CNS 2024 | 专题研讨会:学习记忆,感知、认知和行动

文摘   2024-09-05 00:05   北京  

中国神经科学学会第十七届全国学术会议将于2024年9月26日-29日在苏州市召开,作为我国神经科学领域规模最大的学术会议,其学术质量在国内屈指可数。2024年,中国神经科学学会积极组织召集专题研讨会,通过多轮投票筛选确定51个专题研讨会。

学会将陆续推出2024年专题研讨会的详细介绍,敬请关注。 

以下专题排名不分先后。

参会注册:

The 17th Annual Meeting of Chinese Neuroscience Society (cns.org.cn)

Learning and memory

Memory Coding and Working Memory

Organizer:  Zengcai Guo, Hiroshi Makino

Introduction: Research on neural mechanism of working memory is progressing rapidly in recent years, mainly facilitated by the development of a combination of techniques including large-scale recording, spatiotemporal precise perturbation, quantitative behavioral paradigms and population data analyses. Scientists in this field are interested in an array of questions: How are signals related to sensory information processed in the brain? How are memories stored by distributed brain areas? How are working memory related activity converted to guide goal-directed behavior? This symposium focuses on research at the levels of human psychology, systems neuroscience including neural circuits and animal behavior with a focus on: How is sensory information from the outside world encoded in the brain? How to convert it into memory so that it can be stored and utilized? The symposium invites domestic and international research scholars involved in neuroscience-related and psychology-related research on memory encoding and working memory mechanisms for in-depth discussions.

报告人

Hiroshi Makino

Nanyang Technological University

Dr. Hiroshi Makino is a Nanyang Assistant Professor at the Lee Kong Chian School of Medicine, Nanyang Technological University. He started his scientific career at the Salk Institute for Biological Studies where he studied adult neurogenesis in the mammalian hippocampus. He obtained his PhD from Cold Spring Harbor Laboratory where he studied AMPA receptor dynamics and synaptic plasticity. He conducted his postdoctoral research at University of California, San Diego where he investigated learning-related transformations of micro- and macro-scale cortical activity. At Nanyang Technological University, he studies learning in the brain and machine.

Liping Wang

Center for Excellence in Brain Science and Intelligence Technology, CAS

Dr. Liping Wang is a senior Investigator at Institute of Neuroscience in the Chinese Academy of Sciences, the head of the Laboratory of Cognition. His main interests are the neural mechanisms underlying sequence learning, working memory, and consciousness.

Huan Luo

School of Psychological and Cognitive Sciences, Peking University

Dr. Huan Luo is a tenured associate professor at the School of Psychological and Cognitive Sciences and a PI of IDG/McGovern Institute for Brain Research, Peking University. Her research primarily focuses on the brain mechanisms of perception, attention, and working memory in humans, particularly from a dynamic perspective. She is Chang Jiang Young Scholar and supported by NSFC Key Program and Excellence Young Scientists Funds. She currently serves as the associate editor for Progress in Neurobiology, and editorial members of PLoS Biology and eLife. As one of six labs in the world, her lab recently participated in a high-impact international collaborative project COGITATE supported by Templeton World Charity Foundation.

Tatsuo Sato

Kagoshima University

Dr. Tatsuo Sato is a professor at School of Medicine and Dentistry, Kagoshima University, Japan. His research focus is to clarify cell-physiological bases for cortical processing that involves long-range connectivity. After obtaining his Ph.D. degree from Kyoto University in 2010, he conducted his postdoctoral research at University College London and Technical University of Munich to investigate cell-physiological and circuit bases for visual processing, publishing Nature Neuroscience (2), Nature Communications. After becoming independent in 2018, he developed an approach to image long-range dopamine axons in the medial prefrontal cortex using two-photon microscopy in vivo. He currently investigates what the dopamine axons encode in the medial prefrontal cortex. He joined Kagoshima University in 2022.

Dajun Xing

Beijing Normal University

Dr. Dajun Xing is a professor in the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research at Beijing Normal University.  His research interests focus on neural mechanisms of visual perception and brain oscillations by using electrophysiological, anatomical and computational approaches. In particular, his work aims to understand how visual system processes visual information for perception, what is the relationship between brain oscillations and visual perception (and other cognitive functions such as working memory). He published a series of work in international journals including Nature Communications, PNAS, Cell Reports, PLoS Biology and Journal of Neuroscience Dr. Xing obtained his Ph.D. degree from New York University in 2005 and then worked as a research scientist and faculty at New York University (2006-2012), Dr. Xing joined Beijing Normal University in 2013.

