CNS 2024 | 专题研讨会：神经回路和动物行为

Neural Circuits and Animal Behaviors

报告人

Shaoyu Ge

Stony Brook University,United States

In the first part of my presentation, I will discuss our recent laboratory findings on how environmental exploration impacts hippocampal microvascular blood flow and astrocytic glucose uptake/metabolism dynamics. Environmental exploration can significantly promote the survival of hippocampal newborn neurons in adults, healthy aging, and degenerating brains. In the second part, I will present updated data to demonstrate that both flow and astrocytic glucose dynamics are essential for exploration-induced survival of newborn neurons

Juan Song

University of North Carolina at Chapel Hill,United States

Our primary research interest is to identify the mechanisms that regulate neural circuit organization and function at distinct stages of adult neurogenesis, and to understand how circuit-level information-processing properties are remodeled by the integration of new neurons into existing circuits and how disregulation of this process may contribute to various neurological and mental disorders. Our long-range goals are to translate general principles governing neural network function into directions relevant for understanding neurological and psychiatric diseases. We are addressing these questions using a combination of cutting-edge technologies and approaches, including optogenetics, high-resolution microscopy, in vitro and in vivo electrophysiology, genetic lineage tracing and molecular biology.,Our primary research interest is to identify the mechanisms that regulate neural circuit organization and function at distinct stages of adult neurogenesis, and to understand how circuit-level information-processing properties are remodeled by the integration of new neurons into existing circuits and how disregulation of this process may contribute to various neurological and mental disorders. Our long-range goals are to translate general principles governing neural network function into directions relevant for understanding neurological and psychiatric diseases. We are addressing these questions using a combination of cutting-edge technologies and approaches, including optogenetics, high-resolution microscopy, in vitro and in vivo electrophysiology, genetic lineage tracing and molecular biology.

Weixiang Guo

Institute of Genetics and Developmental Biology, CAS

Adult neurogenesis is a multistage process that newborn neurons are generated through the activation and proliferation of neural stem cells (NSCs) and integrated into existing neural networks. Impaired adult neurogenesis has been observed in various neurological and psychiatric disorders, suggesting its critical role in cognitive function, brain homeostasis, and neural repair. Over the past decades, mounting evidence has identified a strong association between metabolic status and adult neurogenesis. Recently, we have demonstrated the important role of amino acid metabolism (such as lysine and arginine) in adult hippocampal neurogenesis. These studies highlight that systematic elucidation of how amino acid metabolism regulates adult neurogenesis has profound implications not only for understanding the biological underpinnings of brain development but also for providing potential therapeutic strategies to intervene in inborn errors of metabolism. (EMBO J, Cell Rep, J neuro, JCB)

Satoshi Kida

The University of Tokyo

 Professor, Department of Applied Biological Chemistry, The University of Tokyo. Our research projects: 1)Mechanisms underlying the regulation of learning and memory, especially after memory retrieval. 2)Mechanisms of brain disorders such as post-traumatic stress disorder and Alzheimer's disease and the development of methods to treat these disorders. Relationship of brain function with nutrition/food. 3)Mechanisms underlying regulation of feeding behavior through molecular and cellular cognition.

Masanori Sakaguchi

Univ. Tsukuba WPI-IIIS

Our lab is at the University of Tsukuba's International Institute for Integrative Sleep Medicine. Since 2018, our mission has focused on two key areas: understanding memory consolidation during sleep and exploring fear memory relearning through sound. Using advanced techniques like neuronal imaging and behavioral analysis, we delve into the intricacies of memory consolidation. By studying adult-born neurons and their activity during sleep, we uncover groundbreaking insights. Our research holds promise for preventing and treating diseases by advancing our understanding of sleep-related memory processes. Additionally, we investigate the fascinating phenomenon of fear memory relearning, specifically induced by sound. Join us on this captivating journey as we unravel the secrets of memory consolidation, adult-born neurons, and the impact of sound. Together, we can make transformative strides in mental health.

Ya-Dong Li

Songjiang Research Institute, Shanghai Jiao Tong University, school of medicine

As many as 80% of patients with chronic pain are suffering from insomnia, which impairs memory. Here we first report a cortical node in regulating chronic pain-induced insomnia. Then, we find an indirect cortical-hippocampus pathway in regulating memory deficits under chronic pain-induced insomnia. These findings give new evidence that sleep disorder under pathological conditions impairs memory.

Yadong's recent publications include Nat Neuro (2022), and Cell Stem Cell (2023).

报告人

Misha Benjamin Ahrens

Janelia Research Campus, HHMI

Manuel Zimmer is an Adjunct Investigator at the IMP and Professor at the University of Vienna. He is one of the leading scientists who studies how the entire neural network dynamics in the brain represent sensory information and perform computations to generate decisions and subsequent behaviours.

