CNS 2024 | 专题研讨会：神经调节和神经临床

文摘 2024-09-19 09:00 福建

中国神经科学学会第十七届全国学术会议将于2024年9月26日－29日在苏州市召开，作为我国神经科学领域规模最大的学术会议，其学术质量在国内屈指可数。2024年，中国神经科学学会积极组织召集专题研讨会，通过多轮投票筛选确定51个专题研讨会。

学会将陆续推出2024年专题研讨会的详细介绍，敬请关注。

以下专题排名不分先后。

参会注册：

The 17th Annual Meeting of Chinese Neuroscience Society (cns.org.cn)

Neuromodulation and Neuroclinical

Anesthesia and Brain Function

Organizer:Yingwei Wang、Ji Hu

Introduction: General anesthesia serves a critically important function in the clinical care of human patients. However, the mechanism of general anesthesia is still unknown. The neural circuits underlying the distinct endpoints that define general anesthesia remain incompletely understood. It is becoming increasingly evident, however, that distinct pathways in the brain that mediate arousal and pain are involved in various endpoints of general anesthesia. For this symposia, we focus on the fields of the mechanism of general anesthetics, the effects of general anesthetics on brain function in both the developing and elderly population, the mechanism of a mutual relationship between anesthesia and sleep, assessing the depth of anesthesia and consciousness, perioperative analgesia etc.

报告人

Ji Hu

ShanghaiTech University

"Currently serving as Vice Chairman of the Stress Neurobiology Branch of the Chinese Society for Neuroscience and Vice Chairman of the Cognitive Neurobiology Branch of the Chinese Society for Neuroscience.

Awarded the Young Thousand Talents Program by the Organization Department of the Central Committee, National Natural Science Foundation of China (NSFC) General Program, NSFC Major Research Plan, NSFC Major Program, and the Ministry of Science and Technology 973 Program support.

The research results include a series of publications as corresponding authors in international academic journals such as Nature, Science Advances, Neuron, Current Biology, etc.

Received the First Prize of Chongqing Science and Technology Progress (2019, as the second contributor), and the Second Prize of Teaching Achievement Award of the Chinese Academy of Sciences (2020, as the sole contributor)."

Hailong Dong

Xijing Hospital, Air Force Medical University

vice president of Xijing Hospital, Chair and Professor of the Department of Anesthesiology and Perioperative Medicine. Dr. Dong was awarded the visiting professor by Imperial College London, and the Distinguished Professor of Yangtze River Scholar by the Ministry of Education of China. He is the vice president of Chinese Society of Anesthesiology, the vice president of Chinese Association of Anesthesiologists and the associate editor of Chinese Journal of Anesthesiology, etc.

Dr. Dong’s research mainly focuses on the mechanism of general anesthesia. As a principal investigator, he has been presiding over 12 national and international research projects, and published over 100 academic papers in the international journals, such as in the Science, Nature Neuroscience, J Clin Invest, Cereb Cortex, Anesthesiology, etc. Dr. Dong was awarded the “Innovator Awards in the Asia-Pacific” in 2009, the first prize of the National Nature Science and Technology Progress Award in 2011, the first prizes of Shaanxi Provincial Science and Technology Progress Award in 2009 and 2016, the Outstanding Research Award of CSA in 2018, Youth Shulan Medical Award in 2019 and the First Prize of Chinese University Science and Technology Progress Award in 2020."

Xiaohu Zhou

Institute of Automation, CAS

Xiao-Hu Zhou serves as professor (Doctoral Supervisor) in Institute of Automation, Chinese Academy of Sciences (CAS). He is a recipient of Excellent Young Scientists Fund Program from the National Natural Science Foundation of China (NSFC) and Asia Pacific Neural Network Society (APNNS) Young Researcher Award. He is also the Chief Scientist of China National Key R&D Young Program. His main research areas include endovascular robots, tactile bionic perception, and intelligent image navigation. He has published over 70 academic papers in the field. He holds 3 authorized international PCT patents and 23 China invention patents. His researches also are awarded as the “Special Prize of President Scholarship” from CAS, the “Best Paper Award” for 4 times in IEEE RCAR 2022/2023, ROBIO 2023 and ICBIR 2023, and the “Excellent Doctoral Dissertation Award” for twice by CAAI and CAA.

