全球血脂速递（第016期）丨皱纹盘鲍生物活性肽、糖尿病与血脂异常、孕妇空腹血糖和血脂水平、PCSK9单克隆抗体等
健康
2025-01-16 19:29
上海
截至01月16日15点59分，近期共有 282 本期刊发布了 447 篇文章，其中血脂相关的文章共 63 篇，覆盖 20 个领域的内容。其中影响因子最高的是刊登在 Science translational medicine (IF: 15.800) 期刊上标题为《重症哮喘患者痰液中的c-kit+IL-17A+ILC2支持ILC2向ILC3的转分化》的文章。31Atherosclerosis(AS)动脉粥样硬化13Total Cholesterol(TC)总胆固醇3Lipoprotein(a)(Lp(a))脂蛋白a3Hypercholesterolemia高胆固醇血症3Hypertriglyceridemia(HTG)高甘油三酯血症2Bempedoic acidBempedoic acid1High Density Lipoprotein Cholesterol(HDL-C)高密度脂蛋白胆固醇1Low-Density Lipoprotein Cholesterol(LDL-C)低密度脂蛋白胆固醇1Homozygous Familial Hypercholesterolemia(HoFH)纯合子家族性高胆固醇血症1Apolipoprotein B(ApoB)载脂蛋白B1PCSK9 Inhibitors(PCSK9i)前蛋白转化酶枯草溶菌素9抑制剂Frontiers in nutrition IF: 04.000
皱纹盘鲍生物活性肽作为高脂血症治疗潜在HMGCR抑制剂的虚拟筛选与评价
Kun Qiao, Lina Liu, Yihui Chen, Qiongmei Huang, Bei Chen, Jingna Wu, etc.Introduction高脂血症仍然是威胁全球公共卫生的主要疾病。与心血管疾病相关的发病率和死亡率一直在增加。抑制胆固醇合成途径中的关键酶3-羟基-3-甲基戊二酰辅酶A还原酶（HMGCR）可以有效降低胆固醇水平。Methods and results本研究以肽产量和HMGCR抑制率为评价指标，筛选出最适合制备HMGCR抑制肽的蛋白酶。鉴定了分子量＜1 kDa的肽序列，并将肽片段与HMGCR对接进行虚拟筛选。使用高脂Hep-G2细胞模型在体外评估了这些肽对HMGCR活性的抑制作用。筛选的肽具有显著的HMGCR抑制活性，并降低了高脂血症Hep-G2细胞中胆固醇胶束的溶解度以及总胆固醇和甘油三酯的水平。Conclusion这项研究为开发治疗高脂血症的天然药物提供了新的见解；此外，该结果将促进海洋生物活性肽的功能应用。Frontiers in nutrition | Volumn 11, Issue10.3389/fnut.2024.1525768Current medicinal chemistry IF: 03.500
糖尿病血脂异常的现状和治疗方式
Introduction糖尿病与血脂异常相关的动脉粥样硬化风险增加有关。虽然术语高脂血症和糖尿病或糖尿病血脂异常是相互关联的，但这两种情况有一些差异。Aim这项研究旨在强调糖尿病患者高脂血症和/或血脂异常的可能机制，这些机制可以用现有和更新的降血脂药物治疗。研究人员还重新检查了目前关于糖尿病血脂异常患者管理的具体指南及其建议。Method基于广泛的关键词对同行评审期刊进行了全面搜索，包括糖尿病，血脂异常，高脂血症，胰岛素抵抗，游离脂肪酸，心血管疾病，2分计算，他汀类药物，PCSK-9抑制剂和贝特类药物。Discussion无论空腹血糖水平如何，患有血脂异常的糖尿病患者，包括HDL胆固醇降低，小密度LDL颗粒占优势以及甘油三酯水平升高，更容易患微血管和大血管并发症。最近的指南建议使用经过验证的评分系统SCORE2 Diabetes。旨在降低低密度脂蛋白胆固醇的中高剂量他汀类药物仍然是糖尿病血脂异常患者管理的基石。如今，其他推荐的非他汀类药物，包括前蛋白转化酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂或其他新型治疗剂（bempedoic acid，inclisiran），在最近发布的指南中尤为重要。Conclusion糖尿病患者发生动脉粥样硬化性心血管疾病的风险相对高于无糖尿病患者。脂质参数的最佳管理和脂质参数达到预期目标值仍然是临床医生面临的挑战。Current medicinal chemistry | Ahead of Print.10.2174/0109298673336501241001093417European journal of pediatrics IF: 03.000
妊娠晚期孕妇空腹血糖和血脂水平在孕前BMI与后代出生时身体发育之间的中介作用
