慢阻肺月报202212(下)

文摘   科学   2022-12-19 00:50   上海  


JAMA. 2022 Nov 22; 328 (20) : 2022-2032. PMID: 36413230
Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial.
Magnus Ekström, Diana Ferreira, Sungwon Chang, et al 

证明“无用”的研究往往更“有用”,因其能避免出于以为有用而“善意”使用所导致的浪费甚至是不良反应,且对研究设计和实施的要求也更高。  
 
Chest. 2022 Nov 30; PMID: 36462532
Emphysema quantifications with CT: Assessing the effects of acquisition protocols and imaging parameters using virtual imaging trials.
Ehsan Abadi, Giavanna Jadick, David A Lynch, et al

定量CT怎么做,参数设定大有讲究。
 
Chest. 2022 Dec 2; PMID: 36470414
Differential impact of low fat-free mass in people with COPD based on body mass index classifications: results from COSYCONET.
Felipe V C Machado, Claus F Vogelmeier, Rudolf A Jörres, et al

 
Chest. 2022 Dec 9; PMID: 36509123
Generalizability of Risk Stratification Algorithms for Exacerbations in COPD.
Joseph Khoa Ho, Abdollah Safari, Amin Adibi, et al

过去1年的AE病史可预测未来AE风险,这个来自于大样本队列研究的结论具有简洁的美。但是,足够大的n湮没了个体间的差异,导致这个结论应用于具有高度异质性的COPD患者缺乏足够的合理性和说服力,因此有必要在更多维度上进行AE风险评估。又但是,越简单,可行性越强。可见,“对的”和“行的”并不始终落在一个象限里,如何因地制宜而取得最佳结局,正是最值得思考的。

慢阻肺手抄本
To cure technically, to comfort psychologically, to relieve morally