Essential features
Can occur throughout the large intestine but is most common in the sigmoid colon and rectum
Associated with no significant risk of malignant progression
Serrated architecture with a sawtooth appearance, with serrations generally limited to the upper half of the crypts
Main differential diagnosis is with sessile serrated lesions (SSLs)
Microvesicular variant not uncommonly contains a BRAF gene mutation
基本特征:可发生在整个大肠,但最常见于乙状结肠和直肠,无明显恶性进展风险。锯齿状结构有锯齿状外观,通常局限于隐窝的上半部分,主要的鉴别诊断是无蒂锯齿状病变(SSLs),微泡性HP通常含有BRAF基因突变。