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熊智强，男，上海理工大学健康科学与工程学院教授，博士生导师，主要从事益生菌代谢调控方向研究。近5年主持国家自然科学基金面上（2项）、区域联合重点项目（合作方）、国家基础研发计划子课题和上海市自然科学基金面上项目（2项）等科研项目。授权中国发明专利26项和美国发明专利1项，在Bioresource Technology、Cell Research和Food Hydrocolloids等期刊上发表论文168篇，其中第一或者通讯作者论文78篇。入选上海市人才发展资金资助计划，获日内瓦国际发明展金奖和上海市技术发明一等奖各1项。
艾连中，教授/博导，上海理工大学健康科学与工程学院院长，上海食品微生物工程技术研究中心主任，中国食品科学技术学会常务理事及青年委员会主任委员，上海功能食品产业技术创新战略联盟理事长。获得国家“万人计划”科技创新领军人才、国家杰出青年科学基金、国家百千万人才工程、国务院政府特贴专家、教育部新世纪优秀人才、上海市领军人才等人才计划（项目）。从事食品优良微生物选育与利用、乳制品的研究与开发、多糖的结构与功能等方面的研究工作，主持科研项目30多项；主持获得上海市技术发明奖一等奖1项、上海市科技进步奖一等奖1项；授权发明专利80多件；发表科研论文300多篇；多项研究成果已经产业化应用。
Lactiplantibacillus plantarum AR113 alleviates microbiota dysbiosis of tongue coating and cerebral ischemia/reperfusion injury in rat
Zhiqiang Xionga,1, Gang Liub,1, Ling Fanga, Xiuming Lic, Yongjun Xiaa, Guangqiang Wanga, Xin Songa, Lianzhong Aia,*
a Shanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
b Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, China
c Department of Rehabilitation Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
1 Both authors contributed equally.
*Corresponding author.
Abstract
Stroke is one of the leading causes of death and disability worldwide. However, information on stroke-related tongue coating microbiome (TCM) is limited, and whether TCM modulation could benefit for stroke prevention and rehabilitation is unknown. Here, TCM from stroke patients (SP) was characterized using molecular techniques. The occurrence of stroke resulted in TCM dysbiosis with signif icantly reduced species richness and diversity. The abundance of Prevotella, Leptotrichia, Actinomyces, Alloprevotella, Haemophilus, and TM7_[G-1]were greatly reduced, but common infection Streptococcus and Pseudomonas were remarkably increased. Furthermore, an antioxidative probiotic Lactiplantibacillus plantarum AR113 was used for TCM intervention in stroke rats with cerebral ischemia/reperfusion (I/R). AR113 partly restored I/R induced change of TCM and gut microbiota with significantly improved neurological deficit, relieved histopathologic change, increased activities of antioxidant enzymes, and decreased contents of oxidative stress biomarkers. Moreover, the gene expression of antioxidant-related proteins and apoptosis-related factors heme oxygenase-1 (HO-1), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), nuclear factor erythroid 2-related factor 2 (Nrf2), NAD(P)H:quinone oxidoreductase-1 (NQO-1), and Bcl-2 was significantly increased, but cytochrome C, cleaved caspase-3, and Bax were markedly decreased in the brain by AR113 treatment. The results suggested that AR113 could ameliorate cerebral I/R injury through antioxidation and anti-apoptosis pathways, and AR113 intervention of TCM may have the application potential for stroke prevention and control.
XIONG Z Q, LIU G, FANG L, et al. Lactiplantibacillus plantarum AR113 alleviates microbiota dysbiosis of tongue coating and cerebral ischemia/reperfusion injury in rat[J]. Food Science and Human Wellness, 2024, 13(4): 2132-2140. DOI:10.26599/FSHW.2022.9250177.
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