全球血脂速递（第015期）丨碳水化合物限制饮食与血脂异常、心脏代谢疾病、家族性高脂血症等
健康
2025-01-15 19:58
上海
截至01月15日15点59分，近期共有 200 本期刊发布了 370 篇文章，其中血脂相关的文章共 44 篇，覆盖 15 个领域的内容。其中影响因子最高的是刊登在 Cancer discovery (IF: 29.700) 期刊上标题为《PIN1脯氨酰异构酶通过SREBP2介导的胆固醇生物合成途径促进膀胱癌的发生和发展》的文章。18Atherosclerosis(AS)动脉粥样硬化5Total Cholesterol(TC)总胆固醇4Hypercholesterolemia高胆固醇血症3Apolipoprotein B(ApoB)载脂蛋白B3Hypertriglyceridemia(HTG)高甘油三酯血症2High Density Lipoprotein Cholesterol(HDL-C)高密度脂蛋白胆固醇1Colesevelam Hydrochloride考来维仑1Hyperlipoproteinemias高脂蛋白血症
Food & function IF: 05.100
评估不同碳水化合物限制饮食对血脂异常的血脂谱和心血管风险的不同益处：荟萃分析和系统评价
Kang Liu, Hui He, Min Liu, Yu-Qi Hu, Louise Weiwei Lu, Bin Liu, etc.背景：限制碳水化合物饮食（CRD）已引起人们的关注，以解决血脂异常中常见的代谢异常，血脂异常对心血管健康构成重大风险。然而，CRD在改善心血管健康方面的有效性仍存在争议。这项荟萃分析综合评估了CRD对血脂异常患者糖脂代谢和体重减轻的长期影响。方法：在PubMed，Web of Science，Scopus，Cochrane图书馆和EMBASE中进行了广泛的搜索。随机对照试验研究了CRD对血脂异常成年人至少三周内糖脂代谢和体重减轻的影响。该分析比较了中等低碳水化合物饮食（MLCD）和低碳水化合物饮食（LCD）之间的差异效应，包括根据BMI状态对基于动物的CRD和血脂异常个体进行有针对性的评估，从而解决了当前知识的差距。结果：研究结果表明，CRD能显著提高血脂水平，包括总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和载脂蛋白B（ApoB），并有助于血脂异常患者的体重管理。MLCD在改善除TG外的所有血脂谱方面比LCD更有效，TG由LCD更有效地管理。基于动物的CRD不会显著影响血脂谱。超重和肥胖的血脂异常个体的TG和ApoB发生了显著变化。TC，TG和低密度脂蛋白胆固醇水平与膳食纤维摄入量较高之间也存在显著的负相关，支持纤维对心血管健康的有益影响。结论：这些结果首次突出了采用MLCD的潜力，特别是那些纤维含量足够的MLCD，作为降低血脂异常患者心血管疾病风险的有力策略。Food & function | Ahead of Print.Journal of affective disorders IF: 04.900
2005年至2020年美国成年抑郁症患者代谢、心血管和慢性肾脏疾病的患病率和多发病率趋势
Yiyuan Li, Xihao Du, Shuxiao Shi, Meng Chen, Sujing Wang, Yue Huang, etc.Background抑郁症与心脏代谢疾病并发的现象十分普遍，而且会增加死亡风险。然而，抑郁症患者的心血管代谢疾病的患病率和多病症趋势尚不明确。Methods分析了2005-2020年全国健康与营养检查调查中≥20岁抑郁症患者的数据。Joinpoint回归分析用于估计血脂异常，高血压，糖尿病，慢性肾脏疾病，非酒精性脂肪肝病和心血管疾病以及其中≥3种疾病的患病率趋势。在应用倾向评分加权后，使用泊松回归评估这些疾病在抑郁症与无抑郁症中的患病率差异。Results共纳入3412例患有抑郁症的成年人。在2005年至2020年的总体样本中，心脏代谢疾病以及≥3种疾病的患病率保持较高且稳定（趋势P>0.05）。2017-2020年，心血管疾病患病率为17.1%（95%CI 12.7%-21.5%），血脂异常患病率为58.4%（95%CI 50.4%-66.3%）；40.7%（95%CI 34.4%-46.9%）有≥3种疾病。患有抑郁症的成年人的糖尿病，心血管疾病和≥3种疾病的患病率比没有抑郁症的成年人高23%-85%。Limitations使用自我报告的数据和/或一次性实验室测量可能会对参与者进行错误分类。Conclusions心脏代谢疾病的患病率很高，在美国成年抑郁症患者中，多发病率很常见。解决抑郁症心脏代谢疾病的预防，治疗和管理需要更多的公共卫生和临床关注。Journal of affective disorders | Volumn 372, Issue10.1016/j.jad.2024.12.021Curēus IF: 01.000
非酒精性脂肪肝、胰岛素抵抗和代谢综合征之间的病理生理联系综述
Eudith Januario, Aly Barakat, Abhivanditha Rajsundar, Zahra Fatima, Varda Nanda Palienkar, Arjun V Bullapur, etc.非酒精性脂肪性肝病（NAFLD）是一种慢性病，其特征是在没有大量饮酒的情况下发生肝脂肪变性，并且越来越被认为是代谢综合征（MetS）的肝脏表现。本综述旨在探讨NAFLD，胰岛素抵抗（IR）和MetS之间相互作用的分子机制，重点是确定治疗靶点。对NAFLD，IR和MetS的现有文献进行了全面回顾。该综述表明，IR通过增加脂肪分解，升高游离脂肪酸通量和脂肪酸氧化受损而促进肝脏脂质积累，而MetS通过促进内脏肥胖，慢性炎症和脂质代谢受损而加剧病情。此外，肠-肝轴的生态失调和肠道通透性增加会加重IR，导致代谢功能障碍的恶性循环。总之，解决这些相互关联的途径可以加强治疗策略，减轻NAFLD相关并发症的负担。Curēus | Volumn 16, Issue 12Clinical laboratory IF: 00.700
