CNS 2024 | 专题研讨会:神经发育,神经发生和神经再生,通道、突触和神经元兴奋性

文摘   2024-09-05 00:05   北京  

中国神经科学学会第十七届全国学术会议将于2024年9月26日-29日在苏州市召开,作为我国神经科学领域规模最大的学术会议,其学术质量在国内屈指可数。2024年,中国神经科学学会积极组织召集专题研讨会,通过多轮投票筛选确定51个专题研讨会。

学会将陆续推出2024年专题研讨会的详细介绍,敬请关注。 

以下专题排名不分先后。

参会注册:

The 17th Annual Meeting of Chinese Neuroscience Society (cns.org.cn)

Neurodevelopment, Neurogenesis and NeuroRegeneration

Cell Lineages and Neural Cell Identity

Organizer:  Songhai Shi, Jie HE

Introduction: 神经干(前体)细胞如何产生惊人的神经细胞多样性是发育神经生物学的核心命题。近年来,随着细胞谱系追踪前沿技术的发展,我国科学家对一系列重要中枢神经组织(皮层、下丘脑、海马、视网膜等)发育细胞谱系开展了深入的解析,一些神经细胞谱系结构规律和发生逻辑开始涌现,形成了发育神经生物学一个的前沿研究方向。本专题聚焦神经细胞谱系,邀请活跃于领域一线优秀的科学家,探讨神经干细胞衍生细胞谱系进展和未来。

报告人

 Songhai Shi

School of Life Sciences, Tsinghua University

Dr. Shi has focused his research on identifying the common commodities of brain circuits at both the structural and functional levels, and linking them with animal behaviors, with the ultimate goal of arriving at a circuit- and system-level understanding of brain operation and function under normal and disease conditions. His expertise and achievement have been recognized by a number of awards, including the Science Breakthrough of the Year (1999), the Amersham Biosciences and Science Grand Prize for Young Life Scientists (2001), the Helen Hay Whitney Fellowship (2002), the Klingenstein Fellowship (2007), the McKnight Scholar Award (2010), the Blavatnik Award for Young Scientists (2010), the Howard Hughes Medical Institute (HHMI) Faculty Scholar Award (2016), the Beijing Outstanding Young Scientist (2019), and the New Cornerstone Investigator (2023)

Yongchun Yu

Fudan University

禹永春,复旦大学脑科学研究院研究员,博士生导师,目前担任医学神经生物学国家重点实验室副主任,教育部脑科学前沿科学中心副主任。主要从事大脑皮层神经环路发育研究。近几年来,在电突触对大脑皮层神经环路发育、移植中间神经元促进恐惧记忆的消除等研究中取得了突出的研究成果。作为通讯作者,相关论文发表在Nature、Neuron、Nature Communications、PNAS和eLife等学术杂志。获得张香桐神经科学青年科学家奖、上海市优秀学术带头人等多项荣誉称号。

Qing-Feng Wu

Institute of Genetics and Developmental Biology, CAS

先后获得中国科学院院长特别奖、中国科学院优秀博士学位论文奖、礼来优秀博士毕业论文奖、细胞生物学青年论坛学术新人奖、人类前沿科学奖(HFSP Postdoctoral Fellowship)、美国马里兰干细胞研究基金奖(MSCRF Fellowship)、益海嘉里优秀导师奖、神经细胞生物学青年前沿论坛特邀报告人奖。2018年入选中国科学院脑智卓越中心,2020年入选北京脑科学与类脑研究中心合作研究员。现任中国神经科学学会神经发育与再生分会委员、突触与神经可塑性分会委员、生物物理学会单细胞多组学分会委员和北京细胞生物学会理事。研究方向: 1、下丘脑发育:从神经发生到环路组装 2、下丘脑功能、激素分泌与功能失调 3、神经干细胞的稳态调控。

Yi Zhou

Center for Excellence in Brain Science and Intelligence Technology, CAS

Dr. Yi Zhou received his Ph.D. in Neuroscience from Johns Hopkins University in 2018 and completed his postdoctoral training at the University of Pennsylvania. He joined the CEBSIT Institute of Neuroscience at the Chinese Academy of Sciences as an Investigator and Lab Head in July 2023, where he leads the Laboratory of Neurogenesis and Brain Disorders to study neurogenesis, adult neural stem cells, brain disorders, and single-cell biology. His research interests lie at the intersection of neuroscience, stem cell biology, and computational biology and he has published as the first author a series of research articles and reviews in top peer-reviewed journals, including Nature, Nature Reviews Genetics, Cell Stem Cell, among others.