Qing Yu

Center for Excellence in Brain Science and Intelligence Technology, CAS

Dr. Qing Yu received her B.S. in Psychology and Mathematics from Peking University in 2011, and her Ph.D. in Cognitive Neuroscience from Dartmouth College in 2016. She was a postdoctoral research associate from 2016 to 2019, and a research scientist from 2019 to 2020, at University of Wisconsin-Madison. In September 2020, she joined the faculty at Institute of Neuroscience, Chinese Academy of Sciences as a Principal Investigator. Her research combines a variety of methods (fMRI, EEG, MEG, iEEG, psychophysics, computational modeling) to understand the neural mechanisms underlying working memory and mental imagery in humans. Her research has been published in journals including Current Biology (2019), PLOS Biology (2020a,2020b), Cell Reports (2023), The Journal of Neuroscience (2018,2023), Cerebral Cortex (2019), and NeuroImage (2017). She currently serves as the consulting editor of Journal of Cognitive Neuroscience.


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Synaptic and Circuit Mechanisms of Learning and Memory in Healthy and Disease States

Organizer: Wei Lu, Weidong Li

Introduction: The symposium focuses on the synaptic and circuit mechanisms of learning and memory in both healthy and disease states. Topics cover diverse aspects including the learning-induced synaptic plasticity controls experience-dependent behavioral outputs, the epigenetic mechanism of remote memory engrams, the inhibitory cortical ensemble for remote memory retrieval, neural circuit genetics for learning and memory in entorhinal cortical-hippocampal networks, sustaining synaptic resilience and memory through activity-dependent mitochondrial biogenesis in aging brains. These studies represent highly active research directions in the field of learning and memory. The speakers consist of 3 domestic and 3 international investigators, one of whom is a female speaker. The composition of the speaker reflects both international influence and diversity. Research conducted by the speakers employs cutting-edge research methods. A considerable proportion of the presentation content are unpublished research findings. The goal of the symposium is to promote the understanding of the latest research progress in learning and memory.

报告人

Yingxi Lin

University of Texas Southwestern Medical Center

Dr. Yingxi Lin is a Professor and Division Chief at UT Southwestern Medical Center in Dallas, Texas, United States. Her research focuses on understanding the molecular and circuit mechanisms underlying the conversion of transient experiences into long-lasting memories, behavior modifications, and the elicitation of markedly different behavioral responses in both healthy and disease states. Originally from China, Dr. Lin studied Engineering Physics at Tsinghua University and received her PhD in Biophysics from Harvard University. She conducted her postdoctoral research under Dr. Michael Greenberg at Harvard Medical School. She served as an Assistant Professor (2009 - 2015) and an Associate Professor (2015 - 2018) at the McGovern Institute for Brain Research at the Massachusetts Institute of Technology (MIT). Before her current role, she was Full Professor and Director of the Neuroscience Graduate Program at SUNY Upstate Medical University. Since December 2023, she has held the position of Chief of the Psychiatry Neuroscience Research Division at UT Southwestern Medical Center.

Weidong Li

Shanghai Jiao Tong University

Dr. Li obtained his MD. Ph.D. in Japan. He did his postdoc at UCLA with Dr. Alcino Silva and Dr. Tyrone Cannon. Dr. Li started his lab in Shanghai Jiao Tong University since 2009. Dr. Li has been studying on the mechanisms of learning memory and mental disorders. He published more than 80 papers on the SCI journals including Neuron, PNAS, Cell Stem Cell, Nature Communications.

Dan Ehninger

German Center for Neurodegenerative Diseases (DZNE)

He conducted his postdoc at the Department of Neurobiology, Los Angeles, United States. He started his lab as the Research group leader, DZNE Bonn in 2010. His research is focused on the pathogenesis of aging-associated and neuropsychiatric disorders and in the development of novel therapeutics for these diseases. Current work in his laboratory is also focused on clarifying the role of key lifespan-regulatory pathways in influencing aging and the pathogenesis of age-related disorders. He published multiple seminal papers in Nature Neuroscience, Neuron and Journal of Clinical Investigation.

