CNS 2024 | 专题研讨会:神经胶质、神经免疫和代谢

文摘   2024-09-12 09:00   上海  

中国神经科学学会第十七届全国学术会议将于2024年9月26日-29日在苏州市召开,作为我国神经科学领域规模最大的学术会议,其学术质量在国内屈指可数。2024年,中国神经科学学会积极组织召集专题研讨会,通过多轮投票筛选确定51个专题研讨会。

学会将陆续推出2024年专题研讨会的详细介绍,敬请关注。 

以下专题排名不分先后。

参会注册:

The 17th Annual Meeting of Chinese Neuroscience Society (cns.org.cn)

Glia, Neuroimmunity and Metabolism

Brain Beyond Neuronal Network: Astrocytes and Oligodendrocyte Lineage Cells

Organizer: Alexey Semyanov, Xiaoping Tong

Introduction: Despite wide recognition of the importance of glial cells, the majority of modern concepts of brain function and pathology remain neurocentric. They focus on neuron-neuron signaling and neuron-glia interactions. Even though the role of glial cells is generally acknowledged, the neuronal network is considered the basis and the target of glial influence. The recent concept of brain active milieu (BAM) expands this view and suggests that brain function and pathology depend on interactions between all cellular (glia, neurons, cells of blood vessels) and non-cellular (extracellular space and extracellular matrix) elements of the brain. These elements are interlocated in space and form the unique architecture of different brain structures and regions. This arcitecture defines brain region-specific functions. BAM changes in brain development, aging, and pathology. Specific changes in the elements of BAM form memory traces, or engrams. In the symposium, we will focus on astrocytes and oligodendrocyte lineage cells, representing two BAM elements. We will discuss their involvement in normal brain functions and pathological processes.

报告人

Vladimir Parpura

Zhejiang Chinese Medical University

Prof. Vladimir Parpura is a Member of Academia Europaea, Dana Alliance for Brain Initiatives, a corresponding member of the Slovenian Academy of Sciences and Arts, Fellow of The American Association for the Advancement of Science, and a Fellow of American Physiological Society. He discovered astrocyte-neuron glutamate-mediated signaling pathway, i.e. gliotransmission (Nature, 1994). This led to the concept of the tripartite synapse (Trend Neurosci, 1999) whereby astrocytes, by releasing a gliotransmitter, can modulate synaptic transmission and plasticity. Subsequently, gliotransmission has proven to be important for sleep, respiration, learning and memory, gut motility and secretion (Glia 2017), etc.

Alexey Semyanov

College of Medicine, Jiaxing University

Prof. Alexey Semyanov is a Member of Academia Europaea and a corresponding member of the Russian Academy of Sciences. He is known for pioneering works related to extrasynaptic signaling mediated by extrasynaptic GABAA receptors, NMDA receptors, and kainate receptors (Neuron 2000; Nat Neurosci 2001, 2003; Nat Comm 2011; Cell Rep 2012, 2013; PNAS 2014). More recently, this research focus switched to the role of glial cells in brain functions and pathologies (Nat Comm 2020, 2023; Nat Rev Neurosci 2020; Nat Neurosci 2021; Cell Rep 2023, 2023). He also co-authored a novel unifying concept of brain active milieu (TINS 2021).

Anna Fedotova

College of Medicine, Jiaxing University, Jiaxing, China

Dr. Fedotova's research focuses on the biological functions of astrocytes in behavior, as well as their role in pathological disorders, particularly in Alzheimer's disease. Using calcium imaging and in vivo Raman microspectroscopy in mice, insights into the principal dissimilarities in the calcium and metabolic responses of astrocytes and neurons during mouse locomotion were obtained.

Jun Nagai

RIKEN Center for Brain Science

Dr. Nagai has developed multiple astrocyte activation/inactivation tools in vivo. He elucidated detailed astrocyte-neuron interaction mechanisms in the striatum and has investigated astrocyte-mediated therapeutic potentials in neurological and psychiatric disorder models.

Selected publications: 

Nagai et al., Neuron 2021 PMID: 34139149

Nagai et al., Neuron 2021 PMID: 33385325

Yu and Nagai (co-first) et al., Neuron 2020 PMID: 33086039

Yu and Nagai (co-first) et al., Nature Review Neuroscience 2020 PMID: 32042146

Nagai et al., Cell 2019 PMID: 31031006

Xiaoping Tong

Shanghai Jiao Tong University School of Medicine

Prof. Tong’s research focuses on investigating the biological functions of glial cells, particularly astrocytes and oligodendrocyte lineage cells, in the brain, as well as their roles in neuronal disorders. The aim is to uncover novel insights into the roles of glia-neuron interactions and the mechanisms underlying glial modulation and regulation of synaptic plasticity in neuronal circuitry, both in healthy and pathological brains.

