NEURAL REGENERATION RESEARCH
Vol 20｜No. 11｜November 2025
封面文章
2型糖尿病（T2DM）和帕金森病是两种与老龄化社会相关的慢性疾病，对老年人群体影响深远，造成重大社会经济负担。流行病学数据支持T2DM与帕金森病之间存在密切联系，促使科学家探索两者之间的共同机制。脑胰岛素抵抗，即脑细胞对胰岛素反应不足，被认为是导致帕金森病的关键因素之一。研究发现，胰岛素信号传导受损可能引发蛋白质聚集、自噬障碍、线粒体功能异常、氧化应激、神经炎症、突触传递障碍、记忆和神经发生问题，这些都是帕金森病的潜在诱因。文章讨论了恢复大脑胰岛素信号和功能的新方法，这些方法可能为帕金森病患者带来治疗上的益处。
综述
Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury
人诱导多能干细胞衍生疗法用于中枢神经系统再生
Stephen Vidman, Yee Hang Ethan Ma, Nolan Fullenkamp, Giles Plant
Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases
工程化细胞外囊泡治疗神经系统疾病的靶向性能力
Xinyu Yang, Xiangyu Gao, Xiaofan Jiang, Kangyi Yue, Peng Luo
Epigenetic regulation of the inflammatory response in stroke
表观遗传调控脑卒中的炎症反应
Jingyi Liang, Fei Yang, Zixiao Li, Qian Li
Temporal dynamics of neonatal hypoxic–ischemic encephalopathy injuries on magnetic resonance imaging
磁共振成像显示新生儿缺氧缺血性脑病损伤的时间动态
Holly Flyger, Samantha J. Holdsworth, Alistair J. Gunn, Laura Bennet, Hamid Abbasi
Oligodendroglial heterogeneity in health, disease, and recovery: deeper insights into myelin dynamics
健康、疾病和恢复中的少突胶质异质性：髓磷脂动力学的更深入见解
Pieter-Jan Serneels, Julie D. De Schutter, Lies De Groef, Lieve Moons, Steven Bergmans
Copper homeostasis and neurodegenerative diseases
铜稳态与神经退行性疾病
Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang
Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway: a potential therapeutic approach for neurodegenerative diseases
探索肠道微生物群和环腺苷酸-蛋白激酶A信号通路互作：一种潜在的神经退行性疾病治疗方法
Fengcheng Deng, Dan Yang, Lingxi Qing, Yifei Chen, Jilian Zou, Meiling Jia, Qian Wang, Runda Jiang, Lihua Huang
Understanding the link between diabetes type 2 and Parkinson’s disease: role of brain insulin resistance
了解2型糖尿病与帕金森病之间的联系：大脑胰岛素抵抗的作用
Theodora Ntetsika, Sergiu-Bogdan Catrina, Ioanna Markaki
A systematic review of progenitor survival and maturation in Parkinsonian models
帕金森病模型中祖细胞存活和成熟的系统评价
Giulia Comini, Eilís Dowd
Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson’s disease
诱导多能干细胞相关方法产生多巴胺能神经元治疗帕金森病
Ling-Xiao Yi, Hui Ren Woon, Genevieve Saw, Li Zeng, Eng King Tan, Zhi Dong Zhou
Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury: state of the art and future perspectives
治疗周围神经损伤的间充质干细胞及外泌体疗法： "现状 "与 "未来之路"
Fatima Aldali, Chunchu Deng, Mingbo Nie, Hong Chen
观点
Reassessing the AMPK-MTORC1 balance in autophagy in central nervous system
重新评估中枢神经系统自噬中AMPK-MTORC1 的平衡
Marta García-Juan, Mario Villa, Irene Benito-Cuesta, Lara Ordóñez-Gutiérrez, Francisco Wandosell
Iron-handling solute carrier SLC22A17 as a blood–brain barrier target after stroke
铁处理溶质载体 SLC22A17 作为卒中后血脑屏障的靶点
Xueqi Ren, Wenlu Li
Vagus nerve stimulation in intracerebral hemorrhage: the need for further research
迷走神经刺激治疗脑出血：需要进一步研究
Sheharyar S. Baig, Ali Ali, Arshad Majid
Complex role of Protocadherin-19 in brain function: a focus on the oxytocin system
原粘蛋白-19在脑功能中的复杂作用：关注催产素系统
Sara Mazzoleni, Marta Busnelli, Silvia Bassani
Inspires effective alternatives to backpropagation: predictive coding help understanding and building learning
启发反向传播的有效替代方案：预测编码有助于理解和构建学习
Zhenghua Xu, Miao Yu, Yuhang Song
Beginning from the end: the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis
从终点开始：突触前末端作为额颞叶痴呆和肌萎缩侧索硬化的病理机制中心
Laura Huggon, Emma L. Clayton
Misfolded amyloid-beta conformational variant (strains) as drivers of Alzheimer’s disease neuropathology
错误折叠的淀粉样β蛋白构象变体（菌株）是阿尔茨海默病神经病理学的驱动因素
Salvatore Saieva, Rodrigo Morales
Proteostasis failure: at the intersection between aging and Alzheimer's disease
蛋白质稳态失调：衰老与阿尔茨海默病之间的交集
Natalia Poblete, Claudio Hetz
Targeting Epac2 and GluA3-containing AMPARs: a novel therapeutic strategy for Alzheimer’s disease
靶向含有 Epac2 和GluA3 的 AMPAR：阿尔茨海默病的新型治疗策略
Tong Zhang, Martina Schmidt
Context-dependency in medicine: how neuronal excitability influences the impact of dopamine on cognition
医学中的情境依赖性：神经元兴奋性如何影响多巴胺对认知的影响
Mahboubeh Ahmadi, Nahid Rouhi, Javad Mirnajafi-Zadeh, Bechara J. Saab
Role of resident memory T cells in neuroinflammatory and neurodegenerative diseases in the central nervous system
驻留记忆 T 细胞在中枢神经系统神经炎症和神经退行性疾病中的作用
Kimitoshi Kimura
Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis
肌萎缩侧索硬化症中 STAT3 信号的生化解析
Savina Apolloni, Nadia D’Ambrosi
Secretome of polarized macrophages: potential for targeting spinal cord injury inflammation dynamics
极化巨噬细胞的分泌蛋白组：脊髓损伤炎症动力学的潜力
Andreia Monteiro, Susana Monteiro, Nuno A. Silva
研究原著
脑损伤与神经再生
The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury
MAP4K 的 Citron-NIK 同源结构域可改善创伤性脑损伤的治疗效果
Xiaoling Zhong, Wenjiao Tai, Meng-Lu Liu, Shuaipeng Ma, Tianjin Shen, Yuhua Zou, Chun-Li Zhang
Human neural stem cell–derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway
人神经干细胞来源细胞外囊泡对缺血性脑卒中的神经保护
Jiayi Wang, Mengke Zhao, Dong Fu, Meina Wang, Chao Han, Zhongyue Lv, Liang Wang, Jing Liu
Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala: association with enhanced cued fear expression
谷氨酸能神经元中去泛素化酶CYLD缺失导致基底外侧杏仁核异常兴奋活动：与声音恐惧记忆有关
Huidong Li, Faqin Li, Zhaoyi Chen, Erwen Wu, Xiaoxi Dai, Danni Li, Haojie An, Shiyi Zeng, Chunyan Wang, Li Yang, Cheng Long
脊髓损伤与神经再生
Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury
坏死性凋亡神经干细胞分泌的外泌体可参与脊髓损伤后的细胞通讯
Shiming Li, Jianfeng Li, Guoliang Chen, Tao Lin, Penghui Zhang, Kuileung Tong, Ningning Chen, Shaoyu Liu
Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury
药物性靶向cGAS/STING/NF-κB通路调节脊髓损伤后的小胶质细胞极化
Ziwei Fan, Mengxian Jia, Jian Zhou, Zhoule Zhu, Yumin Wu, Xiaowu Lin, Yiming Qian, Jiashu Lian, Xin Hua, Jianhong Dong, Zheyu Fang, Yuqing Liu, Sibing Chen, Xiumin Xue, Juanqing Yue, Minyu Zhu, Ying Wang, Zhihui Huang, Honglin Teng
Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord
空间转录组学结合单核RNA测序揭示人类脊髓神经胶质细胞的异质性
Yali Chen, Yiyong Wei, Jin Liu, Tao Zhu, Cheng Zhou, Donghang Zhang
The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury
谷氨酸转运体的性别二态表达及对脊髓损伤后疼痛的影响
Jennifer M. Colón-Mercado, Aranza I. Torrado-Tapias, Iris K. Salgado, José M. Santiago, Samuel E. Ocasio Rivera, Dina P. Bracho-Rincon, Luis H. Pagan Rivera, Jorge D. Miranda
神经退行性疾病与神经再生
The compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer’s disease
(E)-2-(3,4-二羟基苯基)-3-羟基-4H-吡喃-4-1可减轻阿尔茨海默病神经炎症和认知障碍
Xueyan Liu, Wei Wu, Xuejuan Li, Chengyan Wang, Ke Chai, Fanru Yuan, Huijuan Zheng, Yuxing Yao, Chenlu Li, Zu-Cheng Ye, Daijun Zha
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