CNS 2024 | 专题研讨会：神经退行性疾病，神经学和神经损伤

报告人

Xiaofeng Jia

The University of Maryland School of Medicine, Johns Hopkins University

Xiaofeng Jia, M.D., M.S., Ph.D., FCCM is the Professor with Tenure in the Department of Neurosurgery, Orthopaedics, Anatomy & Neurobiology, the director of the Neurosurgical Stem Cell Research, and the director of Translational Neuroengineering and Neuroscience Laboratory at the University of Maryland School of Medicine and the Adjunct Professor in the Department of Biomedical Engineering at Johns Hopkins University. His current research interests include brain monitoring and stem cell therapy, therapeutic hypothermia, peripheral nerve injury, nerve regeneration, and stem cell therapy. He has published 156 peer-review journal papers with 80+ of them as the first or corresponding author, and 200+ national/international conference publications/abstracts, with 143 platform presentations and invited presentations. He is a recipient of the Annual Research Awards from AAHS, and a recipient of the Society of Critical Care Medicine 2021, 2022, and 2023 Star Research Achievement Award. Dr. JIA is a fellow of the American College of Critical Care Medicine (FCCM) and has served as the Chair of the SCCM Research Section.

Honghong Yao

Southeast University

Dr. Honghong Yao is the chief professor and secretary of the Party Committee of medical school of Southeast University. She was selected as an “Outstanding Young Investigator” from the National Science Foundation of China. Dr. Yao has long been dedicated to the research of "Neuroinflammation/Non coding RNA/Neuropsychiatric Diseases", and her related works have been published in journals such as Circulation; J Extracell Vehicles; Nat Commun; Autophagy; Mol Psychiatry; Biol Psychology; J Neurosci; Adv Function Mater, etc.  A total of 165 papers have been published, of which 6 have been selected as highly cited SCI papers and 2 have been selected as hot topic papers. Professor Yao was selected on the Elsevier 2022 China Highly Cited Scholars and 2023 Global Top 2% Scientists List.

Chao Yan

Nanjing University

Dr. Chao Yan is a professor at the School of Life Sciences of Nanjing University, a principal investigator at the State Key Laboratory of Pharmaceutical Biotechnology, and the Chairman of the Department of Physiology. He got his B.S. in Biochemistry from Nanjing University in 2003 and Ph.D. in Toxicology from the School of Pharmacy at the University of Colorado in 2011. He then received postdoctoral training at the University of Colorado Cancer Center. In 2016 Dr. Yan came back to Nanjing University to start his own lab in 2016 supported by the “Distinguished Overseas Young Talents” program . His lab studies the pathology and pharmacology or neurological diseases including epilepsy and glioma. He has a particular interest in cannabinoids and has published many high-impact articles in prestigious journals such as Nature, Nature Neuroscience, Cell Research, JCI, and Cancer Research.

Zengqiang Yuan

Academy of Military Medical Sciences

Dr. Zengqiang Yuan is currently a professor at the Beijing Institute of Basic Medical Sciences. In 2011, Dr. Yuan was selected as an “Outstanding Young Investigator” from the National Science Foundation of China. He is also the active members of several scientific organizations. His research group has been focusing on the signal transduction mechanism underlying neurodegenerative diseases and cerebrovascular diseases and is now aiming to determine the translational and therapeutic avenues for the treatment of these diseases. During the past few years. Dr. Yuan has published many high impact papers in leading journals, such as Cell, Science, Cell Metabolism, Developmental Cell, and Cell Research. Recently, it has been shown that Intermittent fasting (IF) alters gut microbial composition with a significant enrichment in probiotics such as Lactobacillus. His present finding demonstrates that an IF regimen is a potential approach to prevent AD progression, at least through the gut-microbiota-metabolites-brain axis and constitutes an innovative AD therapeutic avenue (Nature Aging, 2023; Cell Metabolism, 2023).

Yingying Wang

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

Dr. Yingying Wang is currently a research associate in the Center for Translational Neural Regeneration Research at the Run Run Shaw Hospital of Zhejiang University School of Medicine. She obtained her Ph.D. degree of Regenerative Medicine from Institute of Zoology of the Chinese Academy of Science, Beijing. During her graduate research, she focused on investigating how epigenetic modulators play crucial roles in regulation of neurodevelopment, genetic-based psychiatric diseases, and neurodegenerative diseases. She has published several high impact papers in well-known journals, such as Molecular Psychiatry (1st author), Experimental Neurology (co-1st author), and Stem Cell Reports. Her current research focus is to discover novel neuroprotective strategy in aging related neurodegenerative diseases, such as Alzheimer’s Disease, by dissecting single cell RNA-seq data obtained from different cell types of specific brain microenvironment.

Huaye Zhang

Rutgers, the State University of New Jersey

Dr. Huaye Zhang received her Bachelor of Science degree in biology from the University of Science and Technology of China. She obtained her PhD in cell biology from the University of Virginia working with Dr. Rick Horwitz.  After completing her postdoctoral fellowship with Dr. Ian Macara at the University of Virginia, she set up her own laboratory and is now a tenured associate professor at the Robert Wood Johnson Medical School of Rutgers University.  Her research is focused on the role of Par polarity regulators in neurodevelopment and degeneration. Her laboratory has been able to collectively publish extensive analyses of the role of Par polarity proteins in dendritic spine morphogenesis and plasticity, neuroinflammation, traumatic brain injury and Alzheimer’s disease. She has received a number of awards over the years including the NIH Pathway to Independence Award.