家族性高脂血症的家族分析归因于APOB基因的Y2184C突变
Luping Lou, Chunqin Lu, etc.Background家族性高脂血症（家族性高胆固醇血症，FH）是一种常染色体遗传疾病。它包括类型杂合性家族性高脂血症（杂合性家族性高胆固醇血症）。HeFH主要由LDLR、APOB和PCSK9基因突变引起，以血浆低密度脂蛋白胆固醇水平升高为特征。Methods研究人员提出了一例归因于APOB基因突变的HeFH病例。从先证者及其父母的血液中提取外周血的全基因组DNA，并通过高通量测序对外周血的外显子进行测序。通过使用Sanger方法进行测序来验证所选突变位点。Results在先证者和母亲中均鉴定出APOB基因第26外显子（Chr2-21233189）的杂合突变c.6551A>G（p.Y2184C）。结合临床特征，最初考虑了由该突变引起的HeFH。Conclusions对于临床上高度怀疑FH的患者，应通过基因检测确定明确的诊断，使患者能够接受早期治疗并有效预防心血管事件的发生。Clinical laboratory | Volumn 71, Issue 110.7754/Clin.Lab.2024.240751Cancer discovery IF: 29.700
Ahead of Print.No.01PIN1 prolyl isomerase promotes initiation and progression of bladder cancer through the SREBP2-mediated cholesterol biosynthesis pathwayPIN1脯氨酰异构酶通过SREBP2介导的胆固醇生物合成途径促进膀胱癌的发生和发展DOI: 10.1158/2159-8290.CD-24-0866Acta pharmaceutica sinica B IF: 14.700
Volumn 14, Issue 12No.02Aclysiran, an RNAi therapeutic agent targeting ACLY, treats hypercholesterolemia and atherosclerosis in ApoE -/- miceAclysiran是一种靶向ACLY的RNAi治疗剂，可治疗ApoE-/-小鼠的高胆固醇血症和动脉粥样硬化DOI: 10.1016/j.apsb.2024.10.008Advanced science IF: 14.300
Ahead of Print.No.03The Type III Secretion System (T3SS) of Escherichia Coli Promotes Atherosclerosis in Type 2 Diabetes Mellitus大肠杆菌的III型分泌系统（T3SS）促进2型糖尿病的动脉粥样硬化DOI: 10.1002/advs.202413296Environment international IF: 10.300
Ahead of Print.No.04Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage聚苯乙烯纳米塑料通过破坏脂质代谢和诱导DNA损伤促进结肠炎相关癌症DOI: 10.1016/j.envint.2025.109258Int J Biol Macromol IF: 07.700
Ahead of Print.No.05Structural characterization of polysaccharides from Polygonatum Sibiricum and effect on alleviating hyperlipidemia in egg yolk emulsion-induced mice黄精多糖的结构表征及其对蛋黄乳诱导小鼠高脂血症的缓解作用DOI: 10.1016/j.ijbiomac.2025.139808Biomaterials science IF: 05.800
Ahead of Print.No.06Application trends of hydrogen-generating nanomaterials for the treatment of ROS-related diseases产氢纳米材料在活性氧相关疾病治疗中的应用趋势DOI: 10.1039/d4bm01450bAnnals of intensive care IF: 05.700
Volumn 15, Issue 1No.07Procedural sedative effect of remimazolam in ICU patients on invasive mechanical ventilation: a randomised, prospective study瑞马唑仑对ICU患者有创机械通气的程序性镇静作用：一项随机前瞻性研究DOI: 10.1186/s13613-025-01431-5ACS Biomater Sci Eng IF: 05.400
Ahead of Print.No.08Delivery of N-Cadherin Targeting Peptides to Vascular Tissues by Surface-Modified Polyurethane Nanoparticles via a Drug-Coated Balloon通过药物包被的球囊通过表面修饰的聚氨酯纳米颗粒将N-钙粘蛋白靶向肽递送至血管组织DOI: 10.1021/acsbiomaterials.4c02417Food & function IF: 05.100