Jiaqiang Zhang

Henan Provincial People's Hospital

Our lab focus on investigating the mechanisms of anesthetic-induced developmental neurotoxicity and POCD, and we discover that sevoflurane exacerbates neuronal excitatory degeneration via enhancing GABAA receptor on postsynaptic membrane. In addition, we demonstrate that endogenous neuroactive steroids and LHPA axis are involved in neuronal damage caused by narcotic drugs. These evidences provide new clues for the study of anesthetic-induced developmental neuronal decline followed by long-term cognitive dysfunction. We also found that general anesthesia caused long-term cognitive dysfunction in patients after surgery.

Qianzi Yang

Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine

Dr. Yang graduated from the Fourth Military Medical University and then studied at Imperial College London as a postdoc. Her research mainly focuses on the mechanism of general anesthesia, especially how the reversable unconsciousness is induced by general anesthesia. She has published over 60 papers and hosted 5 NSFC grants. She won the NSFC Excellent Young Scientist (EYS) Scheme in 2023. She edited/participated in over 10 books on anesthesiology. Dr. Yang was awarded the first prize of the Outstanding Achievement Award for Research in Institutes of Higher Education universities.

Jinpiao Zhu

Children's Hospital, Zhejiang University School of Medicine

Anesthetics not only induce a state of reversible, controlled consciousness but also demonstrate potent neuroprotective effects. We can thoroughly explore the impact of anesthetics on crucial aspects of brain function, encompassing sleep/wake cycles, consciousness, emotional memory, and more. Recent findings in our research highlight that propofol, as opposed to sevoflurane, improves sleep quality in rats after prolonged sleep deprivation by enhancing functional connectivity in the mPFC and influencing the dynamics of brain glutamate and glucose metabolism. Furthermore, our pioneering work suggests that the involvement of the cerebello-thalamus-motor cortical loop may contribute to the unconsciousness induced by anesthetics.

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Brain Stimulation for Psychiatry: Modeling, Precision, and Efficacy

Organizer:Tifei Yuan、Yihong Yang

Introduction: Mental disorder is a major public health issue, causing considerable global burden epidemiologically and economically. World Health Organization (WHO) reports that mental disorders account for more than 25.3% of all years lived with a disability. Neuromodulation is considered a promising strategy for mental disorders. The rationale for neuromodulation is derived from the neurobiologically localized substrates for psychiatric symptoms. Focusing on the topic of “Brain stimulation for psychiatry: modeling, precision, and efficacy”, this symposium will present cutting-edge progress from six experts in the field from China and USA. Their presentation will focus on three perspectives: 1) computational models for brain stimulation in psychiatry, providing insights into the design, operation, and clinical application; 2) precision-oriented brain stimulation, based on multimodal biomarkers, machine learning algorithm, and close-loop approaches; 3) effectiveness of new strategies in brain stimulation on psychiatry. We believe that the audience will greatly benefit from their presentations.

报告人

Cheng-Ta Li

Taipei Veterans General Hospital

1.Cheng-Ta Li, Tung-Ping Su, Shyh-Jen Wang et al. Prefrontal Glucose Metabolism in Medication-Resistant Major Depression. British Journal of Psychiatry, 2016 (SCI, IF = 10.671)

2. Cheng-Ta Li*, Mu-Hong Chen, Chi-Hung Juan, et al. Efficacy of Prefrontal Theta-Burst Stimulation in Refractory Depression: A Randomized Sham-Controlled Study. Brain, 2014 (SCI, IF=15.255)

3. Cheng-Ta Li* Chih-Ming Cheng, Mu-Hong Chen, et al. Antidepressant Efficacy of Prolonged Intermittent Theta Burst Stimulation Monotherapy for Recurrent Depression and Comparison of Methods for Coil Positioning: A Randomized, Double-Blind, Sham-controlled Study. Biological Psychiatry, Mar. 2020 (SCI, IF=12.810)

