CNS 2024 | 专题研讨会：神经发育和神经精神疾病

报告人

Xiang Yu

Peking University

My laboratory has long-standing interests in studying oxytocin and autism, in the context of neurodevelopment: Yu et al., 2022 Neuron, Cao et al., 2020 Cell Reports, Hu et al., 2018 Autism Research, Wang et al., Neurosci. Bull., Bian et al., 2015 Cell, Zheng et al., 2014 Nat. Neurosci.

Bin Wang

Guangdong Institute of Intelligence Science and Technology

Dr. Wang's research has focused on investigating pathological roles of human genetic variants in neurodevelopmental disorders such as intellectual disability and Autism spectrum disorders. His recent works have been published in journals such as Cell Research, Cell Reports (3 articles), EMBO Reports, Journal of Molecular and Cell Biology, eLife and Brain.

Nan-Jie Xu

Shanghai Jiao Tong University School of Medicine

Our study presents defective social approach and sniffing in EphB2 mutant mice and suggest the critical role of neural activity in prefrontal cortex for partner social interaction. Part of our study was published in Mol Psychiatry (Liu et al, 2021) and PNAS (He et al., 2023).

Zhiheng Xu

The Institute of Genetics and Developmental Biology, CAS

Autism spectrum disorder (ASD) occurs in more than 1% of the population, and unilateral hemisphere dysfunction has been detected in autistic children. However, the underlying mechanism remains to be explored. My lab has long-standing interests in studying the mechanisms underlying autism: Xu et al., 2023 Neurosci. Bull., Yao et al., 2022 Cell Reports, Zhao et al., 2022 Cell Res, Pang et al., 2021 Nat. Metab

Junhai Han

Southeast University

His research primarily focuses on the neurodevelopment and pathogenic mechanisms of autism using fruit fly and mouse models. He has elucidated the novel function and mechanisms of the autism risk factor Neurexin in mediating retinol intercellular transport and regulating axonal projection. As the corresponding author, he has published over 40 papers in journals such as Molecular Cell, Neuron, Developmental Cell, Current Biology, and EMBO J.

Yandong Zhang

Fudan Univerisity

My recent research focuses on investigating the intricate mechanisms that underlie neural development and neurodevelopmental disorders, with a particular emphasis on autism. Our research has successfully identified the pivotal role of the transcription factor 4 in controlling neural and glial development during brain development. Notably, mutations in the transcription factor 4 have been implicated in Pitt-Hopkins syndrome, a disorder within the autism spectrum. Recent publications: Zhang et al., 2021, Molecular Psychiatry; Zhang J, Zhang Y et al., 2023, Movement Disorders

报告人

Xiaohong Xu

Center for Excellence in Brain Science and Intelligence Technology, CAS

The hypothalamus plays a crucial role in coordinating stress responses, yet the precise neural circuit mechanisms are not fully understood. In previous studies, we introduced a simple behavioral paradigm that highlighted individual variations in responses to a novel, potentially stressful object. In this study, we reconstructed the entire brain projectomes of over 7,000 hypothalamic neurons expressing specific neuropeptides. This exploration revealed 31 subtypes characterized by single-cell projectomes, showcasing regionally biased soma distributions and enriched with distinct neuropeptides. Notably, these subtypes exhibited extensive long-range axon collaterals spanning multiple brain regions, featuring unique ipsilateral or bilateral projections within specific downstream areas. This intricate connectivity illustrates how a single axon can co-regulate multiple targets in a structured manner. Our single-neuron projectome dataset illuminates the organization of hypothalamic axons, providing valuable insights into the neural circuit mechanisms governing the hypothalamus's control over stress responses.