Ahead of Print.No.09Monascus pilosus SWM-008 red mold rice and its components, monascinol and monascin, reduce obesity in a high-fat diet-induced rat model through synergistic modulation of gut microbiota and anti-lipogenesis红曲SWM-008红曲米及其成分monascinol和monascin通过协同调节肠道微生物群和抗脂生成来减少高脂饮食诱导的大鼠模型中的肥胖DOI: 10.1039/d4fo05435kAtherosclerosis IF: 04.900
Ahead of Print.No.10New options for young people with dyslipidemia: The future is bright!血脂异常年轻人的新选择：未来是光明的！DOI: 10.1016/j.atherosclerosis.2024.119095Targeted oncology IF: 04.400
Ahead of Print.No.11Fruquintinib Plus Sintilimab in Patients with Treatment-Naive and Previously Treated Advanced Renal Cell Carcinoma: Results from a Phase Ib/II Clinical TrialFruquintinib联合Sintilimab治疗初治和既往治疗的晚期肾细胞癌患者：Ib/II期临床试验的结果DOI: 10.1007/s11523-024-01120-6Am J Prev Cardiol IF: 04.300
Volumn 21, Issue No.12Vascular ageing manifestations and hypertension in the community社区血管衰老表现与高血压DOI: 10.1016/j.ajpc.2024.100918Kidney360 IF: 03.200
Ahead of Print.No.13CKD Management in the Age of Telenephrology: An Observational Analysis of a Hybrid Telenephrology System within a Veteran's Affairs Medical Center远程肾脏病时代的CKD管理：对退伍军人中混合远程肾脏病系统的观察分析'；s事务医疗中心DOI: 10.34067/KID.0000000641Immun Inflamm Dis IF: 03.100
Volumn 13, Issue 1No.14The Relationship Between Novel Inflammatory Markers and Serum 25-Hydroxyvitamin D Among US Adults美国成年人新型炎症标志物与血清25-羟基维生素D的关系DOI: 10.1002/iid3.70115Renal failure IF: 03.000
Volumn 47, Issue 1No.15Monocyte to high-density lipoprotein cholesterol ratio as a marker of the presence and progression of diabetic kidney disease单核细胞与高密度脂蛋白胆固醇比值作为糖尿病肾病存在和进展的标志DOI: 10.1080/0886022X.2024.2438846Clin Transl Gastroenterol IF: 03.000
Ahead of Print.No.16Treatment of bile acid diarrhea with GLP-1 receptor agonists: A Promising Yet Understudied ApproachGLP-1受体激动剂治疗胆汁酸腹泻：一种有前途但尚未得到充分研究的方法DOI: 10.14309/ctg.0000000000000815J Korean Med Sci IF: 03.000
Volumn 40, Issue 2No.17Effects of Genetic Risk and Lifestyle Habits on Gout: A Korean Cohort Study遗传风险和生活习惯对痛风的影响：一项韩国队列研究DOI: 10.3346/jkms.2025.40.e1Renal failure IF: 03.000
Volumn 47, Issue 1No.18Construction of a C-reactive protein-albumin-lymphocyte index-based prediction model for all-cause mortality in patients on maintenance hemodialysis基于C反应蛋白-白蛋白淋巴细胞指数的维持性血液透析患者全因死亡率预测模型的构建DOI: 10.1080/0886022X.2024.2444396PloS one IF: 02.900
Volumn 20, Issue 1No.19A novel combinatorial approach integrating experimental and computational analysis of antioxidant activity: Evaluating catechin and L-ascorbic acid in serum结合抗氧化活性实验和计算分析的新型组合方法：评估血清中的儿茶素和L-抗坏血酸DOI: 10.1371/journal.pone.0309881PloS one IF: 02.900