Jinjin Guo, Yaqi Zhu, Keqin Liu, Yuqi Wang, Jixin Yang, Yanwei Su, etc.虽然先前的研究已经确定了孕前体重指数（BMI），妊娠晚期血糖和妊娠晚期血脂水平与妊娠和后代身体发育之间的相关性，但它们相互作用的潜在机制仍然难以捉摸。对2023年5月至2024年4月期间在武汉市一家三级医院分娩的生理女性孕妇进行了一项出生队列研究，涉及1620例参与者。研究人员通过问卷调查收集了母亲的社会人口统计学数据，并从医疗记录中获得了有关空腹血糖（FPG），妊娠晚期血脂水平和新生儿身体发育的信息。本研究旨在通过进行统计分析以及妊娠晚期FPG水平和血脂水平的介导途径，探讨孕前BMI与后代身体发育之间的相关性。最终分析包括1378例记录完整的参与者。在调整了潜在的混杂因素后，超重或肥胖的孕前BMI组生下巨大胎儿的几率显著升高 （OR=2.997，95%CI 1.238-7.258）。受试者工作特征（ROC）曲线分析显示，BMI、FPG、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）对巨大儿的综合预测效果最好，曲线下面积（AUC）为0.833 （P<0.05）。链式中介分析显示，FPG和TG共同介导孕前BMI与出生体重（BW）、BMI和头围之间的关联，介导比例分别为1.96%、1.84%和1.43%。此外，FPG和HDL-C共同介导母体孕前BMI对BW和BMI的影响，介导比例分别为1.48%和3.8%。Conclusion研究结果表明，孕前BMI与后代出生时的身体发育有关，超重或肥胖的孕前BMI组患巨大儿的风险增加。对巨大儿最有效的预测来自BMI，FPG，TG和HDL-C水平的组合。此外，孕前BMI对后代身体发育的影响部分由FPG，TG和HDL-C介导。What is known先前的研究已经确定了孕前BMI与后代身体发育之间的相关性；先前的研究表明，妊娠晚期血脂和血糖水平可显著预测胎儿的身体发育。What is new孕前BMI，FPG，TG和HDL-C的组合是巨大儿最有效的预测指标FPG，TG和HDL-C共同介导孕前BMI对身体生长的影响。European journal of pediatrics | Volumn 184, Issue 210.1007/s00431-025-05974-4Am J Cardiovasc Drugs IF: 02.800
PCSK9单克隆抗体对直接经皮冠状动脉介入治疗患者血小板反应性和心血管事件的影响：倾向评分匹配分析
Yao Yao, Qining Qiu, Zi Wang, Shikun Xu, Qianzhou Lv, etc.Background前蛋白转化酶枯草杆菌蛋白酶/kexin 9型（PCSK9）单克隆抗体（mAb）在降低急性冠状动脉综合征患者的心血管事件方面显示出有希望的效果。然而，其对直接经皮冠状动脉介入治疗（PPCI）后早期血小板反应性的影响仍不明确。Objectives本研究旨在通过血栓弹力图和接受PPCI并接受替格瑞洛双重抗血小板治疗的患者术后12个月的结果来研究完全人类抗PCSK9抗体对血小板功能的影响。Methods这项单中心前瞻性研究于2021年1月至2023年6月在中国复旦大学中山医院进行。患者分为两组：接受标准他汀类药物治疗的患者（仅他汀类药物组）和接受额外PCSK9 mAb的患者（evolocumab 140 mg或alirocumab 75 mg，每2周皮下注射；PCSK9 mAb组）。共有1250例符合条件的患者入选。为了平衡基线特征，倾向评分匹配以1:1的比例进行，每组310例患者。PPCI后5天用血栓弹力图测定血小板活性，表现为二磷酸腺苷诱导的最大振幅（MAADP）。主要临床结果是在12个月内测量的主要不良心血管事件的发生，包括心血管死亡，心肌梗塞，卒中，不稳定型心绞痛住院和冠状动脉血运重建。Results在PPCI后5天，PCSK9 mAb组的MAADP水平显著低于仅他汀类药物组（17.10±9.52 mm vs. 20.73±12.07 mm，P<0.001）。PCSK9单克隆抗体的使用与MAADP的降低显著相关（β-0.166，P<0.001）。PCSK9 mAb组主要不良心血管事件的发生率显著低于仅他汀类药物组。此外，最高MAADP三分位数（MAADP＞21.7 mm）加上仅他汀类药物亚组的个体累积无事件生存率最低。Conclusion将PCSK9单克隆抗体纳入基于替格瑞洛的双重抗血小板治疗可显著降低血小板反应性，并在12个月内与更好的心血管结果相关。这些发现支持使用PCSK9单克隆抗体作为治疗急性冠状动脉综合征的有效辅助疗法。Am J Cardiovasc Drugs | Ahead of Print.10.1007/s40256-024-00719-4Current pharmaceutical design IF: 02.600
贝特类药物对脂蛋白相关磷脂酶A2质量和活性的影响：对照临床试验的系统综述和荟萃分析
Luis E Simental-Mendía, Mario Simental-Mendía, Claudia I Gamboa-Gómez, Tannaz Jamialahmadi, Amirhossein Sahebkar, etc.Background在血管组织中，巨噬细胞和炎性细胞产生脂蛋白相关磷脂酶A2（Lp-PLA2）酶。贝特类药物治疗可降低肥胖和代谢综合征患者的Lp-PLA2水平；但是，这些发现尚未完全阐明。Objective本研究的目的是通过临床试验的荟萃分析，研究贝特类药物治疗对Lp-PLA2质量和活性的可能影响。Methods使用MeSH术语和关键词搜索Web of Science，PubMed，Scopus，Google Scholar和ClinicalTrials.gov数据库。荟萃分析包括评估他汀类药物对Lp-PLA2质量和/或活性影响的随机对照试验（RCT）。定量数据使用随机效应模型和通用逆方差方法进行分析。