全球血脂速递（第017期）｜血脂水平和胰岛素抵抗标志物、他汀类药物、谷固醇血症
健康
2025-01-17 19:17
上海
截至01月17日15点59分，近期共有 223 本期刊发布了 317 篇文章，其中血脂相关的文章共 27 篇，覆盖 8 个领域的内容。其中影响因子最高的是刊登在 Theranostics (IF: 12.400) 期刊上标题为《基于巨噬细胞的易损斑块发病机制和治疗学》的文章。15Atherosclerosis(AS)动脉粥样硬化3Total Cholesterol(TC)总胆固醇1High Density Lipoprotein Cholesterol(HDL-C)高密度脂蛋白胆固醇1Hypertriglyceridemia(HTG)高甘油三酯血症World J Gastrointest Oncol IF: 02.500
结直肠癌患者的血脂水平和胰岛素抵抗标志物：倾向评分匹配分析
Ren-Hao Hu, Dong-Yi Yan, Ke-Hui Zhang, Di Zhang, Xi-Mao Cui, Xiao-Hua Jiang, etc.Background结直肠癌（CRC）是一种以微妙的早期表现为特征的普遍恶性肿瘤。Aim探讨CRC患者血脂谱、甘油三酯-葡萄糖（TyG）指数和动脉粥样硬化指数（AI）之间的相关性。此外，它探讨了在CRC背景下将血脂与癌症抗原相结合的临床诊断效用。Methods回顾性分析包括277例CRC患者和1034例健康个体。Results倾向评分匹配后，CRC患者的血清甘油三酯（TG），总胆固醇（TC），高密度脂蛋白胆固醇和低密度脂蛋白胆固醇（LDL-C）水平显著降低，TyG指数降低。相反，与健康人相比，他们的AI水平升高。与早期患者相比，晚期患者的血清TG，TC和LDL-C水平较低。淋巴结转移阳性的患者表现出TG，LDL-C和TyG指数降低。接受者操作特征分析显示，TyG指数，癌胚抗原和碳水化合物抗原19-9的组合对CRC的阳性预测率最高，为75.3%。Conclusion术前血脂谱与CRC患者密切相关。同时评估多种血脂和癌症抗原可有效提高CRC的诊断准确性。World J Gastrointest Oncol | Volumn 17, Issue 110.4251/wjgo.v17.i1.100204The annals of pharmacotherapy IF: 02.300
三级县级教学医院新诊断急性缺血性卒中或心肌梗死患者适当使用他汀类药物
Soomin Woo, Charles F Seifert, etc.Background他汀类药物是急性缺血性卒中（AIS）或心肌梗死（MI）患者的主要治疗方法；然而，一些研究表明，处方并不是最佳的。Objective这项研究的主要目的是评估AIS或MI后出院时接受适当他汀类药物治疗的患者百分比。Methods这是一项单中心回顾性队列研究，于2017年9月至2022年9月在一家三级县级教学医院对18至89岁新诊断为AIS或MI的患者进行。Results根据ICD-10代码，有636例因AIS或MI住院。其中，389例患者被排除在外，247例患者被纳入分析。尽管85%的AIS和MI患者未来发生ASCVD事件的风险很高，但超过25%的患者未接受适当的他汀类药物治疗。与在家服用低强度或中等强度他汀类药物的患者相比，入院前服用高强度他汀类药物或未服用他汀类药物的患者（156/194，80.4%）出院的可能性明显更高（27/53，50.9%，P<0.0001，OR=3.41，95%C 1.71-6.79）。Conclusion and relevance尽管大多数患者发生进一步ASCVD事件的风险很高，但AIS和MI后他汀类药物治疗患者的治疗仍然不理想。使用高强度他汀类药物或入院时未使用他汀类药物的患者在出院时接受适当治疗的人数明显增多。The annals of pharmacotherapy | Ahead of Print.10.1177/10600280241305436J Paediatr Child Health IF: 01.600
谷固醇血症是一种诊断不足且异质性脂质紊乱：澳大利亚一家三级医疗中心的病例系列
Dilhara Gamage, Kerryn Chisholm, Tatjana Kilo, Siew Ean Ooi, Shubha Srinivasan, etc.Aims谷固醇血症是一种植物固醇水平升高的疾病，导致不同的表现和血液学表现。尽管被认为是罕见的，但由于可变的表型和诊断挑战，患病率可能被低估了。延迟诊断可能导致心血管并发症。研究人员回顾了诊所中谷固醇血症患者的表现和管理。Method研究报告了4例年龄在18个月至18岁之间的儿童，其表现从黄瘤到溶血性贫血不等，随后通过基因检测证实患有谷固醇血症。Results一例患者出现黄瘤，两例患者出现血液学表现，另一例患者血脂异常。所有患者在年轻时都有很强的脂质紊乱和心血管疾病家族史。所有患者均进行了确认性基因检测，并通过饮食调整和依折麦布进行了管理，从而改善了血脂和血液学状况。Conclusion由于可变的表型和专门的遗传和生化诊断测试，谷固醇血症可能是一种诊断不足的脂质疾病。早期诊断和治疗完全逆转了临床表现和相关并发症。J Paediatr Child Health | Ahead of Print.Theranostics IF: 12.400
Volumn 15, Issue 4No.01Macrophage-based pathogenesis and theranostics of vulnerable plaques基于巨噬细胞的易损斑块发病机制和治疗学DOI: 10.7150/thno.105256Brain : IF: 10.600