Yu Mu

Center for Excellence in Brain Science and Intelligence Technology, CAS

Yu MU is a Principal Investigator at the Institute of Neuroscience, Chinese Academy of Sciences. He graduated from the Institute of Neuroscience of the University of Chinese Academy of Sciences in 2012 and subsequently joined the Janelia Research Campus of the Howard Hughes Medical Institute for postdoctoral research. His research team uses zebrafish as a vertebrate model organism to create a research system that performs whole-brain functional imaging with light sheet microscopy, combined with virtual reality and complex system analysis methods, to study sensory-motor information processing and its regulation, revealing the circuit mechanisms by which the brain generates flexible and robust computations at the whole-brain scale. He has published 30 papers in journals including Cell, Neuron, eLife, and Nature Methods, and has received awards such as the First Prize of Shanghai Natural Science Award and the Chinese Academy of Sciences President's Award. He has been supported by projects such as the Excellent Young Scientists Fund (Overseas), the Chinese Academy of Sciences' "Hundred Talents Program", Shanghai's Talent Recruitment Program (Youth), and Shanghai's "Pujiang Talent" program.

Peng Ji

Fudan University

Ji Peng is a PI at the Institute of Brain-Inspired Intelligence Science and Technology, Fudan University, and a specially appointed professor at universities in Shanghai. He is dedicated to interdisciplinary research driven by complex systems, bridging brain structure-function data and models. He participates in the "Brain Science and Brain-Inspired Research" major project as part of the Science and Technology Innovation 2030, and leads several national and Shanghai municipal projects, including those funded by the National Natural Science Foundation. His long-term research focuses on the non-linear dynamics of complex networks, investigating the conditions for the emergence of macroscopic phenomena, the corresponding intrinsic coupling relationships, adaptability, and other influential factors, from both theoretical and practical perspectives. He has achieved a series of research results, publishing over thirty papers as first or corresponding author in journals such as Nature Physics, Physics Reports, and Physical Review Letters. He is currently a member of the 6th Shanghai Society for Nonlinear Science and a committee member of the Complex Network and Complex System of the China Society for Industrial and Applied Mathematics.

Manuel Zimmer

University of Vienna,Austria

 Manuel Zimmer is an Adjunct Investigator at the IMP and Professor at the University of Vienna. He is one of the leading scientists who studies how the entire neural network dynamics in the brain represent sensory information and perform computations to generate decisions and subsequent behaviours.

Quan Wen

University of Science and Technology of China

Wen Quan is currently a professor at the School of Life Sciences, University of Science and Technology of China. He graduated from the Department of Physics at Fudan University in 2001, earning a Bachelor of Science degree. From 2001 to 2007, he studied at the Department of Physics at Stony Brook University and Cold Spring Harbor Laboratory in New York, where he received his Ph.D. in Physics. In 2008, he was at the Howard Hughes Medical Institute/Janelia Research Campus (HHMI), and from 2009 to 2014, he conducted postdoctoral research at the Department of Physics and the Center for Brain Science at Harvard University.

Yufan Wang

Institute of Neuroscience, CAS

Yufan Wang, postdoctor in center for exellence in brain science and intelligence technology. My studies use zebrafish as an animal model and focus on the brain-wide structural network and functional networks during behavior, including learning and memory, anesthesia etc.

报告人

Da-Ting Lin

National Institutes of Health

We utilized miniScopes to record calcium activities from hundreds of excitatory neurons in the mPFC while mice freely explored restrained social targets. We identified distinct and dynamic ON and OFF neural ensembles that displayed opposing activities tuned to social exploration, which carried salience and novelty information for social targets. Dysfunctions in these ensembles were associated with abnormal social exploration elicited by psychedelic drug phencyclidine (PCP). More recently, we developed deep behavior mapping (DBM) to identify behavioral microstates from behavioral video recordings. We combined DBM with longitudinal miniscope calcium imaging to quantify behavioral tuning in prefrontal neurons as mice learned an operant task. We found that a subset of prefrontal neurons was strongly tuned to highly specific behavioral microstates. Overlapping neural ensembles were tiled across consecutive microstates in the response-reinforcer sequence, forming a continuous map. As mice learned the operant task, prefrontal neurons that were not previously tuned to any behavior came to represent newly learned behaviors, and weakly tuned neurons were preferentially recruited into new ensembles. We will further discuss our efforts in combining DBM and miniscope imaging to study neural coding of mouse social behavior across multiple brain regions.

