全球血脂速递（第014期）｜胆固醇代谢、血脂与COPD、CRISPR-Cas9、佩玛贝特、PCSK9i
健康
2025-01-14 20:20
上海
截至01月14日15点59分，近期共有 330 本期刊发布了 522 篇文章，其中血脂相关的文章共 77 篇，覆盖 24 个领域的内容。其中影响因子最高的是刊登在 Nature Reviews. Cardiology (IF: 41.700) 期刊上标题为《糖尿病动脉粥样硬化：新机制和基于机制的治疗方法》的文章。39Atherosclerosis(AS)动脉粥样硬化17Total Cholesterol(TC)总胆固醇9Hypercholesterolemia高胆固醇血症3Apolipoprotein B(ApoB)载脂蛋白B2Low-Density Lipoprotein Cholesterol(LDL-C)低密度脂蛋白胆固醇2Hypertriglyceridemia(HTG)高甘油三酯血症2Bile acid sequestrants胆酸清除剂1Lipoprotein(a)(Lp(a))脂蛋白a1PCSK9 Inhibitors(PCSK9i)前蛋白转化酶枯草溶菌素9抑制剂1High Density Lipoprotein Cholesterol(HDL-C)高密度脂蛋白胆固醇
Nutrition research IF: 03.400
2008-2014年韩国国家健康与营养调查的一项横断面研究表明，高空气污染暴露、维生素D缺乏和曾经吸烟者与高胆固醇血症患病率相关
Jung Hyun Kwak, Hyun Ja Kim, etc.空气污染物直接或间接导致维生素D缺乏症（VDD）。此外，吸烟会增加氧化应激，加速皮肤衰老，从而降低体内维生素D的浓度。先前的研究报道，VDD通过降低维生素D受体活性来增加总胆固醇浓度。研究人员假设高空气污染暴露，吸烟和VDD会增加高胆固醇血症。研究使用2008-2014年韩国国家健康与营养调查（KNHANES）的数据调查了长期暴露于空气污染物，吸烟状况，VDD及其与高胆固醇血症的组合之间的关联。研究使用KNHANES的链接数据和考试日期前730天的空气污染数据的日移动平均值，使用参与者在经纬度坐标中的地址。分析结果采用调查逻辑回归模型进行复杂样本分析。纳入了28134例成年人，他们有血清维生素D，胆固醇浓度，吸烟状况和空气污染物浓度的数据。在调整了潜在的协变量后，暴露于高浓度空气污染物和曾经吸烟者的成年人显示出明显更高的VDD风险（优势比[OR] 1.70；95%CI 1.44-2.00）。在高空气污染物暴露组中，维生素D水平低且曾经吸烟者的成年人患高胆固醇血症的风险显著高于维生素D水平高且从不吸烟者的成年人（OR 1.55；95%CI 1.09-2.19）。研究发现高空气污染物暴露，吸烟者和VDD可能会增加韩国成年人的高胆固醇血症患病率。因此，为了降低高胆固醇血症的风险，生活在空气污染程度高的地区的成年人可能需要摄入足够的维生素D并避免吸烟。Nutrition research | Ahead of Print.10.1016/j.nutres.2024.12.002Clinical nutrition ESPEN IF: 02.900
基于饮食的方法和治疗剂对胆固醇代谢和主要相关疾病的联合作用
Eugénia C M S Baptista, Cláudia S G P Pereira, Pablo A García, Isabel C F R Ferreira, João C M Barreira, etc.Background血脂异常是导致严重疾病的主要原因之一，尽管低胆固醇血症疗法已得到广泛认可，但降胆固醇疗法仍然面临着潜在副作用（如肌病、肌痛、肝损伤、消化问题或服用他汀类药物的某些人的精神模糊），与其他药物或特定食物的相互作用的重大担忧。因此，本综述描述了控制和调节血脂异常的最有效疗法的最新进展。Scope and approach在此，胆固醇的代谢动力学及其与当前疗法的整合：他汀类药物，胆汁酸螯合剂，贝特类药物，烟酸，前蛋白转化酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂，重组高密度脂蛋白（rHDL）或抗炎和免疫调节疗法。比较了它们的有效性，患者的粘附性和典型的副作用。同样，还考虑了这些疗法与推荐饮食习惯的相互作用，重点是功能性食品和营养保健品的摄取。Key findings and conclusions由于目前的治疗替代品都不是理想的解决方案（主要是由于副作用或患者的耐受性），因此提出了选择饮食（和其他健康习惯）的潜在辅助作用，作为提高降胆固醇效果的一种方法，同时减少由剂量增加或持续摄取替代治疗剂引起的不良反应。一般来说，必须承认适应良好饮食的相关性，并且必须在患者中鼓励其潜在影响，因为患者需要意识到相关的多因素优势。Clinical nutrition ESPEN | Ahead of Print.10.1016/j.clnesp.2025.01.026Int J Chron Obstruct Pulmon Dis IF: 02.700
血脂水平与慢性阻塞性肺疾病之间的因果关系：孟德尔随机分析
Ping Huang, Yong Zhao, Haiyan Wei, Wenhui Wu, Ziwen Guo, Shiyi Ma, etc.Background在初步研究和文献综述中，研究人员确定了慢性阻塞性肺疾病（COPD）与脂质代谢之间的潜在联系。因此，本研究采用孟德尔随机（MR）分析来研究血脂与COPD之间的潜在因果关系。Materials and methods对COPD进行了全基因组关联研究（GWAS），共有来自MRC-IEU的112583名欧洲参与者。此外，与欧洲队列中的血脂谱相关的广泛英国生物库数据包括440546例的低密度脂蛋白胆固醇（LDL-C），403943例的高密度脂蛋白胆固醇（HDL-C），441016例的甘油三酯（TG），187365例的总胆固醇（TC），393193例的载脂蛋白A-I（apoA-I）和439214例的载脂蛋白B（apoB）。然后，分别对脂质和COPD进行MR分析。采用的主要分析技术是逆方差加权（IVW）方法，其中包括95%置信区间（CI）来计算优势比（OR）。此外，还进行了敏感性分析，以评估MR分析结果的可靠性。