β-葡聚糖增强免疫力
β-葡聚糖是附着在真菌、细菌和燕麦等全谷物壁内的多糖。蘑菇中β-葡聚糖含量特别高,也可从酵母中分离出来。
它们有助于维持免疫健康,增强对病毒和其他病原体的防御能力。[13-15]
临床前研究还表明,它们可以降低内毒素(引起炎症的细菌感染产生的有害副产物)的影响。[16,17]
免疫反应有两种类型:先天性和适应性。[18,19]先天 免疫是人体的第一道防线。巨噬细胞吞噬并中和病毒和其他病原体,而自然杀伤 (NK) 细胞则瞄准并摧毁癌变或被病毒和其他病原体感染的不健康细胞。
适应性免疫是一种更具体、更有针对性的反应,在接触特定病原体后产生,并提供长期保护。这种反应由T 细胞和B 细胞驱动。
β-葡聚糖可激活和刺激先天免疫和适应性免疫。[10,20,21]
随着年龄的增长,我们的免疫系统会变弱,失去抵抗感染和癌症的能力,这种情况称为免疫衰老。
动物研究表明,摄入β-葡聚糖可以预防甚至逆转免疫衰老。[20,22]
更新这些免疫反应对老年人来说尤为重要。
具有最大益处的蘑菇
蘑菇含有有益健康的化合物,包括吲哚、多酚和类胡萝卜素。
β-葡聚糖是蘑菇中发现的具有生物活性的免疫支持化合物之一。[23]
有数千种蘑菇对健康有益。[24]已发现三种具有特别强的免疫作用的蘑菇是:香菇,舞茸和白桦茸。
香菇
香菇长期以来一直被用于传统中药。
在严重细菌性肺部感染的动物模型中,香菇中的β-葡聚糖显著减少了肺部的细菌负荷并改善了健康状况。[25]
细胞研究表明,香菇可以灭活病毒并下调病毒复制。[26,27]
临床研究表明,这些增强免疫力的效果可能是由于香菇能够增加免疫系统细胞的数量,包括 T 细胞和 NK 细胞。[10]
香菇还能减少有害慢性炎症的标志物,并刺激保护肠道的抗体的分泌。[10]
舞茸
舞茸经常用于亚洲美食,也能提供强大的免疫益处。
在动物研究中,舞茸提取物显著增加了NK 细胞和细菌消除能力。[28,29]与香菇提取物混合时,这种效果更加明显。[29]
舞茸提取物还能促进干扰素γ(IFN-γ)的分泌,干扰素γ是一种能阻止病毒复制的蛋白质。[29]
白桦茸
白桦茸原产于寒冷气候区,通常生长在桦树上。它们是免疫调节剂,临床前研究表明,白桦茸提取物具有抗病毒活性。[30]
在一项针对免疫功能低下的小鼠的研究中,白桦茸提取物使免疫细胞恢复到接近正常水平,并调节炎症标志物肿瘤坏死因子 α (TNF-α)的水平,这表明白桦茸提取物可以预防过度炎症。[31]
在临床前研究中,白桦茸提取物还表现出对抗多种病毒的有益活性。[12,30,32]
防御传染病
研究表明,β-葡聚糖有助于预防和治疗细菌、病毒和寄生虫感染。[33-35]在多项安慰剂对照的人体试验中,参与者被随机分配接受β-葡聚糖或安慰剂。这些试验每天至少使用250 毫克β-葡聚糖。
β-葡聚糖组的参与者有:[5-8,36,37]
减少上呼吸道感染,包括感冒和流感, 症状持续时间缩短, 减少工作日损失, 循环干扰素增加,以及 更高水平的唾液抗体,可抵御呼吸道和消化道病原体。
蘑菇对免疫系统的益处
蘑菇在传统医学中有着数千年的使用历史。
真菌,包括蘑菇和酵母,富含多种具有免疫支持功效的活性化合物,包括β-葡聚糖。
在人体试验中,服用β-葡聚糖可以减少上呼吸道感染(包括感冒和流感)的次数和持续时间,并缓解季节性过敏症状。
在一项观察性研究的荟萃分析中,吃蘑菇最多的人患癌症的风险比不吃蘑菇的人低 34% 。
将β-葡聚糖与具有免疫力支持的香菇、舞茸和白桦茸提取物相结合,可以增强免疫系统抵抗感染和其他疾病的能力。
更好的肠道健康
抗击癌症
参考文献:
Stamets P, Zwickey H. Medicinal Mushrooms: Ancient Remedies Meet Modern Science. Integr Med (Encinitas). 2014 Feb;13(1):46-7.
