慢阻肺月报202311

文摘   科学   2023-11-09 21:25   上海  


Lancet Respiratory Medicine. 2023 Nov 1; PMID: 37924830
Blood eosinophil-guided oral prednisolone for COPD exacerbations in primary care in the UK (STARR2): a non-inferiority, multicentre, double-blind, placebo-controlled, randomised controlled trial.
Sanjay Ramakrishnan, Helen Jeffers, Beverly Langford-Wiley, et al


American Journal of Respiratory and Critical Care Medicine. 2023 Nov 2; PMID: 37917913
Blood-based Transcriptomic and Proteomic Biomarkers of Emphysema.
Rahul Suryadevara, Andrew Gregory, Robin Lu, et al


European Respiratory Journal. 2023 Oct 26; PMID: 37884305
Fibroblast growth factor 10 reverses cigarette smoke- and elastase-induced emphysema and pulmonary hypertension in mice.
Stefan Hadzic, Cheng-Yu Wu, Marija Gredic, et al


American Journal of Respiratory and Critical Care Medicine. 2023 Nov 7; PMID: 37934672
Spatial Transcriptomics Resolve an Emphysema-specific Lymphoid Follicle B Cell Signature in COPD.
Joselyn Rojas-Quintero, Scott A Ochsner, Felicia New, et al


American Journal of Respiratory and Critical Care Medicine. 2023 Nov 6; PMID: 37931077
Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary Disease.
Bradley W Richmond, Clayton B Marshall, Jessica B Blackburn, et al


Thorax. 2023 Oct 18; PMID: 37852778
Combined effect of ozone and household air pollution on COPD in people aged less than 50 years old.
Zhenzhen Xing, Ting Yang, Su Shi, et al


Chest. 2023 Oct 17; PMID: 37858719
Individual Risk Factors of PM 2.5 Associated with Wintertime Mortality in Urban Patients with Chronic Obstructive Pulmonary Disease (COPD).
Jordan Aron, Arianne K Baldomero, Austin Rau, et al

最后摘一篇综述,Lancet Respiratory Medicine. 2023 Oct 19; PMID: 37866374

Shaping urban environments to improve respiratory health: recommendations for research, planning, and policy.
Mark Nieuwenhuijsen, Audrey de Nazelle, Judith Garcia-Aymerich, Haneen Khreis, Barbara Hoffmann

由于空气污染和人口密度大等环境条件,城市地区的急性(传染性)和慢性呼吸道疾病负担沉重。以汽车为主的城市往往缺乏步行区,这就减少了体育锻炼的机会,而体育锻炼对健康的肺部至关重要。可利用的绿地面积本来就有限,而且植物的选择往往很差,这可能会产生花粉,进而诱发或加重过敏性疾病。较不富裕的居民区往往承担着更大的呼吸道疾病负担。需要采取更多样化的政策措施和城市创新,以减少空气污染(如低排放区)、增加步行和骑自行车的公共空间(如低交通流量街区、超级街区、15 分钟城市和无车城市),以及发展绿色城市(如种植低过敏性树木)。更严格的欧盟空气质量标准可以推动这些变革,改善市民的呼吸健康。医学呼吸学会的宣传也能为这些变革做出重要贡献。

近来,对城市呼吸健康的关注度明显上升,毕竟居住在城市的人口(55%)已经超过了农村,笔者参与撰写的一篇Viewpoint今年早些时候发表在blue journal上,该文简述了城市环境和呼吸慢病、呼吸系统感染之间的关系以及可能的改进措施,有兴趣的读者欢迎阅读全文:

https://doi.org/10.1164/rccm.202304-0759VP

慢阻肺手抄本
To cure technically, to comfort psychologically, to relieve morally