ResultsMR分析主要基于IVW，揭示了COPD与LDL-C（OR=0.994,95%CI 0.989-0.999，P=0.019），TG（OR=1.005，95%CI 1.002-1.009，P=0.006）和apoA-I（OR=0.995，95%CI 0.992-0.999，P=0.008）之间的因果关系，此外，未发现与HDL-C，TC，apoB有因果关系。敏感性分析证明了这些因果关系的稳健性。然而，通过多变量MR（MVMR）和多次测试校正，LDL-C和TG对结果没有因果关系。ApoA-I仍然是COPD风险的保护因素（OR=0.994，95%CI 0.990-0.999，P=0.008）。Conclusion通过MR分析，本研究提供了apoA-I与COPD之间因果关系的证据。这进一步证实了脂质代谢在COPD中的潜在作用，并对COPD的预防和管理具有重要的临床意义。Int J Chron Obstruct Pulmon Dis | Volumn 20, IssueJCTR IF: 02.400
靶向PCSK9的CRISPR-Cas9：一种有前途的动脉粥样硬化治疗方法
Bin Gu, Min Li, Dan Li, Kaisen Huang, etc.CRISPR-Cas9基因编辑技术作为一种创新的生物医学工具，在预防和治疗动脉粥样硬化方面具有重要潜力。通过精确编辑PCSK9等关键基因，CRISPR-Cas9提供了长期调节低密度脂蛋白胆固醇（LDL-C）的可能性，这可能会降低心血管疾病的风险。VERVE-101等基因编辑疗法的早期临床研究取得了令人鼓舞的结果，突显了该技术的可行性和潜在功效。然而，临床应用仍面临脱靶效应、免疫原性和长期安全性等挑战。未来的研究应侧重于提高基因编辑的特异性和效率，优化递送系统，并改进个性化治疗策略。此外，建立道德和法律监管框架对于安全采用这项技术至关重要。随着基因编辑技术的不断进步，CRISPR-Cas9可能成为治疗动脉粥样硬化和其他复杂疾病的重要工具。10.1007/s12265-024-10587-7IJC CRP IF: 01.900
评估佩玛贝特在有或没有饮酒的高甘油三酯血症中的有益作用（PAR-CHAT：PARmodia CHikushi抗血脂异常试验）
Yosuke Takamiya, Chiyori Imanaga, Amane Ike, Akira Kawamura, Hidenori Urata, etc.Purpose检查佩玛贝特在门诊高甘油三酯血症（包括酒精性高甘油三酯血症）患者中的疗效和安全性。Method这项多中心，开放标签，前瞻性观察性研究（C20-07-009）包括在福冈大学Chikushi医院或相关诊所登记的高甘油三酯血症门诊患者。终点是血清甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C），肝脏生物标志物和其他血液值从基线到24周的变化和安全性。根据饮酒情况对患者进行比较。Result2020年10月至2022年3月，14家医疗机构登记 203例患者。分析了174例基线空腹TG值持续佩玛贝特24周的患者（平均年龄65.5岁）；55%的人饮酒，35%的人服用他汀类药物。空腹TG中位数在基线时为284 mg/dL（IQR，228-392 mg/dL），在24周时显著下降至141 mg/dL（IQR，108-194 mg/dL）（P<0.01），与饮酒无关（不饮酒组，259至134 mg/dL；每日饮酒组，318至169 mg/dL；偶尔饮酒组，298至158 mg/dL；所有P<0.01）。中位HDL-C从基线时的46 mg/dL（IQR，39-53 mg/dL）显著增加到24周时的53 mg/dL（IQR，45-60 mg/dL）（P<0.01）。肝脏生物标志物在24周时显著改善。低密度脂蛋白胆固醇（LDL-C）总体上显著增加，但在接受他汀类药物治疗的患者中没有。整个研究期间的副作用包括头晕和恶心（各1例患者）。Conclusion无论饮酒量如何，佩玛贝特均可改善TG，HDL-C，肝脏生物标志物和高甘油三酯血症，并且是安全的。他汀类药物治疗的患者LDL-C升高受到抑制。IJC CRP | Volumn 24, Issue10.1016/j.ijcrp.2024.200359Atherosclerosis Plus IF: 01.400
抑制PCSK9的新兴口服治疗策略
Nicola Ferri, Giorgia Marodin, etc.前蛋白转化酶枯草杆菌蛋白酶/Kexin 9（PCSK9）的药理学抑制已被确定为降低低密度脂蛋白（LDL）胆固醇水平和心血管事件的有效方法。每2或4周皮下注射单克隆抗体（evolocumab和alirocumab）可确定LDL胆固醇水平降低60%，而GalNac siRNA抗PCSK9（inclisiran）在初始皮下剂量后提供有效的降脂活性（-50%），3个月后重复，然后每6个月维持一次。尽管这两种方法有可能使大多数心血管风险高和非常高的患者达到适当的低密度脂蛋白胆固醇目标，但它们的成本和皮下给药对其大规模使用具有很大的限制。这些问题可以通过开发抗PCSK9的小化学分子作为控制高胆固醇血症的口服疗法来克服。在本综述中，总结了目前正在临床开发的口服抗PCSK9分子（DC371739，CVI-LM001和AZD0780）的药理学特性，包括模拟肽enlicitide decanoate（MK-0616）和NNC0385-0434。Atherosclerosis Plus | Volumn 59, Issue10.1016/j.athplu.2024.11.003Nature Reviews. Cardiology IF: 41.700
Ahead of Print.No.01Atherosclerosis in diabetes mellitus: novel mechanisms and mechanism-based therapeutic approaches糖尿病动脉粥样硬化：新机制和基于机制的治疗方法DOI: 10.1038/s41569-024-01115-wEuropean Heart Journal IF: 37.600