Jie HE

Institute of Neuroscience, CAS

Dr. Jie HE received Ph.D. in biophysics at the Institute of Biophysics, Chinese Academy of Sciences in 2005. He did the postdoctoral training at Stowers Institute for Medical Research (USA, 2005-2010) and University of Cambridge (UK, 2010-2013). He became the group leader of the laboratory of Stem Cells and Neurogenesis (2013 – Now) at the Institute of Neuroscience, Chinese Academy of Sciences, China. In the past decade, Dr. He used the zebrafish retina as an experimental model to dissect the lineage logic underlying neural type diversification in the vertebrate retina (JCB, 2017, 2020, 2023; PLOS Biol. 2020; EMBO Rep. 2022: Development 2020)

Miao He

Institutes of Brain Science, Fudan University

复旦大学脑科学研究院研究员。2005 年学士毕业于清华大学生物科学与技术系,2011 年博士毕业于美国纽约州立大学石溪分校遗传项目。博士及博士后期间在美国冷泉港实验室从事神经生物学研究,2013 年入职复旦大学。研究致力于神经细胞多样性和神经环路的遗传解析:一方面发展特异标记和调控神经细胞类型的遗传策略与工具,另一方面借助这些技术解析抑制性神经环路和乳头体神经环路的发育、联接、功能和相关疾病。研究成果发表于 Neuron、Molecular Psychiatry、Cell Reports 等期刊。担任中国神经科学学会神经干细胞和组织工程分会秘书长、上海市神经科学学会女科学家工作委员会主任委员。


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Molecular Mechanisms of Neurodegeneration

Organizer:  Lingqiang Zhu, Jie Zhang

Introduction: Neurodegenerative diseases (NDD) are diverse conditions characterized by selective dysfunction and ongoing loss of neurons, glial cells and the neural networks in the brain and spinal cord. Common pathological features shared among the neurodegenerative disorders are neuronal cell loss, gliosis, atrophy, and pathological protein inclusions. However, the underlying mechanisms of neurodegeneration remain elusive. In this symposium, we gathered six active investigators to diaplay our recent progress in the neurodegeneration, especially on the molecular mechanisms. We aimed to promote the communications between basic researchers and clinical doctors, as well as some companies.

报告人

 Qiang Liu

University of Science and Technology of China

Our recent findings in ApoE and non-coding RNA studies revealed that epigenetic changes play a critical role in Alzheimer's disease pathology and neurodegeneration, which are recently published in Neuron, Nature Structural & Molecular Biology and Trends in Neurosciences.

Yang Shi

Zhejiang University

Dr. Shi’ s research interests are focused on structures and mechanisms of amyloid protein assemblies in neurodegenerative diseases such as tauopathies and synucleinopathies, and PET ligand recognition mechanisms of amyloid filaments. His findings in structure-based classification of tauopathies are believed to be a milestone in the understanding of the broader family of amyloid diseases, which involve the build-up of proteins, and of tauopathies specifically. His selected publications are: Shi et al, Nature 2021, PMID 34588692; Shi et al., Acta Neuropat., 2021, PMID 33830331.

Ge Bai

School of Brain Science and Brain Medicine, Zhejiang University

Dr. Ge Bai, School of Brain Science and Brain Medicine, Zhejiang University. He received his Ph.D. degree from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. He then did postdoctoral training at Salk Institute /HHMI. In 2017, he joined Zhejiang University. The current research of his laboratory is focused on motor-sensory circuit development and disease. His research has been published in Cell (2023, 2011), Nature (2015), Neuron (2011), Dev Cell (2007), etc. He has been awarded the first prize of Shanghai Natural Science, funded by the Original Exploration Project of NSFC and National Talent Project.

