慢阻肺月报202406

文摘   科学   2024-06-15 23:33   上海  


JAMA. 2024 May 19; PMID: 38762800

Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial.
Graham Devereux, Seonaidh Cotton, Mintu Nath, et al


New England Journal of Medicine. 2024 May 20; PMID: 38767614
Dupilumab for COPD with Blood Eosinophil Evidence of Type 2 Inflammation.
Surya P Bhatt, Klaus F Rabe, Nicola A Hanania, et al

“孤证不立”,现在有两项设计相仿的研究得出了一致结论,可信度大大提高了。

European Respiratory Journal. 2024 May 29; PMID: 38811045
Inhaled Treprostinil in Pulmonary Hypertension Associated with COPD: PERFECT study results.
Steven D Nathan, Rahul Argula, Maria G Trivieri, et al

只要设计合理、执行严格,即便是显示治疗失败的研究也有其价值,某种程度上甚至价值更大。

New England Journal of Medicine. 2024 May 19; PMID: 38767248
Early Diagnosis and Treatment of COPD and Asthma - A Randomized, Controlled Trial.
Shawn D Aaron, Katherine L Vandemheen, G Alex Whitmore, et al

在加拿大医疗系统背景下,COPD疾病筛查-按照指南的治疗能减少医疗系统负担。

New England Journal of Medicine. 2024 May 19; PMID: 38767252
Implications of Race Adjustment in Lung-Function Equations.
James A Diao, Yixuan He, Rohan Khazanchi, et al


Chest. 2024 May 24; PMID: 38797279
Small airways obstruction and mortality: Findings from the UK Biobank.
Valentina Quintero Santofimio, Ben Knox-Brown, James Potts, et al

说明的是相关性,而不是因果关系,从而也不能推导出干预SAO能降低死亡风险。

American Journal of Respiratory and Critical Care Medicine. 2024 Jun 6; PMID: 38843116
Association of Ground Glass Opacities with Systemic Inflammation and Progression of Emphysema.
Spyridon Fortis, Junfeng Guo, Prashant Nagpal, et al

慢阻肺手抄本
To cure technically, to comfort psychologically, to relieve morally