Results对10项临床试验的荟萃分析表明，贝特治疗对Lp-PLA2质量无显著影响（贝特与安慰剂/无=WMD：-3.29 ng/ml，95%CI -21.35至14.78，p=0.72；贝特与主动对照=WMD：-1.08 ng/ml，95%CI -51.38至49.22，P=0.97）；Lp-PLA2活性（贝特与活性对照=WMD：0.84 nmol/ml/min，95%CI -0.17至1.84，P=0.10）；HDL-LpPLA2活性（贝特与活性对照=WMD：0.77 nmol/ml/min，95%CI -0.33至1.88，P=0.17）；和分泌型PLA2（贝特与活性对照=WMD：0.37 ng/ml，95%CI -1.22至1.97，P=0.65）。此外，敏感性分析的结果对于所有这些参数都是稳健的。Conclusion总之，贝特治疗并没有降低Lp-PLA2的质量和活性。Current pharmaceutical design | Ahead of Print.10.2174/0113816128345231240925095400Ginekologia Polska IF: 01.200
妊娠期糖尿病患者妊娠晚期血清同型半胱氨酸和血脂水平及其与围产期结局的关系
Yuting Li, Mingrui Wang, Na Zhang, Yueling Wu, Wei Ye, Weichan Chen, etc.Objectives本研究调查了饮食控制的妊娠期糖尿病（GDM）和糖耐量正常（NGT）患者血清同型半胱氨酸，血脂与围产期结局之间的关系。Material and methods根据预定义的标准，选择了150例饮食控制的GDM患者和150例NGT孕妇的前瞻性队列，均在本院分娩。收集了有关人口统计学，身体参数和围产期结局的数据。分娩前收集空腹血糖（FPG），同型半胱氨酸（Hcy），总胆固醇（TC），甘油三酯（TG），高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），载脂蛋白B（apoB）和载脂蛋白A1（apoA1）。Results与NGT组相比，GDM患者的FPG，Hcy和apoB/apoA1比值较高，但HDL-C和apoA1水平较低。在GDM组中，巨大儿，胎膜早破和产后出血等不良结局更为普遍。在GDM患者中，新生儿出生体重与FPG和TG水平呈正相关。GDM中的分层Hcy分析显示围产期结局无显著差异。然而，与第一个四分位数相比，apoB/apoA1比率的第三四分位数的巨大儿发生率较低，而第二四分位数的出生窒息发生率较高。ConclusionsGDM患者表现出Hcy，FPG和apoB/apoA1比值升高，与健康孕妇相比，围产期不良结局更多。Hcy，脂质和这些结果之间的关系仍然没有定论，突出了进一步研究的必要性。Ginekologia Polska | Ahead of Print.Science translational medicine IF: 15.800
Volumn 17, Issue 781No.01A population of c-kit+ IL-17A+ ILC2s in sputum from individuals with severe asthma supports ILC2 to ILC3 trans-differentiation重症哮喘患者痰液中的c-kit+IL-17A+ILC2支持ILC2向ILC3的转分化DOI: 10.1126/scitranslmed.ado6649ACS nano IF: 15.800
Ahead of Print.No.02Multifunctional Nanomedicine for Targeted Atherosclerosis Therapy: Activating Plaque Clearance Cascade and Suppressing Inflammation靶向动脉粥样硬化治疗的多功能纳米医学：激活斑块清除级联反应和抑制炎症DOI: 10.1021/acsnano.4c12131JAMA Cardiology IF: 14.800
Ahead of Print.No.03Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes低密度脂蛋白胆固醇的遗传易感性和2型糖尿病DOI: 10.1001/jamacardio.2024.5072Nature communications IF: 14.700
Volumn 16, Issue 1No.04Single-cell analysis identifies the CNP/GC-B/cGMP axis as marker and regulator of modulated VSMCs in atherosclerosis单细胞分析确定CNP/GC-B/cGMP轴是动脉粥样硬化中调节的VSMC的标志物和调节剂DOI: 10.1038/s41467-024-55687-9Microbiome IF: 13.800
Volumn 13, Issue 1No.05Discovery of robust and highly specific microbiome signatures of non-alcoholic fatty liver disease发现非酒精性脂肪性肝病的强大且高度特异性的微生物组特征DOI: 10.1186/s40168-024-01990-yEJPC IF: 08.400