Ahead of Print.No.02Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry杂合性家族性高胆固醇血症中的超重，肥胖和心血管疾病：EAS FH研究合作登记处DOI: 10.1093/eurheartj/ehae791Clin Gastroenterol Hepatol IF: 11.600
Ahead of Print.No.03Lifestyle and Pharmacologic Approaches to Prevention of MASLD-related HCC生活方式和药理学方法预防MASLD相关性肝癌DOI: 10.1016/j.cgh.2024.09.041Environ Sci Technol IF: 10.800
Ahead of Print.No.04Hepatotoxicity of Three Common Liquid Crystal Monomers in Mus musculus: Differentiation of Actions Across Different Receptors and Pathways三种常见液晶单体对小家鼠的肝毒性：不同受体和途径的作用差异DOI: 10.1021/acs.est.4c08945Journal of controlled release IF: 10.500
Ahead of Print.No.05Design, evaluation, and in vitro-in vivo correlation of self-nanoemulsifying drug delivery systems to improve the oral absorption of exenatide自纳米乳化药物递送系统的设计，评估和体外-体内相关性，以改善艾塞那肽的口服吸收DOI: 10.1016/j.jconrel.2025.01.013Materials today bio IF: 08.700
Volumn 30, Issue No.06Application of therapeutical nanoparticles with neutrophil membrane camouflaging for inflammatory plaques targeting against atherosclerosis具有中性粒细胞膜伪装的治疗性纳米颗粒在针对动脉粥样硬化的炎性斑块中的应用DOI: 10.1016/j.mtbio.2024.101397JPAD IF: 08.500
Volumn 12, Issue 1No.07Cardiovascular health, genetic predisposition, and dementia risk among atherosclerotic cardiovascular disease patients动脉粥样硬化性心血管疾病患者的心血管健康，遗传易感性和痴呆风险DOI: 10.1016/j.tjpad.2024.100020Neurology IF: 07.700
Volumn 104, Issue 2No.08Effect of Triheptanoin on Caudate Atrophy and Motor Scores in Patients With Early-Stage Huntington Disease: A Phase II Study三庚酸对早期亨廷顿病患者尾状核萎缩和运动评分的影响：II期研究DOI: 10.1212/WNL.0000000000210194Investigative radiology IF: 07.000
Ahead of Print.No.09ADAMTS4-Specific MR Peptide Probe for the Assessment of Atherosclerotic Plaque Burden in a Mouse ModelADAMTS4特异性MR肽探针用于评估小鼠模型中的动脉粥样硬化斑块负荷DOI: 10.1097/RLI.0000000000001152Acta pharmacologica Sinica IF: 06.900
Ahead of Print.No.10Endothelial Gsα deficiency promotes ferroptosis and exacerbates atherosclerosis in apolipoprotein E-deficient mice via the inhibition of NRF2 signaling内皮Gsα缺乏通过抑制NRF2信号传导促进载脂蛋白E缺陷小鼠的铁浓化并加剧动脉粥样硬化DOI: 10.1038/s41401-024-01446-xnpj science of food IF: 06.300
Volumn 9, Issue 1No.11Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MSUPLC-Q-Exactive Orbitrap MS探索石斛属植物抗动脉粥样硬化潜在生物活性的异同DOI: 10.1038/s41538-025-00371-5Ecotoxicol Environ Saf IF: 06.200
Ahead of Print.No.12Thiacloprid exposure disrupts the gut-liver axis and induces liver dysfunction in the Reeves' turtles (Mauremys reevesii)噻虫啉暴露会破坏肠-肝轴，并在里夫引起肝功能障碍；海龟（Mauremys reevesii）DOI: 10.1016/j.ecoenv.2025.117710Ecotoxicol Environ Saf IF: 06.200
Ahead of Print.No.13Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion纳米塑料对颈内动脉闭塞小鼠危害的多组学、行为学和形态学综合分析DOI: 10.1016/j.ecoenv.2025.117711Thyroid IF: 05.800
Ahead of Print.No.14Statin Use and the Risk of Graves' Orbitopathy: A Nationwide Population-Based Cohort Study他汀类药物的使用和Graves眼病：一项基于全国人群的队列研究DOI: 10.1089/thy.2024.0536Analytica chimica acta IF: 05.700