Recent Publications:

1. Yan, J., Ding, X., He T., Chen, A., Zhang, W., Yu, Z., Cheng, X., Wei, C., Hu, Q., Liu, X., Zhang, Y., He, M., Xie, Z., Zha. X., Xu, C., Cao, P., Li, H., Xu. X. # (2022) A circuit from the ventral subiculum to anterior hypothalamic nucleus GABAergic neurons essential for anxiety-like behavioral avoidance. Nat. Commun. 2022, 13(1)

2. Projectome-defined subtypes and modular intra-hypothalamic subnetworks of peptidergic neurons.(2023)  bioRxiv. doi: https://doi.org/10.1101/2023.05.25.542241

Lauren M. Osborne

Weill Cornell Medicine

Lauren M. Osborne, MD, graduated from Weill Cornell Medical College and received xher psychiatric training at Columbia University/New York State Psychiatric Institute.  She completed both clinical and research fellowships in women's mental health, and is an expert on the diagnosis and treatment of mood and anxiety disorders during pregnancy, the postpartum, the premenstrual period, and perimenopause.  Dr. Osborne serves as the Vice Chair of Clinical Research in the Department of Obstetrics & Gynecology at Weill Cornell Medicine.  Her research on perinatal mental illness focuses on models of care and on biological mechanisms and biomarkers, with a focus on neurosteroids and the immune system, and she runs the PIPPI Lab – Psychoneuroimmunology in Pregnancy and Postpartum – at Weill Cornell.   Dr. Osborne’s clinical work consists of collaborative care for perinatal mental health within OB/GYN.  She is also the chair of the Education Committee for Marcé of North America; founder and chair of the National Curriculum in Reproductive Psychiatry, a free web-based standardized curriculum; and an editor of The APA Textbook of Women’s Reproductive Mental Health.  Her work has been supported by the Brain and Behavior Foundation, the Doris Duke Foundation, the American Board of Psychiatry and Neurology, the NIMH, and the NICHD.

Recent Publications:

1. Osborne LM, Payne JL, Sherer ML, and Sabunciyan S. Altered Extracellular mRNA Communication in postpartum depression is associated with decreased autophagy. Molecular Psychiatry 2022 Nov;27(11):4526-4535. 

2. Sherer ML, Voegtline KM, Park HS, Miller KN, Shuffrey LC, Klein SL, Osborne LM. The immune phenotype of perinatal anxiety. Brain, Behavior & Immunity 2022 Nov; 106:280-288.

3. Riddle JN, Jager LR, Sherer M, Pangtey M, Osborne LM. Anxiety in pregnancy and stress responsiveness: An exploratory study of heart rate variability, cortisol, and alpha-amylase in the third trimester.  Journal of Neuroendocrinology 2023;e13238.

Weiwen Wang

Institute of Psychology, CAS

The Laboratory of Psychoneuroimmunology aims to contribute to a deeper understanding of the psychological and neural mechanisms of traumatic and stress related psychiatric disorders. Multiple techniques, including behavior, genetic and epigenetic, molecular biology and electrophysiology, are used to elucidate how environmental factors, especially early adverse experiences, cause emotional and cognitive dysfunction of psychiatric disorders, including depression, anxiety, and PTSD, etc. Recent Publications: 1. Xu, H., Li, M., Cai, J., Yuan, Y., He, L., Liu, J., ... & Wang, W.* (2023). Comparison of ACE-IQ and CTQ-SF for child maltreatment assessment: Reliability, prevalence, and risk prediction. Child Abuse & Neglect, 146, 106529 2. Wang Jiesi, Zhang Wei, Xu Hang, Bart Ellenbroek, Dai Jiajie, Wang Li, Yan Chaogan*, Wang Weiwen*. The Changes of Histone Methylation Induced by Adolescent Social Stress Regulate the Resting-State Activity in mPFC. Research. 2023;6:Article0264. https://doi.org/10.34133/research.0264 3. CA1i pyramidal neurons mediate the role of NMDA receptor subunit GluN3A in depressive behavior and D-serine anti-depression. (2024)  BioRxiv. https://doi.org/10.1101/2024.04.24.590964

Nashat Abumaria

Institutes of Brain Science, School of medicine, Fudan University

Dr. Nashat Abumaria obtained his PhD degree from the University of Göttingen in Germany within the International Max-Planck Research Program for Neuroscience (IMPRS). Program Dean is the Nobel laureate Erwin Neher. He is trained as molecular and behavioral neuroscientist. He did a postdoc fellowship in Prof. Eberhard Fuchs’ Lab (Winner of the German presidential award for lifetime achievement), German Primate Center, Goettingen, Germany. In 2007, he moved to China and did a postdoc fellowship in School of Medicine, Tsinghua University, Beijing, China. In 2011, he was appointed as research associated professor in Department of Basic Medical Science, School of Medicine, Tsinghua University. 