Wei Lu

Fudan University

Dr. Lu obtained his Ph.D. at Fudan University Shanghai Medical School. He conducted his postdoc at Massachusetts Institute of Technology and Harvard University. He is now a Professor at Institute for Translational Brain Research (ITBR), Fudan University in Shanghai, China. His research focuses on understanding the cellular and circuit mechanisms underlying remote memory formation and neuropsychiatric diseases (PD, OCD, etc.). He is the recipient of Distinguished Young Investigator Award, National Science Foundation of China (NSFC). His work has been published in Neuron, PNAS, EMBO Journal, Cell Reports.

Takashi Kitamura

University of Texas Southwestern Medical Center

Dr. Kitamura obtained his Ph.D. in Biology at Kyushu University in Japan. He conducted his postdoc at the Picower Institute for Learning and Memory at Massachusetts Institute of Technology under the supervision of Dr. Susumu Tonegawa. Dr. Kitamura started his lab in the Department of Psychiatry at University of Texas Southwestern Medical Center. He recently published multiple seminal papers about observational fear in Neuron (2022), memory consolidation in Nature Communications (2023) and mirror-induced self directed behavior in Neuron (2023). From 2023, he is Associate Professor

Huan Ma

Zhejiang University

Dr. Huan Ma is Qiushi Distinguished Professor at Zhejiang University, Deputy Director of the NHC and CAMS Key Laboratory of Medical Neurobiology, Changjiang Scholar appointed by the Ministry of Education of China. His research interests include neural plasticity, learning and memory, and neuropsychiatric disorders. His work as the corresponding author has been published in top journals in the field, such as Cell, Neuron, Cell Reports, and Nature Communications. His research accomplishments have been recognized by F1000 with exceptional ratings multiple times.


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Perception, Cognition and Action

Neural Mechanisms of the Primate Hippocampus and Related Cortical Areas for Perception and Memory

Organizer:  Yuji Naya, Dun Mao

Introduction: The hippocampus is critically involved in declarative memory, which consists of episodic memory and semantic memory. Its contributions to this cognitive function were thoroughly examined by lesion studies using nonhuman primates as an animal model. However, only a few physiological studies have investigated neuronal mechanisms of the primate hippocampus, in sharp contrast to that of rodents. The recent technological developments such as wireless recording system, virtual reality and human electrophysiology as well as new behavioral paradigms (constructive memory model) have encouraged memory researchers to elucidate how hippocampal neurons work in primates when we explore an environment as well as when we remember it. This symposium introduces six physiological studies (four monkey and two human studies) investigating the primate hippocampus and related cortical areas. In these studies, neuronal operations are related with sensory/motor systems (foveal vision, saccade) and/or their cognitive capability, which are specialized in primates and difficult to investigate using only rodents. We aim to present what we can find in primate electrophysiology to elucidate neural mechanisms responsible for perception and memory in our daily life, which would be useful and interesting not only for memory researchers across all species but also for broad audience (vision, artificial intelligence).

报告人


Edmund T. Rolls

University of Oxford, UK

Edmund T. Rolls is a neuroscientist with research interests in computational neuroscience, including the operation of real neuronal networks in the brain involved in vision, memory, attention, and decision-making; functional neuroimaging of vision, taste, olfaction, feeding, the control of appetite, memory, and emotion; neurological disorder of emotion; psychiatric disorders including schizophrenia and depression; and the brain processes underlying consciousness. These studies include investigations in patients, and are performed with the aim of contributing to understanding the human brain in health and disease, and of treating its disorders. He has published more than 630 full length research papers on these topics, which are shown, with many .pdfs available including some of his books, at https://www.oxcns.org.

Sylvia Wirth

Centre National de la Recherche Scientifique

Dr. Sylvia Wirth’s research centers on the neural basis of spatial memory in the macaque hippocampal system, using behavioral tasks in a virtual reality environment. She will give a talk on the relationship between the hippocampus and parietal cortex, which is not published officially yet (only preprint now). 