Volumn 1337, Issue No.15Aliphatic substrates-mediated unique rapid room temperature synthesis of carbon quantum dots for fenofibrate versatile analysis脂肪族底物介导的碳量子点的独特快速室温合成，用于非诺贝特的多功能分析DOI: 10.1016/j.aca.2024.343539Acta Physiologica IF: 05.600
Volumn 241, Issue 2No.16Transient receptor potential melastatin 7 cation channel, magnesium and cell metabolism in vascular health and disease瞬时受体电位melastatin 7阳离子通道、镁和细胞代谢在血管健康和疾病中的作用DOI: 10.1111/apha.14282Comput Methods Programs Biomed IF: 04.900
Ahead of Print.No.17Effect of plaque micro-watershed changes on carotid atherosclerosis斑块微分水岭变化对颈动脉粥样硬化的影响DOI: 10.1016/j.cmpb.2024.108582Atherosclerosis IF: 04.900
Ahead of Print.No.18Evaluation of a machine learning-based metabolic marker for coronary artery disease in the UK Biobank英国生物库中基于机器学习的冠状动脉疾病代谢标志物的评估DOI: 10.1016/j.atherosclerosis.2024.119103Archives of toxicology IF: 04.800
Ahead of Print.No.19Re-thinking the link between exposure to mercury and blood pressure重新思考汞暴露与血压之间的联系DOI: 10.1007/s00204-024-03919-8CNS neuroscience & therapeutics IF: 04.800
Volumn 31, Issue 1No.20The Efficacy of Intensive Statin Therapy in Acute Ischemic Stroke Following Intravenous Thrombolysis: The CASE II Study强化他汀类药物治疗静脉溶栓后急性缺血性卒中的疗效：病例II研究DOI: 10.1111/cns.70186Probiotics Antimicrob Proteins IF: 04.400
Ahead of Print.No.21Probiotics Supplementation for Improving Glucolipid Parameters in Individuals with Prediabetes: A Systematic Review and Meta-Analysis of Randomized Trials益生菌补充剂改善糖尿病前期患者的糖脂参数：随机试验的系统评价和荟萃分析DOI: 10.1007/s12602-025-10449-xAm J Prev Cardiol IF: 04.300
Volumn 21, Issue No.22Lipoprotein(a), high-sensitivity c-reactive protein, homocysteine and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis脂蛋白（a）、超敏c反应蛋白、同型半胱氨酸与动脉粥样硬化多民族研究中的心血管疾病DOI: 10.1016/j.ajpc.2024.100903J Cell Mol Med IF: 04.300
Volumn 29, Issue 1No.23USP18 Promotes Cholesterol Efflux and Mitigates Atherosclerosis by Deubiquitinating ABCG1USP18通过去泛素化ABCG1促进胆固醇流出并减轻动脉粥样硬化DOI: 10.1111/jcmm.70320Journal of inflammation research IF: 04.200
Volumn 18, Issue No.24Systemic Immune-Inflammation Index (SII) and Neutrophil-to-Lymphocyte Ratio (NLR): A Strong Predictor of Disease Severity in Large-Artery Atherosclerosis (LAA) Stroke Patients全身免疫炎症指数（SII）和中性粒细胞与淋巴细胞比率（NLR）：大动脉粥样硬化（LAA）卒中患者疾病严重程度的有力预测指标DOI: 10.2147/JIR.S500474Aquatic toxicology IF: 04.100
Ahead of Print.No.25Direct and transgenerational effects of simvastatin on the metabolism of the amphipod Gammarus locusta辛伐他汀对两足类蝗虫代谢的直接和跨代影响DOI: 10.1016/j.aquatox.2024.107221Journal of Vascular Surgery IF: 03.900
