慢阻肺月报202212(下)
文摘
科学
2022-12-19 00:50
上海
JAMA. 2022 Nov 22; 328 (20) : 2022-2032. PMID: 36413230Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial.Magnus Ekström, Diana Ferreira, Sungwon Chang, et al 证明“无用”的研究往往更“有用”,因其能避免出于以为有用而“善意”使用所导致的浪费甚至是不良反应,且对研究设计和实施的要求也更高。 Chest. 2022 Nov 30; PMID: 36462532Emphysema quantifications with CT: Assessing the effects of acquisition protocols and imaging parameters using virtual imaging trials.Ehsan Abadi, Giavanna Jadick, David A Lynch, et alChest. 2022 Dec 2; PMID: 36470414Differential impact of low fat-free mass in people with COPD based on body mass index classifications: results from COSYCONET.Felipe V C Machado, Claus F Vogelmeier, Rudolf A Jörres, et alChest. 2022 Dec 9; PMID: 36509123Generalizability of Risk Stratification Algorithms for Exacerbations in COPD.Joseph Khoa Ho, Abdollah Safari, Amin Adibi, et al过去1年的AE病史可预测未来AE风险,这个来自于大样本队列研究的结论具有简洁的美。但是,足够大的n湮没了个体间的差异,导致这个结论应用于具有高度异质性的COPD患者缺乏足够的合理性和说服力,因此有必要在更多维度上进行AE风险评估。又但是,越简单,可行性越强。可见,“对的”和“行的”并不始终落在一个象限里,如何因地制宜而取得最佳结局,正是最值得思考的。