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近日，Human Tumor Atlas Network (HTAN)项目连发包括3篇nature在内的11篇文章，介绍从肿瘤模型以及癌症/癌前病变样本中尽可能获取时空演化及细胞状态等信息的新方法（比如分allele地解析空间转录组中拷贝数变异，从而更好地分析肿瘤演化的方法[1]），提高分析效率[2]降低artifacts的工具（比如识别并去除免疫组化中因抗体聚集、切片皱卷等造成的artifacts的工具[3]）；并进一步结合这些方法和工具重点解析驱动结直肠癌和乳腺癌起始与转移的关键生物学过程，以及肿瘤亚型的异质性[4]，发现染色质中enhancer-promoter远程互作[5]，以及细胞分化可塑性（plasticity）变化[6]等在此过程发挥的关键作用。
以上工作2024年10月30日发表在Nature[1], [2], [11], [3]–[10]。
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[1] C.
Ma, M. Balaban, J. Liu, S. Chen, L. Ding, and B. J. Raphael, “Inferring
Allele-Specific Copy Number Aberrations and Tumor Phylogeography from Spatially
Resolved Transcriptomics,” Lect. Notes Comput. Sci. (including Subser. Lect.
Notes Artif. Intell. Lect. Notes Bioinformatics), vol. 14758 LNCS, pp. 466–469,
2024, doi: 10.1007/978-1-0716-3989-4_54.[2] H.
Kaur et al., “Consensus tissue domain detection in spatial omics data
using multiplex image labeling with regional morphology (MILWRM),” Commun.
Biol., vol. 7, no. 1, p. 1295, Oct. 2024, doi: 10.1038/s42003-024-06281-8.[3] G. J.
Baker et al., “Quality control for single-cell analysis of high-plex
tissue profiles using CyLinter,” Nat. Methods, Oct. 2024, doi:
10.1038/s41592-024-02328-0.[4] M. D.
Iglesia et al., “Differential chromatin accessibility and
transcriptional dynamics define breast cancer subtypes and their lineages,” Nat.
Cancer, Oct. 2024, doi: 10.1038/s43018-024-00773-6.[5] C. Moet al., Tumour evolution and microenvironment interactions in 2D and
3D space, vol. 634, no. November 2023. Springer US, 2024. doi:
10.1038/s41586-024-08087-4.[6] A. R.
Moorman et al., “Progressive plasticity during colorectal cancer
metastasis,” Nature, no. July 2023, Oct. 2024, doi:
10.1038/s41586-024-08150-0.[7] Y.
Zhu et al., “Global loss of promoter – enhancer connectivity and
rebalancing of gene expression during early colorectal cancer carcinogenesis,” Nat.
Cancer, 2024, doi: 10.1038/s43018-024-00823-z.[8] J.
Klughammer et al., “A multi-modal single-cell and spatial expression map
of metastatic breast cancer biopsies across clinicopathological features,” Nat.
Med., 2024, doi: 10.1038/s41591-024-03215-z.[9] M.
Islam et al., “Temporal recording of mammalian development and
precancer,” Nature, vol. 634, no. 8036, pp. 1187–1195, 2024, doi:
10.1038/s41586-024-07954-4.[10] E. D.
Esplin et al., “Multiomic analysis of familial adenomatous polyposis
reveals molecular pathways associated with early tumorigenesis,” Nat. Cancer,
pp. 1–39, Oct. 2024, doi: 10.1038/s43018-024-00831-z.[11] Z.
Sims, G. B. Mills, and Y. H. Chang, “MIM-CyCIF: masked imaging modeling for
enhancing cyclic immunofluorescence (CyCIF) with panel reduction and
imputation,” Commun. Biol., vol. 7, no. 1, pp. 1–6, 2024, doi:
10.1038/s42003-024-06110-y.商务合作：mss@pku.edu.cn（要求：1. 过审核；2. 标题明确标注）