Ahead of Print.No.26Presentation, Treatment and Outcomes of Brachial Artery Aneurysms肱动脉瘤的表现、治疗和预后DOI: 10.1016/j.jvs.2025.01.001Scientific reports IF: 03.800
Volumn 15, Issue 1No.27Exploring the comorbidity mechanisms between atherosclerosis and hashimoto's thyroiditis based on microarray and single-cell sequencing analysis探索动脉粥样硬化与桥本之间的共病机制'；基于微阵列和单细胞测序分析的甲状腺炎DOI: 10.1038/s41598-025-85112-0Poultry science IF: 03.800
Ahead of Print.No.28Effect of dietary microalgae on growth performance and health in meat-type quails饲粮微藻对肉用鹌鹑生长性能和健康的影响DOI: 10.1016/j.psj.2024.104709Scientific reports IF: 03.800
Volumn 15, Issue 1No.29Author Correction: Yindanxinnaotong, a Chinese compound medicine, synergistically attenuates atherosclerosis progress作者更正：中药复方银丹心脑通协同减轻动脉粥样硬化进展DOI: 10.1038/s41598-024-81400-3Journal of nutrition IF: 03.700
Ahead of Print.No.30Effect of prebiotic supplementation on health status in adults with prediabetes: a systematic review and meta-analysis of randomized clinical trials益生元补充剂对糖尿病前期成年人健康状况的影响：随机临床试验的系统评价和荟萃分析DOI: 10.1016/j.tjnut.2025.01.003Food science & nutrition IF: 03.500
Volumn 13, Issue 1No.31Regulatory Roles of Quercetin in Alleviating Fructose-Induced Hepatic Steatosis: Targeting Gut Microbiota and Inflammatory Metabolites槲皮素在减轻果糖诱导的肝脂肪变性中的调节作用：靶向肠道微生物群和炎性代谢物DOI: 10.1002/fsn3.4612Food science & nutrition IF: 03.500
Volumn 13, Issue 1No.32Nutritional, Nutraceutical, and Medicinal Potential of Cantharellus cibarius Fr.: A Comprehensive ReviewCantharellus cibarius Fr的营养，营养和药用潜力：全面综述DOI: 10.1002/fsn3.4641Vascular pharmacology IF: 03.500
Ahead of Print.No.33Elucidating emerging signaling pathways driving endothelial dysfunction in cardiovascular aging阐明心血管衰老中驱动内皮功能障碍的新兴信号通路DOI: 10.1016/j.vph.2025.107462Experimental cell research IF: 03.300
Ahead of Print.No.34SOX11 Silence Inhibits Atherosclerosis Progression in ApoE-Deficient Mice by Alleviating Endothelial DysfunctionSOX11沉默通过减轻内皮功能障碍抑制ApoE缺陷小鼠的动脉粥样硬化进展DOI: 10.1016/j.yexcr.2025.114422NMCD IF: 03.300
Ahead of Print.No.35Association of Naples Prognostic Score with cardiovascular disease risk and its longitudinal prognostic impact on mortality in cardiovascular disease patients: Evidence from NHANES那不勒斯预后评分与心血管疾病风险的关联及其对心血管疾病患者死亡率的纵向预后影响：来自NHANES的证据DOI: 10.1016/j.numecd.2024.103840NMCD IF: 03.300
Ahead of Print.No.36Very low-calorie ketogenic diet reduces central blood pressure and cardiometabolic risk in post-menopausal women with essential hypertension and obesity: a single-center, prospective, open-label, clinical study极低热量生酮饮食可降低绝经后原发性高血压和肥胖女性的中枢血压和心脏代谢风险：一项单中心，前瞻性，开放标签的临床研究DOI: 10.1016/j.numecd.2024.103838Rheumatology international IF: 03.200
Volumn 45, Issue 1No.37Coronary artery calcification progression and renal involvement in patients with systemic lupus erythematosus: a longitudinal cohort study系统性红斑狼疮患者冠状动脉钙化进展和肾脏受累的纵向队列研究DOI: 10.1007/s00296-025-05785-8Current Cardiology Reports IF: 03.100