4. Cheng-Ta Li*, Ying-Zu Huang, Ya-Mei Bai, et al. Critical Role of Glutamatergic and GABAergic Neurotransmission in the Central Mechanisms of Theta Burst Stimulation. Human Brain Mapping. 2019 Apr 15;40(6):2001-2009. (SCI, IF=5.399)

5. Cheng-Ta Li*, Mu-Hong Chen, Chi-Hung Juan, et al. Effects of prefrontal theta-burst stimulation on brain function in treatment-resistant depression: A randomized sham-controlled neuroimaging study. Brain Stimulation. 2018 Sep-Oct. (SCI, IF=9.184)

6.Cheng-Ta Li*, CM Cheng, Lin HC et al. The longer, the better ? Longer left-sided prolonged intermittent theta burst stimulation in patients with major depressive disorder. Asian J Psychiatry. 2023, June (SCI, IF=13.89)

Xiaochu Zhang

Univerisity of Science and Technology of China

1. Zhengde Wei#, Ying Chen#, Qian Zhao, Pengyu Zhang, Longxi Zhou, Jiecheng Ren, Yi Piao, Bensheng Qiu, Xing Xie, Suiping Wang, Jia Liu, Daren Zhang, Roi Cohen Kadosh, Xiaochu Zhang*. Implicit perception differences between NLP-produced and human-produced language in the mentalizing network. Advanced Science, 2023,10: 2203990.

2. Xueli Chen#, Ru Ma#, Wei Zhang, Ginger Qinghong Zeng, Qianying Wu, Ajiguli Yimiti, Xinzhao Xia, Jiangtian Cui, Qiongwei Liu, Xueer Meng, Junjie Bu, Qi Chen, Yu Pan, Nancy Xiaonan Yu, Shouyan Wang, Zhi-De Deng, Alexander T. Sack, Myles Mc Laughlin, Xiaochu Zhang*. Alpha oscillatory activity is causally linked to working memory retention. Plos Biology, 2023, 21: e3001999.

3. Ji-An Li, Daoyi Dong, Zhengde Wei, Ying Liu, Yu Pan, Franco Nori, Xiaochu Zhang*. Quantum Reinforcement Learning during Human Decision Making. Nature Human Behaviour. 2020, 4:294-307.

4. Li-Zhuang Yang, Wei Zhang, Wenjuan Wang, Zhiyu Yang, Hongzhi Wang, Zhi-De Deng, Chuanfu Li, Bensheng Qiu, Da-Ren Zhang, Roi Cohen Kadosh, Hai Li*, Xiaochu Zhang*. Neural and Psychological predictors of cognitive enhancement and impairment from neurostimulation. Advanced Science. 2020, 7: 1902863.

5. Junjie Bu, Kymberly Young, Wei Hong, Ru Ma, Hongwen Song, Ying Wang, Wei Zhang, Michelle Hampson, Talma Hendler, Xiaochu Zhang*. Effect of de-activation of activity patterns related to smoking cue reactivity on nicotine addiction. Brain. 2019, 142: 1827-1841.

Liang Chen

Huashan Hospital,Fudan University

Recent Publications:

1 Peng JY, Qi ZX, Yan Q, Fan XJ, Shen KL, Huang HW, Lu JH, Wang XQ, Fang XX, Mao L, Ni J, Chen L, Zhuang QX. Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus-thalamus circuitry. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2216247120.

2 Zhou N, Fan Z, Tong Y, Xiao X, Xie Y, Qi Z, Chen L. Increased number and domain of interlaminar astrocytes in layer I of the temporal cortex in epilepsy. Neuropathol Appl Neurobiol. 2023 Jun;49(3):e12913.

3 Zou X, Song K, Ji M, Min L, Zhou L, Mao Y, Chen L. A thermodynamic model showing that information recording can drive active ion transport. Signal Transduct Target Ther. 2023 Apr 14;8(1):154.