Liang Zhang

Shanghai Jiao Tong University, School of Medicine, Songjiang Institute

Prof. Zhang’s primary research focuses on glial cells and white matter in the brain, exploring the pathogenic mechanisms of white matter-related diseases, as well as the regulatory mechanisms of myelin sheath generation and regeneration. His work aims to provide a theoretical basis and potential targets for the diagnosis and treatment of brain diseases. In recent years, he has published research papers as a corresponding/co-corresponding author in academic journals such as Neuron (2 papers), Dev Cell (2 papers), JCI, Nat Comm, and Cell Rep.

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Neural-Immune Interactions in Health and Disease

Organizer:Zhihua Gao, Long-Jun Wu

Introduction: How interactions between the nervous system and immune system affect physiology and pathology has become an important and attractive research area. Accumulating evidence demonstrates that neurons not only intimately interact with brain-resident immune cells to maintain brain homeostasis, but also distantly regulate peripheral immune cell function to control the whole body homeostasis. Conversely, both central and peripheral immune cells play important roles in regulating the function of neurons. In this symposium, speakers will introduce the latest progress regarding how neural-immune interactions shape the homeostatic and pathological regulation in the body and reveal both neural and molecular mechanisms involved.

报告人

Hai Qi  

Tsinghua University

Prof. Hai Qi studies humoral immune regulation and germinal center biology. He has been focusing on how cellular interactions critical for germinal center formation are molecular orchestrated and how such interactions are translated into cell fate decision. He also investigates the molecular basis of the sexual dimorphism in humoral immunity and microglia dynamics in the context of neurological disorders. He has recently revealed important mechanisms regarding how the neurons regulate humoral immunity through direct innervation. He will introduce recent progress regarding how neurons regulate B cell immunity. His work has been publsihed in Nature, Neuron etc.

Qiang Liu 

Tianjin Medical University General Hospital

Qiang Liu, MD, PhD, is a clinical neuroimmunologist and a professor in the Department of Neurology at Tianjin Medical University General Hospital, Tianjin, China. He is VP of Tianjin Medical University General Hospital, the Director of Neurodegenerative Diseases Research Laboratory and VP of Research at Tianjin Neurological Institute. His clinical and research interests are centered on multiple sclerosis and stroke. Recently, he identified the activation of bone marrow cellular lineages after acute brain injury (Sci Transl Med 2021), discovered the aberrant bone marrow myelopoiesis in patients with multiple sclerosis (Cell 2022) and revealed innate immune effectors that impair cognition during brain aging (Nat Neurosci 2021). His ongoing projects aim to determine the safety and efficacy of immune therapies targeting bone marrow immunity to treat CNS inflammatory disorders (NCT05154734, NCT05369351). He serves as committee members in Chinese Neurological Association (Neurovascular Disease Section), Chinese Society for Immunology (Neuroimmunology Section) and Chinese Neuroscience Society (Neuroimmunology Section).

Kelei Cao 

Zhejiang University

Kelei Cao is a postdoctoral associate at the School of Brain Science and Brain Medicine, Zhejiang University. He has been interested in microglial biology. He studies the role of microglia in physiology and pathology. Recently, he has found that HK2 is an important metabolic regulator in microglia by gating both glycolytic metabolism. As well, he discovered that microglia plays an important role in general anesthesia thorugh P2RY12-mediated signaling. These important findings have been published in Nature Metabolism and Current Biology (2023). With his efforts and excellence, he has been funded by NSFC, Zhejiang Province and other talented awards.

Yamei Tang 

Sun Yat-sen Memorial Hospital, Sun Yat-sen University 

Prof. Yamei Tang, MD, PhD, Director, Brain Research Center,Chair, Department of Neurology, Vice President, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. She is interested in and focused on studying the Neuro-immune Interaction and Neurovascular Uncoupling in brain injury. Her recent work have been supported by several key fundings from NFSC and Guangdong province. She has published a series of papers in journals such as J Clin Oncol,Sci Transl Med,Neuron,EClinicalmedicine and Neurology.

韩峰

南京医科大学

主要从事基于细胞间通讯的重大脑疾病机制解析、药物靶标确证及新药发现。近期发现脑血管内皮细胞CDK5、IL23A 等是细胞间通讯的关键信号分子。解析“血管内皮细胞—胶质细胞—神经元”三级细胞间通讯规律,有助于阐明复杂脑疾病的共性病理机制,这其中的胶质细胞和脑血管内皮细胞之间的通讯机制研究是重中之重。相关成果发表在Neuron、Mol Psychiatry、Autophagy、J Exp Med、J Clin Invest等权威期刊。