Ahead of Print.No.06Lipoprotein (a) and atherosclerotic cardiovascular disease: does high-sensitive C-reactive protein contribute and quo vadis?脂蛋白（a）与动脉粥样硬化性心血管疾病：高敏C反应蛋白是否有贡献？DOI: 10.1093/eurjpc/zwaf015ACS Appl Mater Interfaces IF: 08.300
Ahead of Print.No.07Core-Shell Nanoparticles with Sequential Drug Release Depleting Cholesterol for Reverse Tumor Multidrug Resistance具有顺序药物释放消耗胆固醇的核壳纳米颗粒用于逆转肿瘤多药耐药性DOI: 10.1021/acsami.4c17858Aging and disease IF: 07.000
Ahead of Print.No.08Mechanisms Underlying Vascular Inflammaging: Current Insights and Potential Treatment Approaches血管炎症的潜在机制：当前的见解和潜在的治疗方法DOI: 10.14336/AD.2024.0922Food chemistry X IF: 06.500
Volumn 25, Issue No.09Integrated electronic nose and multi-omics reveal changes in flavour characterization of cashmere goats and tan sheep meat集成电子鼻和多组学揭示了绒山羊和滩羊肉风味特征的变化DOI: 10.1016/j.fochx.2024.102042Kidney international reports IF: 05.700
Volumn 10, Issue 1No.10XI before X: The Promise of Factor XI InhibitorsX之前的XI：因子XI抑制剂的前景DOI: 10.1016/j.ekir.2024.10.033Diabetes, obesity & metabolism IF: 05.400
Ahead of Print.No.11Baseline and cumulative Chinese visceral adiposity index and diabetic kidney disease: A prospective cohort study基线和累积中国内脏肥胖指数与糖尿病肾病：一项前瞻性队列研究DOI: 10.1111/dom.16184Diabetes, obesity & metabolism IF: 05.400
Ahead of Print.No.12Apolipoprotein CIII correlates with lipoproteins in the fed state and is not regulated by leptin administration in states of hypoleptinemia induced by acute or chronic energy deficiency: Results from two randomised controlled trials载脂蛋白CIII与进食状态下的脂蛋白相关，在急性或慢性能量缺乏引起的低瘦素血症状态下不受瘦素给药的调节：两项随机对照试验的结果DOI: 10.1111/dom.16194Journal of lipid research IF: 05.000
Ahead of Print.No.13Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1脂蛋白脂肪酶从硫酸乙酰肝素中的竞争性置换是由GPIHBP1中无序的酸性簇协调的DOI: 10.1016/j.jlr.2025.100745Atherosclerosis IF: 04.900
Ahead of Print.No.14Non-culprit plaque healing on serial OCT imaging and future outcome in patients with acute coronary syndromes急性冠状动脉综合征患者连续OCT成像的非罪犯斑块愈合和未来结果DOI: 10.1016/j.atherosclerosis.2024.119092Atherosclerosis IF: 04.900
Ahead of Print.No.15AI-derived automated quantification of cardiac chambers and myocardium from non-contrast CT: Prediction of major adverse cardiovascular events in asymptomatic subjectsAI衍生的非对比CT心腔和心肌的自动定量：预测无症状受试者的主要不良心血管事件DOI: 10.1016/j.atherosclerosis.2024.119098Diabetes Metab Res Rev IF: 04.600