Dr. Abumaria’s Lab for Emotion and Cognition is interested in elucidating neural mechanisms underlying aversive stressful experiences, failure, learning & memories, adaptive decision making and associated cognitive disorders. The lab is the first in the world to generate an animal model relevant to give up/quitting behavior in response to failure in rodents.

Ebrahim Haroon

Emory University

Depression and dementia are known to converge on several neurobiological pathways, including those involving neuroinflammation, neurodegeneration, and disruptions in neurotransmitter systems. To better understand these intersecting mechanisms, our study focused on multimodal biomarkers that may identify individuals at an elevated risk for these pathologies. Specifically, we investigated the association between inflammation markers in depression and the subsequent risk of neurodegenerative diseases and cognitive impairments using a combination of immune, imaging, cognitive and clinical phenotyping to identify and target pathologies afflicting inflammation, glutamate and glial systems.

Recent Publications:

1. M. Bekhbat, Z. Li, N. D. Mehta, M. T. Treadway, M. J. Lucido, B. J. Woolwine, E. Haroon, A. H. Miller, J. C. Felger. Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study. Mol Psychiatry 2022 Vol. 27 Issue 10 Pages 4113-4121. DOI: 10.1038/s41380-022-01715-3

2. M. J. Lucido, M. Bekhbat, D. R. Goldsmith, M. T. Treadway, E. Haroon, J. C. Felger, A. H. Miller. Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications. Pharmacol Rev, 2021 Jul;73(3):1084-1117.  doi: 10.1124/pharmrev.120.000043.

Andrew Holmes

National Institute on Alcohol Abuse and Alcoholism,United States

Andrew Holmes was trained in the UK, where received his Bachelor’s (Hons) degree in Psychology and his Doctorate in Behavioral Pharmacology. He received postdoctoral training in behavioral neuroscience and behavioral genetics from Dr. Jacki Crawley at the NIMH. He is currently Chief of the Laboratory of Behavioral and Genomic Neuroscience, where he studies brain regulation of emotion and cognition.

Recent Publications:

1. Gunduz-Cinar O, Castillo LI, Xia M, Leer E, Brockway ET, Pollack GA, Bukalo O, Limoges A, Oreizi-Esfahani S, Kondev V, Báldi R, Dong A, Harvey-White J, Cinar R, Kunos G, Li Y, Zweifel LS, Patel S, Holmes A (2023). A cortico-amygdala circuit substrate for endocannabinoid modulation of fear extinction. Neuron 111:3053-3067. 

2. Hagihara KM, Bukalo O, Zeller M, Aksoy-Aksel A, Karalis N, Limoges A, Rigg T, Campbell T, Mendez A, Weinholtz C, Mahn M, Zweifel LS, Palmiter RD, Ehrlich I, Lüthi A, Holmes A (2021). Intercalated amygdala clusters orchestrate a switch in fear state. Nature 594:403-407.

报告人

Cai Song

Beijing Genomics Institute, Hangzhou

Professor Song is a leading authority in neuroimmunology. A Peking University MD and National University of Ireland PhD graduate, she worked in McGill and Carleton Universities, and was Professor and “Canada Research Chair” (internationally selected by Canadian Government) at Dalhousie University (Canada) and Director of Research Institute at Guangdong Ocean University. She authored 160 papers, trained >60 graduate/PhD students and received Pfizer Psychiatry Award, STA Award (Canada), “Overseas Famous Professor” (China), several Chinese Government Friendship awards and National Leading Scientist awards from Shenzhen Government. She is a “Chinese Highly Cited Scientist, top 2% World scientist and "Lifelong Scientific Impact Scientist”.