4 Wu X, Jiang S, Li G, Liu S, Metcalfe B, Chen L, Zhang D. Deep Learning With Convolutional Neural Networks for Motor Brain-Computer Interfaces Based on Stereo-Electroencephalography (SEEG). IEEE J Biomed Health Inform. 2023 May;27(5):2387-2398.

5 Li Z, Sun W, Duan W, Jiang Y, Chen M, Lin G, Wang Q, Fan Z, Tong Y, Chen L, Li J, Cheng G, Wang C, Li C, Chen L. Guiding Epilepsy Surgery with an LRP1-Targeted SPECT/SERRS Dual-Mode Imaging Probe. ACS Appl Mater Interfaces. 2023 Jan 11;15(1):14-25.

Huichun Luo

Shanghai Mental Health Center

Recent Publications:

1. Zhang C, Zhang Y, Luo H, Xu X, Yuan TF, Li D, Cai YY, Gong H, Peng DH, Fang YR, Voon V, Sun B. Bilateral Habenula deep brain stimulation for treatment-resistant depression: clinical findings and electrophysiological features. Transl Psychiatry. 2022 Feb 3;12(1):52. doi: 10.1038/s41398-022-01818-z. PMID: 35115488; PMCID: PMC8813927.

2. Luo H, Huang Y, Green AL, Aziz TZ, Xiao X, Wang S. Neurophysiological characteristics in the periventricular/periaqueductal gray correlate with pain perception, sensation, and affect in neuropathic pain patients. Neuroimage Clin. 2021;32:102876. doi: 10.1016/j.nicl.2021.102876. Epub 2021 Nov 10. PMID: 34775163; PMCID: PMC8604717.

3. Nie Y, Luo H, Li X, Geng X, Green AL, Aziz TZ, Wang S. Subthalamic dynamic neural states correlate with motor symptoms in Parkinson's Disease. Clin Neurophysiol. 2021 Nov;132(11):2789-2797. doi: 10.1016/j.clinph.2021.07.022. Epub 2021 Aug 25. PMID: 34592557.

4. Luo H, Huang Y, Xiao X, Dai W, Nie Y, Geng X, Green AL, Aziz TZ, Wang S. Functional dynamics of thalamic local field potentials correlate with modulation of neuropathic pain. Eur J Neurosci. 2020 Jan;51(2):628-640. doi: 10.1111/ejn.14569. Epub 2019 Sep 23. PMID: 31483893.

Georg Kranz

Hong Kong Polytechnic University

Recent Publications:

1. Kan RLD, Padberg F, Giron CG, Lin TTZ, Zhang BBB, Brunoni AR, Kranz GS. Effects of repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex on symptom domains in neuropsychiatric disorders: a systematic review and cross-diagnostic meta-analysis. Lancet Psychiatry. 2023 Apr;10(4):252-259. doi: 10.1016/S2215-0366(23)00026-3. Epub 2023 Mar 7. PMID: 36898403.

2. Qin PP, Jin M, Xia AW, Li AS, Lin TT, Liu Y, Kan RL, Zhang BB, Kranz GS. The effectiveness and safety of low-intensity transcranial ultrasound stimulation: A systematic review of human and animal studies. Neurosci Biobehav Rev. 2024 Jan;156:105501. doi: 10.1016/j.neubiorev.2023.105501. Epub 2023 Dec 6. PMID: 38061596.

3. Kan RLD, Lin TTZ, Zhang BBB, Giron CG, Jin M, Qin PPI, Xia AWL, Chan SKW, Chau BKH, Kranz GS. Moderators of stimulation-induced neural excitability in the left DLPFC: A concurrent iTBS/fNIRS case study. Brain Stimul. 2023 Sep-Oct;16(5):1445-1447. doi: 10.1016/j.brs.2023.09.015. Epub 2023 Sep 24. PMID: 37751800.

