CNS 2024 | 专题研讨会：时钟、节奏和睡眠

报告人

Heping Cheng

Peking University

程和平 教授, Ph.D.，钙信号与线粒体生物医学研究室主任，北大清华生命科学联合中心研究员 中国科学院院士，基金委“细胞钙信号研究”创新群体学术带头人，“多模态跨尺度生物医学成像设施”（“十三五”国家重大科技基础设施）首席科学家。迄今发表论文180余篇，其中10多篇刊于Science、Nature和Cell。

Fang Guo

School of Brain Science and Brain Medicine, Zhejiang University

Neuron发表题为“Recurrent Circadian Circuitry Regulates Central Brain Activity to Maintain Sleep", 2022等

Erquan Zhang

National Institute of Biological Science, Beijing

北京生命科学研究所高级研究员。过去多年中我们一直在探索各种哺乳动物的昼夜节律机制和功能。在已取得的一些重要发现的基础上，我们实验室在NIBS的新阶段可以更加专注于以下三个特定的科学目标。Selected Publications : 1. Sang, D.†, Lin, K.†, Yang, Y.†, Ran, G., Li, B., Chen, C., Li, Q., Ma, Y., Lu, L., Cui, X.-Y., Liu, Z., Lv, S.-Q., Luo, M., Liu, Q., Li, Y., and Zhang, E.E.* Prolonged sleep deprivation induces a cytokine storm-like syndrome in mammals. (2023) Cell 186: 5500-5516 {Highlighted by Nature Reviews Immunology: “Sleep deprivation whips up cytokine storm”} 2. Yu, Z. and Zhang, E.E.* Disrupted circadian rhythms in the plateau pika. (2023) Trends in Neurosciences 46: 1005-1007 3. Jiang, W.†*, Jin, L.†, Ju, D.†, Lu, Z.†, Wang, C., Guo, X., Zhao, H., Shen, S., Cheng, Z., Shen, J., Zong, G., Chen, J., Li, K., Yang, L., Zhang, Z., Feng, Y., Shen, J.Z., Zhang, E.E.*, and Wan, R.* The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction. (2022) Science Translational Medicine 14: eabn3586 {Highlighted by Nature Reviews Gastroenterology & Hepatology: “Stopped clock promotes fibrosis in chronic pancreatitis”} 4. Liu, N.†, Tian, H.†, Yu, Z.†, Zhao, H.†, Li, W.†, Sang, D., Lin, K., Cui, Y., Liao, M., Xu, Z., Chen, C., Guo, Y., Wang, Y., Huang, H-w, Wang, J., Zhang, H., Wu, W., Huang, H., Lv, S., Guo, Z., Wang, W., Zheng, S., Wang, F., Zhang, Y.*, Cai, T.*, and Zhang, E.E.* A highland-adaptation mutation of the Epas1 protein increases its stability and disrupts the circadian clock in the plateau pika. (2022) Cell Reports 39: 110816

Jun Yan

Center for Excellence in Brain Science and Intelligence Technology, CAS

严军博士，2009年3月起任德国马普学会青年科学家小组组长。2015年9月起任中国科学院神经科学研究所研究员，研究组组长。严军博士主要通过计算生物学的方法研究以神经网络和基因调控网络为主的生物网络。

Lixia Chen

Huazhong University of Science and Technology

华中科技大学生命科学与技术学院博士后。

Chang Liu

Shenzhen Institute of Advanced Technology, CAS

刘畅，博士，中科院深圳先进技术研究院研究员，隶属于脑认知与脑疾病研究所脑图谱研究中心。2003年于河北师范大学获得学士学位。2009年-2012年获中欧联合培养博士项目资助在德国马普神经生物学研究所开展博士研究，师从马原野研究员和Hiromu Tanimoto教授，2012年于中国科学院昆明动物研究所获得博士学位。2012-2018年在美国布兰迪斯大学（Brandeis University）从事博士后研究，导师为Leslie C. Griffith教授。刘畅博士主要从事调控睡眠以及学习记忆的分子和神经回路机制的研究。已在Nature、eNeuro、Journal of Neurophysiology、Journal of Psychiatric Research等期刊发表多项研究成果。

Sleep-Wake Circuits and Memory

Organizer:Min Xu, Zhian Hu

Introduction: Sleep is a fundamental and complex physiological process that influences various aspects of our daily lives. Recent research has unveiled the pivotal role of sleep in the consolidation of memory, which encompasses the stabilization and integration of newly acquired information into long-term memory storage. This symposium will highlight the latest progress and understanding of the role of sleep-wake regulating circuits in memory formation. Exploring the mechanisms governing the interplay between sleep-wake circuits and memory also holds significant practical implications. Disturbances in sleep, such as insomnia, sleep apnea, or disruptions in sleep patterns, have been linked to impairments in memory and a decline in cognitive abilities. Scientists and clinicians can develop targeted interventions and therapeutic strategies to improve memory performance and mitigate memory-related disorders by understanding the neural mechanisms involved in sleep-dependent memory processes.

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