Volumn 27, Issue 1No.38Role of Trained Immunity in Heath and Disease受过训练的免疫力在健康和疾病中的作用DOI: 10.1007/s11886-024-02167-7J Atheroscler Thromb IF: 03.000
Ahead of Print.No.39A Comprehensive Analysis of Diabetic Complications and Advances in Management Strategies糖尿病并发症综合分析及管理策略进展DOI: 10.5551/jat.65551Journal of women's health IF: 03.000
Ahead of Print.No.40The Association of Menopausal Age with Sex Hormones and Anthropometric Measures Among Postmenopausal Women in the Multi-Ethnic Study of Atherosclerosis Study动脉粥样硬化多民族研究中绝经后妇女绝经年龄与性激素和人体测量的关系DOI: 10.1089/jwh.2024.0508Clinical nutrition ESPEN IF: 02.900
Ahead of Print.No.41Interaction between genetic risk score and dietary carbohydrate intake on high- density lipoprotein cholesterol levels: Findings from the Study of Obesity, Nutrition, Genes and Social factors (SONGS)遗传风险评分和膳食碳水化合物摄入对高密度脂蛋白胆固醇水平的相互作用：肥胖、营养、基因和社会因素（SONGS）研究的结果DOI: 10.1016/j.clnesp.2024.12.027BMC endocrine disorders IF: 02.800
Volumn 25, Issue 1No.42Consequence of War on Diabetic Mellitus patients in Tigray region, Ethiopia: a longitudinal study埃塞俄比亚提格雷地区战争对糖尿病患者的影响：一项纵向研究DOI: 10.1186/s12902-025-01830-6Journal of experimental biology IF: 02.800
Volumn 228, Issue 1No.43Chronic bacterial infections exert metabolic costs in Drosophila melanogaster慢性细菌感染在黑腹果蝇中产生代谢成本DOI: 10.1242/jeb.249424Frontiers in neurology IF: 02.700
Volumn 15, Issue No.44Association between statin use and 30-day mortality among patients with sepsis-associated encephalopathy: a retrospective cohort study脓毒症相关性脑病患者他汀类药物使用与30天死亡率之间的关系：一项回顾性队列研究DOI: 10.3389/fneur.2024.1371314Neurological sciences IF: 02.700
Ahead of Print.No.45Patterns and predictors of statin therapy after ischemic stroke and TIA: insights from the LIPYDS multicenter study缺血性卒中和TIA后他汀类药物治疗的模式和预测因素：来自LIPYDS多中心研究的见解DOI: 10.1007/s10072-024-07969-9Gene IF: 02.600
Ahead of Print.No.46VAMP8 as a biomarker and potential therapeutic target for endothelial cell dysfunction in atherosclerosisVAMP8作为动脉粥样硬化内皮细胞功能障碍的生物标志物和潜在治疗靶点DOI: 10.1016/j.gene.2025.149231Analytical biochemistry IF: 02.600
Ahead of Print.No.47Microplate method for regioselective lipase screening with structured punicic acid triglycerides: finding Lip4 lipase as sn-2-regioselective from Candida rugosa isoforms微孔板法用结构化的石榴酸甘油三酯筛选区域选择性脂肪酶：从Candida rugosa亚型中发现具有sn-2区域选择性的Lip4脂肪酶DOI: 10.1016/j.ab.2025.115769BMC neuroscience IF: 02.400
Volumn 26, Issue 1No.48Identification of key genes associated with oxidative stress in ischemic stroke via bioinformatics integrated analysis通过生物信息学综合分析鉴定与缺血性卒中氧化应激相关的关键基因DOI: 10.1186/s12868-024-00921-9Chemistry & biodiversity IF: 02.300