Quanying Liu

Southern University of Science and Technology

Recent Publications:

1. Wang, M., Lou, K., Liu, Z., Wei, P., & Liu, Q. (2023). Multi-objective optimization via evolutionary algorithm (MOVEA) for high-definition transcranial electrical stimulation of the human brain. NeuroImage, 280, 120331.

2. Ye, Z., Qu, Y., Liang, Z., Wang, M., & Liu, Q. (2023). Explainable fMRI‐based brain decoding via spatial temporal‐pyramid graph convolutional network. Human Brain Mapping, 44(7), 2921-2935.

3. Yin, W., Ma, Z., & Liu, Q. (2023). Discriminative subspace learning via optimization on Riemannian manifold. Pattern Recognition, 139, 109450.

4. Liang, Z., Luo, Z., Liu, K., Qiu, J., & Liu, Q. (2022). Online Learning Koopman operator for closed-loop electrical neurostimulation in epilepsy. IEEE Journal of Biomedical and Health Informatics, 27(1), 492-503.

5. Ran, X., Xu, M., Mei, L., Xu, Q., & Liu, Q. (2022). Detecting out-of-distribution samples via variational auto-encoder with reliable uncertainty estimation. Neural Networks, 145, 199-208.

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Multimodal Neural Modulation and Advanced Neuroimaging

Organizer:Sheng He、Pengmin Qin

Introduction: Neural modulation is one of the fast growing field of neuroscience to probe the causal relationship between brain activity and behavioral response, and show great potential values in clinic. In this symposium, six speakers were invited. The topics of presentations focus on different brain modulation methods, such as transcranial magnetic stimulation (TMS), transcutaneous electrical nerve stimulation (TENS), mid-infrared stimulation (MIRS), and so on. Combined with EEG, sEEG, and high-resolution functional MRI at 7 Tesla , the potential clinical value of brain modulations for patients with mental disorder and patients with brain injury are discussed.

报告人

Peng Zhang

Institute of Biophysics, Chinese Academy of Sciences

中科院生物物理所，脑与认知科学国家重点实验室，研究员, 博士生导师, 创新课题组长，中国科学院大学岗位教授。张朋课题组通过视觉心理物理方法和脑功能成像技术（特别是高分辨率功能磁共振技术），揭示人类视知觉，意识和注意等认知功能的神经机制，以及视觉系统相关疾病的认知和神经机制。研究成果发表在Neuron, PNAS, Curr Biol, Elife，Nat Commun, Cell Reports, NeuroImage等国际高水平杂志。

Joe Yazhuo Kong

Institute of Psychology, CAS

孔亚卓，中国科学院心理研究所研究员，牛津大学脑功能成像中心客座研究员，疼痛综合神经影像实验室PI。近年来以多模态脑脊磁共振成像技术为核心手段，通过研究触觉痛觉痒觉的感知、传导、认知、调节的脊髓-脑干-脑皮层的神经环路来揭示复杂躯体感知觉的神经机制，同时探讨疼痛共情和社会性疼痛的神经机制及其与生理性疼痛的相互作用，在此基础上探索疼痛慢性化的生理心理机制以及对病理性疼痛的预测评估、干预评估及镇痛策略的开发。研究成果发表在包括Brain, PNAS, Journal of Neuroscience等神经科学领域重要杂志上。

Qian Wang

Peking University

Dr. Qian Wang's primary research focus is on elucidating the neural mechanisms underlying auditory and visual processing in humans. She employs a combination of intracranial recordings and direct brain stimulation in patients with epilepsy. Her investigative scope encompasses a range of topics, including speech perception, auditory spatial attention, color perception, perceptual learning, and the development of visual cortical prostheses. Her recent research contributions have been featured in Brain Stimulation, The Journal of Neuroscience, Cerebral Cortex, Science China Life Science, and eLife.

