慢阻肺月报202307(治疗部分)
文摘
科学
2023-07-21 12:17
上海
![]()
American Journal of Respiratory and Critical Care Medicine. 2023 Jun 26; PMID: 37364283Ensifentrine, a Novel PDE3 and PDE4 Inhibitor for the Treatment of COPD: Randomized, Double-Blind, Placebo-controlled, Multicenter, Phase III Trials (The ENHANCE Trials).Antonio Anzueto, Igor Z Barjaktarevic, Thomas M Siler, et al![]()
慢阻肺药物治疗领域近期略兴波澜，一方面是新药研发取得了进展，PDE抑制剂是其中一个类别，一方面是吸入制剂和装置方面的进展。同时，已有药物的优化选择也有持续探讨。这个月治疗方面的文章迎来一个小井喷，为此专列一期。American Journal of Respiratory and Critical Care Medicine. 2023 Jul 6; PMID: 37411039Icenticaftor, a CFTR Potentiator, in COPD: A Multicenter, Parallel-Group, Double-Blind Clinical Trial.Fernando J Martinez, Gerard J Criner, Christian Gessner, et al![]()
CFTR增效剂是治疗囊性纤维化的一类药物，其吸入剂型也在研发中。部分慢阻肺患者具有黏液高分泌表型，而且在慢阻肺患者中观察到了CFTR功能的改变，这建立了用CFTR增效剂治疗慢阻肺的基础。这项2b期研究证实icenticaftor在症状特别是咳嗽咳痰方面的效果，并且得到了最佳剂量，为后续研究的设计和开展提供了数据支撑。American Journal of Respiratory and Critical Care Medicine. 2023 Jul 14; PMID: 37450935A Double-Blind, Randomised, Placebo-controlled Trial of Long-Term Doxycycline Therapy on Exacerbation Rate in Patients with Stable COPD.James P Allinson, Ben H Vlies, Simon E Brill, et al![]()
在抗菌药物干预AECOPD方面，关键在于找到合适人群和药物（包括给药方式），具体内容有兴趣的读者可以阅读述评：https://doi.org/10.2478/jtim-2022-0005。European Respiratory Journal. 2023 Jun 29; PMID: 37385657Airway smooth muscle area to predict steroid responsiveness in COPD patients receiving triple therapy (HISTORIC): a randomised, placebo-controlled, double-blind, investigator-initiated trial.Daiana Stolz, Eleni Papakonstantinou, Maria Pascarella, et al![]()
European Respiratory Journal. 2023 Jun 21; PMID: 37343975Real-world comparative effectiveness of three single-inhaler dual bronchodilators for the treatment of chronic obstructive pulmonary disease.Jiaying Li, Sophie Dell Aniello, Pierre Ernst, et al![]()
Chest. 2023 Jun 17; PMID: 37419145The Effect of Inhaled Corticosteroids on Pneumonia Risk in Patients With COPD-Bronchiectasis Overlap: A UK Population-Based Case-Control Study.Andrew I Ritchie, Aran Singayagam, Sebastian Mitchell, et al![]()
Thorax. 2023 Jun 19; PMID: 37336642Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS).Rayan A Siraj, Charlotte E Bolton, Tricia M McKeever![]()