Jacek Jaworski

International Institute of Molecular and Cell Biology

Professor Jaworski is an internationally acclaimed molecular neuroscientist. He got his MD degree from Warsaw University and was PhD/postdoc at Nencki Institute of Polish Academy of Sciences. In 2002-2005 he worked at MIT and HHMI in USA. His major research success is establishing mechanistic link between brain anatomy and human TSC-Associated Neuropsychiatric Disorders (TANDs), identifying trkB as a target for TAND-specific drugs. Until 2021, he served as Deputy Director for Science of the International Institute of Molecular and Cell Biology (Warsaw, Poland). His lab develops zebrafish genetic models of human neuropsychiatric disorders related to mTOR signaling and its deficits.

Recent Publications:

1. Osborne LM, Payne JL, Sherer ML, and Sabunciyan S. Altered Extracellular mRNA Communication in postpartum depression is associated with decreased autophagy. Molecular Psychiatry 2022 Nov;27(11):4526-4535. 

2. Sherer ML, Voegtline KM, Park HS, Miller KN, Shuffrey LC, Klein SL, Osborne LM. The immune phenotype of perinatal anxiety. Brain, Behavior & Immunity 2022 Nov; 106:280-288.

3. Riddle JN, Jager LR, Sherer M, Pangtey M, Osborne LM. Anxiety in pregnancy and stress responsiveness: An exploratory study of heart rate variability, cortisol, and alpha-amylase in the third trimester.  Journal of Neuroendocrinology 2023;e13238.

Xi Li

The Affiliated Kangning Hospital of Wenzhou Medical University

Dr Xi Li is a nationally recognized physician-scientist and a top expert in zebrafish neurogenetics and clinical psychiatry. After graduating as an MD, from 2010s he did postdoc at Cornell and North Carolina at Chapel Hill Universities in USA. He presently directs the Clinical Research Center at Kangning Hospital affiliated to Wenzhou Medical University, Wenzhou Key Laboratory of Child Psychiatry, and a Top Young Talent of Wenzhou Special Support Plan. He successfully led National Natural Science Foundation, Zhejiang Natural Science Foundation and multiple other projects, and published >20 papers in mainstream journals, such as Blood, Cell Reports, BBI and BBA Mol Cell Research.

Tamara G. Amstislavskaya

Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia

Professor Tamara Amstislavskaya is among Russia’s top researchers in the field of translational neuroscience and biological psychiatry. A graduate from the renowned Institute of Cytology and Genetics, she has over 30 years of experience with experimental models of brain disorders. She presently serves as Deputy Director for Research and Lab Head at Novosibirsk Research Institute of Neurosciences and Medicine. Her current and past research has been continuously supported by the Russian Science Foundation and various international granting bodies. Her field of expertise is the use of rodent and zebrafish models to study neurodegeneration and related CNS disorders.

Konstantin B. Yenkoyan

COBRAIN Center, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia

Professor Yenkoyan is an accomplished physician-scientist, Vice-Rector for Science and Head of Neuroscience Laboratory at Yerevan State Medical University in Armenia. He currently heads the EU-funded Horizon-2020 COBRAIN Program and several projects funded by the Ministry of Science of Armenia. He directs a newly-established COBRAIN Neuroscience Center, the national neuroscience hub in Armenia. His research focuses on neuroscience, molecular biology and neurochemistry of Alzheimer’s disease and autism using both rodent and zebrafish models. He has proven track record in innovative translational research, research management, biomedical teaching and academic leadership, and serves on Editorial boards of various esteemed biomedical journals.

Konstantin A. Demin

RIKEN Brain Institute, Tokyo, Japan

Dr. Demin is a ‘rising star’ of Russian neuroscience research. A 2022 graduate from St. Petersburg University with PhD in Neurobiology, he currently works as a Post-Doctoral Fellow at RIKEN Institute in Tokyo, Japan. His areas of research include modeling human brain disorders using zebrafish and neurotranscriptomic analyses of cross-taxon data. He received SPSU Rector’s Award and the Presidential stipend, the highest possible award for PhD students in Russia. He has led, as a PI, several grants for young scientists and contributed over 60 scholarly publications in international peer-review neuroscience journals, with nearly 2000 citations and H-index of 25.