Volumn 41, Issue 1No.16Early Postpartum Metabolic Heterogeneity Among Women Who Progressed to Type 2 Diabetes After Gestational Diabetes: A Prospective Cohort妊娠期糖尿病后进展为2型糖尿病的女性产后早期代谢异质性：一项前瞻性队列研究DOI: 10.1002/dmrr.70027iScience IF: 04.600
Volumn 28, Issue 1No.17Differences in splicing factors may predict type 2 diabetes remission in the CORDIOPREV studyCORDIOPREV研究中剪接因子的差异可能预测2型糖尿病的缓解DOI: 10.1016/j.isci.2024.111527European journal of pharmacology IF: 04.200
Ahead of Print.No.18Role of 11β-hydroxysteroid dehydrogenase type 1 inhibition in the antiobesity effect of J2H-1702 on adipocytes and a high-fat diet-induced NASH model11β-羟基类固醇脱氢酶1型抑制在J2H-1702对脂肪细胞和高脂饮食诱导的NASH模型的减肥作用中的作用DOI: 10.1016/j.ejphar.2025.177272Journal of Vascular Surgery IF: 03.900
Ahead of Print.No.19Infrainguinal bypass for limb salvage has comparable mortality and affords a better chance of home discharge than amputation among octogenarians用于保肢的腹股沟下搭桥术的死亡率与80岁以上的截肢术相当，并且比截肢术提供更好的家庭出院机会DOI: 10.1016/j.jvs.2025.01.008Poultry science IF: 03.800
Ahead of Print.No.20Porcine bile acids improve performance by altering hepatic lipid metabolism and amino acid metabolism with different protein level diets in late laying hens猪胆汁酸通过改变晚期蛋鸡肝脏脂质代谢和氨基酸代谢来改善生产性能DOI: 10.1016/j.psj.2025.104777Scientific reports IF: 03.800
Volumn 15, Issue 1No.21Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans血浆抗磷酸胆碱IgM抗体水平与人体骨密度呈负相关DOI: 10.1038/s41598-025-85624-9Scientific reports IF: 03.800
Volumn 15, Issue 1No.22Visit-to-visit lipid variability on long-term major adverse cardiovascular events: a prospective multicentre cohort from the CORE-Thailand registry长期主要不良心血管事件的访视脂质变异性：来自泰国核心登记处的前瞻性多中心队列DOI: 10.1038/s41598-025-85453-wScientific reports IF: 03.800
Volumn 15, Issue 1No.23Identification of critical endoplasmic reticulum stress-related genes in advanced atherosclerotic plaque晚期动脉粥样硬化斑块中关键内质网应激相关基因的鉴定DOI: 10.1038/s41598-024-83925-zScientific reports IF: 03.800
Volumn 15, Issue 1No.24The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice人源化胆汁酸成分对高胆固醇血症Cyp2c70基因敲除小鼠动脉粥样硬化发展的影响DOI: 10.1038/s41598-025-86183-9Scientific reports IF: 03.800
Volumn 15, Issue 1No.25Algae extract-based nanoemulsions for photoprotection against UVB radiation: an electrical impedance spectroscopy study基于藻类提取物的抗UVB辐射光保护纳米乳液：电阻抗光谱研究DOI: 10.1038/s41598-025-85604-zBMC public health IF: 03.500