Rongfeng Hu

Fudan University

Prof. Hu developed an automated operant conditioning system to measure social reward in mice and found that adult mice of both sexes display robust reinforcement of social interaction. Utilizing the cutting-edged techniques in systems neuroscience, he identified a crucial role for an inhibitory circuit from the medial amygdala (MeA) to the medial preoptic area (MPOA) in promoting the positive reinforcement of social interaction, providing new insights into the regulation of social reward beyond the classic mesolimbic reward system. In this talk, hee will focus on extending the functional roles of social reward mediated by this pathway in the regulation of pain and immunity at the levels of molecules, cells and circuits.

1. Hu RK, Zuo Y, Ly T, Wang J, Meera P, Wu YE, Hong W. An amygdala-to-hypothalamus circuit for social reward. Nat Neurosci. 2021 Jun;24(6):831-842.

2. Wu YE, Dang J, Kingsbury L, Zhang M, Sun F, Hu RK, Hong W. Neural control of affiliative touch in prosocial interaction. Nature. 2021 Nov;599(7884):262-267.

Kun Li

School of Life Science/IDG/McGOVERN Institute of brain sicence/Tsinghua University

李坤，研究员，清华-IDG/麦戈文脑科学研究院。研究兴趣：两性不仅在正常的社会认知和情绪行为中具有性别差异，而且在多种精神疾病的发病率上也存在明显的区别。目前对导致这些性别二态性产生的神经机理仍知之甚少。我们利用核糖体标记测序技术，单核测序技术，并结合转基因小鼠，电生理记录，光遗传以及钙成像等前沿研究方法，从基因到环路等多个层面探索两性的社交行为和情绪行为在大脑内被差异编码的内在神经基础。 

Long Li

Institute of Biophysics, Chinese Academy of Sciences

 We modified the social operant box into an aggression operant box, and discovered a neural circuit that is specific to social stimuli, and contributes to the transition from aggression to pro-social behaviors. In mice, aggressive behaviour can be broken down into an appetitive phase, which involves approach and investigation, and a consummatory phase, which involves biting, kicking, and wrestling. By performing an unsupervised weighted correlation network analysis on whole-brain c-Fos expression, we identified a cluster of brain regions including hypothalamic and amygdalar sub-regions and olfactory cortical regions highly co-activated in male, but not female aggressors (AGG). The posterolateral cortical amygdala (COApl), an extended olfactory structure, was found to be a hub region based on the number and strength of correlations with other regions in the cluster. Further we showed that in aggressive males, COApl ESR1 cells respond specifically to social stimuli, thereby enhancing their salience and promoting attack behaviour.

Jun Wang 

Zhejiang University

汪军博士长期围绕情绪与认知功能的神经环路机制展开系列研究。在神经科学前沿技术，特别是在体电生理技术，多通道电生理数据分析，光遗传等技术上积累了一定的经验。近年来主要研究方向为社会交互行为和社交行为障碍的神经机制。研究工作受到国家自然科学基金青年项目、中央高校基本科研业务专项资金等项目资助。第一或共同第一作者论文主要发表在Neuron, Science Advances, PNAS等学术期刊。

代表性论文：

1.  Wang J#, Li J#, Yang Q#, Xie Y, Wen Y, Xu Z, Li Y, Xu T, Wu Z, Duan S, and Xu H*. Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons. PNAS (2021) 118(7): e2019295118 (#Equal contributors).

2.  Xu H#, Liu L#, Tian Y#, Wang J#, Li J, Zheng J, Zhao H, He M, Xu T, Duan S, Xu H*. A Disinhibitory Microcircuit Mediates Conditioned Social Fear in the Prefrontal Cortex. Neuron (2019) 102, 1–15 (#Equal contributors).

3.  Liu L#, Xu H#, Wang J#, Li J#, Tian Y#, Zheng J, He M, Xu T, Wu Z, Li X, Duan S, Xu H*. Cell type-differential modulation of prefrontal cortical GABAergic interneurons on low gamma rhythm and social interaction. Sci. Adv. 2020; 6 : eaay4073. (#Equal contributors).

Fei Li

Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Targeting the clinical barriers of childhood autism, our team carry out translational research with multidisciplinary approaches, including clinical medicine, epidemiology, neurobiology, neuroimaging, etc. In the last few years, Dr. Fei Li published up to 57 SCI papers as the first or corresponding author. Her research results were published on the high-profile journals in the neuroscience, psychiatry and pediatrics fields, such as Nature Communication, American Journal of Psychiatry, Molecular Psychiatry, Cell Reports, Science Bulletin and Pediatrics, which were frequently cited by the top journals in the areas of neuroscience and medicine, including Trends in Neurosciences, American Journal of Psychiatry. She was awarded as NSFC Distinguished Young Scholar, NSFC Excellent Young Scholar, Leading Talents of Shanghai, Outstanding Youth Post Expert, Shanghai Dawn Scholar, Shanghai Outstanding Academic Leader, the Medical Tree Award-Clinical Innovation Category, and the Honorable Doctor of China - Young Talent.