Long-Jun Wu  

University of Texas Health Science Center at Houston

Dr. Long-Jun Wu obtained PhD of Neurobiology from University of Science and Technology of China in 2004. He received his postdoc trainings at University of Toronto (2004-2008) and Harvard Medical School (2008-2011). Currently, he is Professor and Consultant at Department of Neurology, Mayo Clinic.  His recent research primarily focuses on the neuroimmune interaction, particularly the function of microglia, in normal and diseased brain. Dr. Wu has published more than 170 peer-reviewed articles, including those in Nature Neuroscience, Neuron, Science Translational Medicine, Nature Communications, Journal of Clinical Investigation, PNAS, eLife, Cell Reports, etc. Dr. Wu serves as an Associate Editor for Molecular Brain, Neuroscience Bulletin and Cell & Biosciences as well as in editorial boards for a number of journals including Glia, Brain Behavior and Immunity, Molecular Pain.

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Sino-German Symposium “Neuron-Glia Interactions in CNS Development and Diseases”

Organizer:Frank Kirchhoff, Yong Tang

Introduction: In the central nervous system (CNS), neurons and glial cells (astrocytes, oligodendrocytes (OLs) including their precursor cells OPC (OPC, also known as NG2 glia), and microglia) communicate with each other, thereby orchestrating the functional diversity of the CNS. Unravelling the molecular and cellular mechanisms regulating the numerous ways of neuron-glia interactions is not only key to understand the development and aging of the CNS, but also the related neuropathologies such as acute brain traumata or degenerative processes associated with Alzheimer’s disease (AD) or multiple sclerosis (MS). For providing an update on the status of knowledge, we invited speakers from Germany and China to present their recent research progress demonstrating the versatile roles of different glial cell types in CNS development and diseases. This symposium is intended as a special dissemination and outreach event of the Mobility project funded by the Sino-German Center for Research Promotion and organized by five research groups (Frank Kirchhoff, University of Saarland (USAAR); Yong Tang, Chengdu University of TCM; Quan-Hong Ma, Soochow University; Wenhui Huang, USAAR; and Shan Bian, Tongji University).

报告人

Chenju Yi 

The Seventh Affiliated Hospital of Sun Yat-sen University

Prof. Chenju Yi holds MD and PhD degrees from Eberhard Karls Universität Tübingen and Huazhong University of Science and Technology. Her postdoctoral training at the Collège de France in Paris, preceded her appointment as a Senior Research Fellow at the National University of Singapore's School of Medicine. Chenju's research delves into glial cell contributions to brain diseases, notably Alzheimer's disease. Her work is funded by various foundations, and she has received multiple Research Talent awards for her impactful contributions. Current research focuses on glial cell roles in neurodegenerative diseases and glial-neuronal interactions in early brain development and cognitive dysfunction.

Recent publications:

1. Yi C*, Verkhratsky A*, Niu J* (2023) Pathological potential of oligodendrocyte precursor cells: terra incognita. Trends Neurosci 46:581-596.

2. Su Y, Wang X, Yang Y, Chen L, Xia W, Hoi KK, Li H, Wang Q, Yu G, Chen X, Wang S, Wang Y, Xiao L, Verkhratsky A, Fancy SPJ, Yi C*, Niu J* (2023) Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development. Neuron 111:190-201.e198.

3. Wang Q, Huang X, Su Y, Yin G, Wang S, Yu B, Li H, Qi J, Chen H, Zeng W, Zhang K, Verkhratsky A*, Niu J*, Yi C* (2022) Activation of Wnt/β-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer's disease. Brain 145:4474-4488.

4. Yi C, Goh KY, Wong LW, Ramanujan A, Tanaka K, Sajikumar S, Ibáñez CF* (2021) Inactive variants of death receptor p75(NTR) reduce Alzheimer's neuropathology by interfering with APP internalization. EMBO J 40:e104450.

5. Wang Y#, Su Y#, Yu G, Wang X, Chen X, Yu B, Cheng Y, Li R, Sáez JC, Yi C*, Xiao L*, Niu J* (2021) Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress. Adv Sci (Weinh) 8:e2101181.


Janos Groh

Institute of Molecular Neurobiology, Technical University of Munich, Germany

Dr. Janos Groh is a neurobiologist interested in myelin, inflammation, and degeneration of the diseased and aging nervous system. More than a decade of research on mechanisms linking neural pathology of the nervous system to innate and adaptive immune reactions. 

Recent publications:

1. Groh J, Abdelwahab T, Kattimani Y, Hörner M, Loserth S, Gudi V, Adalbert R, Imdahl F, Saliba AE, Coleman M, Stangel M, Simons M, Martini R (2023) Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects. Nat Commun.; 14:6911. 

2. Abdelwahab T, Stadler D, Knöpper K, Arampatzi P, Saliba AE, Kastenmüller W, Martini R, Groh J (2023) Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed oligodendrocytes in PLP1 mutant mice. iScience.; 26:106698.