Volumn 20, Issue 1No.20Fracture-healing effects of Rhizoma Musae ethanolic extract: An integrated study using UHPLC-Q-Exactive-MS/MS, network pharmacology, and molecular docking木瓜乙醇提取物的骨折愈合作用：使用UHPLC-Q-Exactive-MS/MS，网络药理学和分子对接的综合研究DOI: 10.1371/journal.pone.0313743PloS one IF: 02.900
Volumn 20, Issue 1No.21Saffron's protective role against atherosclerosis-induced cataract progression in New Zealand white rabbits with phytochemical analysis of saffron's extract藏红花'；藏红花和x27的植物化学分析对新西兰白兔动脉粥样硬化性白内障进展的保护作用；s提取物DOI: 10.1371/journal.pone.0315178PloS one IF: 02.900
Volumn 20, Issue 1No.22Association between cardiometabolic index and overactive bladder in adult American women: A cross-sectional study美国成年女性心脏代谢指数与膀胱过度活动之间的关系：一项横断面研究DOI: 10.1371/journal.pone.0314594BMC pharmacology & toxicology IF: 02.800
Volumn 26, Issue 1No.23Characterization and interactions between piperine and ezetimibe in their Anti-hyperlipidemic efficacy using Biopharmaceutics and Pharmacokinetics使用生物药剂学和药代动力学表征胡椒碱和依折麦布在抗高脂血症功效中的相互作用DOI: 10.1186/s40360-025-00836-zFish physiology and biochemistry IF: 02.500
Volumn 51, Issue 1No.24Physiological responses of pacu (Piaractus mesopotamicus) to intermittent cold exposure: A comprehensive analysis of stress, immunity, antioxidant, and metabolic adaptationspacu（Piaractus mesopotamicus）对间歇性冷暴露的生理反应：应激，免疫，抗氧化和代谢适应的综合分析DOI: 10.1007/s10695-024-01445-zTransfusion IF: 02.500
Ahead of Print.No.25Freeze-dried plasma: Hemostasis and biophysical analyses for damage control resuscitation冻干血浆：止血和生物物理分析，用于损伤控制复苏DOI: 10.1111/trf.18124BMJ open IF: 02.400
Volumn 14, Issue 12No.26DIAMACC: protocol of a prospective diagnostic accuracy study of the maximal systolic acceleration to detect peripheral arterial disease in patients with diabetes-related foot ulceration in the NetherlandsDIAMACC：荷兰糖尿病相关足部溃疡患者最大收缩加速度检测外周动脉疾病的前瞻性诊断准确性研究方案DOI: 10.1136/bmjopen-2024-086629BMJ open IF: 02.400
Volumn 14, Issue 12No.27Randomised, multicentre, placebo-controlled trial of fenofibrate for treatment of diabetic macular oedema with economic evaluation (FORTE study): study protocol for a randomised control trial非诺贝特治疗糖尿病性黄斑水肿的随机、多中心、安慰剂对照试验（FORTE研究）：随机对照试验的研究方案DOI: 10.1136/bmjopen-2024-089518BMJ open IF: 02.400
Volumn 14, Issue 12No.28Digital health technologies for metabolic disorders in older adults: a scoping review protocol老年人代谢紊乱的数字健康技术：范围界定审查协议DOI: 10.1136/bmjopen-2024-085797Current molecular medicine IF: 02.200
Ahead of Print.No.29Mechanisms Underlying the Anti-Atherosclerotic Effects of EGCGEGCG抗动脉粥样硬化作用的机制DOI: 10.2174/0115665240354839241113044604Physiological Research IF: 01.900