Volumn 25, Issue 1No.26The association between neutrophil to high-density lipoprotein cholesterol ratio and gallstones: a cross-sectional study中性粒细胞与高密度脂蛋白胆固醇比值与胆结石的关系：横断面研究DOI: 10.1186/s12889-025-21392-5BMC public health IF: 03.500
Volumn 25, Issue 1No.27Association between Mediterranean diet and metabolic health status among adults was not mediated through serum adropin levels地中海饮食与成年人代谢健康状况之间的关联不是通过血清adropin水平介导的DOI: 10.1186/s12889-025-21299-1Heliyon IF: 03.400
Volumn 11, Issue 1No.28The therapeutic potential of apigenin against atherosclerosis芹菜素对动脉粥样硬化的治疗潜力DOI: 10.1016/j.heliyon.2024.e41272Orphanet J Rare Dis IF: 03.400
Volumn 20, Issue 1No.29Liver transplantation for homozygous familial hypercholesterolemia: a retrospective analysis from Chinese experience肝移植治疗纯合子家族性高胆固醇血症：中国经验的回顾性分析DOI: 10.1186/s13023-024-03443-zHeliyon IF: 03.400
Volumn 11, Issue 1No.30Influence of age on biochemical serum parameters in female alpacas - A retrospective study年龄对雌性羊驼血清生化指标影响的回顾性研究DOI: 10.1016/j.heliyon.2024.e41097Diabetology & metabolic syndrome IF: 03.400
Volumn 17, Issue 1No.31Correlation between metabolic dysfunction-associated steatotic liver disease and subclinical coronary atherosclerosis in eastern China中国东部代谢功能障碍相关脂肪肝与亚临床冠状动脉粥样硬化的相关性DOI: 10.1186/s13098-025-01577-zHeliyon IF: 03.400
Volumn 11, Issue 1No.32Analysis of lipid profile before and after a simulated Brazilian jiu-jitsu para-sport fight: Multiple case analysis模拟巴西柔术对决前后的血脂分析：多案例分析DOI: 10.1016/j.heliyon.2024.e41107NMCD IF: 03.300
Ahead of Print.No.33The influence of serum uric acid on coronary atherosclerosis plaque phenotypes by computed tomography angiography: The missing link?通过计算机断层扫描血管造影，血清尿酸对冠状动脉粥样硬化斑块表型的影响：缺失的环节？DOI: 10.1016/j.numecd.2024.103828Experimental cell research IF: 03.300
Ahead of Print.No.34OTUB1 mediates PARP1 deubiquitination to alleviate NAFLD by regulating HMGB1OTUB1通过调节HMGB1介导PARP1去泛素化以减轻NAFLDDOI: 10.1016/j.yexcr.2025.114425Rheumatology international IF: 03.200
Volumn 45, Issue 1No.35Late-onset Systemic Lupus Erythematosus迟发性系统性红斑狼疮DOI: 10.1007/s00296-024-05784-1Journal of neuroradiology IF: 03.000
Ahead of Print.No.36FRED-EPI study: Safety and efficacy of FRED/FRED Jr aneurysm treatment in current clinical practiceFRED-EPI研究：FRED/FRED Jr动脉瘤治疗在当前临床实践中的安全性和有效性DOI: 10.1016/j.neurad.2024.101240Obesity surgery IF: 02.900