Keqiang Ye

Shenzhen Institute of Advanced Technology,CAS

Dr. Keqiang Ye is a world-renowed neuroscientist in the neurodegenerative disease and drug development field. He is also recognized as an international authority in small molecular drug discovery and development.He has published approximately 259 papers with numerous papers in high-profile journals, including Cell, Nature, Nature Medicine, Nature Cell Biology, Nature Neuroscience, Neuron, and Mol. Cell, EMBO J, PNAS etc. H-Index/Citation: 76/20466 (Google Scholar).

Yan Zhang

Peking University

张研,北京大学生命科学学院教授,长期从事神经退行性疾病,特别是阿尔茨海默氏症中神经元凋亡及淀粉样沉积的代谢途径的研究工作。利用人类原代神经元为模型研究神经退行性疾病,采用细胞内显微注射系统,将外源性蛋白及表达质粒引入细胞等方法分析胞内淀粉样沉积毒性及其作用通路,为淀粉样沉积导致阿尔茨默症的发病机制提供了新的见解。发现并纯化内源性半胱氨酸蛋白酶抑制因子;提出朊蛋白的细胞保护假说。在此基础上,筛选并研究了一系列可以对抗细胞内淀粉样沉积毒性的物质;发现了包含甘丙肽和吗啡在内的临床应用药物的细胞保护作用并研究了其作用机制和分子通路;发现并阐明神经细胞纳米连接的诱导机制;深入探讨了纳米连接在神经退行性疾病中的作用;发现家族型老年性痴呆的突变可以导致microRNA调节和神经元早期发育的异常;揭示了轴突起始节部位异常和老年性痴呆的病理关系;提出了在遗传性AD突变携带者中,神经元存在着早期的发育缺陷。近10年来在国际著名的神经生物学和细胞生物学期刊Neuron, PNAS, Cell Reports,Prog Neurobiol, Nat Methods, Nat Protocol, J Cell Biol, Neurosci Biobehav Rev, J Neurosci, Cell Death Differ, Cell Death Dis, JACS, J Cell Sci等发表学术论文。为诸多国际期刊审稿并担任有影响力的专业期刊的编委。

Zheng Ying

Soochow University

Increasing evidence indicates that further exploration of cellular quality control system is critical for understanding the basic mechanism underlying neurodegenerative disorders including amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson’s disease. The long-term goal of our research is to describe how intracellular protein, organelle and membrane-less organelle quality control systems, including ubiquitin-proteasome system, autophagy and biomolecular condensation machinery, fail to protect neurons at disease stages. Our recent research concentrates on the use of  molecular and cellular techniques in combination with optogenetic platforms to engineer membrane-less organelles and explore their causal relationships with neurodegenerative diseases.


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Channels, Synapses, and Neuronal Excitability

Ion Channels and Neurological Disorders

Organizer: Wei Yang, Boxing Li

Introduction: Ion channels play a fundamental role in neural signal transduction. Understanding physiological and pathological function of ion channels is crucial for drug discovery and disease therapy. This symposium aims to elucidate the relationship between ion channels and neurological disorders. Topics of the symposium covered multiple types of ion channels including potassium channels, sodium channels, calcium channels, and mechanosensitive channels. The symposium encompasses a broad spectrum of research areas including biophysical properties of ion channels, and the role of ion channels in disease and drug development. The speakers include a number of prominent researchers in China. Their researches have distinctive characteristics and innovation in different areas. This symposium will provide researchers with the latest advances and a more comprehensive understanding of ion channel function.

报告人

 Boxing Li

Sun Yat-sen University

中山大学中山医学院教授,博士生导师;中国神经科学学会常务理事,学术委员会秘书长。研究方向包括:1)离子通道及下游信号通路在认知功能中的作用;2)自闭症及认知功能障碍的发病机制;3)神经科学新技术开发。研究成果以第一或通讯作者发表于Cell (2020)、Science (2016)、Nature Neuroscience(2014)等杂志。