3. Groh J, Knöpper K, Arampatzi P, Yuan X, Lößlein L, Saliba AE, Kastenmüller W, Martini R (2021) Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline. Nat Aging.; 1:357-367.


Quanhong Ma 

Soochow University

Prof. Quan-Hong Ma earned her Ph.D. from Hamburg University, Germany, and later worked at Glaxosmithkline (R&D), focusing on Alzheimer's drug development as a senior scientist. Joining Soochow University's Institute of Neuroscience in 2011 as a full professor, she founded a research group concentrating on molecular mechanisms and drug development for Alzheimer's and autism spectrum disorder. Specifically, her team investigates how autophagy contributes to these neurological disorders at the molecular level. Ma's research, featured in prestigious journals such as Nature Cell Biology, has led to multiple licensed international and national patents, solidifying her reputation in advancing the understanding and treatment of neurological disorders.

Recent publications:

1. Zhu JW, Zou MM, Li YF, Chen WJ, Liu JC, Chen H, Fang LP, Zhang Y, Wang ZT, Chen JB, Huang W, Li S, Jia WQ, Wang QQ, Zhen XC, Liu CF, Li S, Xiao ZC, Xu GQ, Schwamborn JC, Schachner M, Ma QH*, Xu RX (2019)  Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling. Cerebral Cortex. pii: bhz306. 

2. Wang ZT, Lu MH, Zhang Y, Ji WL, Lei L, Wang W, Fang LP, Wang LW, Yu F, Wang J, Li ZY, Wang JR, Wang TH, Dou F, Wang QW, Wang XL, Li S*, Ma QH*, Xu RX* (2019) DISC1 Protects Synaptic Plasticity in a Transgenic Mouse Model of Alzheimer’s Disease As a Mitophagy Receptor. Aging Cell. 18(1):e12860. 

3. Xie YY, Pan TT, Xu DE, Huang X, Tang Y, Huang W, Chen R, Lu L, Chi H, Ma QH* (2021)  Clemastine Ameliorates Myelin Deficits via Preventing Senescence of Oligodendrocytes Precursor Cells in Alzheimer's Disease Model Mouse. Front Cell Dev Biol. Oct 21;9:733945


Wenhui Huang

Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, Germany

Dr. Wenhui Huang completed his PhD and postdoctoral training for glia research in Max-Planck Institute for Experimental Medicine and Saarland University, Germany. He generated the first NG2-CreERT2 knockin mouse currently used in many groups of the world. He has systematically investigated the fate of NG2 glia in vivo as well as the NG2 expression patterns under (patho-)physiological conditions. His group at Saarland University is studying molecular mechanisms regulating glial fate and functions with a particular focus on oligodendrocyte development and neuroinflammation, supported by several funding agencies (e.g., the German Research Foundation, Fritz Thyssen Foundation, the Medical Faculty of Saarland University). 

Recent publications:

1. Guo Q, Gobbo D, Zhao N, Liu Q, Fang L,-P, Gampfer T,M, Meyer M,R, Bai X, Bian S, Scheller A, Kirchhoff F* Huang W* (2023). Adenosine triggers early astrocyte reactivity that provokes microglial activation and drives the pathogenesis of sepsis-associated encephalopathy. bioRxiv, doi: 10.1101/2023.10.30.563169.

2. Liu Q, Guo Q, Fang LP, Yao H, Scheller A, Kirchhoff F*, Huang W* (2022) Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo. J Neurochem doi: 10.1111/JNC.15693.

3. Guo Q, Scheller A, Huang W* (2021) Progenies of NG2 glia: what do we learn from transgenic mouse models? Neural Regen Res 16(1):43-48


Wiebke Möbius

Department of Neurogenetics, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany

Dr. Wiebke Möbius, an electron microscopy specialist, explores myelinating glia biology with a focus on CNS myelin turnover and axon-glia interactions in conditional mouse mutants. Her lab pioneers optimized myelin preservation techniques, utilizing transmission and immunoelectron microscopy, Tokuyasu methods, and FIB-SEM. Her lab revealed myelin internodes are continuously renewed by adding newly synthetized membranes at the inner tongue of the myelin sheath and at (juxta)paranodes while removal of myelin most likely happens in the form of myelinoid bodies. Currently, Dr. Möbius investigates the Plp-deficient mouse model, unraveling how the absence of major myelin protein PLP leads to neurodegeneration.

Recent publications:

Selected publications

1. Van den Bosch A, Hümmert S, Steyer AM, Ruhwedel T, Hamann J, Smolders J, Nave KA, Stadelmann C, Maarten K, Möbius W, Huitinga I (2023) Ultrastructural axon-myelin unit alterations in MS correlate with inflammation. Annals of Neurology 93:856–870 http://dx.doi.org/10.1002/ana.26585

2. Steyer AM, Buscham TJ, Lorenz C, Hümmert S, Eichel-Vogel MA, Schadt LC, Edgar JM, Köster S, Möbius W, Nave KA, Werner HB (2022) Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag. Glia Nov 10. doi: 10.1002/glia.24290.