Ray P, Kundu S, Paul D. Exploring the therapeutic properties of chinese mushrooms with a focus on their anti-cancer effects: A systemic review. Pharmacological Research - Modern Chinese Medicine. 2024 2024/06/01/;11:100433.
Cerletti C, Esposito S, Iacoviello L. Edible Mushrooms and Beta-Glucans: Impact on Human Health. Nutrients. 2021 Jun 25;13(7).
Seo DJ, Choi C. Antiviral Bioactive Compounds of Mushrooms and Their Antiviral Mechanisms: A Review. Viruses. 2021 Feb 23;13(2).
Carpenter KC, Breslin WL, Davidson T, et al. Baker’s yeast beta-glucan supplementation increases monocytes and cytokines post-exercise: implications for infection risk? Br J Nutr. 2013 Feb 14;109(3):478-86.
Mah E, Kaden VN, Kelley KM, et al. Beverage Containing Dispersible Yeast beta-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial. J Diet Suppl. 2020;17(2):200-10.
McFarlin BK, Carpenter KC, Davidson T, et al. Baker’s yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013 Sep;10(3):171-83.
Feldman S, Schwartz H, Kalman D, et al. Randomized Phase II Clinical Trials of Wellmune WGP® for Immune Support During Cold and Flu Season. J Appl Res. 2009 01/01;9.
Talbott SM, Talbott JA, Talbott TL, et al. beta-Glucan supplementation, allergy symptoms, and quality of life in self-described ragweed allergy sufferers. Food Sci Nutr. 2013 Jan;1(1):90-101.
Dai X, Stanilka JM, Rowe CA, et al. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. J Am Coll Nutr. 2015;34(6):478-87.
Wu JY, Siu KC, Geng P. Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake). Foods. 2021 Jan 5;10(1).
Lu Y, Jia Y, Xue Z, et al. Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application. Polymers (Basel). 2021 Apr 29;13(9):1441.
Ciecierska A, Drywien ME, Hamulka J, et al. Nutraceutical functions of beta-glucans in human nutrition. Rocz Panstw Zakl Hig. 2019;70(4):315-24.
Jin Y, Li P, Wang F. beta-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties. Vaccine. 2018 Aug 23;36(35):5235-44.
Wang G, Li Z, Tian M, et al. beta-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1. Viruses. 2023 May 19;15(5).
Smiderle FR, Alquini G, Tadra-Sfeir MZ, et al. Agaricus bisporus and Agaricus brasiliensis (1-->6)-beta-D-glucans show immunostimulatory activity on human THP-1 derived macrophages. Carbohydr Polym. 2013 Apr 15;94(1):91-9.
Cheng J, Zhang G, Liu L, et al. Anti-inflammatory activity of beta-glucans from different sources before and after fermentation by fecal bacteria in vitro. J Sci Food Agric. 2024 Jan 30;104(2):1116-31.
Available at: https://www.informedhealth.org/the-innate-and-adaptive-immune-systems.html. Accessed September 5, 2024.
Marshall JS, Warrington R, Watson W, et al. An introduction to immunology and immunopathology. Allergy, Asthma & Clinical Immunology. 2018 2018/09/12;14(2):49.
Song L, Yuan J, Ni S, et al. Enhancement of adaptive immune responses of aged mice by dietary intake of beta-glucans, with special emphasis on anti-aging activity. Mol Immunol. 2020 Jan;117:160-7.
Cognigni V, Ranallo N, Tronconi F, et al. Potential benefit of beta-glucans as adjuvant therapy in immuno-oncology: a review. Explor Target Antitumor Ther. 2021;2(2):122-38.
Xu X, Yang J, Ning Z, et al. Lentinula edodes-derived polysaccharide rejuvenates mice in terms of immune responses and gut microbiota. Food Funct. 2015 Aug;6(8):2653-63.
Riaz S, Ahmad A, Farooq R, et al. Edible Mushrooms, a Sustainable Source of Nutrition, Biochemically Active Compounds and Its Effect on Human Health. In: Naofumi S, Anna S, editors. Current Topics in Functional Food. Rijeka: IntechOpen; 2022:Ch. 12.