Ji Dai

Shenzhen Institute of Advanced Technology, CAS

Ji Dai is a Principal Investigator at the Brain Cognition and Brain Disease Institute, Shenzhen Institute of advanced technology CAS; the Director of Shenzhen Technological Research Center for Primate Translational Medicine. Dr. Dai's Lab mainly studies the neural basis and regulation mechanism of cognitive function using nonhuman primates and develops novel techniques and methods for both research and clinical application. Recent publications in Dai’s lab include Cell (2023), Nature (2022), The Innovation (2023). Dr. Dai is a member of the Youth Innovation Promotion Association of CAS, one of Shenzhen’s overseas high-level talents and Shenzhen Nanshan District pilot talents.

Yan Yang

Institute of Biophysics, CAS

杨艳，研究员，博士生导师，主要结合认知行为检测、电生理技术、脑功能调控技术、功能成像技术及神经计算仿真研究脑精确控制行为动作的神经机制。同时也将探索其在脑疾病的防治、诊断，以及智能技术，例如仿人机器人中应用的可能。文章发表在nature, nature neuroscience, elife 等高水平学术期刊。

Hanjun Liu

Sun Yat-sen University

Hanjun Liu is a professor at the First Affiliated Hospital of Sun Yat-sen University. His research focuses on the neural basis of speech production and the rehabilitation mechanisms of speech disorders using neuroimaging and non-invasive brain stimulation techniques. He has led over research funds including four National Natural Science Foundation of China projects and one Outstanding Young Scientist Fund of Guangdong Province. He has published 75 papers in high-impact internationally-recognized journals such as NPJ Digit. Med., J. Neurosci., Cereb. Cortex, NeuroImage., and Hum. Brain Map. His works have been cited over 2800 times, earning him an H-index of 31.

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Perioperative Neuroscience: Advances in Clinical and Basic Research

Organizer:Junli Cao、Ruotian Jiang

Introduction: Anesthesia and surgery is one of the biggest medical burdens globally. Approximately 300 million surgical procedures were performed in 2022 and this number continues to rise. Perioperative neuroscience is a multidisciplinary field in neuroscience that aims to understand the neural basis for neurological complications before, during, and after any surgical procedure involving anesthesia. This symposium presents advances in the latest basic and clinical researches on major perioperative neurological complications, such as pain/itch, delayed neurocognitive recovery, awareness under anesthesia, and delirium, which are all associated with considerable morbidity. The research included covers from molecular, synaptic, neural circuit mechanisms to clinical trials/observations related to perioperative medicine and neurobiology.

报告人

Junli Cao

Xuzhou Medical University

Junli Cao, M.D., Ph.D., is a Distinguished Professor of Yangtze River Scholars Program, and director at Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University. He earned a M.D. degree from Xuzhou Medical University and a Ph.D. degree from China Medical University, completed his postdoc training in UT Southwestern Medical Center at Dallas and Institute of Behavioral Genetics, University of Colorado at Boulder. His research interests is: 1) to understand the roles of neuroadaptations in mesolimbic reward system in mediating behavioral changes of pain and depression and co-morbidity of pain-depression. 2) to explore the neurobiological mechanisms in spinal cord underlying chronic pain. He has published his works in some international journals including Biological Psychiatry, PNAS, Current Biology，Nature Communications, Journal of Neuroscience, Pain, Anesthesiology et al. He serves on Reviewer for Neuron, Nature Communications, Biological Psychiatry, Journal of Neuroscience, et al.

Li Tian

Shanghai Fourth People’s Hospital, Tongji University School of Medicine

Dr. Li Tian currently presides as the Dean of Scientific Research at Shanghai Fourth People's Hospital, affiliated with Tongji University. She concurrently holds the position of Deputy Director at the Key Laboratory of Anesthesia and Brain Function Regulation in Shanghai. In the academic realm, she is lauded as a Distinguished Professor at Tongji University School of Medicine.

Inaugurating an academic portfolio, she serves as the Deputy Chair of the Youth Committee of the Anesthesiology Branch of the Shanghai Medical Association and as the Secretary-General of the Anesthesia and Brain Science Branch of the Shanghai Neuroscience Society. Her remarkable strides in her field have garnered numerous accolades, including the National Science Foundation for Distinguished Young Scholars (NSFC), Shanghai Dawn Project (SMEC), Shanghai Talent Development Fund (SMHR), Shanghai Rising-Star (SMSTC), Young Backbone Teacher of Higher Education Institution (MOE), and Outstanding Young Anesthesiologist (CSA), etc.

