慢阻肺月报202302

文摘   科学   2023-02-19 21:12   上海  

GOLD 2023更新概览


JAMA. 2023 Feb 14; 329 (6) : 490-501. PMID: 36786790

Discriminative Accuracy of the CAPTURE Tool for Identifying Chronic Obstructive Pulmonary Disease in US Primary Care Settings.
Fernando J Martinez, MeiLan K Han, Camden Lopez, et al

从该研究的疾病定义看,并非用作筛查早期COPD,一秒量已经是低于60%预计值或者有急性加重史,即便如此,敏感度仍低于50%。

Chest. 2023 Jan 31; PMID: 36736486
Stronger associations of centrilobular than paraseptal emphysema with longitudinal changes in diffusing capacity and mortality in COPD.
Yusuke Shiraishi, Naoya Tanabe, Kaoruko Shimizu, et al


Thorax. 2023 Feb 1; PMID: 36725331
Budesonide/formoterol maintenance and reliever therapy versus fluticasone/salmeterol fixed-dose treatment in patients with COPD.
Susan Muiser, Kai Imkamp, Dianne Seigers, et al

讨论COPD患者是以MART还是FDC策略来使用ICS,很SMART啊
顺及,关于GOLD 2023在稳定期吸入治疗中移除了ICS/LABA,更多的是作为参考。实践中究竟是否选择ICS/LABA,结合地区(例如双支扩和闭合三联药物的可及性)和患者实际情况(例如是否合并哮喘)更为合适。GOLD 2023更新概览

Thorax. 2023 Feb 1; PMID: 36725332
Characterising airway obstructive, dysanaptic and PRISm phenotypes of prematurity-associated lung disease.
Michael Cousins, Kylie Hart, Sarah J Kotecha, et al


Thorax. 2023 Feb 2; PMID: 36732083
Air pollution associated with incidence and progression trajectory of chronic lung diseases: a population-based cohort study.
Xiaojie Wang, Lan Chen, Miao Cai, et al

听说UK biobank是一个公开数据库,看了这个研究的authorship,我终于信了。

European Respiratory Journal. 2022 Dec 22; PMID: 36549711
RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD.
Hannelore P Van Eeckhoutte, Chantal Donovan, Richard Y Kim, et al


American Journal of Respiratory and Critical Care Medicine. 2023 Feb 1; PMID: 36724365
NRF2 Activation Reprogrammes Defects in Oxidative Metabolism to Restore Macrophage Function in COPD.
Eilise M Ryan, Pranvera Sadiku, Patricia Coelho, et al


American Journal of Respiratory and Critical Care Medicine. 2023 Feb 16; PMID: 36796082
A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease.
Samir Rustam, Yang Hu, Seyed Babak Mahjour, et al

慢阻肺手抄本
To cure technically, to comfort psychologically, to relieve morally