Anusiya G, Gowthama Prabu U, Yamini NV, et al. A review of the therapeutic and biological effects of edible and wild mushrooms. Bioengineered. 2021 Dec;12(2):11239-68.
Masterson CH, Murphy EJ, Gonzalez H, et al. Purified beta-glucans from the Shiitake mushroom ameliorates antibiotic-resistant Klebsiella pneumoniae-induced pulmonary sepsis. Lett Appl Microbiol. 2020 Oct;71(4):405-12.
Ren G, Xu L, Lu T, et al. Structural characterization and antiviral activity of lentinan from Lentinus edodes mycelia against infectious hematopoietic necrosis virus. Int J Biol Macromol. 2018 Aug;115:1202-10.
Rincao VP, Yamamoto KA, Ricardo NM, et al. Polysaccharide and extracts from Lentinula edodes: structural features and antiviral activity. Virol J. 2012 Feb 15;9:37.
Hou L, Meng M, Chen Y, et al. A water-soluble polysaccharide from Grifola frondosa induced macrophages activation via TLR4-MyD88-IKKbeta-NF-kappaB p65 pathways. Oncotarget. 2017 Oct 17;8(49):86604-14.
Vetvicka V, Vetvickova J. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014 Feb;2(2):14.
Fordjour E, Manful CF, Javed R, et al. Chaga mushroom: a super-fungus with countless facets and untapped potential. Front Pharmacol. 2023;14:1273786.
Kim YR. Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus. Mycobiology. 2005 Sep;33(3):158-62.
Shibnev VA, Garaev TM, Finogenova MP, et al. [Antiviral activity of aqueous extracts of the birch fungus Inonotus obliquus on the human immunodeficiency virus]. Vopr Virusol. 2015;60(2):35-8.
Ji L, Sun G, Li J, et al. Effect of dietary beta-glucan on growth, survival and regulation of immune processes in rainbow trout (Oncorhynchus mykiss) infected by Aeromonas salmonicida. Fish Shellfish Immunol. 2017 May;64:56-67.
Udayangani RMC, Dananjaya SHS, Fronte B, et al. Feeding of nano scale oats beta-glucan enhances the host resistance against Edwardsiella tarda and protective immune modulation in zebrafish larvae. Fish Shellfish Immunol. 2017 Jan;60:72-7.
Yun CH, Estrada A, Van Kessel A, et al. Beta-glucan, extracted from oat, enhances disease resistance against bacterial and parasitic infections. FEMS Immunol Med Microbiol. 2003 Jan 21;35(1):67-75.
McFarlin BK, Venable AS, Carpenter KC, et al. Oral Supplementation with Baker’s Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines following a Bout of Strenuous Exercise. Front Physiol. 2017;8:786.
Talbott S, Talbott J. Effect of BETA 1, 3/1, 6 GLUCAN on Upper Respiratory Tract Infection Symptoms and Mood State in Marathon Athletes. J Sports Sci Med. 2009;8(4):509-15.
Wiertsema SP, van Bergenhenegouwen J, Garssen J, et al. The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies. Nutrients. 2021 Mar 9;13(3).
Shoukat M, Sorrentino A. Cereal β‐glucan: a promising prebiotic polysaccharide and its impact on the gut health. International Journal of Food Science & Technology. 2021;56(5):2088-97.
Jayachandran M, Chen J, Chung SSM, et al. A critical review on the impacts of beta-glucans on gut microbiota and human health. J Nutr Biochem. 2018 Nov;61:101-10.
Jayachandran M, Xiao J, Xu B. A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota. Int J Mol Sci. 2017 Sep 8;18(9).
Mitsou EK, Saxami G, Stamoulou E, et al. Effects of Rich in Beta-Glucans Edible Mushrooms on Aging Gut Microbiota Characteristics: An In Vitro Study. Molecules. 2020 Jun 18;25(12).
Ba DM, Gao X, Al-Shaar L, et al. Prospective study of dietary mushroom intake and risk of mortality: results from continuous National Health and Nutrition Examination Survey (NHANES) 2003-2014 and a meta-analysis. Nutr J. 2021 Sep 21;20(1):80.
Ba DM, Ssentongo P, Beelman RB, et al. Higher Mushroom Consumption Is Associated with Lower Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies. Adv Nutr. 2021 Oct 1;12(5):1691-704.
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