Over the past five years, she has published 18 papers as the first and corresponding author in various journals. Her research focuses on the development of accurate assessment and intervention strategies for perioperative cognitive dysfunction. In addition to her publications, she has also been awarded several patents and edited a monograph on the relationship between brain function and AI.

Ruotian Jiang

West China Hospital of Sichuan University

Dr. Ruotian Jiang graduated from the University of Strasbourg in 2011 and then spent four years as a postdoctoral researcher at the University of California, Los Angeles in the United States in Prof. Baljit Khakh lab. Since 2016, he has been working as a PI in the Department of Anesthesiology at West China Hospital, Sichuan University. In 2022, he was selected into the National High-Level Talent Program. He is an executive committee member of the Sensory and Motor Subdivision of the Chinese Society for Neuroscience, a member of the Translational Pain Committee of the Chinese Physiological Society, an editorial board member of Anesthesiology and Perioperative Science, a young editorial board member of Neuroscience Bulletin and so on. His primary research area is in the neural mechanisms and translational applications in the regulation or dysfunction of sensory neural circuits (such as anesthesia, pain, itch, etc.). His recent studies have been published in international academic journals including Cell Research (cover paper), Science Advances (highlighted paper on the Science website), Science Translational Medicine, PNAS, PLOS Biology, EMBO J, and others.

Fengxian Li

Zhujiang Hospital of Southern Medical University

Fengxian Li is an anesthesiologist from Zhujiang Hospital of Southern Medical University. She finishes her postdoc training in Washington University in Saint Louis. She is a physician scientist, and her research interest is to elucidate the peripheral mechanism of sensory disorders including itch, pain and sneezing, and explore roles of neuroimmune in sensory-autonomic interaction in the context of diseases including but not limit to diabetes. Her recent publications include CELL, NATURE COMMUNICATIONS, and ANESTHESIOLOGY.

Xiao Yu

Center for Excellence in Brain Science and Intelligence Technology, CAS

Dr. Xiao Yu received his Ph.D. in Neuroscience from Imperial College London, UK. From 2014 to 2019, he worked as a Postdoctoral Research Associate at Imperial College London, UK. From 2019 to 2021, he was a Research Fellow at Boston Children's Hospital and Harvard Medical School. From 2020 to 2021, he served as an Honorary Visiting Scholar at Imperial College London, UK. From 2021 to 2022, he was a Senior Scientist at King's College London, UK. He joined CEBSIT/ION in March 2023 as Principal Investigator and the Head of the Laboratory of Sleep and Mood. His major research interests are the neurocircuitry of sleep and mood and how sleep and mood are interlinked. His recent publications include Science, Nature neuroscience.

Xia Zhu

University of Science and Technology of China

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Translational Neuromodulation Research from Technology to Exploratory Clinical Application

Organizer:Shouyan Wang、Huiling Tan

Introduction: Neuromodulation has become increasingly essential for treating neurological and psychiatric diseases and exploring the mechanisms of neurophysiological and cognitive functions of the brain. Deep brain stimulation has been widely used for the treatment of Parkinson’s disease and transcranial magnetic stimulation is routinely prescribed for major depression in several thousand hospitals in China. There remain huge challenges in effectively treating large population in addiction, minimal consciousness state, epilepsy and Alzheimer disease, etc. The translational research from advanced technologies of artificial intelligence, brain network modelling and big data analysis to exploratory clinical research is urgent and highly demanding in advancing the novel strategies for precision neuromodulation. The proposed symposium will begin with talks of overview on recent world-wide progresses in both deep brain stimulation and non-invasive neuromodulation. The research of brain modelling for neuromodulation and closed-loop stimulation provides solutions to intervene the brain network and neuro-dynamics. There is vigorous exploratory clinical research in China. There will be talks on deep brain stimulation for minimal consciousness state, transcranial magnetic stimulation for drug addition, closed-loop deep brain stimulation for Parkinson’s disease. The future development will be discussed in a roundtable and promoted with interdisciplinary collaboration.