3. Meschkat M., Steyer A.M., Weil M.-T., Kusch K., Jahn O., Piepkorn L., Agüi-Gonzalez P., Phan N.T.N., Ruhwedel T., Sadowski B., Rizzoli S.O., Werner H.B., Ehrenreich H., Nave K.A. and Möbius W (2022) White matter integrity requires continuous myelin synthesis at the inner tongue. Nature Comm. Mar 4;13(1):1163


Yixun Su 

Seventh Affiliated Hospital, Sun Yat-sen University

Dr. Yixun Su earned his Bachelor's degree from Zhejiang University and completed his PhD at the National University of Singapore under the co-supervision of Prof. Xin-Yuan Fu and Prof. Kenneth Ban. Following his doctoral studies, he underwent postdoctoral training at Sun Yat-sen University. Yixun’s research is focused on the intricate interplay between glial cells and neurons in the development and diseases of the central nervous system. His previous work has been published in renowned journals such as Neuron and Molecular Psychiatry. Notably, his research has received funding from esteemed organizations, including the National Natural Science Foundation of China.

Recent publications:

1. Su Y; Wang X, Yang Y, Chen L, Xia W, Hoi KK, Li H, Wang Q, Yu G, Chen X, Wang S, Wang Y, Xiao L, Verkhratsky A, Fancy SPJ, Yi C*, Niu J* (2023) Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development. Neuron 111:190-201.e198

2. Yu G#, Su Y#, Guo C, Yi C, Yu B, Chen H, Cui Y, Wang X, Wang Y, Chen X, Wang S, Wang Q, Hu X, Mei F, Verkhratsky A*, Xiao L*, Niu J* (2022) Pathological oligodendrocyte precursor cells revealed in human schizophrenic brains and trigger schizophrenia-like behaviors and synaptic defects in genetic animal model. Mol Psychiatry 27:5154-51663.

3. Wang Y#, Su Y#, Yu G, Wang X, Chen X, Yu B, Cheng Y, Li R, Sáez JC, Yi C*, Xiao L*, Niu J* (2021) Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress. Adv Sci (Weinh) 8:e21011812021, 8(16): 0-2101181.


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The Physiology and Pathology of Microglia

Organizer: Bo Peng

Introduction: Microglia are resident immune cells in the central nervous system (CNS) that play critical roles in the maintenance of CNS homeostasis. With technological advances in the past decades, researchers have extended understanding on the microglial function in development, anesthesia and diseases. Now, microglia study has become a hot topic in neuroscience. Investigation of the fundamental roles of microglia is essential for understanding how the CNS maintains its homeostasis. In this symposium, we invited 6 outstanding speakers of the microglia field. We will take this opportunity to discuss the physiology and pathology of microglia, aiming to exchange the cutting-edge knowledge in microglia studies.

报告人

Xiaofen Chen 

Institute of Neuroscience, Xiamen University

Xiao-Fen Chen is a full professor of the Institute of Neuroscience at Xiamen University, China. She obtained her PhD from the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, and performed her postdoctoral work during 2009-2012 at the University of California, Los Angeles. After that, she joined the School of Medicine at Xiamen University as an associate professor, and was promoted to professor in 2018. Her research focuses on exploring the Alzheimer's disease-related pathogenic pathways in microglia to inform early diagnosis and therapy. Her primary interest is to understand why TREM2 is the strongest immune-specific genetic risk factor for Alzheimer’s disease and how TREM2-related molecular pathways can be targeted for therapy. She has published more than 25 peer-reviewed papers, including those in Immunity, Nature Communications, the Journal of Experimental Medicine, Molecular Neurodegeneration, etc. as the corresponding author. In 2019, she was awarded the National Natural Science Fund for Excellent Young Scholars.

Peng Xie 

The First Affiliated Hospital of Chongqing Medical University

Professor and doctoral supervisor of the First Clinical College of Chongqing Medical University. He is 973 chief scientist, honorary president of Neurology branch of Chinese Medical Association, chairman of neuropsychological and affective disorders special committee of Neurology branch of Chinese Medical Association, and director of Key Laboratory for diagnosis and treatment of functional brain diseases of NHC.

His team presided over project of 973, project of National Key Research and Development, project of 863, project from Chinese Academy of Medical Sciences, international cooperation project of National Natural Science Foundation of China and others.

He committed to clinical research on depression, cerebrovascular disease, central nervous system virus infection. In recent years, a series of original scientific research achievements of international significance have been made in the basic research of depression and cerebrovascular disease by his team.