Ahead of Print.No.49Phytochemical Profiling and Biological Activities of Nigella sativa Vinegar Extract: An Insight Into Hypoglycemic Potential Using In Vivo and In Silico Studies黑种草醋提取物的植物化学特征和生物活性：使用体内和计算机研究了解降血糖潜力DOI: 10.1002/cbdv.202402512Int J Gen Med IF: 02.100
Volumn 18, Issue No.50Association of Diabetes Mellitus with Carotid Artery Stenosis Undergoing Coronary Artery Bypass Graft in Bangladesh: A Prospective Cross-Sectional Study孟加拉国接受冠状动脉旁路移植术的糖尿病与颈动脉狭窄的关系：一项前瞻性横断面研究DOI: 10.2147/IJGM.S502441J Eval Clin Pract IF: 02.100
Volumn 31, Issue 1No.51Low Attainment of Treatment Targets for Cardiovascular Risk Factors in Indonesian Adults With Established Coronary Artery Disease印尼成年冠心病患者心血管危险因素治疗目标实现率低DOI: 10.1111/jep.14311Int J Gen Med IF: 02.100
Volumn 18, Issue No.52Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic Criteria不同诊断标准下甘油三酯-葡萄糖指数与高血压的关系DOI: 10.2147/IJGM.S499194Int J Gen Med IF: 02.100
Volumn 18, Issue No.53Patterns and Factors Associated with Dyslipidemia Among Patients with Diabetes Mellitus Attending Hoima Regional Referral Hospital, Uganda乌干达霍伊马地区转诊医院糖尿病患者血脂异常的模式和相关因素DOI: 10.2147/IJGM.S494941Urology IF: 02.100
Ahead of Print.No.54RETHINKING LOW TESTOSTERONE IN OLDER MEN: ASSOCIATION WITH OBESITY RATHER THAN AGING反思老年男性睾丸激素水平低：与肥胖而非衰老有关DOI: 10.1016/j.urology.2024.12.036J Exp Zool A Ecol Integr Physiol IF: 01.900
Ahead of Print.No.55Body Condition and Blood Biochemistry of Free-Range Caiman latirostris in Northeast Brazilian Atlantic Forest巴西大西洋森林东北部自由放养凯门鳄的身体状况和血液生化DOI: 10.1002/jez.2897J Diabetes Metab Disord IF: 01.800
Volumn 24, Issue 1No.56Health indicators in the management of diabetes in Primary health care: Iran-package of Essential Non-communicable diseases (IraPEN) program初级卫生保健中糖尿病管理的健康指标：伊朗基本非传染性疾病包（IraPEN）计划DOI: 10.1007/s40200-024-01550-zFolia Histochem Cytobiol IF: 01.700
Ahead of Print.No.57Anti-atherosclerotic effects of LncRNA NEXN-AS1 by regulation of the canonical inflammasome pathway of pyroptosis via NEXNLncRNA NEXN-AS1通过NEXN调节pyroptosis的典型炎性体途径的抗动脉粥样硬化作用DOI: 10.5603/fhc.102206In Vitro Cell Dev Biol Anim IF: 01.500
Ahead of Print.No.58Urolithin B suppresses phenotypic switch in vascular smooth muscle cells induced by PDGF-BB via inhibiting the PI3K-AKT pathway尿石素B通过抑制PI3K-AKT通路抑制PDGF-BB诱导的血管平滑肌细胞表型转换DOI: 10.1007/s11626-024-01005-yNeuro-chirurgie IF: 01.500
Ahead of Print.No.59Is there a relationship between lumbosacral epidural spinal injections and lumbosacral epidural lipomatosis? A retrospective study腰骶部硬膜外注射与腰骶部硬膜外脂肪增多症之间有关系吗？回顾性研究DOI: 10.1016/j.neuchi.2025.101636Atherosclerosis Plus IF: 01.400
Volumn 59, Issue No.60Familial hypercholesterolemia - Targeted whole gene sequencing as a diagnostic approach家族性高胆固醇血症靶向全基因测序作为诊断方法DOI: 10.1016/j.athplu.2024.12.001Atherosclerosis Plus IF: 01.400