Volumn 73, Issue S3No.30Involvement of circulating microRNAs in the pathogenesis of atherosclerosis in young patients with obesity循环microRNA参与年轻肥胖患者动脉粥样硬化的发病机制https://pubmed.ncbi.nlm.nih.gov/39808176Journal of clinical neuroscience IF: 01.900
Ahead of Print.No.31Beyond arrhythmias in the ECG: Is there any correlation between QT interval and stroke subtype and severity?心电图心律失常之外：QT间期与卒中亚型和严重程度之间是否存在相关性？DOI: 10.1016/j.jocn.2025.111045Physiological Research IF: 01.900
Volumn 73, Issue S3No.32In silico validation of non-invasive arterial compliance estimation and potential determinants of its variability无创动脉顺应性估计的计算机验证及其变异性的潜在决定因素https://pubmed.ncbi.nlm.nih.gov/39808177J Taibah Univ Med Sci IF: 01.500
Volumn 19, Issue 6No.33Sygyzium claviflorum fruit extract preadipocyte differentiation inhibition in 3T3-L1 cells棒状Sygyzium claviflorum果实提取物对3T3-L1细胞前脂肪细胞分化的抑制作用DOI: 10.1016/j.jtumed.2024.12.008In Vitro Cell Dev Biol Anim IF: 01.500
Ahead of Print.No.34Tianxiangdan suppresses foam cell formation by enhancing lipophagy and reduces the progression of atherosclerosis天香丹通过增强脂质自噬抑制泡沫细胞的形成，减少动脉粥样硬化的进展DOI: 10.1007/s11626-024-01004-zRevista de investigación clínica IF: 01.400
Ahead of Print.No.35MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular centerMIR-155作为st段抬高型心肌梗死疾病严重程度的潜在生物标志物：来自大学附属心血管中心的见解DOI: 10.24875/RIC.24000189Medicine IF: 01.300
Volumn 103, Issue 47No.36Causal relationships between uremic metabolites or toxins and heart failure: Univariate and multivariate Mendelian randomization尿毒症代谢物或毒素与心力衰竭之间的因果关系：单变量和多变量孟德尔随机化DOI: 10.1097/MD.0000000000040614Medicine IF: 01.300
Volumn 103, Issue 47No.37Primary care research on hypertension: A bibliometric analysis using machine-learning高血压的初级保健研究：使用机器学习的文献计量分析DOI: 10.1097/MD.0000000000040482Clinical laboratory IF: 00.700
Volumn 71, Issue 1No.38Determination of the Reference Intervals of Clinical Biochemistry Tests by Direct and Indirect Methods: a Multicentric Study通过直接和间接方法确定临床生化测试的参考区间：一项多中心研究DOI: 10.7754/Clin.Lab.2024.240526Chinese Journal of Cardiology
Volumn 53, Issue 1No.39[Advancements in understanding iron metabolism in atherosclerosis][了解动脉粥样硬化中铁代谢的进展]DOI: 10.3760/cma.j.cn112148-20241121-00723Zhejiang Da Xue Xue Bao Yi Xue Ban
Ahead of Print.No.40Pachymic acid promotes brown/beige adipocyte differentiation and lipid metabolism in preadipocytes 3T3-L1 MBX茯苓酸促进前脂肪细胞3T3-L1 MBX中棕色/米色脂肪细胞分化和脂质代谢DOI: 10.3724/zdxbyxb-2024-0355
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