Ahead of Print.No.37Lipid Changes 10-15 Years After Roux-en-Y Gastric Bypass: A Prospective Observational StudyRoux-en-Y胃旁路术后10-15年的血脂变化：一项前瞻性观察性研究DOI: 10.1007/s11695-024-07601-xCurrent Vascular Pharmacology IF: 02.800
Ahead of Print.No.38Promising Adventitia in Atherosclerosis动脉粥样硬化中有希望的外膜DOI: 10.2174/0115701611306375241211084246Frontiers in neurology IF: 02.700
Volumn 15, Issue No.39Decreased neuronal excitability in hypertriglyceridemia hamsters with acute seizures高甘油三酯血症仓鼠急性癫痫发作时神经元兴奋性降低DOI: 10.3389/fneur.2024.1500737J Microbiol Biotechnol IF: 02.500
Volumn 35, Issue No.40Cholesterol-Lowering Activity of Lactiplantibacillus pentosus KS6I1 in High-Cholesterol Diet-Induced Hypercholesterolemic Mice戊糖乳杆菌KS6I1在高胆固醇饮食诱导的高胆固醇血症小鼠中的降胆固醇活性DOI: 10.4014/jmb.2409.04029JCTR IF: 02.400
Ahead of Print.No.41Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis几丁质酶-3样蛋白1通过损害巨噬细胞胞吞作用降低动脉粥样硬化斑块的稳定性DOI: 10.1007/s12265-024-10576-wChemistry & biodiversity IF: 02.300
Ahead of Print.No.42Phytochemical Profile, Acute and Subacute Toxicity of Spray-Dried Hydroethanolic Extract from Punica granatum Leaves石榴叶喷雾干燥水乙醇提取物的植物化学特征、急性和亚急性毒性DOI: 10.1002/cbdv.202402429Clin Exp Nephrol IF: 02.200
Ahead of Print.No.43Chronic kidney disease is a major risk factor for mortality in triglyceride deposit cardiomyovasculopathy patients慢性肾脏疾病是甘油三酯沉积型心肌血管病患者死亡的主要危险因素DOI: 10.1007/s10157-024-02618-zInt Urogynecol J IF: 01.800
Ahead of Print.No.44Cardiometabolic Index and Stress Urinary Incontinence in US Women: The Mediating Role of the Triglyceride Glucose Index美国女性的心脏代谢指数和压力性尿失禁：甘油三酯-葡萄糖指数的中介作用DOI: 10.1007/s00192-025-06044-xClin Neurol Neurosurg IF: 01.800
Ahead of Print.No.45Efficacy and safety of intravenous tirofiban in patients with acute ischemic stroke due to large artery atherosclerosis undergoing endovascular thrombectomy: A systematic review and meta-analysis静脉注射替罗非班治疗大动脉粥样硬化所致急性缺血性卒中患者血管内血栓切除术的疗效和安全性：系统评价和荟萃分析DOI: 10.1016/j.clineuro.2025.108727Future Cardiology IF: 01.600
Ahead of Print.No.46Biomarkers in coronary artery disease: systematic review and meta-analysis冠状动脉疾病的生物标志物：系统综述和荟萃分析DOI: 10.1080/14796678.2024.2442214Echocardiography IF: 01.600
Volumn 42, Issue 1No.47Is Myocardial Work a Surrogate Marker for Functional Coronary Artery Stenosis or a Marker of Coronary Atherosclerosis?心肌工作是功能性冠状动脉狭窄的替代标志物还是冠状动脉粥样硬化的标志物？DOI: 10.1111/echo.70073Echocardiography IF: 01.600