Peng Shi

Zhejiang University School of Medicine, Institute of Translational Medicine

Dr. Peng Shi obtained her Ph.D from the University of Texas Health Science Center at San Antonio 2007, and received post-doc training in the University of Florida 2007-2012. Dr. Shi took an Assistant Professor position in Cedars-Sinai Medical Center in Los Angeles 2012-2016. Since April 2016, she joined Zhejiang University Institute of Translational Medicine as a Principal Investigator. Her research is focusing on the resident immune cell microglia, and their roles on neuronal activity and brain homeostasis in cardiovascular and neurodegenerative diseases. Her work has be published in Immunity, Circulation Research, Hypertension, Stroke, Pharmacological Research et al.. Dr. Shi’s research has received continuous funding supports from American Heart Association, National Natural Science Foundation of China and Natural Science Foundation of Zhejiang Province. She used to be the senior editor of Cellular Molecular Neurobiology 2016-2022, currently serves as a junior editor of Neuroscience Bulletin.

Hanjie Li 

Shenzhen Institute of Advanced Technology, CAS

The Li Lab integrates data- and hypothesis- driven approaches to understand human immunology in development, health, and diseases. Dr. Li is the recipients of many prestigious awards, including Humboldt Fellowship and Marie Curie Fellowship. He has published in many top journals including, Cell, Cell Research, etc.

1) An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development

Wang Z*, Wu Z*, Wang H*, Feng R*, Wang G*#, Li M*, Wang S*, Chen X*, Su Y, Wang J, Zhang W, Bao Y, Lan Z, Song Z, Wang Y, Luo X, Zhao L, Hou A, Tian S, Gao H, Miao W, Liu Y, Wang H, Yin C, Ji Z, Feng M, Liu H, Diao L, Amit l, Chen Y, Zeng Y, Ginhoux F #, Wu X #, Zhu Y #, Li H#. Cell. 2023 (*equal contribution;#Corresponding authors.)


Bo Peng

Fudan University

Dr. Bo Peng is a professor and assistant director at Institute for Translational Brain Research, Fudan University. He obtained his bachelor's degree in biotechnology in 2008 at Huazhong University of Science and Technology. He then studied neurophysiology at the Institute of Neuroscience at the Chinese Academy of Sciences from 2008 to 2011. After that, he investigated retinal degenerative disorders at The University of Hong Kong and obtained his Ph.D. degree in neuroscience in 2015. After that, Dr. Bo Peng joined Shenzhen Institutes of Advanced Technology at the Chinese Academy of Sciences as an associate professor and established his lab. In 2019, Dr. Bo Peng moved to Fudan University.

Dr. Bo Peng's laboratory is mainly focusing on understanding how microglia turnover in physiological and pathological conditions. In addition, his lab is developing therapeutic approaches for treating CNS disorders. Dr. Bo Peng published a series of last-author papers, including Nature Neuroscience (2018), Nature Aging (2023), Neuron (2021), Cell Reports (2020), Nature Communications (2022), and eLife (2023).

Qifei Cong 

Soochow University

My research expertise is in the area of developmental neuroscience. Specifically, we seek to identify the molecular and cellular mechanisms of synapse formation and elimination, with a focus on the innate immune mechanisms regulating synapse elimination and loss. Recent work has shown that the brain endogenously expresses many immune proteins. In particular, components of the complement system are upregulated during brain development as well as in diseases. Our research aims to understand innate neuro-immune mechanisms in the brain to prevent aberrant synapse loss during disease. We first identifiy an endogenous neuronal complement inhibitor that protects synapses from developmental complement-mediated synapse elimination (Nature Neuroscience, 2020; Glia, 2022). I am collaborating with Dr. Weifeng Luo, a Neurologist doctor specializing in stress and depression, to characterize the innate neuro-immune mechanisms of Botulinum neurotoxin A ameliorating depressive symptoms (Acta Pharmacol Sin, 2023). Another collaboration with Dr. Chao Yan, Nanjing Univeristy, is to uncover the selectively synaptic pruning during neuronal hyperexcitability. This work is now under review (Nature Neuroscience).

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Central Regulation of Energy Metabolism

Organizer: Yu-Dong Zhou,Hao Wang

Introduction: The central nervous system is a master regulator of various physiological functions including energy metabolism. Complex central mechanisms have evolved to regulate energy intake and expenditure to maintain energy homeostasis. The goal of the symposium is to provide an overview across the latest developments on the central regulation and central-peripheral interactions in energy metabolism spanning from metabolic sensing, feeding, and maintaning energy homeostasis. The symposium will provide insights into the neural circuits and mechanisms, as well as genetics and lifestyle underlying energy metabolism, and will focus on the latest advances on metabolic conditions such as obesity that result from energy imbalance.