Volumn 59, Issue No.61Impact of NAFLD-related SNPs on the carotid atherosclerosis development; a five-year prospective observational studyNAFLD相关SNP对颈动脉粥样硬化发展的影响；一项为期五年的前瞻性观察性研究DOI: 10.1016/j.athplu.2024.12.003J Int Med Res IF: 01.400
Volumn 53, Issue 1No.62Steatotic liver disease diagnosed in a 24-year-old woman with Rett syndrome: a case report24岁Rett综合征女性脂肪变性肝病1例DOI: 10.1177/03000605241310158Curēus IF: 01.000
Volumn 16, Issue 12No.63Trends in Cardiovascular Diseases and Costs Among Type 2 Diabetes Mellitus (T2DM) Patients in Malaysia: A Cohort Study of 240,611 Public Hospital Inpatients马来西亚2型糖尿病（T2DM）患者心血管疾病和费用的趋势：对240611名公立医院住院患者的队列研究DOI: 10.7759/cureus.75531Zhongguo zhongyao zazhi
Volumn 49, Issue 23No.64[Mechanism of Tanyu Tongzhi Formula in treatment of atherosclerosis by maintaining vascular homeostasis based on TGF-β signaling pathway][痰瘀通脂方基于TGF-β信号通路维持血管稳态治疗动脉粥样硬化的机制]DOI: 10.19540/j.cnki.cjcmm.20240802.709Zhongguo zhongyao zazhi
Volumn 49, Issue 23No.65[Mechanism of chrysophanol in inhibiting ox-LDL-induced macrophage foaminess through NF-κB/HMGB1-PI3K/Akt/mTOR pathway][大黄酚通过NF-κB/HMGB1-PI3K/Akt/mTOR通路抑制ox-LDL诱导的巨噬细胞泡沫形成的机制]DOI: 10.19540/j.cnki.cjcmm.20240912.702JACC: Advances
Volumn 4, Issue 1No.66Changes in Cardiovascular Health at Midlife and Subsequent Cardiovascular Outcomes in Individuals With Diabetes糖尿病患者中年心血管健康的变化及随后的心血管结局DOI: 10.1016/j.jacadv.2024.101450Dental research journal
Volumn 21, Issue No.67Antifungal effect of atorvastatin in comparison with fluconazole on Candida species isolated from patients undergoing head-and-neck radiotherapy阿托伐他汀与氟康唑对头颈部放疗患者念珠菌的抗真菌作用比较DOI: 10.4103/drj.drj_550_23JMCC PLUS
Volumn 11, Issue No.68Circulating autophagy regulator Rubicon is linked to increased myocardial infarction risk循环自噬调节剂Rubicon与心肌梗死风险增加有关DOI: 10.1016/j.jmccpl.2024.100279Biomolecules & biomedicine
Ahead of Print.No.69L-theanine promotes angiogenesis in limb ischemic mice by modulating NRP1/VEGFR2 signalingL-茶氨酸通过调节NRP1/VEGFR2信号传导促进肢体缺血小鼠的血管生成DOI: 10.17305/bb.2024.11256Circulation reports
Volumn 7, Issue 1No.70CORRIGENDUM: Impact of Controlling Serum Low-Density Lipoprotein Cholesterol and Triglycerides on Long-Term Clinical Outcomes in Diabetic Patients Who Have Undergone Percutaneous Coronary Intervention勘误：控制血清低密度脂蛋白胆固醇和甘油三酯对接受经皮冠状动脉介入治疗的糖尿病患者长期临床结局的影响DOI: 10.1253/circrep.CR-66-0020Euroasian J Hepatogastroenterol
Volumn 14, Issue 2No.71Characterizing Nonalcoholic Fatty Liver Disease (NAFLD) in Lean Individuals at a Tertiary Care Hospital: A Cross-sectional Study三级医院瘦人非酒精性脂肪性肝病（NAFLD）的横断面研究DOI: 10.5005/jp-journals-10018-1452
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