Ahead of Print.No.02The association of seizure control with neuropathology in dementia癫痫发作控制与痴呆神经病理学的关系DOI: 10.1093/brain/awaf017Pharmacological research IF: 09.100
Ahead of Print.No.03Blocking ANGPTL3 and CD47 impact on atherosclerosis-correspondence阻断ANGPTL3和CD47对动脉粥样硬化对应的影响DOI: 10.1016/j.phrs.2025.107601Am J Gastroenterol IF: 08.000
Ahead of Print.No.04Clinical Outcomes in A Multi-center Cohort Involving 919 Patients with Hypertriglyceridemia-associated Acute Pancreatitis919例高甘油三酯血症相关性急性胰腺炎患者的多中心队列研究DOI: 10.14309/ajg.0000000000003319Int J Biol Macromol IF: 07.700
Ahead of Print.No.05Molecular cloning and heterologous expression of lipase gene from Pseudomonas aeruginosa in Escherichia coli铜绿假单胞菌脂肪酶基因的克隆及其在大肠杆菌中的异源表达DOI: 10.1016/j.ijbiomac.2025.139866ATVB IF: 07.400
Ahead of Print.No.06Reevaluating Anti-Inflammatory Therapy: Targeting Senescence to Balance Anti-Cancer Efficacy and Vascular Disease重新评估抗炎疗法：靶向衰老以平衡抗癌功效和血管疾病DOI: 10.1161/ATVBAHA.124.319870Antioxidants & redox signaling IF: 05.900
Ahead of Print.No.07ALOX15 Aggravates Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice with Type 2 Diabetes via Activating the PPARγ/CD36 AxisALOX15通过激活PPARγ/CD36轴加重2型糖尿病小鼠代谢功能障碍相关的脂肪变性肝病DOI: 10.1089/ars.2024.0670Life sciences IF: 05.200
Ahead of Print.No.08UGP2, a novel target gene of TP53, inhibits endothelial cells apoptosis and atherosclerosisTP53的新靶基因UGP2抑制内皮细胞凋亡和动脉粥样硬化DOI: 10.1016/j.lfs.2025.123393J Clin Endocrinol Metab IF: 05.000
Ahead of Print.No.09Genetic Variants Associated with the Biochemical Response to Vitamin D3 in the Multi-Ethnic Study of Atherosclerosis动脉粥样硬化多种族研究中与维生素D3生化反应相关的遗传变异DOI: 10.1210/clinem/dgaf025Atherosclerosis IF: 04.900
Ahead of Print.No.10Risk of atherosclerosis-related diseases in polymyositis and dermatomyositis patients: A large-scale population-based study多发性肌炎和皮肌炎患者动脉粥样硬化相关疾病的风险：一项基于人群的大规模研究DOI: 10.1016/j.atherosclerosis.2024.119100Expert Opin Ther Targets IF: 04.600
Ahead of Print.No.11Assessing platelet-derived extracellular vesicles for potential as therapeutic targets in cardiovascular diseases评估血小板衍生的细胞外囊泡作为心血管疾病治疗靶点的潜力DOI: 10.1080/14728222.2025.2454617Matrix biology IF: 04.500
Ahead of Print.No.12Endothelial cell (EC)-specific CTGF/CCN2 Expression Increases EC Reprogramming and Atherosclerosis内皮细胞（EC）特异性CTGF/CCN2表达增加EC重编程和动脉粥样硬化DOI: 10.1016/j.matbio.2025.01.003World journal of diabetes IF: 04.200
Volumn 16, Issue 1No.13Enhancing metformin efficacy with cholecalciferol and taurine in diabetes therapy: Potential and limitations胆钙化醇和牛磺酸在糖尿病治疗中增强二甲双胍疗效：潜力和局限性DOI: 10.4239/wjd.v16.i1.100066World journal of diabetes IF: 04.200