Yousheng Shu

Institute for Translational Brain Research, Fudan University

2020年至今,复旦大学脑科学转化研究院教授、常务副院长。中国神经科学学会,理事;中国生理学会转化神经科学专业委员会主委。致力于从神经元兴奋性和神经环路电活动调控的角度阐明正常脑功能的机制和脑疾病的发病机理,探索针对不同脑疾病的神经调控治疗策略。原创性研究工作发表在Nature、Nature Neuroscience、Neuron、PNAS等学术期刊上。

ZhaoBing Gao

Shanghai Institute of Materia Medica, CAS

中科院上海分院副院长,上海药物所研究员,原创新药研究全国重点实验室主任,神经精神疾病研究中心主任。国家杰出青年基金获得者。从事离子通道药理学研究和新药发现工作,建成系统完备的离子通道药物研发平台,发现新型离子通道,开发通道的新功能,研发靶向离子通道新药。

Ye Yu

China Pharmaceutical University

于烨,中国药科大学教授、博导、兴药领军学者,近年来一直从事重大疾病相关膜蛋白跨膜信号转导过程中的关键生物物理问题,发病机制以及创新药物发现等方面的研究。在Neuron, PloS Biol, PNAS, J Clin Invest, Nat Coummun, Cell Res等本领域知名期刊发表80多篇SCI论文。

Xiaona Du

Hebei Medical University

杜肖娜教授,博士生导师。河北医科大学临床医学学士,免疫学硕士,药理学博士。英国利兹大学和美国德克萨斯大学高级访问学者。河北医科大学机能学系负责人、药理教研室主任、健康与医学研究院创新药物研发与评价中心主任。研究方向主要为离子通道在神经及心血管系统中的生理及病理意义,寻找相关神经和心血管系统疾病的治疗新靶点及研究新型药物。以第一作者或通讯作者在JCI,Cell Reports,PloS Biol,Pain,Brit J Pharmacol,J Biol Chem等发表论文。

Heng Zhang

Zhejiang University

张恒,现为浙江大学医学中心(余杭)博士后,合作导师为杨帆长聘副教授和徐浩新教授,研究方向为配体门控离子通道配体的发现、理性设计及门控机制的研究及其药理学功能研究。获得2023年度博士后创新人才支持计划,以第一作者(含共同)在Nature Communications, Nature Chemical Biology, Advanced Science, Nature Plants等杂志发表研究论文。

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Ion Channels, Glutamatergic Synapses, and Neuronal Excitability in Autism

Organizer:  Yingmei Lu, Wei Xie

Introduction: Autism spectrum disorder (ASD), classified as an early developmental disorders, manifests with notable deficits in social communication, and the presence of restricted, repetitive behaviors. Despite ongoing research, no medications have thus far demonstrated efficacy in addressing the core diagnostic symptoms of ASD. Furthermore, a comprehensive understanding of the disorder’s electrophysiological, circuitry, cellular and molecular mechanisms remain elusive. In our symposium, we focus on elucidating the intricate interplay of HCN1 channels, glutamatergic synapses, and neuronal hyperexcitability in the pathogenesis of ASD. We also leverage CRISPR/Cas9 gene editing systems to model ASD-related genes and the potential gene therapy methodology. Here, we invite 6 speakers from clinic and basic research who will present the latest advancements in research, delving into the mechanisms and interventions of ASD, spanning channels, synapses, neuronal excitability and gene editing. Our speakers will share cutting-edge research findings on ASD, with some publications dating to 2023 and others awaiting publication.

报告人

Kun Xia

Xiangya School of Medicine of Central South University

Xia Kun currently serves as a member of the Party Committee and Vice President at the University of South China. With a distinguished academic background as a doctor, researcher, and doctoral supervisor, he is further recognized as a member of the Changjiang Distinguished Professor and leads as the PI for the National Science Fund for Distinguished Young Scholars. His research is prominently focused on Family collection, pathogenic/susceptible gene mapping, and conducting cloning and functional mechanism studies related to human genetic diseases. Prof. Xia has notably contributed to the identification of over 20 novel disease-causing genes across various genetic diseases, and he has successfully cloned more than 10 new genes implicated in genetic diseases such as corneal annular dermoid tumor and high myopia. Prof. Xia’s pioneering efforts extend into the forefront of genetic research, particularly in the field of childhood autism in China. He stands as the trailblazer for China’s inaugural comprehensive GWAS on autism, whole-genome CNVs research and large-sample targeted sequencing. Through these endeavors, Prof. Xia has uncovered nearly a hundred new autism risk genes, CNVs and susceptibility loci.