报告人

Jianwei Jiao

Institute of Zoology, Chinese Academy of Sciences

Jianwei Jiao is a principal investigator at the Institute of Zoology, Chinese Academy of Sciences. The laboratory focuses on studying what mechanisms and signaling pathways control stem cell proliferation and neurogenesis. Identification of neuron-specific genes or miRNAs from neural stem cells is the direction of this study. There are several research directions including what mechanisms involving neural stem cell proliferation and neurogenesis and how to convert fibroblasts to neurons.

Yunwu Zhang

Xiamen University

Dr. Zhang’s research focuses on deciphering the molecular mechanisms underlying neurological disorders such as Alzheimer’s disease (AD) and autism. He has identified a series of new genes participating in AD and autism. Dr. Zhang has published over 100 SCI papers on high-profile journals such as Neuron, Biological Psychiatry, PNAS, Cell Death & Differentiation, etc.

Boxun Lu

Fudan University

Dr. Boxun Lu is currently a professor at Fudan University and a New Cornerstone Investigator. He obtained his Ph.D. degree at the University of Pennsylvania and then became a Presidential Postdoctoral Fellow at Novartis. In 2012, Dr. Lu started his own lab at Fudan University, China, studying Huntington’s disease and other neurodegenerative disorders with a focus on lowering the pathogenic proteins for potential therapeutic treatment for these diseases. He proposed the original concept of ATTEC (Autophagy-tethering compounds) and worked with key collaborators to lead the studies of ATTECs tackling various targets such as polyQ proteins and organelles such as lipid droplets and mitochondria. He published over 50 papers in top-tier journals including Nature, Cell, Neuron, Nature Neuroscience, etc. He has also obtained several awards/grants such as the New Cornerstone Investigator, Newton Advance Fellow from the Academy of Medical Sciences (UK), the Xplorer Prize, the CC’Tan Award of Life Sciences, etc.

Xing Guo

Nanjing Medical University

Dr. Xing Guo is a principal investigator at Nanjing medical university. The laboratory focuses on studying the mitochondrial dysfunction and neurodegenerative diseases, including Huntington’s disease (HD) and Amyotrophic lateral sclerosis  (ALS). Dr. Xing Guo has published over 20 SCI papers on high-profile journals such as EMBO molecular medicine, Nature communications, Journal of Clinical Investigation, etc.

Sen Yan

Jinan Univeristy

Dr. Yan Sen is a researcher and doctoral supervisor at the Guangdong-Hong Kong-Macao Institute of Central Nervous System Regeneration, Jinan University. She is a recipient of the National Excellent Youth Fund, a young Pearl River Scholar, and a council member of the Chinese Young Scientists Association. Her primary research involves establishing animal models for neurodegenerative diseases (mice, pigs, monkeys), gene therapy, and studying the molecular mechanisms of neurological disorders. Using CRISPR/Cas9 gene editing technology and somatic cell nuclear transfer, Dr. Yan and her team successfully created the world's first Huntington's pig model, ALS transgenic pig model, aged dementia monkey model, immunodeficiency monkey model, among others. Her work has been published in authoritative journals such as Cell, Nature Biomedical Engineering, Signal Transduction and Targeted Therapy, and Advanced Science. Dr. Yan has accumulated rich experience in establishing disease models in miniature pigs and non-human primates and researching the mechanisms of disease onset. She leads the National Key R&D Program for Young Scientists and is responsible for the national major research program "Study on the Brain Molecular Mechanism of Non-Human Primates." Additionally, she oversees projects such as the National Natural Science Foundation of China, Guangdong Provincial Science and Technology Program, and the sub-project "Stem Cell Therapy and Functional Evaluation of Major Animal Neurological Diseases" under the national key research program.

Jie Xiang

Air Force Medical University

Jie Xiang’s main research direction: molecular mechanisms and early-diagnosis strategy of neurodegenerative diseases. Jie Xiang has published over 10 SCI papers on high-profile journals such as Cell, PNAS, Cell Reports etc.

Risk Factors in Neurodegenerative Diseases: Fundamental Mechanisms and Translational Interventions

Organizer:Zhuohao He

Introduction: The theme of this symposium is about new research progress in studying pathogenesis mechanisms underlying neurodegenerative diseases (NDD), including Alzheimer’s disease (AD) and Amyotrophic lateral sclerosis (ALS). This year, the symposium would focus on risk factors that are involved in such NDD, such as ApoE, TREM2, Immune factors and transcription factors. In addition to the basic mechanism research, we will also present some translational studies. We believe new mechanistic insights about how different risk factors are involved in disease progression would always lead to new intervention strategies. It comprises 6 talks covering different areas of neurodegenerative diseases, with an emphasis on fundamental mechanisms and translational interventions, from the perspective of risk factors in NDD. The attendees will gain knowledge from the following 6 subtopics: 1. Pathobiology of ApoE in AD. 2. ApoE and tau pathogenesis. 3. TREM2 and Abeta pathogenesis. 4. Crosstalk between nervous and immune systems in neurodegeneration. 5. Blood brain barrier and AD pathogenesis. 6. The protein translation and ALS.

关于NeuExpress