Liang Wang

Institute of psychology, CAS

Dr. Liang Wang’s research centers on the neural basis of human navigation and memory, combining a variety of intracranial EEG and brain stimulation techniques. 

1. Liu J, Chen D, Xiao X, Zhang H, Zhou W, Liang S, Kunz L, Schulze-Bonhage A, Axmacher N, Wang L. Multi-scale goal distance representations in human hippocampus during virtual spatial navigation. Current Biology 2023; 33:2024-2033.

2.Chen D, Kunz L, Lv PC, Zhang H, Zhou WJ, Liang SL, Axmacher N, Wang L. Theta oscillations coordinate grid-like representations between ventromedial prefrontal and entorhinal cortex. Science Advances 2021; 7:eabj0200

Inah Lee

Department of Brain and Cognitive Sciences, Seoul National University

Dr. Inah Lee is a well-established physiologist who did very important jobs in memory study using rodents. Based on his expertise, Dr Inah Lee started memory study using nonhuman primates and obtained interesting findings. He will present his unpublished results.

Cen Yang

Peking University

Dr. Cen Yang’s research focus on the neuronal mechanism of declarative memory in macaque hippocampus and related cortical areas, examining constructive memory process at single-neuron level. 

1. Yang C. and Naya Y. (2023) Sequential involvements of the perirhinal cortex and hippocampus in the recall of item-location associative memory in macaques. PLoS Biol, 21(6):e3002145

2. Yang C., Chen H. and Naya Y., (2023) Allocentric information represented by self-referenced spatial coding in the primate medial temporal lobe, Hippocampus, 33(5):522-532.

3.Yang C. and Naya Y., (2020) Hippocampal cells integrate past memory and present perception for the future. PLoS Biol 18(11): e3000876.

Sze Chai Kwok

Duke Kunshan University

Dr. Sze Chai Kwok’s research centers on functional roles of the primate hippocampus in episodic memory. He will unpublished data highlighting the link between hippocampus and neocortices during memory encoding, maintenance, and retrieval in human. 


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Spatial Navigation and Cognitive Map

Organizer: Chun Xu, Xiaohui Zhang

Introduction: Spatial navigation is critical for animal survival and requires the formation and retrieval of an environmental cognitive map. The hippocampal-entorhinal circuit underlying the spatial navigation and cognitive map have been the research frontier in the system neuroscience for decades. This symposium aims to present the latest progresses in these research directions by taking advantage of 2-photo calcium imaging, multi-channel electrophysiology and computational modeling. 

We will present how distinct sub-populations of neurons in hippocampal and entorhinal circuits differentially process spatial and non-spatial sensory inputs. We will show how gravity regulates spatial information processing by studying animals’ spatial navigation (rodents vs. primates) in a 3D space and a simulated spaceflight special environment. Finally, we will show new computational models (including oscillatory interference model) to explain the gravity modulation of grid cell and place cell activity in 2D and 3D space.

报告人


Xiaohui Zhang

State Key Laboratory of Cognitive Neuroscience and Learning, 

Beijing Normal University

2013年至今,担任北京师范大学认知神经科学和学习国家重点实验室教授(二级)、以及IDG-麦戈文脑研究所PI。致力于研究大脑皮层与海马神经环路的神经连接、功能特征与可塑性,重点解析皮层-海马参与空间表征和学习的环路基础与活动机制。近些年以通讯作者在Nat Neurosci, Nat Methods, Neuron, Nat Commun, Sci Bulletin, PNAS等国际学术期刊上发表论文。曾获国际HFSP Career Development Award(2004)、中国神经科学学会张香桐青年神经科学家奖(2017)。

Li Lu

Kunming Institute of Zoology

Dr. Lu completed his PHD in Norwegian University of Science and Technology, post-doc training in Baylor College of Medicine and started his own group at Kunming Institute of Zoology, CAS since 2019. He is interested in spatial coding in three-dimensional space and cognitive maps across species. His team is now focusing on the spatial navigation system in tree shrews. His work has been published in Nature Neuroscience, Neuron and Cerebral Cortex.