Volumn 42, Issue 1No.48Understanding the Link Between Lipoprotein (A) and Thoracic Aortic Damage: A Step Toward to Improve Prevention了解脂蛋白（A）与胸主动脉损伤之间的联系：改善预防的一步DOI: 10.1111/echo.70074J Educ Health Promot IF: 01.400
Volumn 13, Issue No.49The effects of synbiotic supplementation along with non-surgical periodontal therapy in improving the metabolic status and inflammatory markers in type 2 diabetes mellitus patients with periodontal disease: A double-blind randomized clinical trial合生元补充剂联合非手术牙周治疗对改善2型糖尿病牙周病患者代谢状态和炎症标志物的影响：一项双盲随机临床试验DOI: 10.4103/jehp.jehp_1382_23Medicine IF: 01.300
Volumn 103, Issue 47No.50Impact of sodium-glucose cotransporter inhibitors in acute coronary syndrome patients on endothelial function and atherosclerosis related-biomarkers: ATH-SGLT2i pilot study急性冠状动脉综合征患者钠-葡萄糖协同转运蛋白抑制剂对内皮功能和动脉粥样硬化相关生物标志物的影响：ATH-SGLT2i初步研究DOI: 10.1097/MD.0000000000040536Internal medicine IF: 01.000
Ahead of Print.No.51Occlusion of Dorsalis Pedis Artery in an Athlete运动员足背动脉闭塞1例DOI: 10.2169/internalmedicine.4584-24Int J Clin Pharmacol Ther IF: 00.900
Ahead of Print.No.52Treatment of delayed fracture healing with Bushen Tiansui decoction: Analysis of active agents and targets using bioinformatics and network pharmacology analysis补肾天髓汤治疗骨折延迟愈合：使用生物信息学和网络药理学分析活性剂和靶标DOI: 10.5414/CP204705JVS-CIT IF: 00.700
Volumn 11, Issue 2No.53A novel technique for external iliac artery reconstruction in renal transplant patients with extensively atherosclerotic lower limb vasculature具有广泛动脉粥样硬化下肢血管的肾移植患者髂外动脉重建的新技术DOI: 10.1016/j.jvscit.2024.101698JVS-CIT IF: 00.700
Volumn 11, Issue 2No.54Ultrasonic emulsification and aspiration for coral reef atherosclerosis as a novel alternative to transaortic endarterectomy and thoracic aorta-based bypass grafting超声乳化和抽吸治疗珊瑚礁动脉粥样硬化作为经主动脉内膜切除术和胸主动脉旁路移植术的新替代方法DOI: 10.1016/j.jvscit.2024.101690Int Med Case Rep J IF: 00.700
Volumn 18, Issue No.55Fat Liquefaction and Lipo Particles in a CIED Pocket During Generator Change-Not an Infection: A Rare Case Report发电机更换期间CIED口袋中的脂肪液化和脂质颗粒不是感染：罕见病例报告DOI: 10.2147/IMCRJ.S505053Revue médicale suisse
Volumn 21, Issue 900-1No.56[Cardiology. Coronary and structural interventional cardiology][心脏病学。冠状动脉和结构性介入心脏病学]DOI: 10.53738/REVMED.2025.21.900-1.13Vascular biology
Ahead of Print.No.57Lack of intracranial atherosclerosis in various atherosclerotic mouse models在各种动脉粥样硬化小鼠模型中缺乏颅内动脉粥样硬化DOI: 10.1530/VB-23-0013
心关注
一个有深度更有温度的心血管医生学术交流平台。