Chengkun Wang

Nanjing Medical University

Dr. Chengkun Wang, professor from Nanjing Medical University. Specializing in the development and application of gene editing systems, Dr. Wang employs a comprehensive methodology that integrates CRISPR/Cas9 gene editing systems, single-cell sequencing, iPSC-directed differentiation, lineage tracing, and other advanced techniques. His research focuses on:

1) Exploration of novel gene editing system and its application in the field of gene therapy.

2) In-depth molecular mechanism analysis of gene mutations associated with neuro-psychiatric disorders, coupled with the identification of potential drug targets.

Dr. Wang's scholarly contributions are notably published in prestigious international journals, including Nature Cell Biology, Nucleic Acids Research, Journal of Pineal Research, and Cell Discovery, with over twenty SCI papers to his credit. Cumulatively, these publications boast an impact factor exceeding 300. Additionally, Dr. Wang holds six authorized patents, including two on an international scale.

Menglong Zeng

Massachusetts Institute of Technology,USA

Normal brain function requires a delicate balance between excitatory and inhibitory neurons. While only representing a small population of all neurons, GABAergic interneurons are essential to maintaining functional homeostasis across the brain. Genes encoding excitatory synaptic proteins tend to be one of the most prevalent hits in the screens of autism risk genes. However, the molecular architecture of excitatory synapses onto GABAergic interneurons has not been studied in sufficient details to establish the mechanistic insights needed to improve our understanding and treatment of autism. 

Minjie Shen

Fudan Univerisity

Dr. Minjie Shen received his B.S. degree in medicine from Fudan University in 2011 and PhD degree in neuropharmacology from Fudan University in 2016 with 2 national scholarships (China). From 2016 to 2023, Dr. Minjie Shen conducted postdoctoral research at University of Wisconsin – Madison, he was a Research Associate from 2016 through 2022 and then was appointed as a Researcher I in 2022. He was awarded FRAXA postdoctoral fellowship by Fragile X Research Foundation (2019-2021).  He joined the Institutes of Brain Science at Fudan University as a Principal Investigator in April 2023. His research focuses on genetic and epigenetic mechanisms regulating neuronal development and their implications in neurodevelopmental disorders such as autism, Fragile X syndrome, Rett syndrome and schizophrenia etc. His recent work yielded several publications on Nature Neuroscience, Neuron, Molecular Psychiatry, Nature Communications, Cell Reports, Cerebral Cortex, Translational Psychiatry and other peer-reviewed scientific journals.

Ling Yuan

Central South University

2012-2018, Ph. D., Institute of Genetics and Developmental Biology, Chinese Academy of Sciences.Yuan laboratory is interested in understanding the pathogenesis of different neurodevelopment associated diseases, especially autism spectrum disorder (ASD). His recent work yielded several publications on  Science, Neuron, Cell Stem Cell,  J Clin Invest, PNAS,PLoS Biology.

Wei Xie

Southeast University

Wei Xie holds the position of Director of Key Laboratory for Developmental Genes and Human Disease of the Ministry of Education, Executive Director of the Chinese Neuroscience Society and Chairman of the Jiangsu Provincial Neuroscience Society. His research expertise centers on the meticulous exploration of synaptic development regulation and the intricate mechanisms of social behaviors. Porf. Xie’s investigations involve a fucus on neuron surface protein molecules, employing a comprehensive research methods and leveraging model organisms to dissect synaptogenesis, maturation, circuit formation, and their roles in advanced neural activities and social behaviors. Furthermore, his work extends to exploration of genetic and epigenetic regulatory mechanism, shedding light on their implications for cognitive diseases. Prof. Xie’s scholarly pursuits have garnered support from the National Science Fund for Distinguished Young Scholars, and he is honored as a member of Changjiang Distinguished Professor. Notably, his recent contributions include multiple publications in renowned journals, including Nature, Autophagy, Nat Cell Biol, Proc Natl Acad Sci USA.


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