Jiajia Yang

Tianjin University

杨佳佳教授,博士生导师,天津大学医学院院长助理,先进医用材料与医疗器械全国重点实验室PI,教育部智能医学工程研究中心副主任。研究方向聚焦于特种医学领域基础理论、关键技术及工程应用,以神经功能解码与调控为主线,系统开展特种环境下多尺度认知功能解码及无创神经调控技术研究,为特种环境下脑功能调节与保护提供了新方法和新技术。

Chenglin Miao

Peking University

苗成林博士,北京大学生命科学学院研究员,主要研究了空间定位导航和学习记忆相关的神经网络,以海马位置细胞和内嗅皮层网格细胞为模型研究了这些细胞的形成机制和调控机制,揭示了动物空间定位和导航的相关脑环路内神经细胞连接和功能。申请人从事科研工作期间发表 SCI 论文共 计 16 篇,累计引用 GoogleScholar 统计达 900 次,SCI 统计他引达 856 次,近五年以第一作者发表文章在 Cell 和 Neuron 杂志,以第二作者发表文章在 Science 和 PNAS 等重要杂志上。

代表性论文:

1. Miao C#, Cao Q#, Moser M.‐B and Moser E.I. Parvalbumin and somatostatin interneurons control different space‐coding networks in the medial entorhinal cortex. (2017) Cell.171(3). :507-521.e17. (#co‐first author)

2. Miao C*, Cao Q, Hiroshi I, Yamahachi H, Witter M, Moser M.‐B and Moser E.I* (2015). Hippocampal remapping after partial inactivation of the medial entorhinal cortex. Neuron. 2015 Nov 4; 88(3):590‐603. (* corresponding author) 

3. Alme CB, Miao C, Jezek K, Treves A, Moser E, Moser M‐B (2014) Place cells in the hippocampus: 11 maps for 11 rooms. Proceedings of the National Academy of Sciences. 111(52):18428‐35.

4.Zhang S, Ye J, Miao C, Tsao A, Cerniauskas I, Ledergerber D, Moser M.‐B, Moser E. I (2013) Optogenetic Dissection of Entorhinal‐hippocampal Functional Connectivity. Science 340(6128).

Bailu Si

Beijing Normal University

Dr. Bailu Si received the Ph.D. in Neurophysics from University of Bremen, Germany. His research interests include computational neuroscience and brain-inspired robotics. He studied computational mechanisms of spatial memory, and developed a series models of grid cells and place cells. His work has been published in Nature Neuroscience, and Progress in Neurobiology.

Yihong Wang

East China University of Science and Technology

Dr. Wang is an associate professor and the deputy director of the Center for Intelligent Computing at the School of Mathematics, East China University of Science and Technology. His research interests lie in cognitive neurodynamics, involving the neural computing mechanisms of spatial cognition, memory, and decision-making, as well as bio-inspired intelligence. He has led several research projects supported by NSFC, and published research papers in Artificial Intelligence Review, Neural Networks, Nonlinear Dynamics. He serves as the coordinating editor for the SCI journal Cognitive Neurodynamics.


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Thalamic Function-Beyond a Simple Relay

Organizer:Kexin Yuan,Chaoran Ren

Introduction: This symposium delves into the multifaceted roles of the thalamus beyond its conventional perception as solely a relay station for sensory information. Emphasizing the intricate functionalities of this brain region, this event aims to illuminate its diverse contributions to brain state control, cognition, and emotion and its connections to neurological disorders. Experts from different modal systems convene to elucidate emerging theories, technological advancements, and innovative methodologies employed in deciphering the complex roles of the thalamus. The symposium aspires to foster collaboration, inspire novel research avenues, and deepen our understanding of how the thalamus intricately orchestrates various cognitive and behavioral functions.

报告人


Zhi Zhang

University of Science and Technology of China

Dr. Zhang is from department of biophysics and neurobiology of University of Science and Technology of China. His research is focused on understanding the neurobiological mechanisms of chronic pain, with an emphasis on the neural circuits for interactions of pain and other sensory systems. Additionally, they are also interested in developing new approaches to alleviate chronic pain by targeting non-pain sensory systems. As a corresponding author, paper was published in Science (2022), Nature Metabolism (2022), Nature Neuroscience (2021 and 2019), and Neuron (2021).

