic syndrome in women with overactive bladder代谢综合征与膀胱过度活动症相关性的系统评价和荟萃分析DOI: 10.1080/09513590.2024.2445682
Cerebrovascular Diseases. Extra IF: 02.000
Ahead of Print.No.38Correlation between Neuroimaging Scores and Carotid Artery Ultrasound Features in Cerebral Small Vessel Disease Patients脑小血管病患者神经影像学评分与颈动脉超声特征的相关性DOI: 10.1159/000543355
Viral immunology IF: 01.500
Ahead of Print.No.39Levels of Cytomegalovirus-Reactive Antibody and γδ T Cell Phenotypes Align with Vascular Changes in People Living With HIV巨细胞病毒反应性抗体和γδT细胞表型的水平与HIV感染者的血管变化一致DOI: 10.1089/vim.2024.0075
J Res Med Sci IF: 01.500
Volumn 29, Issue No.40The efficacy of curcumin-piperine supplementation in patients with nonproliferative diabetic retinopathy: An optical coherence tomography angiography-based randomized controlled trial姜黄素-胡椒碱补充剂对非增殖性糖尿病视网膜病变患者的疗效：基于光学相干断层扫描血管造影的随机对照试验DOI: 10.4103/jrms.jrms_174_24
AIDS care IF: 01.200
Ahead of Print.No.41Comparing Life's Simple Seven between newly diagnosed, ART-naive people living with HIV and HIV-uninfected adults in Tanzania: clues for cardiovascular disease prevention比较寿命'；坦桑尼亚新诊断的未接受抗逆转录病毒治疗的艾滋病毒感染者和未感染艾滋病毒的成年人之间的简单七：预防心血管疾病的线索DOI: 10.1080/09540121.2024.2445198
Vascular IF: 01.000
Ahead of Print.No.42The relation between estimated pulse wave velocity and peripheral arterial disease: A study based on NHANES估计脉搏波速度与外周动脉疾病的关系：基于NHANES的研究DOI: 10.1177/17085381241312469
Curēus IF: 01.000
Volumn 16, Issue 12No.43A Complex Case of Acute Liver Failure Following Idiosyncratic Drug-Induced Liver Injury, Potentiated by Herpes Simplex Virus Infection单纯疱疹病毒感染加重的特异性药物性肝损伤后急性肝衰竭的复杂病例DOI: 10.7759/cureus.74955
Zhonghua ganzangbing zazhi
Ahead of Print.No.44[Statin for the prevention and treatment of hepatocellular carcinoma: use or wait?][他汀类药物预防和治疗肝细胞癌：使用还是等待？]DOI: 10.3760/cma.j.cn501113-20231207-00269作者：天纳乾排版：天纳坤编辑：TIANNA审校：Sissy