报告人

Qingchun Tong 

McGovern Medical School,UTHealth

Dr. Tong is currently Professor and Cullen Chair in Molecular Medicine of IMM of McGovern Medical School of UTHealth. He is also an adjunct faculty member of Department of Neurobiology and Anatomy of McGovern Medical School, and of Endocrine division of Department of Medicine at Baylor College Medicine.  Dr, Tong's team aims to delineate important neurons and neural pathways that underscore interactive regulation of feeding and emotion. This line of research is highly significant to current clinical treatments for obesity, psychiatric patients and eating disorders.

徐华泰 

临港实验室

徐华泰博士,中国科学院上海生命科学研究院神经科学研究所研究员,2023年起任职于临港国家实验室。主要研究方向是基于多通道全细胞膜片钳电生理记录,神经环路追踪,单细胞RNA测序等多种方法,致力于跨物种跨脑区神经环路的系统比较和研究部分下丘脑部分神经环路的功能,同时关注AD病发早期的神经环路基础。

王晓萌 浙江大学

王晓萌博士,2020年获浙江大学神经生物学专业理学博士,2023年11月起任南湖脑机交叉研究院研究员。博后期间获得国家自然基金委青年项目资助。主要研究方向是能量平衡的神经调控机制以及水凝胶柔性神经接口的研发,相关研究结果以第一作者身份发表在Science Advances, Biomaterials等高水平杂志。

熊伟

中国科学技术大学

熊伟教授现任中国科学技术大学生命科学学院副院长,兼任中国科学院脑科学与脑疾病重点实验室副主任。以通讯作者在Cell、Cell Metabolism等高水平期刊发表论文 50 余篇。最近工作揭示了“微生物-肠-脑轴”环路对于机体能量平衡的调控作用,为今后过度进食障碍的干预治疗提供了新策略。


曾文文 

清华大学医学院

曾文文,现为清华大学医学院长聘教授,获国家自然科学基金委“杰出青年科学基金”。科研方向为脑-体链接的生理和相关病理机制,着重研究交感神经、感觉神经的支配、功能和紊乱,探索免疫和神经系统参与代谢的重要功能,促进基于神经免疫干预重塑代谢的策略研发。

Yang He 

Baylor College of Medicine

Dr. He Yang is an Assistant Professor at Baylor College of Medicine and a principal investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital. The research in Dr. He’s lab focuses on the cross-disciplinary study of the central nervous system’s regulation of energy homeostasis. Dr. He Yang has published multiple research papers in renowned journals such as Nature, Nature Medicine, Nature Metabolism.

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White Matter Development and Diseases: From Glial Regulation to MRI Imaging

Organizer:Feng Mei,Gaolang Gong

Introduction: White matter occupies about 60% of the human brain in volume and comprises glial cells and neuronal axons. White matter undergoes dynamic growth in developing CNS. Injuries or maldevelopment of white matter in neonatal brains contribute to long-term functional deficits, including defects of cognition, memory, and learning capabilities. White matter development requires dynamic interactions between neuronal axons and multiple types of glial cells. Oligodendrocyte myelination fast proceeds in the neonatal brain, which is essential for establishing proper neural circuitry functions for neuronal functions. Angiogenesis, astrocytes, and neuronal axons govern this process. These homeostatic mechanisms ensure fast and efficient myelination in developing brains. Notably, MRI imaging of white matter imaging can reflect the neuronal connectome microstructure, and characterizing the patterns of structural white matter development represents a promising strategy for predicting long-term functional deficits. This session includes talks on aspects of white matter development from neuroglial regulation to MRI imaging. The speakers will present intriguing stories and unpublished data regarding the glial mechanisms and cutting-edge techniques of white matter imaging in developing brains.

报告人

Gaolang Gong

Beijing Normal University

Dr. Gaolang Gong is a distinguished professor at Beijing Normal University, serving as a group leader of the State Key Laboratory of Cognitive Neuroscience and Learning and the IDG-McGovern Institute for Brain Research at Beijing Normal University. His research primarily focuses on human brain white matter connectivity, hemispheric differences in the brain, and brain imaging computational methods. He is a recipient of the National Science Fund for Distinguished Young Scholars, and has published over 40 papers as the corresponding or first author in prestigious journals like Nature Human Behaviour, Journal of Neuroscience, and Neuroimage. He also serves as the vice-chair of the Brain Imaging Committee of the Chinese Psychological Society, as well as an Associate Editor for Human Brain Mapping and Brain Research.