Xiaoke Chen

Kunming Institute of Zoology

Xiaoke Chen is an associate professor in Department of Biology at Stanford University. He received his Ph.D. in Institute of Neuroscience, Chinese Academy of Sciences in 2005, then moved to the U.S. for postdoc training at UC San Diego and Columbia University. Since 2012, his lab at Stanford University studies circuitry and molecular mechanisms underlying motivated behaviors and how maladaptive changes in these circuits lead to neuropsychiatric disorders, such as pain, addiction and depression. His lab revealed key roles of the paraventricular nucleus of the thalamus (PVT) in tracking the dynamics of stimulus salience and gates learning (Zhu et al., 2018 Science). They also demonstrated unique roles of the PVT in controlling the formation and maintenance of opioid associated memories through its different downstream targets (Zhu et al., 2016 Nature; Piper et al., 2020 Neuron). These results has rejuvenated the study of the PVT and attracting many labs to explore specific role of the PVT in varies contexts.

Chaoran Ren

Jinan University

Chaoran Ren, PhD; Principal Investigator, Professor, GHM Institute of CNS Regeneration, Jinan University, Jinan University; Key Laboratory of CNS Regeneration (Ministry of Education); From 2007 to 2012, he received Ph. D. from Peking University. His research endeavors to elucidate the circuit mechanisms of the non-image-forming visual functions. In the past five years, he has made a series of research accomplishment. He found that the ventral part of the lateral geniculate nucleus (vLGN/IGL) is a key brain structure to mediate the non-image-forming visual functions. Light information transmitted by the vLGN/IGL can regulate mood, memory and pain perception by controlling several downstream brain regions. These results improve our understanding of the structure and function of the non-image-forming visual system. He published a series of papers with corresponding author, including ones in high-profile journals such as Neuron (3), Nature Communications, Science Advances.

Siyu Zhang

Shanghai Jiaotong University

Dr. Zhang is a Principal Investigator in the Department of Anatomy and Physiology in Shanghai Jiao Tong University School of Medicine. She obtained her B.S. degree from the Nanjing University in 2004, and did her PhD study in the Institute of Neuroscience, CAS. From 2010 to 2016, she conducted her postdoctoral training with Dr. Yang Dan in UC Berkeley. Since joining Shanghai Jiao Tong University in 2016, she has focused on visual attention and visual cue-guided decision-making at the level of individual neurons and neural circuits. Her lab uncovered general principles of innervation patterns to cortical interneurons for bottom-up and top-down connections (Ma et al., 2021, Science Advances), and revealed a frontal transcallosal inhibition loop that mediating interhemispheric balance in visuospatial competition (Wang et al., 2023, Nature Communications). Her lab is working on the principals that top-down thalamocortical and corticocortical inputs interact with distinct subtypes of cortical pyramidal neurons.

Shuancheng Ren

Army Medical University

Dr. Ren is an associate professor of Department of Physiology, Army Medical University. In 2013-2019, he got his PhD degree in physiology from Army Medical University. His research interest is the neural circuit mechanisms for wakefulness/sleep, particularly the role thalamus in wakefulness regulation. His work has been published in the Science (2018) and Cell Reports (2022). His team now is working on how the sensory inputs from the environment affects our wakefulness/sleep.

Kexin Yuan

Tsinghua University

Kexin Yuan, PhD; Principal Investigator, Tenured Associate Professor, Department of Biomedical Engineering, School of Medicine, Tsinghua University; IDG-McGovern Institute for Brain Research at Tsinghua, Tsinghua Laboratory of Brain and Intelligence, Center for Brain-Inspired Computing Research. From 2001 to 2006, he received Ph. D. training in biophysics from the Institute of Biophysics, Chinese Academy of Sciences. From 2006 to 2012, he received postdoctoral training in neurophysiology at the University of California, San Francisco. From 2006 to 2008, he received postdoctoral training in neuroanatomy at the University of California, Berkeley. In the past 6 years, his research has been focusing on the neural mechanisms underlying the modulation of perception. His lab was the first to characterize the whole-brain input-output architecture of different subdivisions of the multimodal auditory thalamus (Cai et al., 2019, Cerebral Cortex), which facilitated their discovery of a hub for the control of different forms of arousal (Wang et al., 2023, Neuron) and inspired an advanced AI model for speech separation (Li et al., IEEE TPAMI, in revision).


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