报告人

Huiling Tan

University of Oxford

Tan and her group have made major advances in understanding how abnormal brain activities cause slowness of movement, tremor and stiffness in people with movement disorders. Meanwhile they leverage these insights to design and test closed-loop approaches for therapeutic brain stimulation by recording and interpreting brain signals in real-time as the feedback signal with sufficient temporal and spatial resolution. Recent publication of Tan group include:

He S, et al (2023). Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson's disease. Brain, 146(12): 5015-5030

Torrecillos F, He S, Kühn AA, Tan H (2023) Average power and burst analysis revealed complementary information on drug-related changes of motor performance in Parkinson’s disease. npj Parkinson's Disease, 9(1): 93.

Wiest C, et al (2023) The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism. Elife, 12:e82467.

Wiest C, et al (2022) Subthalamic stimulation-induced local field potential changes in dystonia. Mov Disord, doi:10.1002/mds.29302

Yuxiao Yang

Zhejiang University

Yuxiao Yang’s research centers on designing closed-loop brain-machine interface systems for neural decoding and control, aiming to provide new therapies for neurological and neuropsychiatric disorders. He has published in prestigious neural engineering journals, including cover articles in Nature Biotechnology and Nature Biomedical Engineering. He received the Annual Brain-Computer Interface Award in 2019 and the IEEE EMBS Best Student Paper Award in 2015.

Yi Yang

Beijing Tiantan Hospital,Capital Medical University

Disorders of consciousness (DOC) refer to impairments in consciousness and arousal resulting from severe brain injury. The central thalamus circuitry, particularly the CM-pf nucleus, is believed to be responsible for DOC. Deep brain stimulation (DBS) is a potential therapeutic approach for awakening consciousness, but its regulatory mechanisms are not well understood. In this study, we implanted DBS electrodes into the Centromedian-parafascicular complex (CM-pf) nucleus of DOC patients and compared the effects on clinical behavior at different stimulation frequencies (50Hz and 100Hz). We also analyzed the clinical efficacy of DBS and examined changes in electrophysiological activity of central thalamic local field potentials (LFP). By gaining a deeper understanding of the therapeutic effects of DBS in this patient population and uncovering the physiological mechanisms behind DBS-induced arousal, we aim to provide guidance for optimizing future treatments using DBS. Recent review ' Clinical neuromodulatory effects of deep brain stimulation in disorder of consciousness: A literature review' in CNS Neurosci Ther. 2023;00:1–17.

Tianyi Yan

Beijing Institute of Technology

To target brain regions more focally in individual level, this study uses functional magnetic resonance imaging (fMRI) to map individual-level functional brain network parcellation for localization, and develop high frequency and multi-channel tES devices for modulation of deep brain structures. Our findings have been applied in neuromodulation intervention of patients with insomnia, anxiety, and cognitive impairment. Publications: Resting-state functional MRI of healthy adults: temporal dynamic brain co-activation patterns [J]. Radiology. 2022; Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions[J]. Mol Psychiatry, 2023

Di Zhao

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine

Her work has elucidated aberrant cognitive function and neural mechanisms underlying addictive behavior (Sci Adv 2019, Mol Psychiatry 2021, Cell Rep Med 2023), and explored targeted intervention methods (Cereb Cortex 2018, Brain Stimul 2015, 2023). Currently serving as the Deputy Secretary-General and member of the Cognitive and Brain Regulation Branch of the Chinese Cognitive Science Society. Recipient of the Oriental Talent Youth Program (formerly Shanghai Outstanding Youth Talent), leading projects funded by the National Natural Science Foundation of China (NSFC), and receiving accolades such as the Shanghai Medical Science and Technology Youth Award and the Clinical Neuroscience Innovation Award at the Yangtze River Delta Brain Science Youth Forum.

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