Volumn 16, Issue 1No.14Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes空肠侧侧吻合对2型糖尿病患者代谢指标影响的临床研究DOI: 10.4239/wjd.v16.i1.99526EHJ-ACVC IF: 03.900
Ahead of Print.No.15Ischemia with Non-Obstructive Coronary Arteries (INOCA) in the 2024 European Society of Cardiology (ESC) Guidelines for the management of chronic coronary syndromes2024年欧洲心脏病学会（ESC）慢性冠状动脉综合征管理指南中的非阻塞性冠状动脉缺血（INOCA）DOI: 10.1093/ehjacc/zuaf005Clinical interventions in aging IF: 03.500
Volumn 20, Issue No.16Association Between Four Non-Insulin-Based Insulin Resistance Indices and the Risk of Post-Stroke Depression四种基于非胰岛素的胰岛素抵抗指数与卒中后抑郁风险的关系DOI: 10.2147/CIA.S501569Current medicinal chemistry IF: 03.500
Ahead of Print.No.17Mitochondrial DNA Mutations as a Factor in the Heritability of Atherosclerosis and Other Diseases线粒体DNA突变是动脉粥样硬化和其他疾病遗传力的一个因素DOI: 10.2174/0109298673291199241129044139Domestic animal endocrinology IF: 01.900
Ahead of Print.No.18Alterations in serum concentrations of visfatin and betatrophin in dogs with diabetes mellitus糖尿病犬血清内脂素和β-内啡肽浓度的变化DOI: 10.1016/j.domaniend.2025.106914Physiological Research IF: 01.900
Volumn 73, Issue S3No.19In silico validation of non-invasive arterial compliance estimation and potential determinants of its variability无创动脉顺应性估计的计算机验证及其变异性的潜在决定因素DOI: 10.33549/physiolres.935466Physiological Research IF: 01.900
Volumn 73, Issue S3No.20Involvement of circulating microRNAs in the pathogenesis of atherosclerosis in young patients with obesity循环microRNA参与年轻肥胖患者动脉粥样硬化的发病机制DOI: 10.33549/physiolres.935467Health physics IF: 01.000
Ahead of Print.No.21Characterization of Cutaneous Radiation Syndrome in a Mouse Model Using [18F]F- Fluorodeoxyglucose Positron Emission Tomography使用[18F]F-氟脱氧葡萄糖正电子发射断层扫描表征小鼠模型中的皮肤放射综合征DOI: 10.1097/HP.0000000000001947Sisli Etfal Hastan T?p Bul IF: 01.000
Volumn 58, Issue 4No.22Adipsin and Leptin Levels in Type 2 Diabetic Patients on Sitagliptin and Metformin Versus Metformin Therapy西他列汀和二甲双胍与二甲双胍治疗2型糖尿病患者的Adipsin和瘦素水平DOI: 10.14744/SEMB.2024.74483JACC: Advances
Volumn 3, Issue 12No.23PREVENT and Pooled Cohort Equations in Mortality Risk Prediction: National Health and Nutrition Examination Survey死亡率风险预测中的预防和汇总队列方程：国家健康和营养检查调查DOI: 10.1016/j.jacadv.2024.101372Immunometabolism
Volumn 7, Issue 1No.24Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activation揭示NLRP3的舞蹈：炎性体激活的时空模式DOI: 10.1097/IN9.0000000000000053
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