Jianqin Niu

Army Medical University

Jianqin Niu is currently a professor, deputy director, and doctoral supervisor in the Department of Histology and Embryology, School of Basic Medical Sciences, Army Medical University (formerly Third Military Medical University). He was a joint graduate student at the University of Texas Southwestern Medical Center (UT Southwestern). He then received postdoctoral training at the Collège de France in Paris and the University of California, San Francisco (UCSF). He was awarded the Youth Chang Jiang Scholar from the Ministry of Education, the High-level Talent of the Army, the Science and Technology Talent of the Army, and the Talent of Chongqing. His research has been focusing on oligodendrocyte development and myelination. He has been funded by the Science and Technology Innovation 2030 - "Brain Science and Brain-like Intelligence Technology" major program (Key participant), the Key R&D plan of the Ministry of Science and Technology (sub-program), and the military's "High-level Science and Technology Innovation Talent Project". His work was published in esteemed journals such as Science, Nature Neuroscience, Neuron, Molecular Psychiatry, Advanced Science, and Brain as the first/corresponding authors, with over 1200 citations.

郭辉

中南大学

博士,研究员,博士生导师,国家优秀青年科学基金获得者。2020年在中南大学晋升为研究员;2022年担任中南大学遗传学系主任;2023年担任生命科学学院副院长。郭辉博士实验室主要利用医学遗传学和生物信息学手段,结合神经生物学、细胞生物学、生化与分子生物学以及模式生物等手段开展孤独症等神经发育障碍的遗传调控机制和精准诊疗研究。研究成果发表在JCI(2022)、Sci Adv(2022,2019)、Am J Hum Genet(2020)、Nat Commun(2019a,2019b,2016)、Mol Psychiatry(2014)、Genet Med(2022,2019,2015)、Nat Genet(2021)、Nat Neurosci(2017)等杂志。共主持5项国家自然科学基金项目,承担脑科学与类脑研究重大项目等。

现任中国遗传学会理事、中国神经科学学会儿童认知与脑功能障碍分会秘书长、中国遗传学会青年委员会委员、中国遗传学会行为遗传学分会委员。担任Cellular and Molecular Life Sciences副主编。受邀为Cell Rep、Genet Med、JMG、Mol Autism、Aut Res等杂志审稿。


Zhe Zhang

Hangzhou Normal University

Dr. Zhang's research develops new approaches to understanding the foundational principles of brain organization, the development of cognitive functions, and the underpinnings of neuropsychiatric disorders. In particular, his work focuses on mapping and modelling the brain structure-function relationship in health and disease, resulting in over 30 publications in internationally prestigious journals, such as Translational Psychiatry, IEEE Journal of Biomedical and Health Informatics, Psychological Medicine, Journal of Neural Engineering, and Human Brain Mapping. Furthermore, Dr. Zhang extends his expertise as a guest editor for esteemed journals including Brain Sciences and Frontiers in Human Neuroscience. He also serves as a peer reviewer for various high-impact journals like Schizophrenia Bulletin and IEEE Transactions on Affective Computing.

Recent publications:

1.Zhang Z, Wei W, Wang SJ, Li ML, Li XJ, Li XY, Wang Q, Yu H, Zhang YM, Guo WJ, Ma XH, Zhao LS, Deng W, Sham PC, Sun Y*, Li T*. Dynamic structure-function coupling across three major psychiatric disorders. Psychol Med, 2023; 1-12.  

2.Liu GY, Zheng WH, Liu H, Guo M, Ma LY, Hu WJ, Ke M, Sun Y*, Zhang J*, Zhang Z*. Aberrant dynamic structure-function relationship of rich-club organization in treatment-naïve newly diagnosed juvenile myoclonic epilepsy. Hum Brain Mapp 2022; 43, 3633-3645.

Yanmei Tao

Southeast University, School of Medicine

Yanmei Tao is now a professer at Southeast University, School of Medicine. She is interested in exploring the functions and molecular mechanisms of genetic factors associated with psychiatric disorders. She has mainly focused on synapses and myelin. These two microstructures mature at last during development and remain highly plastic after maturation and have published dozens of reports in prestigious journals, including Nat Neurosci, PNAS, J Neurosci, and Cell Discov.

Feng Mei  

Third Military Medical University (army Medical University)

Feng Mei is a full professor and director of the Department of Tissue and Embryology of the School of Basic Medical Sciences of the Army Medical University, the secretary-general of the glial cell branch of the Chinese Neuroscience Society. His research interests include the role and mechanism of oligodendrocytes and myelin sheath in regulating brain function. His research was funded by 15 projects, such as the 2030-"Brain Science and Brain Research" major project (project leader), the National Natural Science Foundation of China, and the Chongqing Outstanding Youth Fund, with a funding of 17 million yuan, and has published 15 papers in neuroscience journals such as Nature Neuroscience, Neuron (2 papers), J Neurosci, GLIA and other neuroscience journals as a corresponding author in the past five years, and he has been cited 2500 times. 3 papers have been recommended by F1000 evaluation. 3 papers were reviewed and recommended as highlight papers of the current issue, 2 cover papers, and 1 paper was selected as the best paper of the year by Cell Magazine (2021).

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